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Biomarkers for neuromyelitis optica:a visual analysis of emerging research trends

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Neural Regeneration Research 2024年第12期19卷 2735-2749页

作者： Xiangjun li Jiandong Zhang Siqi Zhang Shengling Shi Yi’an Lu Ying Leng chunyan li Department of Ophthalmology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina Department of Ophthalmology Changchun Bright Eye HospitalChangchunJilin ProvinceChina Departemt of Endocrinology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina

Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system that differs from multiple *** the past 20 years,the search for biomarke rs for neuromyelitis optica has been ***,we used a bibliometric approach to analyze the main research focus in the field of biomarkers for neuromyelitis *** in this area is consistently increasing,with China and the United States leading the way on the number of studies *** Mayo Clinic is a highly reputable institution in the United States,and was identified as the most authoritative institution in this ***,Professor Wingerchuk from the Mayo Clinic was the most authoritative expe rt in this *** analysis revealed that the terms "neuro myelitis optica"(261 times), "multiple sclerosis"(220 times), "neuromyelitis optica spectrum disorder"(132 times), "aquaporin4"(99 times),and "optical neuritis"(87 times) were the most frequently used keywords in literature related to this *** analysis of the classical literature showed that the majority of publications provide conclusive research evidence supporting the use of aquaporin-4-IgG and neuromyelitis optica-IgG to effectively diagnose and differentiate neuromyelitis optica from multiple ***,aquaporin-4-IgG has emerged as a highly specific diagnostic biomarker for neuromyelitis optica spectrum *** oligodendrocyte glycoprotein-IgG is a diagnostic biomarke r for myelin oligodendrocyte glycoprotein antibody-associated *** biomarkers for neuromyelitis optica in clude cerebrospinal fluid immunological biomarkers such as glial fibrillary acidic protein,serum astrocyte damage biomarkers like FAM19A5,serum albumin,and gammaaminobutyric *** latest prospective clinical trials are exploring the potential of these *** results indicate that glial fibrillary acidic protein is emerging as a promising candidate biomarker for neuromyelit

关键词： aquaporin-4 autoantibody multiple sclerosis myelin oligodendrocyte glycoprotein antibody-associated disease neuromyelitis optica neuromyelitis optica spectrum disorder optical coherence tomography

Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial

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Neural Regeneration Research 2024年第4期19卷 923-928页

作者： Xiangjun li chunyan li Hai Huang Dan Bai Jingyi Wang Anqi Chen Yu Gong Ying Leng Department of Ophthalmology Affiliated Hospital of Beihua University Department of Endocrinology Affiliated Hospital of Beihua University

The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting *** major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser ***,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many *** might result from the incomplete recovery of retinal ganglion cell ***,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision *** this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their *** patients will be followed up for 12 *** primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after *** secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after *** measure is the incidence of adverse events at 1,3,6,9,and 12 months after *** study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up *** trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal

关键词： choroidal thickness diabetic macular edema laser photocoagulation retinal ganglion cell-inner plexiform layer thickness retinal ganglion cells retinal nerve fiber layer thickness thickness of the macular area vascular endothelial growth factor visual acuity

Capacity Allocation of Renewable Energy Sources Considering Complementarity

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1415-1426页

作者： Yinzhe Hu Kaigui Xie Bo Hu Hengming Tai Changzheng Shao chunyan li Xueying Yu State Key Laboratory of Power Transmission Equipment and System Security at the Chongqing University Chongqing 400030China Department of Electrical and Computer Engineering University of TulsaTulsaOK 74104USA

The outputs of renewable energy sources(RESs)are inherently variable and uncertain,such as wind power(WP)and photovoltaic(PV).However,the outputs of various types of RESs in different regions are *** the capacity of RESs could be properly allocated during system planning,variability of the total output could be ***,system reliability and renewable energy(RE)consumption could be *** paper proposes an analytical model for optimal complementary capacity allocation of RESs to decrease variability of the total *** model considers the capacity ratio of RESs as decision variables and the coefficient of variation(CV)of the total output as the objective *** proposed approach transforms the single-level optimization model into a bilevel optimization model and derives an analytical equation that can directly calculate the optimal complementary capacity ratio(OCCR)of system *** studies on wind and solar farms in Xinjiang and Qinghai,China,are performed to verify the effectiveness of the proposed analytical allocation method.

关键词： Analytical equation capacity allocation complementary optimization renewable energy variability

In-situ electrochemical study on the eff ects of Fe(Ⅲ)on kinetics of pyrite acidic pressure oxidation

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Acta Geochimica 2024年第4期43卷 814-825页

作者： Yu Zhang Can Cui Sen lin Heping li lian Yang Yadian Xie Hailiang Hu lingyun Zhou Huanjiang Wang chunyan li School of Chemical Engineering Guizhou Minzu UniversityGuiyang 550025China Key Laboratory of High-Temperature and High-Pressure Study of the Earth’s Interior Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

Fe(Ⅲ)has been proved to be a more eff ective oxidant than dissolved oxygen at ambient temperature,however,the role of Fe(Ⅲ)in pyrite acidic pressure oxidation was rarely discussed so *** this paper,in-situ electrochemical investigation was performed using a flow-through autoclave system in acidic pressure oxidation *** results illustrated that increasing Fe(Ⅲ)concentrations led to raising in redox potential of the solution,and decreased passivation of pyrite caused by deposition of elemental *** of Fe(Ⅲ)at pyrite surface was a fast reaction with low activation energy,it was only slightly promoted by rising ***,the oxidation rate of pyrite at all investigated Fe(Ⅲ)concentrations increased obviously with rising temperatures,the anodic reaction was the rate-limiting step in the overall *** energy of pyrite oxidation decreased from 47.74 to 28.79 kJ/mol when Fe(Ⅲ)concentration was increased from 0.05 to 0.50 g/L,showing that the reaction kinetics were limited by the rate of electrochemical reaction at low Fe(Ⅲ)concentrations,while,it gradually turned to be diffusion control with increasing Fe(Ⅲ)concentrations.

关键词： Pyrite Pressure oxidation Fe(Ⅲ) In-situ electrochemistry Hydrothermal experiment

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy G.White chunyan li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty:a prospective,double-blind,pilot,randomised controlled trial

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General Psychiatry 2024年第2期37卷 224-233页

作者： Jie Yang Mingshu Tao Rongguang liu Jiaxing Fang chunyan li Dexian Chen Qi Wei Xingyu Xiong Wenxin Zhao Wen Tan Yuan Han Hongxing Zhang He liu Song Zhang Junli Cao Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Hospital of Chengdu University of Traditional Chinese Medicine&Traditional Chinese Medicine Hospital of Sichuan ProvinceChengduSichuanChina NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs&Jiangsu Province Key Laboratory of Anesthesiology&Jiangsu Key Laboratory of Applied Technology of Anesthesia and Analgesia Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Eye&ENT Hospital of Fudan UniversityShanghaiChina Department of Anesthesiology&Clinical Research Center for Anesthesia and Perioperative Medicine&Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University||Huzhou Central Hospital||The Affiliated Huzhou HospitalZhejiang University School of Medicine||Affiliated Central Hospital Huzhou UniversityHuzhouZhejiangChina Department of Anesthesiology Renji Hospital School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Postoperative sleep disturbance(PSD)is a common and serious postoperative complication and is associated with poor postoperative *** This study aimed to investigate the effect of transcranial direct current stimulation(tDCS)on PSD in older patients undergoing lower limb major *** In this prospective,double-blind,pilot,randomised,sham-controlled trial,patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS(a-tDCS)or sham tDCS(s-tDCS).The primary outcomes were the objective sleep measures on postoperative nights(N)1 and *** 116 inpatients were assessed for eligibility,and a total of 92 patients were enrolled;47 received a-tDCS and 45 received *** improved PSD by altering the following sleep measures in the a-tDCS and s-tDCS groups;the respective comparisons were as follows:the promotion of rapid eye movement(REM)sleep time on N1(64.5(33.5-105.5)vs 19.0(0.0,45.0)min,F=20.10,plight sleep and REM sleep on N1 and N2(plimb major arthroplasty,a single session of anodal tDCS over the left dorsolateral prefrontal cortex showed a potentially prophylactic effect in improving postoperative short-term objective sleep ***,this benefit was temporary and was not maintained over time.

关键词： sleep stimulation postoperative

风电网源波动对并网点等值阻抗估计影响及电网阻抗在线辨识

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电网技术 2024年第6期48卷 2376-2384,I0037页

作者：李春彦李少林王伟胜秦世耀李庆可再生能源并网全国重点实验室(中国电力科学研究院有限公司) 北京市海淀区100192

风电等新能源发电并网性能对电网强度较为敏感,作为衡量新能源场站接入点电网强度的重要指标,风电场并网点电网侧的戴维南等值阻抗在线辨识对风电稳定运行风险评估及策略优化意义重大。首先介绍了戴维南等值阻抗估计原理,揭示了网源两... 详细信息

风电等新能源发电并网性能对电网强度较为敏感,作为衡量新能源场站接入点电网强度的重要指标,风电场并网点电网侧的戴维南等值阻抗在线辨识对风电稳定运行风险评估及策略优化意义重大。首先介绍了戴维南等值阻抗估计原理,揭示了网源两侧波动对等值阻抗辨识精度的影响与变化规律,明确了实现等值阻抗准确辨识及在线应用的波动数据筛选原则。在此基础上,设计了测量点电压相量和功率波动信息相融合的数据筛选指标,提出了网源数据波动特征筛选与等值阻抗线性关系描述相结合的电网阻抗的在线辨识方法,有效克服了复杂网源条件下等值阻抗辨识误差大的问题。最后通过仿真和现场实测数据证明了理论分析与所提方法的准确性与有效性。

关键词：风电并网点戴维南等值阻抗辨识

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EGFR-mutant non-small cell lung cancer patients harboring CDK4 amplification show favorable response to afatinib:Two case reports

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Chinese Medical Journal 2024年第12期137卷 1465-1467页

作者： Shuting Zhan Bo Cheng Xiwen liu Jianfu li Ge Bai Qi Cai Huiting Wang Yang Xiang chunyan li Jianxing He Wenhua liang Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical University&Guangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhouGuangdong 510120China National Center for Respiratory Medicine State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseasesGuangzhou Institute of Respiratory Health&The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China Southern Medical University GuangzhouGuangdong 510120China Department of Respiratory and Critical Care Medicine The Tenth Affiliated Hospital of Southern Medical UniversityDongguanGuangdong 523108China

To the Editor:Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)show significant efficacy in patients with advanced-stage non-small cell lung cancer(NSCLC)with sensitive EGFR mutations and significantly prolong the survival of these ***,drug resistance emerges in most *** studies indicated that cyclin-dependent kinase 4/6(CDK4/6)gene amplification was one of the resistance mechanisms of the EGFR-TKI osimertinib,weakening its *** options for EGFR-mutant NSCLC patients with CDK4 amplification are limited to add CDK4 inhibitors.

关键词： CDK4 NSCLC EGFR

GRIN色散物镜光学像差对峰值波长提取的影响

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光子学报 2024年第3期53卷 100-113页

作者：李春艳李丹琳刘继红李可蒋杰伟西安邮电大学电子工程学院西安710121

为提高光谱共焦位移传感系统接收信号峰值波长提取精度,基于设计的梯度折射率(Gradient Index,GRIN)色散物镜,系统分析了光学像差对峰值波长提取的影响。首先结合GRIN色散透镜的光学性能,利用光学像差理论,建立了优化后GRIN色散物镜的... 详细信息

为提高光谱共焦位移传感系统接收信号峰值波长提取精度,基于设计的梯度折射率(Gradient Index,GRIN)色散物镜,系统分析了光学像差对峰值波长提取的影响。首先结合GRIN色散透镜的光学性能,利用光学像差理论,建立了优化后GRIN色散物镜的像差分布函数,获得了各类像差与波长分布之间的关系;然后仿真分析了各类单色像差以及组合像差对峰值波长分布的影响,利用三种拟合算法分别提取存在不同像差下的峰值波长,得到了光学像差引起的GRIN色散物镜峰值波长偏移;最后利用不同的拟合方法对像差影响下的轴向响应信号进行了数据拟合和拟合误差分析。结果表明,球差为1时,引起峰值波长偏移6.28 nm;当球差大于1时,出现双峰,球差越大引起的峰值波长偏移越大;像散对峰值波长偏移的影响小于球差;组合像差对峰值波长的影响最大,出现了三峰旁瓣同时升高。研究结果对建立像差影响的峰值波长提取误差修正和补偿算法,并进一步提高系统测量精度具有参考意义。

关键词：梯度折射率色散物镜光学像差峰值波长提取数据拟合光谱共焦