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Folate and vitamin b12 in idiopathic male infertility

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Asian Journal of Andrology 2011年第6期13卷 856-861页

作者： Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J levine Division of Epidemiology Statistics and Prevention Research Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda MD 20892 USA School of Medicine Trinity College Dublin Dublin Ireland Glotech Inc Rockville MD 20850 USA Department of Obstetrics and Gynecology Sk~ne University Hospital in Lund Lund University S-221 85 Lund Sweden Reproductive Medicine Centre Skane University Hospital Maimo Lund University S-205 02 Malmo Sweden

Although methylenetetrahydrofolate reductase, a folate enzyme gene, has been associated with idiopathic male infertility, few studies have examined other folate-related metabolites and genes. We investigated whether idiopathic male infertility is associated with variants in folate, vitamin b12 （b12） and total homocysteine （tHcy）-related genes and measured these metabolites in blood. We conducted a case-control study that included 153 men with idiopathic infertility and 184 fertile male controls recruited at the Fertility Center and Antenatal Care Center, University Hospital, Malmo and Lund, Sweden. Serum folate, red cell folate （RCF）, serum b12, plasma tHcy and semen quality were measured. Subjects were genotyped for 20 common variants in 12 genes related to folate/b12/ homocysteine metabolism. Metabolite concentrations and genotype distributions were compared between cases and controls using linear and logistic regression with adjustment for covariates. The phosphatidylethanolamine N-methyltransferase （PEMT） M 175V and TCblR rs173665 polymorphisms were significantly associated with infertility （P=0.01 and P=0.009, respectively）, but not with semen quality. Among non-users of supplements, infertile men had lower serum folate concentrations than fertile men （12.89 vs. 14.73 nmoll^- 1 P=0.02）, but there were no significant differences in RCF, b 12 or tHcy. Folate, b 12 and tHcy concentrations were not correlated with any semen parameters. This study provides little support for low folate or b12 status in the pathogenesis of idiopathic male infertility. Although additional data are needed to confirm these initial findings, our results suggest that PEMTand TCbIR, genes involved in choline and b12 metabolism, merit further investigation in idiopathic male infertility.

关键词： folate idiopathic male infertility semen quality vitamin b12

Targeting adenosine receptor 2b in triple negative breast cancer

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 171-177页

作者： Carola A.Neumann Kevin levine Steffi Oesterreich Department of Pharmacology&Chemical biology University of Pittsburgh Medical Center Hillman Cancer CenterWomens Cancer Research CenterMagee Womens Research InstitutePittsburghPA 15213USA Department of Pathology University of PittsburghPittsburghPA 15261USA

In the review“Role of adenosine in tumor progression:focus on A2b receptor as potential therapeutic target”,Sorrentino and Morello make a compelling case for considering adenosine 2b receptor(A2bR)as a target in cancer therapy(J Cancer Metastasis Treat 2017;3:127-38).A large body of evidence has accumulated suggesting A2bR to play an active role in tumor immune suppression and ***,this commentary will discuss the intriguing possibility of targeting A2bR in specific breast cancers that express high levels of A2bR and attract infiltrating immune cells.

关键词： breast cancer Cancer

business statistics /.4th ed 4th ed.

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丛书名：工商管理经典敎材.

2006年

作者： levine David M.

本书涵盖了应用统计学在当代商务经济领域中几乎所有的重要应用，并且将统计软件（包括Excel，SPSS，Minitab）的使用贯穿全书始终。书中提供了大量的实例。

ISBN: (数字)7300061249

ISBN: (纸本)7300061249

关键词： Industrial management

来源：畅想之星图书光盘版（南... 评论

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低阈值微解理(GaAl)As激光器

半导体光电 1983年第1期 18-19页

作者： b·F·levine 沈家树美国贝尔实验室

在激光器的两面形成微解理镜面,获得了单模、衰减稳定的双异质结(DH)(GaAl)As激光器。这里叙述的用微解理技术制得的激光器能够得到在普通腐蚀镜面激光器中所能得到的许多优点,而且大大地改善了腐蚀镜面激光器由镜面质量所引起的特性,... 详细信息

在激光器的两面形成微解理镜面,获得了单模、衰减稳定的双异质结(DH)(GaAl)As激光器。这里叙述的用微解理技术制得的激光器能够得到在普通腐蚀镜面激光器中所能得到的许多优点,而且大大地改善了腐蚀镜面激光器由镜面质量所引起的特性,这一点完全可以和通常的解理镜面激光器相媲美。这种技术允许在通常容易制得(250×500μm)管芯尺寸的基片上设计出超短的激

关键词：激光器镜面光激射器电子器件 GaAl)As 解理

Depression and race affect hospitalization costs of heart failure patients

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Family Medicine and Community Health 2015年第2期3卷 39-47页

作者： baqar A.Husaini Robert S.levine Meggan L.Novotny Van A.Cain Uchechukwu K.A.Sampson Majaz Moonis Center for Prevention Research Tennessee State UniversityNashvilleTNUSA Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Vanderbilt University Medical Center NashvilleTNUSA Department of Neurology Memorial HospitalWorcesterMAUSA

Objective:Depression and anxiety are frequently observed in heart failure(HF)patients;however,the effect of such factors on hospitalization costs of HF patients,and whether such costs vary by race and gender remain poorly *** analysis delineated the preva-lence of depression/anxiety among HF patients and estimated the effect of race and gender on hospitalization ***:We examined the 2008 files of the Tennessee Hospital Discharge Data System(HDDS)on patients(≥20 years of age)with a primary diagnosis of HF(ICD-9 codes 402,404,and 428)along with demographic data,depression/anxiety diagnoses,hospital costs,and *** the HF sample(n=16,889)53%were female and 23%were *** and gender differences in hospital costs were evaluated for the following three groups:(1)HF patients with depression/anxiety(HF+D);(2)HF-only patients without depression/anxiety(HFO);and(3)HF patients with other mental diagnoses(HF+M).Results:HF was significantly(pblacks compared to whites,and higher among males than *** 25%of HF patients had depression/anxiety(more whites and females were depressed).HF patients averaged more than 3 comorbidities(blacks had a greater number of comorbidities and hospitalization cost for the year).Costs were higher among HF+D patients compared to HFO *** HF+D patients,costs were higher for black males compared with white *** cost patterns prevailed largely because of higher comorbidities that required more re-admissions and longer hospital ***:Race and depression/anxiety are associated with increased hospitalization costs of HF *** higher costs among blacks reflect the higher burden of comorbidities,such as hypertension and diabetes,which calls for widespread dissemination,adoption,and implementation of proven interventions for the control of these comorbidities.

关键词： Hospitalization costs heart failure race gender depression

Evaluating indicators of human well-being for ecosystem-based management

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Ecosystem Health and Sustainability 2017年第12期3卷 2-19页

作者： Sara Jo breslow Margaret Allen Danielle Holstein brit Sojka Raz barnea Xavier basurto Courtney Carothers Susan Charnley arah Coulthard Nives Dolsak Jamie Donatuto Carlos Garcia-Quijano Christina C.Hicks Arielle levine Michael b.Masci Karma Norman Melissa Poe Terre Satterfield Kevin St.Martin Phillip S.Levin Center for Creative Conservation University of WashingtonSeattleWAUSA School of Marine and Environmental Affairs University of WashingtonSeattleWAUSA Nicholas School of the Environment Duke UniversityBeaufortNCUSA College of Fisheries and Ocean Sciences University of Alaska FairbanksAnchorageAKUSA Pacific Northwest Research Station USDA Forest ServicePortlandORUSA Department of Social Sciences and Languages Northumbria UniversityNewcastle upon TyneUK Community Environmental Health Program Swinomish Indian Tribal CommunityLa ConnerWAUSA Department of Sociology and Anthropology The University of Rhode IslandKingstonRI USA Center for Ocean Solutions Stanford UniversityMontereyCAUSA Lancaster Environment Center Lancaster UniversityLancasterUK Department of Geography San Diego State UniversitySan DiegoCAUSA Moore Center for Science Conservation InternationalArlingtonVAUS Northwest Fisheries Science Center National Oceanic and Atmospheric AdministrationSeattleWAUSA Washington Sea Grant University of WashingtonSeattleWAUSA Institute for Resources Environment and SustainabilityUniversity of British ColumbiaVancouverBCCanada Department of Geography RutgersThe State University of New JerseyPiscatawayNJUSA School of Environmental and Forest Sciences University of WashingtonSeattleWAUSA

Introduction:Interrelated social and ecological challenges demand an understanding of how environmental change and management decisions affect human *** paper out-lines a framework for measuring human well-being for ecosystem-based management(EbM).We present a prototype that can be adapted and developed for various scales and *** and managers use indicators to assess status and trends in integrated ecosystem assessments(IEAs).To improve the social science rigor and success of EbM,we developed a systematic and transparent approach for evaluating indicators of human well-being for an ***:Our process is based on a comprehensive conceptualization of human well-being,a scalable analysis of management priorities,and a set of indicator screening criteria tailored to the needs of *** tested our approach by evaluating more than 2000 existing social indicators related to ocean and coastal management of the US West *** focused on two foundational attributes of human well-being:resource access and *** and Discussion:Our results suggest that existing indicators and data are limited in their ability to reflect linkages between environmental change and human well-being,and extremely limited in their ability to assess social equity and *** reveal a critical need for new social indicators tailored to answer environmental questions and new data that are disaggregated by social variables to measure *** both,we stress the importance of collaborating with the people whose well-being is to be ***:Our framework is designed to encourage governments and communities to carefully assess the complex tradeoffs inherent in environmental decision-making.

关键词： Human well-being indicators ecosystem-based management integrated ecosystem assessment resource access self-determination

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热应激对充血性心衰患者体温调节反应的影响

世界核心医学期刊文摘(心脏病学分册) 2006年第3期 42-43页

作者： Arbab-Zadeh A. Prasad A. b.D. levine 马超 Institute for Exercise and Environmental Medicine Presbyterian Hospital of Dallas 7232 Greenville Ave Dallas TX 75231 United States Dr.

background-Clinical observations suggest that tolerance to heat stress may be impaired in patients with cardiovascular diseases, particularly those associated with impaired ventricular function and congestive heart failure(CHF). However, thermoregulatory function during a controlled heat stress challenge in patients with CHF has not been studied. Methods and Results -To test the hypothesis that thermoregulatory responses are attenuated in such patients, we assessed cutaneous vasodilation and sweat rate in patients with stable class II-III CHF and in matched healthy subjects during passive whole-body heating. Whole-body heating induced a similar increase in internal temperature(≈ 0.85° C) in both groups. The sweating responses in patients with CHF were not significantly different from that in control subjects. In contrast, the elevation in forearm cutaneous vascular conductance in patients with CHF was reduced by nearly 50% relative to the control subjects(3.8± 0.8 versus 6.9± 1.0 mL/100 mL tissue per minute per 100 mm Hg, P=0.04). Moreover, maximal cutaneous vasodilator capacity to direct local heating in patients with CHF was also significantly lower than in control subjects, suggesting that vascular remodeling may be limiting cutaneous vasodilation during hyperthermia. Conclusions -These observations suggest that patients with CHF exhibit attenuated cutaneous vasodilator responses to both whole-body and local heating, whereas sweating responses are preserved. Attenuated cutaneous vasodilation may be a potential mechanism for heat intolerance in patients with CHF.

关键词：充血性心衰皮肤解剖部位患者体温调节反应热应激

basic business statistics : concepts and applications / Mark L. berenson, David M. levine. 7th ed.

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1999年

作者： Mark L. berenson David M. levine.

来源：畅想之星图书光盘版（南... 评论

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世俗主义之乐

世俗主义之乐