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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang xinyi li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Low-Temperature Fabrication of Stable Black-Phase CsPbI₃ Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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NANO-MICRO LETTERS 2025年第1期17卷 1-14页

作者： Zhao, Yingjie Sun, Yicheng Pei, Chaoxin Yin, Xing li, xinyi Hao, Yi Zhang, Mengru Yuan, Meng Zhou, Jinglin Chen, Yu Song, Yanlin Zhengzhou Univ Coll Chem Zhengzhou 450001 Peoples R China Zhengzhou Univ Pingyuan Lab Zhengzhou 450001 Peoples R China Chinese Acad Sci Inst Chem Key Lab Green Printing Beijing 100190 Peoples R China Chinese Acad Sci Tech Inst Phys & Chem Key Lab Bioinspired Mat & Interfacial Sci Beijing 100190 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China

Low-temperature fabrication of black-phase CsPbI3 perovskite films is first demonstrated by using diphenylphosphinic chloride additive under 30-50 degrees C, arising from the steric effect and chloride insertion ***-area high-quality all-inorganic perovskite films with fewer defects enhanced crystallographic orientation, and excellent environmental stability is *** record performances are demonstrated for flexible wearable photodetectors with a responsivity of 42.1 A W-1, a detectivity of 1.3 x 1014 Jones, high-fidelity image, photoplethysmography sensor functions, and high mechanical stability. Flexible wearable optoelectronic devices fabricated from organic-inorganic hybrid perovskites significantly accelerate the development of portable energy, biomedicine, and sensing fields, but their poor thermal stability hinders further applications. Conversely, all-inorganic perovskites possess excellent thermal stability, but black-phase all-inorganic perovskite film usually requires high-temperature annealing steps, which increases energy consumption and is not conducive to the fabrication of flexible wearable devices. In this work, an unprecedented low-temperature fabrication of stable black-phase CsPbI3 perovskite films is demonstrated by the in situ hydrolysis reaction of diphenylphosphinic chloride additive. The released diphenyl phosphate and chloride ions during the hydrolysis reaction significantly lower the phase transition temperature and effectively passivate the defects in the perovskite films, yielding high-performance photodetectors with a responsivity of 42.1 A W-1 and a detectivity of 1.3 x 1014 Jones. Furthermore, high-fidelity image and photoplethysmography sensors are demonstrated based on the fabricated flexible wearable photodetectors. This work provides a new perspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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Machine learning driven rational design of dual atom catalysts on graphene for carbon dioxide electroreduction

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Nano Research 2025年第1期18卷 186-194页

作者： Dongxu Jiao xinyi li Mingzi Sun lin liu Jinchang Fan Jingxiang Zhao Bolong Huang Xiaoqiang Cui State Key Laboratory of Automotive Simulation and Control School of Materials Science and Engineeringand Key Laboratory of Automobile Materials of MOEJilin UniversityChangchun 130012China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina College of Chemistry and Chemical Engineering and Key Laboratory of Photonic and Electronic Bandgap MaterialsMinistry of EducationHarbin Normal UniversityHarbin 150025China

The development of high-performance atomiccatalysts for the carbon dioxide reduction reaction(CO_(2)RR)is atime-consuming process due to the complexity of the reactionmechanism and the uncertainty of the active ***,wehave proposed combining density functional theory(DFT)andmachine learning(ML)to investigate the potential of topologicalgraphene-based dual-atom catalysts(DACs)as CO_(2)*** analyzing the ML results,we identify thenumber of d-orbital electrons in the active site as a key factorinfluencing the CO_(2)RR catalytic ***,wepropose a simple descriptor to measure the CO_(2)RR activity ofthese *** findings provide plausible explanations for thesynergistic interactions between bimetallic atoms in CO_(2)RR andallow us to screen the homogeneous Ni-Ni pair as the mostpromising dual-atom *** work offers a fast MLapproach based on limited DFT calculations to predict the mostelectroactive and stable DACs on carbon support for CO_(2)RR,facilitating rapid screening of high-performance dual-atomcatalysts.

关键词： CO_(2)reaction reduction dual-atom catalysts density functional theory machine learning

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A novel electron-phonon coupling thermoelasticity with Burgers electronic heat transfer

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Applied Mathematics and Mechanics(English Edition) 2023年第11期44卷 1927-1940页

作者： Hua WU xinyi li Yajun YU Zichen DENG School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China MIIT Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical UniversityXi'an 710072China State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Jiaotong UniversityXi'an 710049China

The electron-phonon interaction can reveal the microscopic mechanism of heat transfer in *** two-step heat conduction considering electron-phonon interaction has become an effective theoretical model for extreme environments,such as micro-scale and ultrafast *** this work,the two-step heat transfer model is further extended by considering the Burgers heat conduction model with the secondorder heat flux rate for ***,a novel generalized electron-phonon coupling thermoelasticity is proposed with the Burgers electronic heat ***,the problem of one-dimensional semi-infinite copper strip subject to a thermal shock at one side is studied by the Burgers two-step(BTS)*** thermoelastic analytical solutions are systematically derived in the Laplace domain,and the numerical Laplace inversion method is adopted to obtain the transient *** new model is compared with the parabolic two-step(PTS)model and the hyperbolic two-step(HTS)*** results show that in ultrafast heating,the BTS model has the same wave front jump as the HTS *** present model has the faster wave speed,and predicts the bigger disturbed regions than the HTS *** deeply,all two-step models also have the faster wave speeds than one-step *** work may benefit the theoretical modeling of ultrafast heating of metals.

关键词： Burgers heat transfer electron-phonon coupling two-step generalized thermoelasticity

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Guest-adaptive chiral coassembly of a conformationally locked host into supramolecular boxes and ladders through arene-perfluoroarene force

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Science China Chemistry 2024年第10期67卷 3482-3492页

作者： Weilong Ma xinyi li Aiyou Hao Pengyao Xing School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100China

Unveiling the role of weak non-covalent forces in chiral self-assembly is pivotal in the design and fabrication of functional chiroptical *** nature of arene-perfluoroarene(AP)force is the electrostatic attraction betweenπ-hole andπplanes of perfluoroarenes and polyaromatic hydrocarbons(PAHs),which is emerging in constructing supramolecular motifs and coassembled optical *** this work,we reveal the potential of AP forces in building diversified levels of chiral coassemblies adaptive to the geometries of *** naphthalene-F8was covalently conjugated with a chiral amine,which folded into a semi-rectangular geometry via two intramolecular F···H *** of naphthalene,anthracene,pyrene,carbazole,perylene and benzoperylene were introduced to afford coassemblies in the crystalline state.X-ray structures suggest the formation of supramolecular boxes that encapsulate the PAHs with a 2:1 stoichiometric ratio,as well as the formation of consecutive layered ladders with a 1:1 stoichiometric *** preference is adaptive to the geometries of PAHs,and experimental and computational results evidenced the ladder structures possess strong binding *** this top,the selective chiral recognition in the mixtures of PAHs was realized,which shows promising applications in the separation of PAHs and rational design of crystalline chiroptical materials.

关键词： arene-perfluoroarene force coassembly supramolecular chirality selectivity

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Distributed Predefined-Time Control for Cooperative Tracking of Multiple Quadrotor UAVs

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2179-2181页

作者： Kewei Xia xinyi li Kaidan li Yao Zou Advanced Research Institute of Multidisciplinary Sciences Beijing Institute of TechnologyBeijing 100081China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China the School of Automation Beijing Institute of TechnologyBeijing 100081China the School of Intelligence Science and Technology University of Science and Technology BeijingBeijing 100083China the Key Laboratory of Intelligent Bionic Unmanned Systems Ministry of EducationUniversity of Science and Technology BeijingBeijing 100083China

Dear Editor,This letter addresses the predefined-time control for cooperative tracking of multiple quadrotor unmanned aerial vehicles(UAVs)under a directed communication network.A predefined-time distributed estimator... 详细信息

关键词： acceleration letter estimator

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Cold sintered BaTiO_(3)–poly(ether imide)nanocomposites with superior comprehensive performances

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Journal of Advanced Ceramics 2024年第9期13卷 1453-1460页

作者： xinyi li li li Mingming Si Xiaoqian Tai Hong Wang Jing Guo State Key Laboratory for Mechanical Behavior of Materials&School of Materials Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China Guangdong Provisional Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering&Shenzhen Engineering Research Center for Novel Electronic Information Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

With the rapid development of the electronics industry,the demand for dielectric materials with high permittivities,low losses,and excellent electrical breakdown strengths prepared via low-temperature fabrication techniques is ***,we propose a one-step cold sintering process route to improve the comprehensive performance of BaTiO_(3)−based ceramics by integrating polyetherimide(PEI).Dense BaTiO_(3)–PEI nanocomposites can be prepared via a cold sintering process at 250℃ using Ba(OH)_(2∙8)H_(2)O and H_(2)TiO_(3) as the transient liquid *** grain growth of BaTiO_(3) is inhibited,and thin PEI layers less than 10 nm in size are located at the grain *** dissolution‒precipitation process triggered by the transient liquid phase and viscous flow assisted by PEI dominates the cold sintering mechanism of the(1−x)BaTiO_(3)–xPEI *** dielectric properties are stable over a broad temperature range up to 200℃.Compared with BaTiO_(3),80%BaTiO_(3)–20%PEI has superior performance,with a relative permittivity of 163 and a low dielectric loss of 0.014,and the electrical breakdown strength is increased by 80.65%compared with BaTiO_(3).Overall,the cold sintering process provides a potential way to develop dielectric nanocomposites with excellent comprehensive performance.

关键词： cold sintering process(CSP) dielectrics BaTiO_(3) ceramic-polymer composites

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Estimation of Chlorophyll-a Concentration in Lake Taihu from Gaofen-1 Wide-Field-of-View Data through a Machine Learning Trained Algorithm

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Journal of Meteorological Research 2022年第1期36卷 208-226页

作者： Xin HANG Yachun li xinyi li Meng XU liangxiao SUN Jiangsu Climate Center Jiangsu Meteorological BureauNanjing 210008 Nanjing Joint Institute for Atmospheric Sciences Nanjing 210009

Wide-field-of-view(WFV) imager that observes the earth environment with four solar reflective bands in a spatial resolution of 16 m is equipped on board Gaofen-1(GF-1) satellite. Chlorophyll-a(Chl-a) concentration in Lake Taihu, China from 2018 to 2019 is collected and collocated with GF-1 satellite data. This study develops a general and reliable estimation of Chl-a concentration from GF-1 WFV data under turbid inland water conditions. The collocated data are classified according to season and used in random forest(RF) regression to train models for retrieving the lake Chl-a concentration. A composite index is developed to select the most important variables in the models. The models trained for each season show a better performance than the model trained by using the whole year data in terms of the coefficient of determination(R^(2)) between retrievals and observations. Specifically, the R2 values in spring, summer, autumn, and winter are 0.88, 0.88, 0.94, and 0.74, respectively;whereas that using the whole year data is only 0.71. The Chl-a concentration in Lake Taihu exhibits an obvious seasonal change with the highest in summer, followed by autumn and spring, and the lowest in winter. The Chl-a concentration also displays an obvious spatial variation with season. A high concentration occurs mainly in the northwest of the lake. The temporal and spatial changes of Chl-a concentration are almost consistent with the changes in the areas and times of cyanobacteria blooms based on Moderate Resolution Imaging Spectroradiometer(MODIS) data. The proposed algorithm can be operated without a priori knowledge on atmospheric conditions and water quality. Our study also demonstrates that GF-1 data are increasingly valuable for monitoring the Chl-a concentration of inland water bodies in China at a high spatial resolution.

关键词： chlorophyll-a concentration Gaofen-1(GF-1) wide-field-of-view random forest algorithm Lake Taihu

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Norepinephrine-Astrocyte Signaling Regulates Cortical State Homeostasis

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Neuroscience Bulletin 2024年第7期40卷 1021-1024页

作者： Yulan li lixuan li Yibei Wang xinyi li Zhong Chen Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Department of Neurology Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China

Cortical states such as high and low arousal during wakefulness or rapid eye movement(REM)and non-REM(NREM)phases of sleep are fundamental biological processes that are highly conserved across *** intricate balance or... 详细信息

关键词： homeostasis NREM stasis

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Deep tectonics and seismogenic mechanisms of the seismic source zone of the Jishishan M_(s)6.2 earthquake on December 18,2023,at the northeast margin of the Tibetan Plateau

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Earth and Planetary Physics 2024年第3期8卷 514-521页

作者： Qiong Wang ShuYu li xinyi li Yue Wu PanPan Zhao Yuan Gao Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing 100036China Institute of Geophysics China Earthquake AdministrationBeijing 100081China

On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,*** earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of the Tibetan Plateau(i.e.,Qinghai-Tibet Plateau),encompassing a rhombic-shaped area that intersects the Qilian-Qaidam Basin,Alxa Block,Ordos Block,and South China *** this study,we analyzed the deep tectonic pattern of the Jishishan earthquake by incorporating data on the crustal thickness,velocity structure,global navigation satellite system(GNSS)strain field,and *** discovered that the location of the earthquake was related to changes in the crustal *** results showed that the Jishishan M_(s)6.2 earthquake occurred in a unique position,with rapid changes in the crustal thickness,Vp/Vs,phase velocity,and S-wave *** epicenter of the earthquake was situated at the transition zone between high and low velocities and was in proximity to a low-velocity ***,the source area is flanked by two high-velocity anomalies from the east and *** principal compressive strain orientation near the Lajishan Fault is primarily in the NNE and NE directions,which align with the principal compressive stress direction in this *** some areas of the Lajishan Fault,the principal compressive strain orientations show the NNW direction,consistent with the direction of the upper crustal fast-wave polarization from local earthquakes and the phase velocity azimuthal *** features underscore the relationship between the occurrence of the Jishishan M_(s)6.2 earthquake and the deep inhomogeneous structure and deep tectonic *** NE margin of the Tibetan Plateau was thickened by crustal extension in the process of northeastward expansion,and the middle and lower crustal materials underwent structural deformation and may have been filled with salt-containing fluids during the extension *** presence

关键词： Jishishan M_(s)6.2 earthquake crustal structure anisotropy stress and strain seismogenic mechanism northeast margin of the Tibetan Plateau

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