检索结果-南通市图书馆

[Recent progress in mass spectrometry imaging using nanospray desorption electrospray ionization]

Se pu = Chinese journal of chromatography 2025年第1期43卷 43-49页

作者： Jing-Bo Wang Xiao-lan li Rui-Xia Fan Ping Lü Rui-Chuan Yin West China School of Pharmacy Sichuan University Chengdu 610041 China.

Ambient mass spectrometry imaging (MSI) enables hundreds of analytes in tissue sections to be directly mapped at atmospheric pressure with minimal sample preparation. This field is currently experiencing rapid growth, with numerous reported ambient ionization techniques resulting in a "hundred flowers bloom" situation. Nanospray desorption electrospray ionization (nano-DESI), developed by the Laskin group in 2010, is a widely used liquid-extraction-based ambient ionization technique that was first used for mass spectrometry imaging of tissue in 2012. The nano-DESI probe comprises a primary capillary and a nanospray capillary, with the latter efficiently transferring analyte-containing droplets via a tiny liquid bridge formed between the probe and sample surface, thereby enabling nanoelectrospray ionization (nano-ESI) in front of the inlet of a mass spectrometer. The advantages of nano-DESI MSI include minimal sample preparation, high spatial resolution, and high sensitivity. These features are well-suited for imaging various sample types, including frozen tissue sections, microbial communities, and environmental samples. A PubMed-database search using the "nano-DESI" keyword revealed 72 related articles in the 2010-2024 period, with 34 of them published between 2021 and 2024, which indicates that nano-DESI has rapidly developed as an ambient ionization technique over recent years. Herein, we briefly introduce key nano-DESI-MSI research progress reported in the past three years with the aim of better understanding and facilitating the use of this technology. We first discuss advances in ion-source development. Since no commercial nano-DESI source exists, designing and constructing ion sources remain technical challenges that limit its development. Nano-DESI has been successfully coupled with various types of mass spectrometer, including LTQ Orbitrap, quadrupole-Orbitrap (Q Exactive), 6560 IM QTOF, timsTOF Pro2, triple quadrupole, and FTICR. These couplings have signi

关键词： ambient mass spectrometry imaging nanospray desorption electrospray ionization spatial proteomics structural characterization of lipid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

达州市统筹职业教育、高等教育协同创新路径研究

引用

四川文理学院学报 2025年第1期35卷 116-121页

作者：李岚谭菁菁达州职业技术学院数字文旅与艺术学院四川达州635000

面对人口负增长和老龄化的挑战,达州市需通过统筹职业教育、高等教育协同创新来提升劳动力素质,从而挖掘人口质量红利,支持经济社会发展。统筹职业教育、高等教育协同创新是职业教育和高等教育发挥各自优势,互补各自短板,互相沟通衔接,... 详细信息

面对人口负增长和老龄化的挑战,达州市需通过统筹职业教育、高等教育协同创新来提升劳动力素质,从而挖掘人口质量红利,支持经济社会发展。统筹职业教育、高等教育协同创新是职业教育和高等教育发挥各自优势,互补各自短板,互相沟通衔接,培养高素质人才的过程。当前,达州市经济和教育持续发展,各级各类教育初步融通,统筹职业教育、高等教育协同创新的现实条件越来越充分,但在顶层设计、职业教育与高等教育协调发展、各级各类教育融通、文化理念上仍面临阻碍。对此,需要通过加强顶层设计、提升职业教育办学规模和水平、构建促进各级各类教育融通的“立交桥”、营造文化支持氛围等措施来应对。

关键词：职业教育高等教育协同创新路径研究

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Psu： a novel low-latency constant-degree overlay networ

引用

Frontiers of Computer Science 2011年第2期5卷 250-258页

作者： lan li Wenjun XLAO School of Software Engineering South China University of Technology Guangzhou 510641 China School of Software Nanchang University Nanchang 330031 China

Many structured peer-to-peer （P2P） systems supported by distributed hash table （DHT） schemas have been proposed recently to improve the scalability of distributed virtual application systems. By organizing the peers based on interconnection topologies, existing proposed schemas are purely based on the logical relationship without knowledge of the physical networks. In this paper, we propose a new structured DHT schema, which receives routing information not just from virtual neighbors in P2P overlay network, but also from nearby physical neighbors. The average degree of our model is 5, the diameter is logarithmic. The simulation shows that our model achieves shorter query path length, higher clustering, and better robustness than other overlay networks which have the same level of degree and diameter.

关键词： overlay network Cayley graph physical approximation semi-direct product peer server

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis, Crystal Structure and Antimicrobial Property of 4-Bromo-2-[(3-methypyridin-2-ylimino)methyl]phenol

引用

Chinese Journal of Structural Chemistry 2008年第2期27卷 230-232页

作者： ZHANG li li Kang-lan Institute of Green Chemistry Experiment and Teaching Lanzhou City University Lanzhou 730070 China

The title Schiff base compound 4-bromo-2-[（3-methylpyridin-2-ylimino）methyl]phenol was prepared and structurally characterized by elemental analysis, IR spectrum, and single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group P2 1/n, with a = 4.4870（9）, b = 19.953（4）, c = 13.860（3）A, β = 93.13（3）°, V = 1239.0（4）A3 Z = 4, Dc = 1.561 g/cm3, C13H11BrN2O2 , Mr = 291.15, p = 3.302 mm-1 and F（000） = 584. The final refinement gave R = 0.0608 and wR = 0.1377 for 1329 observed reflections with I 〉 2σ（I）. X-ray diffraction reveals that the non-hydrogen atoms in the compound are nearly coplanar, with the mean deviation of 0.0197A from the plane. The molecule adopts an E configuration about the central C=N functional bond. The compound possesses moderate antimicrobial property.

关键词： Schiff base synthesis crystal structure antimicrobial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fractal Characteristics and Prediction of Backsilting Quantity in Yangtze Estuary Deepwater Channel

引用

China Ocean Engineering 2018年第3期32卷 341-346页

作者： li lan-xi PAN Yun li li Business School Hohai University Marine Science and Technology College Zhejiang Ocean University Institute of Port Coastal and Offshore Engineering Ocean Collage Zhejiang University

Fractal interpolation has been an important method applied to engineering in recent years. It can not only be used to fit smooth curve and stationary data but also show its unique superiorities in the fatting of non-smooth curve and non-stationary data. Through analyzing such characteristic values as average value, standard deviations, skewness and kurtosis of measured backsilting quantities in the Yangtze Estuary 12.5 m Deepwater Channel during2011–2017, the fractal interpolation method can be used to study the backsilting quantity distribution with *** to the fractal interpolation made on the channel backsilting quantities from January 2011 to December2017, there was a good corresponding relationship between the annual(monthly) siltation quantities and the vertical scaling factor. On this basis, a calculation formula for prediction of the backsilting quantity in the Yangtze Estuary Deepwater Channel was constructed. With the relationship between the predicted annual backsilting quantities and the vertical scaling factor, the monthly backsilting quantities can be obtained. Thus, it provides a new method for estimating the backsilting quantity of the Yangtze Estuary Deepwater Channel.

关键词： Yangtze Estuary Deepwater Channel backsilting quantity fractal interpolation prediction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

运动对大学生肠道菌群影响的系统综述

引用

中国组织工程研究 2025年第11期29卷 2394-2401页

作者：刘昭志黄丽田浩冬李岚陈晓陶云飞彭莉西南大学体育学院重庆市400715 西南大学体育学院国家体育总局体质评价与运动机能监控重点实验室重庆市400715 山东中医药大学健康学院山东省济南市250000

背景:运动对肠道菌群的调节与人体健康密切相关,但肠道菌群涉及多方面因素影响,国内外研究尚缺乏有关运动对大学生肠道菌群影响的较为一致的证据。目的:探讨运动对大学生肠道菌群多样性和物种组成的影响。方法:通过系统检索PubMed、Web ... 详细信息

背景:运动对肠道菌群的调节与人体健康密切相关,但肠道菌群涉及多方面因素影响,国内外研究尚缺乏有关运动对大学生肠道菌群影响的较为一致的证据。目的:探讨运动对大学生肠道菌群多样性和物种组成的影响。方法:通过系统检索PubMed、Web of Science、Embase、Medline、Cochrane library、中国知网、万方、维普数据库,筛选后纳入8篇实证研究,对其采用半定量的方法进行分析。结果与结论:①在运动改变大学生肠道菌群物种多样性方面,高强度间歇训练和太极拳运动均能显著提升大学生肠道菌群的物种多样性,而有氧运动对大学生肠道菌群多样性的提升效果不显著;②在运动影响肠道菌群物种组成方面,3种运动方式均能显著改变大学生肠道中菌群的组成结构,可以提高瘤胃球菌、普氏粪杆菌、布劳提亚菌等有益菌的丰度,降低埃希氏菌属等有害菌的丰度;相较于高强度间歇训练,有氧运动和太极拳运动引起了更多有益菌丰度的提升;③除肠道菌群特征的变化外,运动还可以改善大学生体成分、心肺功能以及执行功能等,这些健康效益与运动引起的菌群变化密切相关,这些菌群可通过代谢调节、屏障功能以及神经调节对机体产生健康效益;④虽然目前已有研究证实了运动与肠道菌群存在关联,但运动影响肠道菌群的机制尚未明确,同时定位与宿主健康相关的菌群是未来以肠道菌群为治疗靶点的关键,这些均值得学者进一步关注和探究。

关键词：运动干预大学生肠道菌群菌群多样性物种组成

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A direct electrochemical biosensor for rapid glucose detection based on nitrogen-doped carbon nanocages

引用

Rare Metals 2024年第5期43卷 2184-2192页

作者： lan-lan li Yu Zhao li-Jia Pan Jian-Bin Xu Yi Shi College of Mechanical and Electrical Engineering Henan Agricultural UniversityZhengzhou 450002China School of Electronic Science and Engineering Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China Department of Electronic Engineering The Chinese University of HongKongHongkong 999077China

Given the increasing number of diabetic patients,rapid and accurate detection of glucose in body fluids is *** study developed a direct electrochemical biosensor for glucose based on nitrogen-doped carbon nanocages(NCNCs).NCNCs possess a large specific surface area of 1395 m^(2)·g^(-1),a high N atomic content of 9.37%and good biocompatibility,which is favorable for enzyme loading and electron *** surface average concentration of electroactive glucose oxidase on NCNCs was 2.82×10^(-10)mol·cm^(-2).The NCNC-based direct electrochemical biosensor exhibited a high sensitivity of 13.7μA·(mmol·L^(-1))^(-1)·cm^(-2),rapid response time of 5 s and an impressive electron-transferrate constant(ks)of 1.87 s^(-1).Furthermore,we investigated an NCNC-based direct electron transfer(DET)biosensor for sweat glucose detection,which demonstrated tremendous promise for non-invasive wearable diabetes diagnosis.

关键词： Direct electron transfer(DET) Nitrogen-doped carbon nanocages(NCNCs) Glucose oxidase Biosensor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Existence of Pseudo-Almost Automorphic Solutions for Nonlinear Differential Equations

引用

Acta Mathematicae Applicatae Sinica 2014年第4期30卷 977-988页

作者： lan li YAN WANG College of Mathematics and Computational Science Shenzhen University School of Mathematical Sciences Dalian University of Technology

In this paper, we discuss the existence of pseudo-almost automorphic solutions to linear differential equation which has an exponential trichotomy~ and the results also hold for some nonlinear equations with the form x＇（t） = f（t,x（t））＋ λg（t,x（t））, where f,g are pseudo-almost automorphic functions. We prove our main result by the application of Leray-Schauder fixed point theorem.

关键词： Pseudo-almost automorphic exponential trichotomy Leray-Schauder fixed point theorem

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of forcing data and land surface properties on snow simulation in a regional climate model:a case study over the Tianshan Mountains,Central Asia

引用

Journal of Mountain Science 2021年第12期18卷 3147-3164页

作者： li Qian YANG Tao li lan-hai State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China Ili Station for Watershed Ecosystem Research Chinese Academy of SciencesXinyuan 835800China Key Laboratory for Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China CAS Research Centre for Ecology and Environment of Central Asia Urumqi 830011China Xinjiang Key Laboratory of Water Cycle and Utilization in Arid Zone Urumqi 830011China

Snow is a key variable that influences hydrological and climatic *** surface models employing snow physics-modules can simulate the snow accumulation and ablation ***,there are still uncertainties in modeling snow resources over complex terrain such as *** study employed the National Center for Atmospheric Research’s Weather Research and Forecasting(WRF)model coupled with the Noah-Multiparameterization(Noah-MP)land surface model to run one-year simulations to assess its ability to simulate snow across the Tianshan *** tests were conducted based on different reanalysis forcing datasets and different land surface *** results indicated that the snow dynamics were reproduced in a snow hydrological year by the WRF/Noah-MP model for all of the *** model produced a low bias in snow depth and snow water equivalent(SWE)regardless of the forcing ***,the underestimation of snow depth and SWE could be relatively alleviated by modifying the land cover and vegetation ***,no significant improvement in accuracy was found in the date of snow depth maximum and melt *** best performance was achieved using ERA5 with modified land cover and vegetation parameters(mean bias=−4.03 mm and−1.441 mm for snow depth and SWE,respectively).This study highlights the importance of selecting forcing data for snow simulation over the Tianshan Mountains.

关键词： WRF/Noah-MP model Initial and lateral boundary conditions land surface properties Snow depth Snow water equivalent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Damping of displaced chaotic light field in amplitude dissipation channel

引用

Chinese Physics B 2020年第10期29卷 161-166页

作者： Ke Zhang lan-lan li Hong-Yi Fan School of Electronic Engineering Huainan Normal UniversityHuainan 232038China University of Science and Technology of China Hefei 230031China

We explore how a displaced chaotic light (DCL) behaves in an amplitude dissipation channel, and what is its time evolution formula of photon number distribution. With the use of the method of integration within ordered product product of operator (IWOP) and the new binomial theorem involving two-variable Hermite polynomials we obtain the evolution law of DCL in the channel.

关键词： displaced chaotic light amplitude dissipation channel time evolution formula IWOP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：