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Particuology 2024年第8期91卷 226-234页

作者： Qingyuan An Jiantao li Lei Zhang Nailiang Wang Pengfei Zhang Zhenghong Luo Chunxi Lu State Key Laboratory of High-Efficiency Coal Utilization and Green Chemical Engineering Ningxia UniversityYinchuan750021China State Key Laboratory of Heavy Oil Processing College of Chemical Engineering and EnvironmentChina University of Petroleum BeijingBeijing102249China Department of Chemical&Biological Engineering Monash UniversityVictoria3800Australia

A pilot-scale experimental setup was constructed to investigate the effect of mild agitation on the bubble characteristics and phase holdup in a slurry bubble *** agitation positively impacts the axial uniform distribution of solid holdup,though it shows insignificant influence on the radial *** homogenous regime,mild agitation promotes the coalescence of bubbles,and the effect becomes stronger with increasing agitator *** mild agitation contributes to a decrease in bubble size in heterogeneous flow *** agitation presents a significant effect on the gas holdup by adjusting the bubble size and bubble motion *** modification was introduced to predict the gas holdup considering the effects of mild agitation,a necessary consideration for applications requiring mild *** adapted model predicts gas holdup with a maximum error of 12.9%.

关键词： Slurry bubble column Mild agitation Phase holdup Bubble characteristics

什么是“中国美学(Chinese Meixue)”?

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山东社会科学 2024年第8期 51-60页

作者：刘康王一凡山东大学文艺美学研究中心美国杜克大学亚洲与中东研究系

美学(感性学)在中国现代性话语中有着举足轻重的地位,它横跨文学与哲学两大学科领域,独具中国特色。与中国不同,“aesthetics”作为传统意义上的学科在欧美早已式微,但其所涉及的情感、感性与意识形态等议题始终是欧美思想界和学术界关... 详细信息

美学(感性学)在中国现代性话语中有着举足轻重的地位,它横跨文学与哲学两大学科领域,独具中国特色。与中国不同,“aesthetics”作为传统意义上的学科在欧美早已式微,但其所涉及的情感、感性与意识形态等议题始终是欧美思想界和学术界关注的焦点,尤其是西方左翼思潮的核心议题,它们虽无美学之名,却有美学之实。当下,中国美学与那些较少或不再使用“aesthetics”话语概念的“后学”理论之间交流甚少。有鉴于此,“中国美学”的英文或许可译为“Chinese Meixue”,以与“aesthetics”相区分,凸显其中国特色。同时,这也为我们在更广泛的情感、感性与意识形态等内涵的基础上,将中国美学与20世纪以来西方现代及后现代左翼思潮进行比较研究提供了契机,我们也可借此进一步探讨“中国美学马克思主义”的思想史意义。

关键词：中国美学 Chinese Meixue aesthetics 中国美学马克思主义

The Complete Classification of Graphs whose Second Largest Eigenvalue of the Eccentricity Matrix is Less Than 1

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1741-1766页

作者： Jian Feng WANG Xing Yu LEI Shu Chao li Zoran STANIC School of Mathematics and Statistics Shandong University of TechnologyZibo255049P.R.China Faculty of Mathematics and Statistics Central China Normal UniversityWuhan430079P.R.China Faculty of Mathematics University of BelgradeStudentski trg 1611000BelgradeSerbia

The eccentricity matrix of a graph is obtained from the distance matrix by keeping the entries that are largest in their row or column,and replacing the remaining entries by *** matrix can be interpreted as an opposite to the adjacency matrix,which is on the contrary obtained from the distance matrix by keeping only the entries equal to *** the paper,we determine graphs having the second largest eigenvalue of eccentricity matrix less than 1.

关键词： Eccentricity matrix eigenvalue diameter principal submatrix forbidden subgraph

Design and implementation of dual-mode configurable memory architecture for CNN accelerator

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High Technology Letters 2024年第2期30卷 211-220页

作者：山蕊 li Xiaoshuo GAO Xu HUO Ziqing School of Electronic Engineering Xi'an University of Posts and TelecommunicationsXi’an 710121P.R.China

With the rapid development of deep learning algorithms,the computational complexity and functional diversity are increasing ***,the gap between high computational density and insufficient memory bandwidth under the traditional von Neumann architecture is getting *** the algorithmic characteristics of convolutional neural network(CNN),it is found that the access characteristics of convolution(CONV)and fully connected(FC)operations are very *** on this feature,a dual-mode reronfigurable distributed memory architecture for CNN accelerator is *** can be configured in Bank mode or first input first output(FIFO)mode to accommodate the access needs of different *** the same time,a programmable memory control unit is designed,which can effectively control the dual-mode configurable distributed memory architecture by using customized special accessing instructions and reduce the data accessing *** proposed architecture is verified and tested by parallel implementation of some CNN *** experimental results show that the peak bandwidth can reach 13.44 GB·s^(-1)at an operating frequency of 120 *** work can achieve 1.40,1.12,2.80 and 4.70 times the peak bandwidth compared with the existing work.

关键词： distributed memory structure neural network accelerator reconfigurable arrayprocessor configurable memory structure

Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula:Evidence,mechanisms and perspective

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World Journal of Hepatology 2024年第10期16卷 1208-1212页

作者： Nabil Eid Payal Bhatnagar li-li Chan Marina Garcia-Macia Department of Anatomy Division of Human BiologySchool of MedicineIMU UniversityKuala Lumpur 57000Malaysia Department of Pharmaceutical Technology School of pharmacyIMU UniversityKuala Lumpur 57000Malaysia Department of Pathology and Pharmacology School of MedicineIMU UniversityKuala Lumpur 57000Malaysia Institute of Functional Biology and Genomics Department of Biochemistry and Molecular BiologyUniversity of SalamancaSalamanca 37007Spain

In this letter,we comment on a recent publication by Mei et al,in the World Journal of Hepatology,investigating the hepatoprotective effects of the modified Xiaoyao San(MXS)formula in a male rat model of non-alcoholic steatohepatitis(NASH).The authors found that MXS treatment mitigated hepatic steatosis and inflam-mation in the NASH model,as evidenced by the reduction in lipid droplets(LDs),fibrosis markers and lipogenic ***,these hepatoprotective effects were associated with androgen upregulation(based on metabolomics analysis of male steroid hormone metabolites),adenosine 5’-monophosphate-activated protein kinase(AMPK)activation,and restoration of phosphatase and tensin homolog(PTEN)***,the authors did not clearly discuss the relationships between MXS-induced hepatic steatosis reduction in the NASH model,and androgen upregulation,AMPK activation,and restoration of PTEN *** editorial emphasizes the reported mechanisms and explains how they act or interact with each other to reduce hepatic steatosis and inflammation in the NASH *** a perspective,we propose additional mechanisms(such as autophagy/lipophagy activation in hepatocytes)for the clearance of LDs and suppression of hepatic steatosis by MXS in the NASH model.A proper understanding of the mechanisms of MXS-induced reduction of hepatic steatosis might help in the treatment of NASH and related diseases.

关键词： Steatosis liver Xiaoyao San Inflammation Androgen Adenosine 5’-monophosphate-activated protein kinase Phosphatase and tensin homolog Autophagy lipophagy Alpha smooth muscle actin

Cytospora pyri promotes Erwinia amylovora virulence by providing metabolites and hyphae

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Journal of Integrative Agriculture 2024年第9期23卷 3045-3054页

作者： Tong Shen Mengdi Ye Yeping Xu Bohan Ding Hongtao li li Zhang Jun Wang Yanli Tian Baishi Hu Youfu Zhao College of Plant Protection/Key Laboratory of Integrated Management of Crop Diseases and Pests Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Plant Quarantine Pests Monitoring and Control Ministry of Agriculture and Rural AffairsNanjing 210095China Plant Protection and Quarantine Station of Xinjiang Uygur Autonomous Region Urumqi 830001China Xinjiang Key Laboratory of Agricultural Biosafety Institute of Plant ProtectionXinjiang Academy of Agricultural SciencesUrumqi 830013China College of Agriculture Xinjiang Agricultural UniversityUrumqi 830052China Plant Pathology Department Washington State UniversityProsserWA 24106USA

Bacterial-fungal interactions are widespread in *** observed that pear orchards affected by Cytospora pyri(formerly Valsa pyri)were often accompanied with Erwinia ***,the relationship of the two pathogens was *** objective of this study was to determine whether the synergistic effect exists between *** and *** first analyzed the coexistence frequencies of *** and *** in pear *** of the two pathogens,growth,physical interactions,amylovoran production,and expression of genes for amylovoran biosynthesis were *** results showed that *** and *** could coexist on the same lesion and caused much more severe *** also found that *** could physically attach to *** and the expression of amylovoran biosynthesis genes were up-regulated with fungal metabolite *** results indicate that *** and *** can cooperatively interact,which provides *** with an opportunity to promote bacterial dispersal and production of virulence factor in ***.

关键词： pear fire blight Erwinia amylovora Valsa canker amylovoran synergy

Cationic ordering transition in oxygen-redox layered oxide cathodes

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Carbon Energy 2024年第1期6卷 197-206页

作者： Xinyan li Ang Gao Qinghua Zhang Hao Yu Pengxiang Ji Dongdong Xiao Xuefeng Wang Dong Su Xiaohui Rong Xiqian Yu Hong li Yong-Sheng Hu lin Gu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijingChina College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijingChina Beijing National Center for Electron Microscopy and Laboratory of Advanced Materials School of Materials Science and EngineeringTsinghua UniversityBeijingChina Beijing Advanced Innovation Center for Materials Genome Engineering Huairou DivisionInstitute of PhysicsChinese Academy of SciencesBeijingChina

Understanding the structural origin of the competition between oxygen 2p and transition-metal 3d orbitals in oxygen-redox(OR)layered oxides is eminently desirable for exploring reversible and high-energy-density li/Na-ion ***,we reveal the correlation between cationic ordering transition and OR degradation in ribbon-ordered P3-Na_(0.6)li_(0.2)Mn_(0.8)O_(2) via in situ structural *** two different voltage windows,the OR capacity can be improved approximately twofold when suppressing the in-plane cationic ordering *** find that the intralayer cationic migration is promoted by electrochemical reduction from Mn^(4+)to Jahn–Teller Mn^(3+)and the concomitant NaO_(6) stacking transformation from triangular prisms to octahedra,resulting in the loss of ribbon ordering and electrochemical ***-principles calculations reveal that Mn^(4+)/Mn^(3+)charge ordering and alignment of the degenerate eg orbital induce lattice-level collective Jahn–Teller distortion,which favors intralayer Mn-ion migration and thereby accelerates OR *** findings unravel the relationship between in-plane cationic ordering and OR reversibility and highlight the importance of superstructure protection for the rational design of reversible OR-active layered oxide cathodes.

关键词： cationic ordering layered oxide cathodes oxygen redox sodium-ion batteries

Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3585-3599页

作者： De-Gang li Jia-Peng Jiang Fan-Ye Chen Wei Wu Jun Fu Gong-He Wang Yu-Bo li Department of Gastrointestinal and Anorectal Surgery The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are typical gastrointestinal tract *** is the first-line therapy for GIST *** resistance limits the long-term effectiveness of *** regulatory effect of insulin-like growth factor 2(IGF2)has been confirmed in various cancers and is related to resistance to chemotherapy and a worse *** To further investigate the mechanism of IGF2 specific to *** IGF2 was screened and analyzed using Gene Expression Omnibus(GEO:GSE225819)*** IGF2 knockdown or overexpression by transfection,the phenotypes(proliferation,migration,invasion,apoptosis)of GIST cells were characterized by cell counting kit 8,Transwell,and flow cytometry *** used western blotting to evaluate pathway-associated and epithelial-mesenchymal transition(EMT)-associated *** injected transfected cells into nude mice to establish a tumor xenograft model and observed the occurrence and metastasis of *** Data from the GEO indicated that IGF2 expression is high in GISTs,associated with liver metastasis,and closely related to drug *** cells with high expression of IGF2 had increased proliferation and migration,invasiveness and *** of IGF2 significantly inhibited those *** addition,OEIGF2 promoted GIST metastasis in vivo in nude ***2 activated IGF1R signaling in GIST cells,and IGF2/IGF1R-mediated glycolysis was required for GIST with liver *** cells with IGF2 knockdown were sensitive to imatinib treatment when IGF2 overexpression significantly raised imatinib ***,2-deoxy-D-glucose(a glycolysis inhibitor)treatment reversed IGF2 overexpressionmediated imatinib resistance in *** IGF2 targeting of IGF1R signaling inhibited metastasis and decreased imatinib resistance by driving glycolysis in GISTs.

关键词： Insulin-like growth factor 2 Gastrointestinal stromal tumors IGF1R Glycolysis Imatinib resistance

Refined symmetry-resolved Page curve and charged black holes

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Chinese Physics C 2024年第5期48卷 134-140页

作者：李磐凌意 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics University of Chinese Academy of SciencesBeijing 100049China

The Page curve plotted using the typical random state approximation is not applicable to a system with conserved quantities,such as the evaporation process of a charged black hole,during which the electric charge does not macroscopically radiate out with a uniform *** this context,the symmetry-resolved entanglement entropy may play a significant role in describing the entanglement structure of such a *** attempt to impose constraints on microscopic quantum states to match the macroscopic phenomenon of charge radiation during black hole ***,we consider a simple qubit system with conserved spin/charge serving as a toy model for the evaporation of charged black *** propose refined rules for selecting a random state with conserved quantities to simulate the distribution of charges during the different stages of evaporation and obtain refined Page curves that exhibit distinct features in contrast to the original Page *** find that the refined Page curve may have a different Page time and exhibit asymmetric behavior on both sides of the Page *** refined Page curves may provide a more realistic description for the entanglement between the charged black hole and radiation during the evaporation process.

关键词： quantum entanglement Page curve charged black hole black hole evaporation Hawking radiation Schwinger effect random state average entropy

Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 414-435页

作者： You-Wang Lu Zhao-li Ding Rui Mao Gui-Gang Zhao Yu-Qi He Xiao-Lu li Jiang liu Department of Dermatology and Venereology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Kunming Biological Diversity Regional Center of Large Apparatus and Equipments Public Technical Service CenterKunming Institute of ZoologyKunming 650223Yunnan ProvinceChina School of Stomatology Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Genome Center of Biodiversity Kunming Institute of ZoologyChinese Academy of ScienceKunming 650223Yunnan ProvinceChina Department of Reproduction and Genetics The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Aberrant methylation is common during the initiation and progression of colorectal cancer(CRC),and detecting these changes that occur during early adenoma(ADE)formation and CRC progression has clinical *** To identify potential DNA methylation markers specific to ADE and *** Here,we performed SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic *** Comparing 22 CRC and 25 ADE samples,global methylation was higher in the former,but both showed similar methylation patterns regarding differentially methylated gene positions,chromatin signatures,and repeated ***-grade CRC tended to exhibit elevated methylation levels in gene promoter regions compared to those in low-grade *** with RNA-seq gene expression data,we identified 14 methylation-regulated differentially expressed genes,of which only AGTR1 and NECAB1 methylation had prognostic *** Our results suggest that genome-wide alterations in DNA methylation occur during the early stages of CRC and demonstrate the methylation signatures associated with colorectal ADEs and CRC,suggesting prognostic biomarkers for CRC.

关键词： Colorectal cancer Epigenomic alteration Transcriptome Methylation-regulated differentially expressed genes