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Journ.l of En.rgy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye li Shuan. Pan.Yihuan. Chen.Qion. liu College of Chemistry an. Materials En.in.erin. Wenzhou University Guan.don. Provin.ial Key Laboratory of Chemical Measuremen. an. Emergen.y Test Techn.logy (Chin.) Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photocatalytic oxygen.reduction.for hydrogen.peroxide （H2O2） syn.hesis presen.s a green.an. costeffective production.***,achievin. highly selective H2O2syn.hesis remain. challen.in.,n.cessitatin. precise con.rol over free radical reaction.pathways an. min.mizin. un.esirable oxidative ***,we report for the visible light-driven.simultan.ous co-photocatalytic reduction.of O2to H2O2an. oxidation.of biomass usin. the atomic rubidium-n.tride modified carbon.1}tride（Cn.b）.The optimized Cn.b catalyst demon.trates a record photoreduction.rate of 8.01 mM h-1for H2O2gen.ration.an. photooxidation.rate of 3.75 mM h-1for furfuryl alcohol to furoic acid,achievin. a remarkable solar-to-chemical con.ersion.（SCC） efficien.y of up to 2.27%.Experimen.al characterization. an. DFT calculation.disclosed that the in.roducin. atomic Rb–n.con.iguration. allows for the high-selective gen.ration.of superoxide radicals while suppressin. hydroxyl free radical *** is because the Rb–n.serves as the n.w altern.tive site to perceive a stron.er con.ection.position.for O2adsorption.an. rein.orce the capability to extract proton.,thereby triggerin. a high selective redox product *** study holds great poten.ial in.precisely regulatin. reactive radical processes at the atomic level,thereby pavin. the way for efficien. syn.hesis of H2O2coupled with biomass valorization.

关键词： Free radical reaction.

Sex differen.es in.agin. an. in.ured brain

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n.ural Regen.ration.Research 2025年第10期20卷 2901-2902页

作者： Jordan.0}Williamson.Yuan.Yan. Un.versity of Illin.is Urban.-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foun.ation.Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA Un.versity of Illin.is Urban.-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA n.rthwestern.Un.versity Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Backgroun.:The prevalen.e,age of on.et,an. symptomatology of traumatic brain.in.ury,stroke,an. n.urodegen.rative diseases(such as Alzheimer’s disease(AD),Parkin.on.s disease,amyotrophic lateral sclerosis,an. Hun.in.ton.s disease)differ substan.ially between.males an. *** higher prevalen.e of these brain.disorders has been.attributed to females havin. a greater lon.evity compared with *** on. of the greatest risk factors of acquired brain.in.ury(such as stroke,traumatic brain.in.ury caused by fall)an. n.urodegen.rative disease is age.

关键词： Hun.in.ton prevalen.e traumatic

Targetin. cholesterol traffickin. to mitigate axon.l degen.ration.in.hereditary spastic paraplegia

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n.ural Regen.ration.Research 2025年第5期20卷 1397-1398页

作者： Zhen.u Chen.Xue-Jun.li Departmen. of Biomedical Scien.es University of Illinois College of Medicine RockfordRockfordILUSA Departmen. of Bioen.in.erin. University of Illinois at ChicagoChicagoILUSA

Axon.l degen.ration.un.erlies man. debilitatin. diseases in.ludin. hereditary spastic paraplegia(HSP),a gen.tically an. clin.cally diverse group of disorders characterized by spasticity an. weakn.ss of the lower *** is on. sign.fican. cause of chron.c n.urodisability due to the lack of effective treatmen.s an. a wide ran.e of on.et ages from early childhood to 70 years.

关键词： degen.ration diseases hereditary

Gradien. maturation.experimen. on.hairs implies taphon.mic chan.es in.fossil hairs

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Scien.e Chin. Earth Scien.es 2025年第1期68卷 62-73页

作者： Xin.li Yibo ZHOU Tao ZHAO Xin.jian.HE Yan.on. PAn State Key Laboratory for Min.ral Deposits Research Center for Critical Earth Material Cycling Centre for Research and Education on Biological Evolution and Environment and Frontiers Science School of Earth Sciences and Engineering Nanjing University In.titute of Palaeon.ology Yunnan Key Laboratory of Earth System Science Yunnan Key Laboratory for PalaeobiologyYunnan University

Mammalian.hair, as a key feature related to en.othermy, physical protection. an. camouflage, has a lon. geohistorical record that dates back even.to the Mesozoic. However, the limited in.ormation.on.the taphon.my of hair hin.ers the un.erstan.in. of its evolution.ry sign.fican.e in.deep time. To address this, we con.ucted taphon.mic experimen.s to simulate the tran.formation.process of black hair. The chan.es in.the morphological structure, microscopic characteristics, an. chemical composition.of hair durin. the simulated fossilization.process were documen.ed by scan.in. electron.microscopy, Fourier tran.form in.rared(FTIR) spectroscopy, an. Raman.spectroscopy. Our results revealed that damage to the morphology of hair began.at a mild temperature(150–175°C), an. hair tran.formed in.o a fluid-like mass at a relatively high temperature(200°C). In.addition. the morphological structure of melan.somes had relatively greater preservation.poten.ial than.keratin. did, an. the microscopic features of melan.somes were persisten.ly stable. The Raman.an. FTIR spectra in.icated that the characteristic melan.n.an. keratin.peaks chan.ed as the temperature in.reased. Although the chemical sign.ls were n.t lost completely, the variation. in.the characteristic amide ban.s in.the FTIR spectra in.icate that the keratin. severely degraded at high temperatures(>200°C), whereas the characteristic melan.n.ban.s in.the Raman.spectra suggested that melan.n.sign.ls were still recogn.zable, even.at high temperatures(>200°C). These results were con.irmed by prin.ipal compon.n. an.lysis(PCA) an. prin.ipal compon.n. an.lysis lin.ar discrimin.n. an.lysis(PCA–LDA). In.addition. the Raman.sign.ls of all the samples in.the simulated experimen.s were distin.uished from the sign.ls of common.geological carbon.ceous materials(humic acid), which suggested that Raman.spectroscopy can.be used to detect melan.n.in.fossils.

关键词： Mammalian.hair Melan.n Keratin Fossilization Experimen.al taphon.my

Emergin. progress: photochemical tran.formation.of n.troso compoun.s

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Scien.e Chin. Chemistry 2025年第1期68卷 118-133页

作者： Ze-Le Chen.Qian.-Qian. li Armido Studer Jun.Xuan An.ui Provin.e Key Laboratory of Chemistry for In.rgan.c/Organ.c Hybrid Fun.tion.lized Materials School of Chemistry & Chemical Engineering Anhui University Organ.sch-Chemisches In.titut Universitat Münster

n.troso compoun.s have emerged as highly valuable reaction.partn.rs or reagen.s in.organ.c syn.hesis due to their rich *** versatile profile of these compoun.s allows them to fun.tion.as electrophiles, n.cleophiles, diradicals, an. radical acceptors in.diverse tran.formation.. In.recen. years, n.table progress has been.made in.harn.ssin. photochemical reaction. with n.troso compoun.s to prepare n.O-con.ain.n. structures usin. mild an. eco-frien.ly con.ition.. Various n.troso compoun.s like n.trosoaren.s, acyloxy n.troso compoun.s, n.n.trosoamin.s an. n.trites have received sign.fican. atten.ion.for their ability to in.roduce n. moieties in.o complex molecules that are otherwise difficult to access. In.this review, we provide an.overview of the recen. advan.emen.s in.the visible light-in.uced con.ersion.of n.troso compoun.s, with particular emphasis on.their role as bifun.tion.l reagen.s an. acceptors of radicals, carben.s an. n.tren.s.

关键词： n.troso compoun.s photochemistry radical reaction carben. tran.formation n.trosoaren.s

Hypidon. hydrochloride(YL-0919)ameliorates fun.tion.l deficits after traumatic brain.in.ury in.mice by activatin. the sigma-1 receptor for an.ioxidation

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n.ural Regen.ration.Research 2025年第8期20卷 2325-2336页

作者： Yafan.Bai Hui Ma Yue Zhan. Jin.en. li Xiaojuan.Hou Yixin.Yan. Guyan.Wan. Yun.en. li Departmen. of An.sthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijin. In.titute of Basic Medical Scien.es BeijingChina Hebei n.rth Un.versity ZhangjiakouHebei ProvinceChina Beijin. In.titute of Pharmacology an. Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain.in.ury in.olves complex pathophysiological mechan.sms,amon. which oxidative stress sign.fican.ly con.ributes to the occurren.e of secon.ary *** this study,we evaluated hypidon. hydrochloride(YL-0919),a self-developed an.idepressan. with selective sigma-1 receptor agon.st properties,an. its associated mechan.sms an. targets in.traumatic brain.*** experimen.s to assess fun.tion.l deficits were followed by assessmen. of n.uron.l damage through histological an.lyses an. examin.tion.of blood-brain.barrier permeability an. brain.***,we in.estigated the an.ioxidative effects of YL-0919 by assessin. the levels of tradition.l markers of oxidative stress in.vivo in.mice an. in.vitro in.HT22 ***,the targeted action.of YL-0919 was verified by employin. a sigma-1 receptor an.agon.st(BD-1047).Our fin.in.s demon.trated that YL-0919 markedly improved deficits in.motor fun.tion.an. spatial cogn.tion.on.day 3 post traumatic brain.in.ury,while also decreasin. n.uron.l mortality an. reversin. blood-brain.barrier disruption.an. brain.***,YL-0919 effectively combated oxidative stress both in.vivo an. in.*** protective effects of YL-0919 were partially in.ibited by *** results in.icated that YL-0919 relieved impairmen.s in.motor an. spatial cogn.tion.by restrain.n. oxidative stress,a n.uroprotective effect that was partially reversed by the sigma-1 receptor an.agon.st ***-0919 may have poten.ial as a n.w treatmen. for traumatic brain.in.ury.

关键词： an.idepressan. drug blood-brain.barrier cogn.tive fun.tion hypidon. hydrochloride(YL-0919) n.urological fun.tion n.clear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain.in.ury

Tran.formin. growth factor-beta 1 en.an.es discharge activity of cortical n.uron.

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n.ural Regen.ration.Research 2025年第2期20卷 548-556页

作者： Zhihui Ren.Tian.li Xueer liu Zelin.Zhan. Xiaoxuan.Chen.Weiqian. Chen.Kan.shen. li Jian.tao Shen. Departmen. of Microbiology an. Immun.logy Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Departmen. of n.urosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Tran.formin. growth factor-beta 1(TGF-β1)has been.exten.ively studied for its pleiotropic effects on.cen.ral n.rvous system *** n.uroprotective or n.urotoxic effects of TGF-β1 in.specific brain.areas may depen. on.the pathological process an. cell types ***-gated sodium chan.els(VGSCs)are essen.ial ion.chan.els for the gen.ration.of action.poten.ials in.0}uron.,an. are in.olved in.various n.uroexcitation.related ***,the effects of TGF-β1 on.the fun.tion.l properties of VGSCs an. firin. properties in.cortical n.uron. remain.*** this study,we in.estigated the effects of TGF-β1 on.VGSC fun.tion.an. firin. properties in.primary cortical n.uron. from *** foun. that TGF-β1 in.reased VGSC curren. den.ity in.a dose-an. time-depen.en. man.er,which was attributable to the upregulation.of n.v1.3 *** VGSC curren. den.ity an. n.v1.3 expression.were sign.fican.ly abolished by prein.ubation.with in.ibitors of mitogen.activated protein.kin.se kin.se(PD98059),p38 mitogen.activated protein.kin.se(SB203580),an. Jun.0}2-termin.l kin.se 1/2 in.ibitor(SP600125).In.erestin.ly,TGF-β1 sign.fican.ly in.reased the firin. threshold of action.poten.ials but did n.t chan.e their firin. rate in.cortical *** fin.in.s suggest that TGF-β1 can.in.rease n.v1.3 expression.through activation.of the ERK1/2-Jn.-MAPK pathway,which leads to a decrease in.the firin. threshold of action.poten.ials in.cortical n.uron. un.er pathological ***,this con.ributes to the occurren.e an. progression.of n.uroexcitatory-related diseases of the cen.ral n.rvous system.

关键词： cen.ral n.rvous system cortical n.uron. ERK firin. properties Jn. n.v1.3 p38 tran.formin. growth factor-beta 1 traumatic brain.in.ury voltage-gated sodium curren.s

Astrocytes, reactive astrogliosis, an. glial scar formation.in.traumatic brain.in.ury

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n.ural Regen.ration.Research 2025年第4期20卷 973-989页

作者： María Belén.Cieri Alberto Javier Ramos Laboratorio de n.uropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain.in.ury is a global health crisis,causin. sign.fican. death an. disability *** that follows traumatic brain.in.ury has serious con.equen.es for n.uron.l survival an. cogn.tive impairmen.s,with astrocytes in.olved in.this *** traumatic brain.in.ury,astrocytes rapidly become reactive,an. astrogliosis propagates from the in.ury core to distan. brain.*** astroglial protein. are down.egulated n.ar the traumatic brain.in.ury core,while pro-in.lammatory astroglial gen.s are *** altered gen. expression.is con.idered a pathological remodelin. of astrocytes that produces serious con.equen.es for n.uron.l survival an. cogn.tive *** addition.glial scar formed by reactive astrocytes is in.tially n.cessary to limit immun. cell in.iltration.but in.the lon. term impedes axon.l recon.ection.an. fun.tion.l *** therapeutic strategies for traumatic brain.in.ury are focused on.preven.in. acute ***,can.abin.ids,progesteron.,beta-blockers,an. cerebrolysin.demon.trate n.uroprotective ben.fits but most of them have n.t been.studied in.the con.ext of *** this review,we discuss the cell sign.lin. pathways activated in.reactive astrocytes followin. traumatic brain.in.ury an. we discuss some of the poten.ial n.w strategies aimed to modulate astroglial respon.es in.traumatic brain.in.ury,especially usin. cell-targeted strategies with miRn.s or ln.Rn.,viral vectors,an. repurposed drugs.

关键词： astrocyte glial scar in.ate immun.ty n.uroin.lammation stab in.ury Toll-like receptors

FUBP3 mediates the amyloid-β-in.uced n.uron.l n.RP3 expression

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n.ural Regen.ration.Research 2025年第7期20卷 2068-2083页

作者： Jin. Yao Yuan.li Xi liu Wen.in. lian. Yu li liyon. Wu Zhe Wan. Weihon. Son. The n.tion.l Clin.cal Research Cen.er for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Departmen. of n.urology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Departmen. of n.urosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Departmen. of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujian. Laboratory(Zhejian. Laboratory for Regen.rative Medicin. Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition.of amyloid-β,which forms extracellular n.uritic plaques,an. accumulation.of hyperphosphorylated tau,which aggregates to form in.ran.uron.l n.urofibrillary tan.les,in.the *** n.RP3 in.lammasome may play a role in.the tran.ition.from amyloid-βdeposition.to tau phosphorylation.an. *** n.RP3 is primarily foun. in.brain.microglia,an. tau is predomin.n.ly located in.0}uron.,it has been.suggested that n.RP3 expressed by microglia in.irectly triggers tau phosphorylation.by upregulatin. the expression.of pro-in.lammatory ***,we foun. that n.uron. also express n.RP3 in.vitro an. in.vivo,an. that n.uron.l n.RP3 regulates tau *** biochemical methods,we mapped the min.mal n.RP3 promoter an. iden.ified FUBP3 as a tran.cription.factor regulatin. n.RP3 expression.in.*** primary n.uron. an. the n.uroblastoma cell lin. n.uro2A,FUBP3 is required for en.ogen.us n.RP3 expression.an. tau phosphorylation.on.y when.amyloid-βis *** the brain. of aged wild-type mice an. a mouse model of Alzheimer's disease,FUBP3 expression.was markedly in.reased in.cortical *** an.lysis suggested that FUBP3 plays a role in.0}uron.mediated immun. *** also foun. that FUBP3 trimmed the 5′en. of Dn. fragmen.s that it boun.,implyin. that FUBP3 fun.tion. in.stress-in.uced *** fin.in.s suggest that n.uron.l n.RP3 may be more directly in.olved in.the amyloid-β-to–phospho-tau tran.ition.than.microglial n.RP3,an. that amyloid-βfun.amen.ally alters the regulatory mechan.sm of n.RP3 expression.in.*** that FUBP3 was on.y expressed at low levels in.youn. wild-type mice an. was stron.ly upregulated in.the brain. of aged mice an. Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preven.in. Alzheimer's disease progression.

关键词： 5′en. trimmin. Alzheimer's disease amyloid-beta amyloid-β-depen.en. tran.cription FUBP3 in.lammasome in.lammation n.uron n.RP3 tau tran.cription.factor

Aquaporin.4-IgG-seropositive n.uromyelitis optica spectrum disorders:progress of experimen.al models based on.disease pathogen.sis

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n.ural Regen.ration.Research 2025年第2期20卷 354-365页

作者： li Xu Huimin. Xu Chan.yon. Tan. Departmen. of n.urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

n.uromyelitis optica spectrum disorders are n.uroin.lammatory demyelin.tin. disorders that lead to perman.n. visual loss an. motor *** date,n. effective treatmen. exists as the exact causative mechan.sm remain. ***,experimen.al models of n.uromyelitis optica spectrum disorders are essen.ial for explorin. its pathogen.sis an. in.screen.n. for therapeutic *** most patien.s with n.uromyelitis optica spectrum disorders are seropositive for IgG autoan.ibodies again.t aquaporin.4,which is highly expressed on.the membran. of astrocyte en.feet,most curren. experimen.al models are based on.aquaporin.4-IgG that in.tially targets *** experimen.al models have successfully simulated man. pathological features of n.uromyelitis optica spectrum disorders,such as aquaporin.4 loss,astrocytopathy,gran.locyte an. macrophage in.iltration.complemen. activation.demyelin.tion.an. n.uron.l loss;however,they do n.t fully capture the pathological process of human.1}uromyelitis optica spectrum *** this review,we summarize the curren.ly kn.wn.pathogen.c mechan.sms an. the developmen. of associated experimen.al models in.vitro,ex vivo,an. in.vivo for n.uromyelitis optica spectrum disorders,suggest poten.ial pathogen.c mechan.sms for further in.estigation.an. provide guidan.e on.experimen.al model *** addition.this review summarizes the latest in.ormation.on.pathologies an. therapies for n.uromyelitis optica spectrum disorders based on.experimen.al models of aquaporin.4-IgG-seropositive n.uromyelitis optica spectrum disorders,offerin. further therapeutic targets an. a theoretical basis for clin.cal trials.

关键词： aquaporin.4 experimen.al model n.uromyelitis optica spectrum disorder pathogen.sis