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知识产权私有化与不可诉研发补贴规则——基于美国《拜杜法案》补贴争端的思考

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国际经济评论 2020年第4期 116-134,7页

作者：李仲平广东金融学院法学院

中国参考美国《拜杜法案》的相关规定,将政府资助项目下的知识产权授予私人研发实体。然而,美国这一知识产权私有化规则与实践已被世界贸易组织争端解决机构认定为可诉性研发补贴。知识产权私有化与可诉性研发补贴之间的耦合,使得恢复... 详细信息

中国参考美国《拜杜法案》的相关规定,将政府资助项目下的知识产权授予私人研发实体。然而,美国这一知识产权私有化规则与实践已被世界贸易组织争端解决机构认定为可诉性研发补贴。知识产权私有化与可诉性研发补贴之间的耦合,使得恢复并扩大不可诉研发补贴规则具有一定的必要性、正当性和可行性。基于私人研发实体在创新能力、市场规模和营利与否等方面存在的客观差异,中国可在对其进行类型化识别的基础上,提出共同但有区别的变革方案。具体而言,将知识产权私有化纳入不可诉研发补贴的范畴;认定高等教育机构、中小企业和非营利性科研机构获得政府资助项目下的知识产权属于不可诉补贴;明确大企业仅在采用竞争性招投标程序获得政府资助项目下的知识产权时,其获得知识产权才可被视为不可诉补贴。

关键词：知识产权私有化研发补贴不可诉补贴

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基于分级诊疗体系的下转决策及支付机制研究

系统工程理论与实践 2019年第8期39卷 2126-2137页

作者：李忠萍王建军单巍大连理工大学经济管理学院大连116024 大连医科大学附属二院眼科部大连116027

在分级诊疗体系下,运用M/M/1排队与博弈论,构建了从综合医院到社区医疗服务中心转诊的期望效益函数模型.获得了医院的均衡下转率及均衡效益,研究发现病人对综合医院越偏好,医院的均衡下转率越高;两阶段治疗划分标准的差异性越低,均衡转... 详细信息

在分级诊疗体系下,运用M/M/1排队与博弈论,构建了从综合医院到社区医疗服务中心转诊的期望效益函数模型.获得了医院的均衡下转率及均衡效益,研究发现病人对综合医院越偏好,医院的均衡下转率越高;两阶段治疗划分标准的差异性越低,均衡转诊越低以及对医院越有利.给出一种支付策略,有效刺激了综合医院将病人下转,并实现了综合医院、社区医疗服务中心及整个医疗系统的共赢.通过数值实验探讨了支付费用对均衡下转率及均衡效益的影响,并比较了支付策略下、非支付策略下的均衡下转率与均衡效益等,进而给出一些管理启示,为转诊有效实施提供理论支撑及政策参考.

关键词： M/M/1排队博弈论支付策略下转率效益

Knock-out of GhPDCT with the CRISPR/Cas9 system increases the oleic acid content in cottonseed oil

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Journal of Integrative Agriculture 2024年第10期23卷 3468-3471页

作者： Tingwan li Lu Long Yingchao Tang zhongping Xu Guanying Wang Man Jiang Shuangxia Jin Wei Gao National Key Laboratory of Cotton Bio-breeding and Integrated Utilization/School of life Science Henan UniversityKaifeng475004China Hubei Hongshan Laboratory/National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan430070China

Cotton is a pivotal economic crop for natural textile fibers that also serves as an important source of edible oil(Long et al.2023).Cottonseed oil contains approximately14%oleic acid and 59%linoleic *** increase in monounsaturated fatty acids,particularly oleic acid,enhances the oxidative stability and nutritional value of edible oil(Chen et al.2021).

关键词： CRISPR/Cas9 fibers system

2021—2022年广州地区献血人群ABO血型筛查结果分析

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中国输血杂志 2024年第4期37卷 439-443页

作者：刘旭映黄伯泉廖芬芳李仲平梁浩坚杜荣松谢君谋黄爱琼王淏广州血液中心广州市血液安全重点实验室广东广州510095

目的了解广州地区无偿献血者ABO、RhD血型的分布情况,为保证临床用血安全和更好为献血者服务提供依据。方法对2021年1月—2022年12月的无偿献血者进行常规ABO、RhD血型检测,统计分析ABO血型构成比,对ABO正反不一致血型、RhD初筛阴性... 详细信息

目的了解广州地区无偿献血者ABO、RhD血型的分布情况,为保证临床用血安全和更好为献血者服务提供依据。方法对2021年1月—2022年12月的无偿献血者进行常规ABO、RhD血型检测,统计分析ABO血型构成比,对ABO正反不一致血型、RhD初筛阴性的标本进行血型血清学确证,分析ABO亚型检出情况及漏检原因。结果 2021年1月—2022年12月共筛查献血者标本749 123份,剔除重复献血者后的标本513 291份,其中ABO血型分布为:O型208 126份(40.55%)、A型138 859份(27.05%)、B型130 987份(25.52%)、AB型35 319份(6.88%)。ABO血型初筛正反不一致506份,其中弱/无红细胞反应58份、额外的红细胞反应16份、弱/无血清反应215份、额外的血清反应217份;经血型血清学或分子生物学确认ABO亚型44份,其中A亚型13份、B亚型26份、AB亚型5份;B(A)3份;类孟买血型14份。重复献血者漏检率最高的血型是A_3/B_3类亚型(68.42%)。在513 291份标本中共检出意外抗体阳性128份;RhD血型初筛阴性共2 277份,其中RhD阴性确认2 188份[2 188/513 291(0.43%)],RhD变异型89份[89/513 291(0.02%)],合并检出意外抗体30份[30/2 188(1.37%)]。结论广州地区献血人群ABO分布O>A>B>AB,RhD阴性人群占比为0.43%,略高于全国汉族人群0.3%~0.4%;ABO血型亚型以B亚型为主;A_3/B_3类亚型的检出率及在常规血型检验中漏检率最高。

关键词： ABO血型 RhD血型正反不一致血型无偿献血者

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热透波机理及热透波材料进展与展望

中国材料进展 2013年第4期32卷 193-202,242页

作者：李仲平航天材料及工艺研究所先进功能复合材料技术重点实验室北京100076

简要阐述了热透波问题的产生背景及其科学技术内涵,从烧蚀传热行为规律、热电行为规律与热透波机理、高温介电性能测试、热透波模拟试验和热透波材料5个方面对国内外研究进展进行了系统总结,在此基础上展望了热透波材料的发展方向。研... 详细信息

简要阐述了热透波问题的产生背景及其科学技术内涵,从烧蚀传热行为规律、热电行为规律与热透波机理、高温介电性能测试、热透波模拟试验和热透波材料5个方面对国内外研究进展进行了系统总结,在此基础上展望了热透波材料的发展方向。研究结果表明:附有熔体的高温壁面和动态变化的固液气三相状态导致天线窗/罩电性能发生突变,是高超声速航天器产生"黑障"的主要原因。氧化硅、氮化硼和硅-氧-氮材料分别属熔融型、气化型和熔融/汽化混合型烧蚀热透波材料。气化型氮化硼的微波传输效率受电子电导损耗控制,熔融型氧化硅的微波传输效率则受离子电导损耗控制。大尺度、高精度和宽温宽频是热透波材料性能评测和分析模拟技术的重要发展方向,向大尺寸"Si(B)-O-N-(M)"三元体系跨越是热透波材料制备技术创新发展的主要趋势。

关键词：热透波黑障热障熔融型烧蚀汽化型烧蚀熔融汽化混合型

Carboniferous Post-collisional Rift Volcanism of the Tianshan Mountains, Northwestern China

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Acta Geologica Sinica(English Edition) 2003年第3期77卷 338-360页

作者： XIA linqi, XU Xueyi, XIA Zuchun, li Xiangmin, MA zhongping and WANG lishe Xi’an Institute of Geology and Mineral Resources, China Geological Survey, Xi’an, Shaanxi 710054 E-mail: geologyx@***. liu Shuchun and liu Xinzhu Xian Inst Geol & Mineral Resources China Geol Surv Xian 710054 Shaanxi Peoples R China

The Tianshan Carboniferous post-collisional rift volcanic rocks occur in northwestern China as a large igneous province. Based on petrogeochemical data, the Tianshan Carboniferous post-collisional rift basic lavas can be classified into two major magma types: (1) the low-Ti/Y type situated in the eastern-central Tianshan area, which exhibits low Ti/Y (500), Ce/Yb (>11) and SiO2 (49-55%), and relatively low Fe2O3T (5.8-7.8%). Elemental data suggest that chemical variations of the low-Ti/Y and high-Ti/Y lavas cannot be explained by fractional crystallization from a common parental magma. The Tianshan Carboniferous basic lavas originated most likely from an OIB-like asthenospheric mantle source (87Sr/86Sr(t) ≈ 0.703-0.705, eNd(0 = +4 to +7). The crustal contamination and continental lithospheric mantle have also contributed significantly to the formation of the basic lavas of the Tianshan Carboniferous post-collisional rift. The silicic lavas were probably generated by partial melting of the crust. The data of this study show that spatial petrogeochemical variations exist in the Carboniferous post-collisional rift volcanics province in the Tianshan region. Occurrence of the thickest volcanics dominated by tholeiitic lavas may imply that the center of the mantle-melting anomaly (mantle plume) was in the eastern Tianshan area at that time. The basic volcanic magmas in the eastern Tianshan area were generated by a relatively high degree of partial melting of the mantle source around the spinel-garnet transition zone, whereas the alkaline basaltic lavas are of the dominant magma type in the western Tianshan area, which were generated by a low degree of partial melting of the mantle source within the stable garnet region, thus the basic lavas of the western Tianshan area might have resulted from relatively thick li

关键词： Carboniferous post-collisional rift volcanics geochemistry petrogenesis asthenosphere lithosphere Tianshan Mountains NW China

Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp.c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1a/XBP-1s axis and JNK signaling

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Acta Pharmaceutica Sinica B 2024年第1期14卷 304-318页

作者： Yong Rao Rui Su Chenyan Wu Xingxing Chai Jinjian li Guanyu Yang Junjie Wu Tingting Fu zhongping Jiang Zhikai Guo Congjun Xu ling Huang Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Hainan Key Laboratory of Tropical Microbe Resources Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan ProvinceHainan Institute for Tropical Agricultural ResourcesHaikou 571101China School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510275China Laboratory Animal Center of Guangdong Medical University Dongguan 523808China

lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease(MAFLD).However,there are few reported lipotoxicity ***,we identified a natural anti-lipotoxicity candidate,HN-001,from the marine fungus Aspergillus ***-001 dose-and time-dependently reversed palmitic acid(PA)-induced hepatocyte *** protection was associated with IRE-1a-mediated XBP-1 splicing inhibition,which resulted in suppression of XBP-1s nuclear translocation and transcriptional *** of XBP-1s attenuated lipotoxicity,but no additional ameliorative effect of HN-001 on lipotoxicity was observed in XBP-1s knockdown ***,the ER stress and lipotoxicity amelioration was associated with *** HN-001 and the PLA2 inhibitor MAFP inhibited PLA2 activity,reduced lysophosphatidylcholine(LPC)level,subsequently ameliorated *** contrast,overexpression of PLA2 caused exacerbation of lipotoxicity and weakened the anti-lipotoxic effects of ***,HN-001 treatment suppressed the downstream pro-apoptotic JNK *** vivo,chronic administration of HN-001(i.p.)in mice alleviated all manifestations of MAFLD,including hepatic steatosis,liver injury,inflammation,and *** effects were correlated with PLA2/IRE-1a/XBP-1s axis and JNK signaling *** data indicate that HN-001 has therapeutic potential for MAFLD because it suppresses lipotoxicity,and provide a natural structural basis for developing anti-MAFLD candidates.

关键词： lipotoxicity MAFLD ER stress IRE-1a XBP-1s JNK PLA2