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Association between inflammatory mediators and angiographic morphologic features indicating thrombus formation in patients with acute myocardial infarction

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Chinese Medical Journal 2009年第15期122卷 1738-1742页

作者： li dong-bao hua qi liu zhi li jing xu li-qing wang shan jin wei-ying Department of Cardiology Xuanwu Hospital of Capital Medical University Beijing 100053 China

Background Inflammatory mechanisms had played an important role in the occurrence and prognosis of acute myocardial infarction, inflammatory mediators was associated with adverse outcomes of acute myocardial infarction. This study tested the hypothesis that in the acute phase of myocardial infarction with ST-segment elevation, neutrophil count and high-sensitivity C-reactive protein are predictive of angiographic morphologic features that indicate thrombus formation in the infarct-related artery. Methods This retrospective study included 182 consecutive patients with acute myocardial infarction and ST-segment elevation. Patients were assigned to a thrombus-formation group （n=77） and a non-thrombus-formation group （n=-106）. All patients had a Killip＇s classification 〈3 and onset 〈12 hours prior to presentation. All the cases were going to undergo coronary angiography, including primary percutaneous coronary intervention, simple coronary angiography, or thrombolysis in a coronary artery （or arteries） or coronary artery bypass graft（s）. Blood samples for measurement of high-sensitivity C-reactive protein and for routine blood laboratory studies were collected prior to coronary angiography. Results The levels of high-sensitivity C-reactive protein, total leukocyte counts, neutrophil counts, and neutrophil/ lymphocyte ratios were substantially higher in the thrombus-formation group than in the non-thrombus-formation group patients （for each, P 〈0.05）. Stepwise Logistic regression analyses identified high-sensitivity C-reactive protein, neutrophil count, and neutrophil/lymphocyte ratio as independent predictors of thrombus formation in the infarct-related artery （for each, P 〈0.05）. Conclusions In patients with acute myocardial infarction levels of high-sensitivity C-reactive protein are predictors to higher neutrophil counts, neutrophil/lymphocyte ratio, and ndicate thrombus formation

关键词： acute myocardial infarction thrombosis neutrophil percutaneous coronary intervention C-reactive protein

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An Integrated QTL Map of Fungal Disease Resistance in Soybean (Glycine max L. Merr):A Method of Meta-Analysis for Mining R Genes

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Agricultural Sciences in China 2010年第2期9卷 223-232页

作者： wang Jia-lin liu Chun-yan wang jing qi Zhao-ming li Hui HU Guo-hua CHEN qing-shan College of Agriculture Northeast Agricultural University Harbin 150030 P.R.China Land Reclamation Research ＆ Breeding Centre of Heilongjiang Harbin 150090 P.R.China The National Research Center of Soybean Engineering and Technology Harbin 150050 P.R.China College of Science Northeast Agricultural University Harbin 150030 P.R.China

Diseases caused by fungal pathogens account for approximately 50% of all soybean disease losses around the world. Conflicting results of fungal disease resistance QTLs from different populations often occurred. The objectives of this study were to：（i） evaluate evidence for reported fungal disease resistance QTLs associations in soybean and （ii） extract relatively reliable and useful information from the ＂real＂ QTLs and mine putative genes in soybean. An integrated map of fungal disease resistance QTLs in soybean was established with soymap 2 published in 2004 as a reference map. QTLs of fungal disease resistance developed from each of separate populations in recent 10 years were integrated into a combinative map for gene cloning and marker assisted selection in soybean. 107 QTLs from different maps were integrated and projected to the reference map with the software BioMercator 2.1. A method of meta-analysis was used to narrow down the confidence interval, and 23 ＂real＂ QTLs and their corresponding markers were obtained from 12 linkage groups （LG）, respectively. Two published R genes were found in these ＂real＂ QTLs intervals. Sequences in the ＂real＂ QTLs intervals were predicted by GENSCAN, and these predicted genes were annotated in Goblet. 228 resistance gene analogs （RGAs） in 12 different terms were mined. The results will lay the foundation for a bioinformatics platform combining abundant QTLs, and offer the basis for marker assisted selection and gene cloning in soybean.

关键词： soybean fungal disease QTL meta-analysis resistance gene analogs

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The Chinese Society of Clinical Oncology(CSCO):clinical guidelines for the diagnosis and treatment of gastric cancer

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Cancer Communications 2019年第1期39卷 75-105页

作者： Feng-hua wang lin Shen jin li zhi-wei Zhou Han liang Xiao-Tian Zhang Lei Tang Yan Xin jing jin Yu-jing Zhang Xiang-lin Yuan Tian-Shu liu Guo-Xin li qi Wu Hui-Mian xu Jia-Fu Ji Yuan-Fang li Xin wang shan Yu Hao liu Wen-Long Guan Rui-hua xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060GuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Department of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijing 100142P.R.China Department of Oncology Shanghai East HospitalTongji University School of MedicineShanghai 200120P.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060GuangdongP.R.China Department of Gastric Cancer Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center of CancerTianjin’s Clinical Research Cancer for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060P.R.China Medical Imaging Department Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Department of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijing 100142P.R.China Pathology Laboratory of Gastrointestinal Tumor The First Hospital of China Medical UniversityShenyang 110001LiaoningP.R.China Department of Radiation Oncology National Cancer CenterChina and Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060GuangdongP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhan 430030HubeiP.R.China Department of Medical Oncology Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032P.R.China Department of General Surgery Nanfang Hospital Affi

China is one of the countries with the highest incidence of gastric *** are differences in epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selection between gastric cancer patients from the Eastern and Western ***-Chinese guidelines cannot specifically reflect the diagnosis and treatment characteristics for the Chinese gastric cancer *** Chinese Society of Clinical Oncology(CSCO)arranged for a panel of senior experts specializing in all sub-specialties of gastric cancer to compile,discuss,and revise the guidelines on the diagnosis and treatment of gastric cancer based on the findings of evidence-based medicine in China and *** referring to the opinions of industry experts,taking into account of regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted experts’consensus judgement on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic *** guideline uses tables and is complemented by explanatory and descriptive notes covering the diagnosis,comprehensive treatment,and follow-up visits for gastric cancer.

关键词： Chinese Society of Clinical Oncology(CSCO) Gastric cancer Diagnosis Surgery Neoadjuvant Adjuvant Radiotherapy Chemotherapy Targeted therapy Immunotherapy

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High-Tech Acupuncture for Prevention of lifestyle Diseases--A Sino-Austrian Cooperation Research Protocol on Heart Rate Variability

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Chinese Journal of Integrative Medicine 2018年第6期24卷 423-428页

作者： liANG Feng-xia CHEN Ze-bin WU Song liu Jian-min wang jing-zhi LU Ji-dong wang Lu-shan CHEN li SHU qing Daniela litscher wang Lu wang hua Gerhard litscher College of Acupuncture and Orthopaedics Hubei University of Chinese Medicine Wuhan 430061 China Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture & Moxibustion Wuhan 430061 China Traditional Chinese Medicine Research Center Graz Research Unit for Complementary and Integrative Laser Medicine Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine Medical University of Graz Graz 8036 Austria

Background： Acupuncture can not only be used for well-known diseases, but also for so-called modern lifestyle-related diseases. Using innovative methods like e.g. new analyses of heart rate variability （HRV）, it is also possible to investigate diseases like burnout syndrome, ie., qi deficiency in Chinese medicine （CM）. Objective： The main object of this research protocol is to perform research on the relationship of burnout syndrome and heart rate （HR） and HRV. Methods： A total of 175 patients with burnout syndrome （qi deficiency syndrome） in five groups and 35 healthy volunteers will be investigated. Based on random numbers generated by computer and concealed in opaque envelops, the patients will be assigned to four acupuncture groups using Zusanli （ST 36） acupuncture stimulation, Guanyuan （CV4） acupuncture stimulation, both points, and both points with Streitberger device respectively, and a moxibustion group using both points mentioned above, with 35 cases in each group. Altogether four different experiments are planned. Experiment 1 includes 70 subjects and is a comparison between a burnout group and a control group （healthy volunteers）. The evaluation parameters are different scores and indices of HR and HRV. Experiment 2 includes 140 subjects and compares the efficacy of different acupuncture points. In experiment 3 （105 subjects）, acupuncture and moxibustion should be compared to healthy volunteers. Experiment 4 （70 subjects） investigates the long-term therapeutic effects of acupuncture and moxibustion on the scores of qi deficiency and HR/HRV in qi deficiency patients. In both the acupuncture and moxibustion groups, a total of 10 treatments will be performed. Conclusions： The joint research aims at the scientific evaluation of CM, mainly in the field of HRV. This parameter could be a very good indicator of the state of health and can be influenced by different acupuncture methods, as shown in the past.

关键词： heart rate variability burnout syndrome qi deficiency acupuncture moxibustion

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Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao dong li Shao-lin Xiong Yan-qiu Zhang Yang Su wei Chen Yi Zhao Xiao-Bo li Jia-Cong liu Wen-Xi Peng Rui qiao Xin-qiao li Xiang-Yang Wen li-Ming Song Shi-Jie Zheng Xin-ying Song Xiao-Yun Zhao Yue huang Shuang-Nan Zhang Shuo Xiao Ce Cai Zheng-hua An Can Chen Gang Chen wei Chen Yan-qi Du Min Gao Ke Gong dong-Ya Guo zhi-wei Guo Jian-Jian He Bin li Chao li Chao-Yang li Gang li Jian-Hui li Lu li qing-Xin li Yan-Guo li jing liang Xiao-hua liang jin-Yuan liao Xiao-jing liu Ya-qing liu qi Luo Xiang Ma Bin Meng Ge Ou dong-li Shi jing-Yan Shi Gong-Xing Sun Xi-Lei Sun You-li Tuo Chen-wei wang Hui wang jin wang jin-Zhou wang Ping wang Wen-Shuai wang Hong Wu Sheng-Lun Xie Yan-Bing xu Yu-Peng xu wang-Chen xue Sheng Yang Min Yao Jian-ying Ye qi-Bin Yi Chao-Yue Zhang Da-li Zhang Fan Zhang Fei Zhang Hong-Mei Zhang Kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

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SAPT:a synchrotron-based proton therapy facility in shanghai

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Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-Zhou Zhang De-Ming li li-Ren Shen Hai-Rong Zhang zhi-ling Chen Han-Wen Du Ming Gu Rui li De-Kang liu Yue-Hu Pu Jun-Feng Yu Jian-Feng Chen Chu Chen Chun-Long Guo Hao Guo Ge-Yang Jiang zhi-qiang Jiang lin jin Wen-jing li Xiu-Fang li Ye lin Ming liu Yong-Hao liu Ya-Juan liu Ming Lv qing-Ru Mi lian-hua Ouyang wei-Guo Shi Hang Shu qi-Sheng Tang Kun wang zhi-shan wang Jun Wu Xiao-Bing Wu Jia-qiang xu Wen-Zhen xu Chong-Xian Yin Cheng Yu Ren-Xian Yuan qi-Bing Yuan Hai-Qun Zhang Miao Zhang Wen-zhi Zhang li-ying Zhao wei-Min Zhou Shou-Xian Fang Xi-dong Sun Zhen-Tang Zhao shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

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Design of hadronic calorimeter for DarkSHINE experiment

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Nuclear Science and Techniques 2024年第9期35卷 155-167页

作者： Zhen wang Rui Yuan Han-qing liu jing Chen Xiang Chen Kim Siang Khaw liang li Shu li Kun liu qi-Bin liu Si-Yuan Song Tong Sun Xiao-Long wang Yu-Feng wang Hai-Jun Yang Jun-hua Zhang Yu-Lei Zhang zhi-Yu Zhao Chun-Xiang Zhu xu-liang Zhu Yi-Fan Zhu Tsung-Dao Lee Institute Shanghai Jiao Tong University1 Lisuo RoadShanghai 201210China Institute of Nuclear and Particle Physics School of Physics and Astronomy800 Dongchuan RoadShanghai 200240China Key Laboratory for Particle Astrophysics and Cosmology(MOE) Shanghai Key Laboratory for Particle Physics and Cosmology(SKLPPC)Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200443China Institute of Modern Physics Fudan UniversityShanghai 200443China

The sensitivity of the dark photon search through invisible decay final states in low-background experiments relies sig-nificantly on the neutron and muon veto efficiencies,which depend on the amount of material used and the design of the detector *** paper presents the optimized design of the hadronic calorimeter(HCAL)used in the DarkSHINE experiment,which is studied using a GEANT4-based simulation *** geometry is optimized by comparing a traditional design with uniform absorbers to one that uses different thicknesses at different locations on the detector,which enhances the efficiency of vetoing low-energy neutrons at the sub-GeV *** overall size and total amount of material used in the HCAL are optimized to be lower,owing to the load and budget requirements,whereas the overall performance is studied to satisfy the physical objectives.

关键词： Hadronic calorimeter GEANT4 simulation Neutron background Scintillation detector Dark photon

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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling qiao-Nan shan xu-Yong wei Rui wang Chang-Ku Jia li Zhuang Tian Shen li-Min Ding zhi-Dan xu Lai-Bang Luo li-Bo Sun Guang-Ming li Tai-Shi Fang Nan Jiang Kun Zhang Zhao-Jie Su zhi-Hai Peng Ren Lang Tao Jiang qiang He lin-Sen Ye Yang Yang Yu-Ting He Wen-zhi Guo liu-Gen Lan xu-Yong Sun dong Chen zhi-Shui Chen Da-wei Zhou Shao-Jun Ye qi-Fa Ye Min Tian Jian-hua Shi Bo wang Jiang liu qian Lu wei Rao jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen wang lin Zhong jing-Sheng Ma qi-Gen li Sheng-dong Wu Chang-Jiang Lu Cai-De Lu dong-hua Zhang xuan wang Zi-qiang li Mu-Jian Teng Jun-Jie li Wen-Tao Jiang Jian-hua li Quan-bao Zhang Ning-qi Zhu Zheng-Xin wang Kang He qiang Xia Shao-hua Song zhi-Ren Fu wei qiu Guo-Yue Lv Rui-Peng Song Ji-Zhou wang Zheng wang Jian Zhou Gang Chen ying-Peng Zhao li li Ze-Min Hu qi-Jie Luo Zhong-Zhou Si Bin Xie Xiao-Shun He zhi-Yong Guo Shu-Sen Zheng Xiao xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion

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Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： Yang Zhang Sheng-Quan Yan Ming He qing-Zhang Zhao Wen-Hui Zhang Chao-Xin Kan Jian-Ming Zhou Kang-Ning li Xiao-Fei wang Jian-Cheng liu Zhao-hua Peng Zhuo liang Ai-ling li Jian Zheng qi-Wen Fan Yun-Ju li You-bao wang zhi-Hong li Yang-Ping Shen Ding Nan wei Nan Yu-qiang Zhang Jia-ying-Hao li Jun-Wen Tian Jiang-lin Hou Chang-Xin Guo zhi-Cheng Zhang Ming-Hao Zhu Yu-Wen Chen Yu-Chen Jiang Tao Tian jin-Long Ma Yi-Hui liu jing-Yu dong Run-Long liu Mei-Yue-Nan Ma Yong-Shou Chen wei-Ping liu Bing Guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation Supernovae Chang'e-5 lunar samples

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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun liu Dan-Dan li wei dong Yu-qi liu Yang Wu Da-xuan Tang Fu-Chun Zhang Meng qiu qi hua jing-Yu He Jun li Bai Du Ting-Hai Du lin-lin Niu xue-Jun Jiang Bo Cui Jiang-Bin Chen Yang-Gan wang Hai-Rong wang qin Yu jing He Yi-lin Mao Xiao-Fang Bin Yue Deng Yu-Dan Tian qing-hua Han Da-jin liu li-qin Duan Ming-Jun Zhao Cui-ying Zhang Hai-ying Dai Ze-hua li ying Xiao You-zhi Hu Xiao-Yu huang Kun Xing Xin Jiang Chao-Feng liu jing An Feng-Chun li Tao Tao jin-Fa Jiang ying Yang Yao-Rong dong Lei Zhang Guang Fu ying li Shu-wei huang li-Ping Dou Lan-Jun Sun ying-qiang Zhao Jie li Yun Xia Jun liu Fan liu Wen-jin He ying li Jian-Cong Tan Yang lin Ya-Bin Zhou Jian-Fei Yang Guo-qing Ma Hui-Jun Chen He-Ping liu Zong-Wu liu Jian-Xiong liu Xiao-Jia Luo Xiao-Hong Bin Ya-Nan Yu Hai-Xia Dang Bing li Fei Teng wang-Min qiao Xiao-Long Zhu Bing-wei Chen qi-Guang Chen Chun-Ti Shen Yong-Yan wang Yun-Dai Chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

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建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

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