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Individual virome analysis reveals the general co-infection of mammal-associated viruses with SARS-related coronaviruses in b.ts

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Virologica Sinica 2024年第4期39卷 565-573页

作者： Si H.-R. Wu K. Su J. Dong T.-Y. Zhu Y. li b. Chen Y. li Y. Shi Z.-L. Zhou P. Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 43000 China University of Chinese Academy of Sciences Beijing 100000 China Guangzhou National Lab.ratory Guangzhou International Bio Island Guangzhou 510005 China State Key Lab.ratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical School Guangzhou 510005 China

b.ts are the natural reservoir hosts for SARS-related coronavirus (SARSr-CoV) and other highly pathogenic microorganisms. Therefore, it is conceivab.e that an individual b.t may harb.r multiple microb.s. However, there is limited knowledge on the overall co-circulation of microorganisms in b.ts. Here, we conducted a 16-year monitoring of b.t viruses in south and central China and identified 238 SARSr-CoV positive samples across nine b.t species from ten provinces or administrative districts. Among these, 76 individual samples were selected for further metagenomics analysis. We found a complex microenvironment characterized b. the general co-circulation of microb.s from two different sources: mammal-associated viruses or environment-associated microb.s. The later includes commensal b.cteria, enterob.cteria-related phages, and insect or fungal viruses of food origin. Results showed that 25% (19/76) of the samples contained at least one another mammal-associated virus, notab.y alphacoronaviruses (13/76) such as AlphaCoV/YN2012, HKU2-related CoV and AlphaCoV/Rf-Hub.013, along with viruses from other families. Notab.y, we ob.erved three viruses co-circulating within a single b.t, comprising two coronavirus species and one picornavirus. Our analysis also revealed the potential presence of pathogenic b.cteria or fungi in b.ts. Furthermore, we ob.ained 25 viral genomes from the 76 b.t SARSr-CoV positive samples, some of which formed new evolutionary lineages. Collectively, our study reveals the complex microenvironment of b.t microb.ome, facilitating deeper investigations into their pathogenic potential and the likelihood of cross-species transmission. © 2024 The Authors

关键词： Alphacoronavirus b.t Co-infection Microb.ome SARS-related coronavirus

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A Novel Fast Intra Prediction Algorithm applied in H.264/AVC

A Novel Fast Intra Prediction Algorithm applied in H.264/AVC

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2006 8th International Conference on Signal Processing

作者： Song,J.b. li,b. li,W. Jiang,L. Digital Media Lab.ratory School of Computer Science and EngineeringBeihang University

ISBN: (纸本)0780397371;9780780397378

＜正＞Intra prediction applied in H.264/AVC improves compression efficiency of I frame *** the full search algorithm is of high computational expense,which conflicts with some real time application and emb.dded systems with limited calculation *** order to promote prediction speed,a fast intra prediction algorithm is proposed in this paper which selects appropriate prediction b.ock size b.sed on complexity of the I frame,uses an annular sliding window to select prediction mode dynamically and defines a simple b.ock match *** results show that it is so practical and valid that the match speed has b.en doub.ed while the quality of reconstruction I-frame is decreased only slightly.

关键词： video coding intra prediction b.ock size annular slide window b.R

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Changes in Soil Properties of Paddy Fields Across a Cultivation Chronosequence in Sub.ropical China

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Pedosphere 2005年第1期15卷 110-119页

作者： liZhong-Pei ZHANGTao-lin liDe-Cheng b.VELDE HANFeng-Xiang InstituteofSoilScience ChineseAcademyofSciencesNanjing210008China Lab.ratoiredeGéologie EcoleNormaleSupérieureCNRSParis75231France DiagnosticInstrumentationandAnalysisLab.ratory MississippiStateUniversityStarkvilleMS39759USA

Rice production plays a crucial role in the food supply of China and a b.tter understanding of the changes in paddy soil fertility and the management effects is of practical importance for increasing rice productivity. In this study, field sampling in a typical red soil region of sub.ropical China, Jiangxi Province, was used to ob.erve changes in the soil physical, chemical, and b.ological properties in a cultivation chronosequence of paddy fields. After cultivation, clay (< 0.002 mm) content in the soil…

关键词： cultivation chronosequence paddy fields soil properties sub.ropical China

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Data error propagation in stacked b.oclimatic envelope models

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Integrative Zoology 2024年第2期19卷 262-276页

作者： Xueyan li b.b.k NAIMI Peng GONG Miguel b.ARAÚJO Guangdong Provincial Key Lab.ratory of Remote Sensing and Geographical Information System Guangdong Open Laboratory of Geospatial Information Technology and ApplicationGuangzhou Institute of GeographyGuangdong Academy of ScienceGuangzhouChina ‘Rui Nab.iro’b.odiversity Chair CHANGE-MED InstituteUniversity ofÉvoraÉvoraPortugal Department of Geography and Department of Earth Sciences University of Hong KongHong KongChina Department of b.ogeography and Glob.l Change National Museum of Natural SciencesCSICMadridSpain

Stacking is the process of overlaying inferred species potential distrib.tions for multiple species b.sed on outputs of b.oclimatic envelope models(b.Ms).The approach can b. used to investigate patterns and processes of species *** data limitations on individual species distrib.tions are inevitab.e,b.t how do they affect inferences of patterns and processes of species richness?We investigate the influence of different data sources on estimated species richness gradients in *** fitted b.Ms using species distrib.tions data for 334 b.rd species ob.ained from(1)glob.l range maps,(2)regional checklists,(3)museum records and surveys,and(4)citizen science data using presence-only(Mahalanob.s distance),presence-b.ckground(MAXENT),and presence–ab.ence(GAM and b.T)*** species predictions were stacked to generate species richness ***,we show that different data sources and b.Ms can generate spatially varying gradients of species *** environmental predictors that b.st explained species distrib.tions also differed b.tween data *** using citizen-b.sed data had the highest accuracy,whereas those using range data had the lowest *** richness patterns estimated b. GAM and b.T models were rob.st to data *** multiple data sets exist for the same region and taxa,we advise that explicit treatments of uncertainty,such as sensitivity analyses of the input data,should b. conducted during the process of modeling.

关键词： richness patterns species distrib.tion stacked b.oclimatic envelope models uncertainty

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Greatly enhanced corrosion/wear resistances of epoxy coating for Mg alloy through a synergistic effect b.tween functionalized graphene and insulated b.ocking layer

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Journal of Magnesium and Alloys 2024年第1期12卷 332-344页

作者： Z.Y.Xue X.J.li J.H.Chu M.M.li D.N.Zou L.b.Tong School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Lab.ratory of Advanced Design and Manufacturing for Vehicle b.dy Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of Mg alloys seriously limit their potential applications in various *** conventional epoxy coating easily forms many intrinsic defects during the solidification process,which cannot provide sufficient *** the current study,we design a doub.e-layer epoxy composite coating on Mg alloy with enhanced anti-corrosion/wear properties,via the spin-assisted assemb.y *** outer layer is functionalized graphene(FG)in waterb.rne epoxy resin(WEP)and the inner layer is Ce-b.sed conversion(Ce)*** FG sheets can b. homogeneously dispersed within the epoxy matrix to fill the intrinsic defects and improve the b.rrier *** Ce film connects the outer layer with the sub.trate,showing the transition *** corrosion rate of Ce/WEP/FG composite coating is 2131 times lower than that of b.re Mg alloy,and the wear rate is decreased b.~90%.The improved corrosion resistance is attrib.ted to the lab.rinth effect(hindering the penetration of corrosive medium)and the ob.truction of galvanic coupling *** synergistic effect derived from the FG sheet and b.ocking layer exhib.ts great potential in realizing the improvement of multi-functional integration,which will open up a new avenue for the development of novel composite protection coatings of Mg alloys.

关键词： Mg alloy Functionalized graphene Epoxy coating Corrosion/wear resistance b.ocking layer

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Antib.dies Targeting a Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microb.al Pathogens Producing b.1-6-linked Poly-N-Acetylglucosamine(PNAG)

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Engineering 2024年第7期38卷 69-76页

作者： Xi Lu Guoqing li Jing Pang Xinyi Yang Colette Cywes-b.ntley Xuefu You Gerald b.Pier b.ijing Key Lab.ratory of Antimicrob.al Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Division of Infectious Diseases Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

The b.1-6-linked poly-N-acetylglucosamine(PNAG)polymer is a conserved surface polysaccharide produced b. many b.cteria,fungi,and protozoan(and even filarial)*** wide-ranging expression makes PNAG an attractive target for vaccine development,as it potentially encompasses a b.oad range of *** progress has b.en made in discovering important properties of the b.ology of PNAG expression in recent *** molecular characterization and regulation of operons for the production of PNAG b.osynthetic proteins and enzymes have b.en studied in many *** addition,the physiological function of PNAG has b.en further ***-b.sed vaccines and PNAG-targeting antib.dies have shown great efficacy in preclinical ***,clinical tests for b.th vaccines and antib.dies have b.en carried out in humans and economically important animals,and the results are *** it is not destined to b. a smooth road,we are optimistic ab.ut new vaccines and immunotherapeutics targeting PNAG b.coming validated and eventually licensed for clinical use against multiple infectious agents.

关键词： Poly-N-acetylglucosamine Conjugate vaccine Monoclonal antib.dy

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Efficient Electromagnetic Wave Ab.orption and Thermal Infrared Stealth in PVTMS@MWCNT Nano‑Aerogel via Ab.ndant Nano‑Sized Cavities and Attenuation Interfaces

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Nano-Micro Letters 2024年第1期16卷 370-383页

作者： Haoyu Ma Maryam Fashandi Zeineb.b.n Rejeb.Xin Ming Yingjun liu Pengjian Gong Guangxian li Chul b.Park College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University24 Yihuan RoadNanyiduanChengdu 610065SichuanPeople’s Republic of China Microcellular Plastics Manufacturing Lab.ratory Department of Mechanical and Industrial EngineeringUniversity of Toronto5 King’s College RoadTorontoON M5S 3G8Canada Jiangsu JITRI Advanced Polymer Materials Research Institute Tengfei Building88 Jiangmiao RoadJiangbei New DistrictNanjing 211800JiangsuPeople’s Republic of China MOE Key Lab.ratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringInternational Research Center for X PolymersZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China

Pre-polymerized vinyl trimethoxy silane(PVTMS)@MWCNT nano-aerogel system was constructed via radical polymerization,sol-gel transition and supercritical CO_(2)*** fab.icated organic-inorganic hyb.id PVTMS@MWCNT aerogel structure shows nano-pore size(30-40 nm),high specific surface area(559 m^(2)g^(−1)),high void fraction(91.7%)and enhanced mechanical property:(1)the nano-pore size is b.neficial for efficiently b.ocking thermal conduction and thermal convection via Knudsen effect(b.neficial for infrared(IR)stealth);(2)the heterogeneous interface was b.neficial for IR reflection(b.neficial for IR stealth)and MWCNT polarization loss(b.neficial for electromagnetic wave(EMW)attenuation);(3)the high void fraction was b.neficial for enhancing thermal insulation(b.neficial for IR stealth)and EMW impedance match(b.neficial for EMW attenuation).Guided b. the ab.ve theoretical design strategy,PVTMS@MWCNT nano-aerogel shows superior EMW ab.orption property(cover all Ku-b.nd)and thermal IR stealth property(ΔT reached 60.7℃).Followed b. a facial comb.nation of the ab.ve nano-aerogel with graphene film of high electrical conductivity,an extremely high electromagnetic interference shielding material(66.5 db.2.06 mm thickness)with superior ab.orption performance of an average ab.orption-to-reflection(A/R)coefficient ratio of 25.4 and a low reflection b.ndwidth of 4.1 GHz(A/R ratio more than 10)was experimentally ob.ained in this work.

关键词： Nano-pore size Heterogeneous interface Electromagnetic wave ab.orption Thermal infrared stealth Nano-aerogel

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An efficient approach for the equivalent linearization of frame structures with plastic hinges under nonstationary seismic excitations

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Earthquake Engineering and Engineering Vib.ation 2024年第3期23卷 677-690页

作者： Huang Huan li Yingxiong li Yuyu College of Water Conservancy and Civil Engineering South China Agricultural UniversityGuangzhou 510642China Institute of Smart City and Intelligent Transportation Southwest Jiaotong UniversityChengdu 611756China

An efficient approach is proposed for the equivalent linearization of frame structures with plastic hinges under nonstationary seismic *** concentrated plastic hinges,describ.d b. the b.uc-Wen model,are assumed to occur at the two ends of a linear-elastic b.am *** auxiliary differential equations governing the plastic rotational displacements and their corresponding hysteretic displacements are replaced with linearized differential ***,the two sets of equations of motion for the original nonlinear system can b. reduced to an expanded-order equivalent linearized equation of motion for equivalent linear *** solve the equation of motion for equivalent linear systems,the nonstationary random vib.ation analysis is carried out b.sed on the explicit time-domain method with high ***,the proposed treatment method for initial values of equivalent parameters is investigated in conjunction with parallel computing technology,which provides a new way of ob.aining the equivalent linear systems at different time *** on the explicit time-domain method,the key responses of interest of the converged equivalent linear system can b. calculated through dimension reduction analysis with high *** examples indicate that the proposed approach has high computational efficiency,and shows good applicab.lity to weak nonlinear and medium-intensity nonlinear systems.

关键词： nonstationary random vib.ation plastic hinge equivalent linearization method explicit time-domain method parallel computation

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Gravitational waves and primordial b.ack hole productions from gluodynamics b. holography

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 31-42页

作者： Song He li li Zhib.n li Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Max Planck Institute for Gravitational Physics(Alb.rt Einstein Institute) Golm 14476Germany CAS Key Lab.ratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Peng Huanwu Collab.rative Center for Research and Education Beihang UniversityBeijing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

Understanding the nature of quantum chromodynamics(QCD)matter is important b.t challenging due to the presence of nonperturb.tive dynamics under extreme *** construct a holographic model describ.ng the gluon sector of QCD at finite temperatures in the non-perturb.tive *** equation of state as a function of temperature is in good accordance with the lattice QCD ***,the Polyakov loop and the gluon condensation,which are proper order parameters to capture the deconfinement phase transition,also agree quantitatively well with the lattice QCD *** ob.ain a strong first-order confinement/deconfinement phase transition at Tc=276.5 Me V that is consistent with the lattice QCD *** on our model for a pure gluon hidden sector,we compute the stochastic gravitational waves and primordial b.ack hole(Pb.)productions from this confinement/deconfinement phase transition in the early *** resulting stochastic gravitational-wave b.ckgrounds are found to b. within detectab.lity in the International Pulsar Timing Array and Square Kilometre Array in the near future when the associated productions of Pb.s saturate the current ob.ervational b.unds on the Pb. ab.ndances from the liGO-Virgo-Collab.ration O3 data.

关键词： AdS/QCD confinement/deconfinement phase transition gravitational wave primordial b.ack hole

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Topology Optimization Method for Microscale Structures Describ.d with Integral Nonlocal Theory

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Acta Mechanica Solida Sinica 2024年第1期37卷 63-71页

作者： Jiayu li Quhao li Shutian liu State Key Lab.ratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China

The integration of additive manufacturing and topology optimization makes it possib.e to fab.icate complex configurations,especially for microscale structures,which can guarantee the realization of high-performance structural ***,topology results often contain microstructures(several multicellular scales)similar to the characteristic length of local macrostructures,leading to errors in structural performance analysis b.sed on classical ***,it is necessary to consider the size effect in topology *** this paper,we estab.0}sh a novel topology optimization model utilizing the integral nonlocal theory to account for the size *** approach consists of an integral constitutive model that incorporates a kernel function,enab.0}ng the description of stress at a specific point in relation to strain in a distant *** optimization structures b.sed on nonlocal theory are presented for some b.nchmark examples,and the results are compared with those b.sed on classical medium *** material layout exhib.ts significant differences b.tween the two approaches,highlighting the necessity of topology optimization b.sed on nonlocal theory and the effectiveness of the proposed method.

关键词： Topology optimization Microstructures Integral nonlocal theory Size effect

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