检索结果-南通市图书馆

Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2022年第5期11卷 1121-1133页

作者： Chong Ning Yuhan Jiao Jiaqi Wang Weiwei Li Jingqiu Zhou Yi-Chieh Lee Dik-Lung Ma chung-Hang leung Rugang Zhu Hui-Min David Wang College of Light Industry Liaoning UniversityShenyang 110036China Department of Life Sciences National Chung Hsing UniversityTaichung 402TaiwanChina Department of Chemistry Hong Kong Baptist UniversityKowloon Tong 999077Hong KongChina State Key Laboratoryof Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Graduate Institute of Biomedical Engineering National Chung Hsing UniversityTaichung 402TaiwanChina Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiung City 807TaiwanChina Department of Medical Laboratory Science and Biotechnology China Medical UniversityTaichung City 404TaiwanChina

Diabetes has become a global concern at present,among which type 2 diabetes mellitus(T2DM)accounts for approximately 90%-95%of patients.T2DM is a type of metabolic disorder syndrome that results from a genetic defect,and it is based on insulin resistance and an insulin secretion *** occurrence of T2DM is usually the outcome of both genetic and environmental factors and their *** etiology and pathogenesis of diabetes have not been fully elucidated,and no radical therapeutic cure has been *** with T2DM suffer from complications such as the development of a chronic hyperglycemic condition and even serious metabolic disorders and organ damage in the body and depression and dementia,in addition to other chronic *** studies have suggested that diet is crucial in the development of diabetes and the control of blood *** substances have the characteristics of low toxicity and few side effects and may be key to the development of diabetic health products and preventive *** paper reviews the etiology,pathogenesis,risks,treatments and diets related to T2DM to summarize the types of recently available natural products,from both local and foreign sources,for lowering blood glucose at home and their application in supplementary hypoglycemic *** key findings and conclusions suggest that there are various known T2DM-inducing factors,including genetic and environmental factors and three types of hybrid factors.

关键词： Obesity Type 2 diabetes mellitus Etiological agent Diet Insulin resistance Natural substances

同方期刊数据库

Solution procedure of residue harmonic balance method and its applications

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2014年第8期57卷 1581-1591页

作者： GUO ZhongJin leung A Y T MA XiaoYan School of Mathematics and Statistics Taishan University Department of Civil and Architectural Engineering City University of Hong Kong

This paper presents a simple and rigorous solution procedure of residue harmonic balance for predicting the accurate approximation of certain autonomous ordinary differential *** this solution procedure,no small parameter is *** harmonic residue of balance equation is separated in two parts at each *** first part has the same number of Fourier terms as the present order of approximation and the remaining part is used in the subsequent *** corrections are governed by linear ordinary differential equation so that they can be solved easily by means of harmonic balance method *** kinds of different differential equations involving general,fractional and delay ordinary differential systems are given as numerical examples *** accurate limited cycle frequency and amplitude are *** results match well with the exact solutions or numerical solutions for a wide range of control *** with those available shows that the residue harmonic balance solution procedure is very effective for these autonomous differential ***,the present method works not only in predicting the amplitude but also the frequency of bifurcated period solution for delay ordinary differential equation.

关键词： residue harmonic balance accurate approximation fractional ordinary differential system delay ordinary differential system

Potential Use of Strain Hardening ECC in Permanent Formwork with Small Scale Flexural Beams

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2009年第3期24卷 482-487页

作者：李贺东 Christopher K Y leung Department of Civil Engineering Hong Kong University of Science and Technology

Utilizing pre-cast ECC panels as participating permanent formwork of concrete members, and the validity of using ECC to disperse the single crack in concrete into multiple ones in ECC were studied. In the process, totally two kinds of ECC with different tensile properties, 7 series of flat panels with different top surface figures and 3 U-shape panels with different inner surface forms were investigated. To evaluate the performance of the permanent formworks, small ECC-concrete composite beams were cast and tested mechanically. The 4-point bending test results show that the use of pre-cast ECC panels as permanent formwork can significantly improve the load capacity and toughness of a concrete member, effectively dispersing single widely opened crack in concrete into multiple ones in ECC. Most permanent formworks show perfect bond with the concrete cast on them, while the ones with partially debonded zone achieve the best mechanical performance. The U-shape permanent formworks show better performances than the flat ones, achieving much betler improvements in both the load capacity and toughness, together with better crack width control.

关键词： pseudo strain hardening cementitious composites permanent formwork toughness crack

A Time Neighborhood Method for the Verification of Landfalling Typhoon Track Forecast

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2023年第2期40卷 273-284页

作者： Daosheng XU Jeremy Cheuk-Hin leung Banglin ZHANG Guangzhou Institute of Tropical and Marine Meteorology/Guangdong Provincial Key Laboratory of Regional Numerical Weather Prediction CMAGuangzhou 510640China

Landfalling typhoons can cause disasters over large *** government and emergency responders need to take measures to mitigate disasters according to the forecast of landfall position,while slight timing error can be *** reliability of operational model forecasts of typhoon landfall position needs to be evaluated beforehand,according to the forecasts and observation of historical *** the evaluation of landfalling typhoon track,the traditional method based on point-to-point matching methods could be influenced by the predicted typhoon translation ***,the traditional track evaluation method may result in a large track error even if the predicted landfall position is close to *** purpose of this paper is to address the above issue using a simple evaluation method of landfalling typhoon track forecast based on the time neighborhood *** this new method,the timing error was lessened to highlight the importance of the position error during the landfall of *** properties of the time neighborhood method are compared with the traditional method based on numerical forecast results of 12 landfalling typhoon *** demonstrated that the new method is not sensitive to the sampling frequency,and that the difference between the time neighborhood and traditional method will be more obvious when the moving speed of typhoon is moderate(between 15−30 km h^(−1)).The time neighborhood concept can be easily extended to a broader context when one attempts to examine the position error more than the timing error.

关键词： time neighborhood method typhoon track landfalling typhoon model evaluation

Abscisic Acid Signal off the STARTing Block

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2011年第4期4卷 562-580页

作者： Archana Joshi-Saha Christiane Valon Jeffrey leung Institut des Sciences du Vegetal Centre National de la Recherche Scientifique UPR2355 1 Avenue de la Terrasse Bat. 23 91198 Gif-sur-Yvette France

The year 2009 marked a real turnaround in our understanding of the mode of abscisic acid （ABA） action. Nearly 25 years had elapsed since the first biochemical detection of ABA-binding proteins in the plasmalemma of Vicia guard cells was reported. This recent--and laudable--achievement is owed largely to the discovery of the soluble ABA receptors whose major interacting proteins happen to be some of the most well-established components of earliest steps in ABA signaling. These soluble receptors, with the double name of PYRABACTIN RESISTANCE （PYR） or REGULATORY COMPONENT OF ABA RECEPTOR （RCAR）, are a family of Arabidopsis proteins of about 150-200 amino acids that share a conserved START domain. The ABA signal transduction circuitry under non-stress conditions is muted by the clade A protein phosphatases 2C （PP2C）（notably HAB1, ABI1, and ABI2）. During the initial steps of ABA signaling, the binding of the hormone to the receptor induces a conformational change in the latter that allows it to sequester the PP2Cs. This excludes them from the negative regulation of the downstream ABA-activated kinases （OST1/SnRK2.6/SRK2E, SnRK2.2, and SnRK2.3）, thus unleashing the pathway by freeing them to phosphorylate downstream targets that now include several b-ZIP transcription factors, ion channels （SLAC1, KAT1）, and a NADPH oxidase （AtrbohF）. The discovery of this family of soluble receptors and the rich insight already gained from structural studies of their complexes with different isoforms of ABA, PP2C, and the synthetic agonist pyrabactin lay the foundation towards rational design of chemical switches that can bolster drought hardiness in plants.

关键词： Abiotic/environmental stress hormone biology signal transduction.

CUF, a herbal formula for the treatment of asthma: A randomized, double-blind, placebo-controlled study in the treatment of childhood asthma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2013年第10期5卷 1580-1589页

作者： Eliza L. Y. Wong Rita Y. T. Sung ping-chung leung King-Fai Cheng Department of Paediatrics Faculty of Medicine The Chinese University of Hong Kong Hong Kong China Institute of Chinese Medicine The Chinese University of Hong Kong Hong Kong China The Jockey Club School of Public Health and Primary Care Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

Background: Complementary and alternative medicines are increasingly used for the treatment of asthma worldwide. A five-herb herbal formula (CUF) has been found to be effective and safe in an animal model of asthma and in a preliminary clinical study. Objective: The objective of this study was to evaluate the safety and efficacy of CUF in children suffering from asthma. Design: A randomized, double blind, and placebo-controlled, parallel study. Interventions: Subjects received CUF or placebo for 6 months. Efficacy variables included changes in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), Paediatric Asthma Quality of Life Questionnaire (PAQLQ), and steroidal consumption. Results: A total of 100 asthmatic children were enrolled and assigned to two treatment groups. The first group received CUF 6 capsules (3 g/day) and the second group received placebo. There was a statistically significant difference in mean spirometric indexes in CUF group at baseline and follow-up visits. In the CUF group, the activity domain showed significant improvement (p = 0.045). FEV% was significantly improved in the CUF group (p strated. It improved the pulmonary functions of the children, namely, FEV1 and FVC. However, further research on a larger scale is warranted.

关键词： Asthma Children Herbal Formula Lung Function Paediatric Asthma Quality of Life Questionnaire (PAQLQ)

Characteristics of urban ozone level in Hong kong

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2001年第1期13卷 1-7页

作者： D.Y.C.leung D.N.ZHANG Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong KongChina Research Institute of Environmental Engineering East China University of Science and TechnologyShanghai 200237China

The long term trend of ozone level in Hong Kong has been investigated. One of the characteristics of ozone level in Hong Kong is the existence of autumn maximum and summer minimum. Observations of the diurnal variation of ozone level have been made in different area categories. There are early morning peak and afternoon peak occurred in the diurnal variation, which are different from some metropolitans where only an afternoon peak is observed. A negative correlation coefficient was found between monthly ozone level with nitric oxide level. On the contrary, there is a positive correlation between ozone and nitrogen dioxide. The positive correlation coefficient between nitric oxide and nitrogen dioxide shows that the total amount of nitric oxide emitted from a series of moving and fixed sources greatly exceeded the stoichiometric amount of ozone formed from chemical reactions of precursors and long distance transportation.

关键词： ozone urban air pollution Hong kong China

Lanthanide mechanoluminescence

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2018年第1期36卷 1-41页

作者： Jean-Claude G.Bünzli Ka-leung Wong Institute of Chemical Sciences and Engineering Swiss Federal Institute of Technology Lausanne (EPFL) CH-1015 Lausanne Switzerland Department of Chemistry Hong Kong Baptist University Kowloon Tong Hong Kong China

Mechanoluminescence （ML） is the emission of light consecutive to a mechanical force or stress imposed to a crystalline material. Many inorganic and organic compounds present this phenomenon that is known for over 400 years. Lanthanide and uranyl salts were among the first substances investigated for this property. Mechanoluminescence, also referred to as triboluminescence, is often considered as being a badly understood phenomenon. In fact it is because of two main reasons. Firstly, a variety of different mechanical stresses, from simple rubbing, to applied pressure, crushing, impact of a weight, ultrasound, laser-generated shock wave, crystallization, dissolution of crystals, or even wind can trigger it. Secondly, ML is very sensitive to the purity and morphology of the sample： in inorganic compounds, generation of traps by doping ＂impurities＂（e.g. lanthanide ions） is responsible for light emission so that the exact composition of the sample has to be known to a very detailed level; for chelates, the crystallization conditions are crucial since they often generate extended networks of weak interactions that are instrumental in triggering ML when they are broken. In fact mechanisms of ML are relatively well known and theories and models often reproduce very well the experiments. Additionally, practical applications are at hand, for example stress, crack, and impact sensors based on SrAI204：Eu11 or Et3NH[Eu（dbm）4] are used to test structures and materials as diverse as road bridges, reinforced concrete elements, pressur- ized containers or airplane wings and to image the propagation of cracks or stress distribution. Military and security applications involve detecting the passage of vehicle or soldiers and producing counter- feiting inks while more joyful applications are luminous balls, wrapping papers and adhesive tapes. Not only bulk materials, but micro- and nanoparticles feature mechanoluminescent properties and single particle manipulation under an AFM allows

关键词： MechanoluminescenceRare earthsStress sensorsPressure sensorsImpact sensors

Gastrointestinal bleeding in patients on novel oral anticoagulants:Risk,prevention and management

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第11期23卷 1954-1963页

作者： Ka-Shing Cheung Wai K leung Department of Medicine The University of Hong KongQueen Mary HospitalHong KongChina

Novel oral anticoagulants(NOACs), which include direct thrombin inhibitor(dabigatran) and direct factor Xa inhibitors(rivaroxaban, apixaban and edoxaban), are gaining popularity in the prevention of embolic stroke in non-valvular atrial fibrillation as well as in the prevention and treatment of venous thromboembolism. However, similar to traditional anticoagulants, NOACs have the side effects of bleeding, including gastrointestinal bleeding(GIB). Results from both randomized clinical trials and observations studies suggest that high-dose dabigatran(150 mg b.i.d), rivaroxaban and high-dose edoxaban(60 mg daily) are associated with a higher risk of GIB compared with warfarin. Other risk factors of NOAC-related GIB include concomitant use of ulcerogenic agents, older age, renal impairment, Helicobacter pylori infection and a past history of GIB. Prevention of NOAC-related GIB includes proper patient selection, using a lower dose of certain NOACs and in patients with renal impairment, correction of modifiable risk factors, and prescription of gastroprotective agents. Overt GIB can be managed by withholding NOACs followed by delayed endoscopic treatment. In severe bleeding, additional measures include administration of activated charcoal, use of specific reversal agents such as idarucizumab for dabigatran and andexanent alfa for factor Xa inhibitors, and urgent endoscopic management.

关键词： Warfarin Endoscopy Apixaban Edoxaban Gastrointestinal bleeding Dabigatran Rivaroxaban Novel anticoagulants