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Rhodium-catalyzed aerobic N-alkylation of sulfonamides with alcohols

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Chinese Chemical Letters 2011年第9期22卷 1021-1024页

作者： Sun lin Feng Chuan Zhi liu Qiang li Xiao chun yu Qing Xu College of Chemistry and Materials Engineering Wenzhou University Wenzhou 325035 China

By using the famous Wilkinson＇s catalyst, N-alkylation of sulfonamides can be easily realized under mild aerobic conditions by using alcohols as the alkylating reagent, giving monoalkylated sulfonamides in high yields and selectivities with water produced as the only byproduct. This advantageous aerobic method is potentially general in substrate scope that it can also be applied to other amides, amines and alcohols.

关键词： Alcohols Sulfonamides Rhodium catalyst N-Alkylation reaction Aerobic reaction

Idiosyncratic Drug-Induced liver Injury linked to Polygonum multiflorum:A Case Study by Pharmacognosy

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Chinese Journal of Integrative Medicine 2017年第8期23卷 625-630页

作者： li chun-yu HE Qin GAO Dan li Rui-yu ZHU yun li Hui-fang FENG Wu-wen YANG Mei-hua XIAO Xiao-he WANG Jia-bo Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College China Military Institute of Chinese Medicine 302 Military Hospital School of Pharmacy Hunan University of Traditional Chinese Medicine School of Pharmacy Shanxi University of Traditional Chinese Medicine

The use of Chinese medicinal herbs（CMH）continues to expand rapidly across the world with a deep belief that herbs are safe because they are＂natural＂.（1）However,a survey of the literature indicates that CMH related hepatotoxicity is increasing and has been a worldwide problem.（2,3）Polygonum multiflorum Thunb.（***）,officially listed in the Pharmacopoeia of the People＇s Republic of China.

关键词： Idiosyncratic Drug-Induced liver Injury linked to Polygonum multiflorum:A Case Study by Pharmacognosy UHPLC DIli

串联质谱仪在新生儿遗传代谢病筛查中的应用(英文)

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北京大学学报（医学版） 2006年第1期38卷 103-106页

作者： chun-li yu 顾学范 Department of Human Genetics Emory University School of Medicine Atlanta Georgia USA 上海第二医科大学附属新华医院、上海市儿科医学研究所上海200092

Application of TMS technology in newborn screening has resulted in major expansion of disorder panel for metabolic diseases in recent years. This automated, multiplex testing methodology detects multiple analytes from single analysis of one blood spot, which leads to detection of 30-35 disorders of amino acids, organic acids, and fatty acids metabolism. The early identification of persons affected with inborn errors of metabolism has led to unexpected discoveries related to the natural history of the disorder or options for therapy. This article summarized (1) the basic principles of this technology and methodology. (2) Current status of application of this methodology in the United States, European countries and in China. (3) The positive impacts on the public health and advances in medical genetics. Finally (4) Challenges, issues and possible solutions. The purpose of this article aimed at introducing new technology and exploring the possibilities of implementing into developing countries where medical genetics is not developed and foreseeing the possible problems and obstacles.

关键词：光谱分析质量新生儿筛查代谢缺陷先天性遗传病代谢病串联质谱仪

Sclerostin regulation:a promising therapy for periodontitis by modulating alveolar bone

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Chinese Medical Journal 2020年第12期133卷 1456-1461页

作者： Tian-Jiao li Rui Wang Qin-Yang li chun-yu li li Jiang State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China

Periodontitis is one of the most prevalent epidemics affecting human health and life recently,and exploration of the pathogenesis and treatment of periodontitis has been valued by *** recent years,sclerostin,a new factor on bone resorption and reconstruction caused by inflammation and mechanical stimulation,has been a research *** article summarizes the researches on sclerostin in periodontitis development in recent *** them,sclerostin has been shown to be a critical negative regulator of bone formation,thereby inhibiting bone remodeling in periodontitis development,and is closely associated with tooth ***,evidence indicates that the removal of sclerostin seems to reasonably protect the alveolar bone from *** of sclerostin expression is a novel,promising treatment for periodontitis and addresses several complications seen with traditional therapies;accordingly,many drugs with similar mechanisms have ***,the application prospect of sclerostin in periodontal therapy combined with orthodontic treatment is another promising *** are also a lot of drugs that regulate ***-sclerostin antibody(Scl-Ab)is the most direct one that inhibits bone resorption caused by *** present,drugs that inhibit the expression of sclerostin have been applied to the treatment of diseases such as multiple myeloma and ***,the application of sclerostin in the oral field is just around the corner,which provides a new therapeutic bone regulation strategy in oral and general health.

关键词： Sclerostin Periodontitis Orthodontics Tooth movement Mechanical forces Adjunctive therapy

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二维晃动模态的统一Ritz计算格式

振动与冲击 2014年第19期33卷 81-85页

作者：李遇春张皓同济大学水利工程系上海200092

基于线性势流理论,推导了液体二维晃动的特征值方程,对于任意二维容器,通过引入第一Green公式,将矩形截面晃动模态的精确解作为基函数,提出了特征值问题Ritz统一计算格式,避免不同截面(不同的边界条件)需要引入不同基函数的复杂性,使得R... 详细信息

基于线性势流理论,推导了液体二维晃动的特征值方程,对于任意二维容器,通过引入第一Green公式,将矩形截面晃动模态的精确解作为基函数,提出了特征值问题Ritz统一计算格式,避免不同截面(不同的边界条件)需要引入不同基函数的复杂性,使得Ritz方法适用于任意截面内液体的二维晃动模态分析,可同时求解晃动频率与振型。本文方法分别用于求解半顶角为45°的三角形渠道、半椭圆形截面内液体的晃动频率,计算结果与其它解析方法的结果吻合良好,其计算精度完全满足工程要求。

关键词：液体二维晃动 Ritz方法模态分析统一计算格式

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晃动的流体对渡槽结构振动的抑制与放大效应

振动与冲击 2012年第17期31卷 106-110页

作者：李遇春邸庆霜同济大学土木工程学院水利工程系上海200092

对渡槽结构横向流-固耦合动力特性及其幅频响应特性进行了较为详尽的分析,分析表明:①结构体系存在二个横向振动固有振动频率ω1、ω2,当系统以较小的频率ω1(同相位频率)振动时,结构振动的方向与流体的晃动方向一致;当系统以较大的频率... 详细信息

对渡槽结构横向流-固耦合动力特性及其幅频响应特性进行了较为详尽的分析,分析表明:①结构体系存在二个横向振动固有振动频率ω1、ω2,当系统以较小的频率ω1(同相位频率)振动时,结构振动的方向与流体的晃动方向一致;当系统以较大的频率ω2(异相位频率)振动时,结构振动的方向与流体的晃动方向相反。②当外动力荷载的频率(或卓越频率)与ω1(或ω2)接近时,结构体系会发生共振反应,流体对结构振动会产生放大效应。③渡槽结构体系还存在一个特殊的振动频率ω3,当外动力荷载的频率(或卓越频率)与ω3接近时,晃动的流体对结构起到减振的作用。④渡槽内的流体质量可以分为固定质量与晃动质量两部分,其中固定质量会加大结构顶端的动力惯性反应,可能会对结构安全构成不利影响。

关键词：流体的晃动影响结构振动振动抑制振动放大

Stroke-like Migraine Attacks after Radiation Therapy Syndrome

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Chinese Medical Journal 2015年第15期128卷 2097-2101页

作者： Qian Zheng li Yang li-Ming Tan li-Xia Qin chun-yu Wang Hai-Nan Zhang Department of Neurology Second Xiangya Hospital Central South University Changsha Hunan 410011 China

Objective：To summarize the clinical presentation,pathogenesis,neuroimaging,treatment,and outcome of stroke-like migraine attacks after radiation therapy （SMART） syndrome,and to propose diagnostic criteria for this *** Sources：We searched the PubMed database for articles in English published from 1995 to 2015 using the terms of ＂stroke-like AND migraine AND radiation.＂ Reference lists of the identified articles and reviews were used to retrieve additional *** Selection：Data and articles related to late-onset effects of cerebral radiation were selected and ***：SMART is a rare condition that involves complex migraines with focal neurologic deficits following cranial irradiation for central nervous system *** recovery,which ranges from hours to days to weeks,can be partial or *** propose the following diagnostic criteria for SMART：（1） Remote history of therapeutic external beam cranial irradiation for malignancy;（2） prolonged,reversible clinical manifestations mostly years after irradiation,which may include migraine,seizures,hemiparesis,hemisensory deficits,visuospatial defect,aphasia,confusion and so on;（3） reversible,transient,unilateral cortical gadolinium enhancement correlative abnormal T2 and fluid-attenuated inversion recovery signal of the affected cerebral region;（4） eventual complete or partial recovery,the length of duration of recovery ranging from hours to days to weeks;（5） no evidence of residual or recurrent tumor;（6） not attributable to another *** date,no specific treatment has been identified for this ***：SMART is an extremely rare delayed complication of brain ***,improvements in cancer survival rates have resulted in a rise in its ***,awareness and recognition of the syndrome is important to make a rapid diagnosis and avoid aggressive interventions such as brain biopsy and cerebral angiography.

关键词： Cranial Irradiation Epilepsy Migraine Stroke-like Migraine Attacks after Radiation Therapy

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排架式渡槽流—固耦合动力特性分析

水利学报 2000年第12期31卷 31-37页

作者：李遇春楼梦麟同济大学土木工程防灾国家重点实验室上海200092

本文分析了排架式渡槽横向流—固耦合动力特性 ,计算结果表明 :排架式渡槽流—固耦合系统的模态可分为两类 :一类为“流体振荡模态” ,以流体的晃动为主 ,反映了流体固有晃动模态在耦合系统中的影响 ;另一类为“结构振荡模态” ,以结构... 详细信息

本文分析了排架式渡槽横向流—固耦合动力特性 ,计算结果表明 :排架式渡槽流—固耦合系统的模态可分为两类 :一类为“流体振荡模态” ,以流体的晃动为主 ,反映了流体固有晃动模态在耦合系统中的影响 ;另一类为“结构振荡模态” ,以结构的振动为主 ,反映了结构固有振动模态在耦合系统中的影响 .提出了两种特征值问题的计算方法 ,将其应用于实例计算 ,讨论了两种方法的优缺点 .

关键词：排架式渡槽流-固耦合动力特性特征值问题

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二维晃动自然频率与阻尼比系数的试验识别

振动与冲击 2016年第8期35卷 173-176,206页

作者：王立时李遇春张皓同济大学土木工程学院上海200092

液体的晃动模态(自然频率、振型与阻尼比系数)是贮液结构设计以及振动控制的重要参数。在液体晃动的模态试验中,需要激发液面的模态运动,但液面的对称模态运动一般较难激发出来,使得对称模态参数(特别是阻尼比系数)难以精确识别。采用... 详细信息

液体的晃动模态(自然频率、振型与阻尼比系数)是贮液结构设计以及振动控制的重要参数。在液体晃动的模态试验中,需要激发液面的模态运动,但液面的对称模态运动一般较难激发出来,使得对称模态参数(特别是阻尼比系数)难以精确识别。采用参数激振的方法对矩形、U形和圆形截面容器进行竖向激振,容易激发出液体表面的前四阶模态(包括对称模态)运动,撤除激励后液体表面按某一特定的振型作自由衰减振动,通过激光测量液体表面波高的自由衰减曲线,从而精确得到液体晃动的自然频率与对应的阻尼比系数,测得晃动频率与理论频率结果吻合良好,表明该试验识别方法有效。

关键词：二维晃动参数振动实验液体模态参数