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Focus on alcoholic liver disease:From nosography to treatment

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World Journal of Gastroenterology 2014年第25期20卷 8040-8047页

作者： letitia Adela maria streba Cristin Constantin Vere Costin Teodor streba Marius Eugen Ciurea Internal Medicine-Medical Semiology University of Medicine and Pharmacy of Craiova 200639 Craiova Romania Research Center of Gastroenterology and Hepatology of Craiova University of Medicine and Pharmacy of Craiova200639 CraiovaRomania University of Medicine and Pharmacy of Craiova 200639 Craiova Romania

Abusive alcohol intake currently ranks as a major cause of liver disease, and is associated with significant mortality worldwide. Alcoholic liver disease(ALD) generically defines liver abnormalities ranging from liver steatosis to the end-stages of disease such as liver cirrhosis. Information regarding the precise incidence and prevalence of ALD is still limited by a lack of large population-based studies and by the absence of large systematic reviews of all epidemiological data available. However, existing collected data show an overall increase in the number of alcohol abusers and alcoholrelated liver disease. The burden exerted on medical systems worldwide is significant, with hospitalization and management costs rising constantly over the years. A great number of all cirrhosis-related deaths in Europe and a significant percentage worldwide areassociated with alcohol consumption. The main possible risk factors for ALD are the amount and duration of alcohol abuse, patterns of drinking and the type of alcoholic beverage consumed. However, ALD does not progress to cirrhosis in all patients, therefore a series of additional factors are implicated. Even though insufficiently studied, genetic factors are generally regarded as highly important, and the presence of comorbidities and dietary habits seem to play a role in disease onset and progression. This lack of clear pathophysiological data further translates in the absence of definite treatment for ALD and shall prove challenging in the coming years. In this article, we aimed to briefly review epidemiologic data on the burden of ALD, risk factors, clinical and nosographic as well as therapeutic aspects of this disease. Without attempting to be exhaustive, this short topic highlight emphasizes each point and may serve as a general guidance tool in the complicated literature related to ALD.

关键词： Alcoholic liver disease Epidemiology Risk factors Diagnosis Treatment

Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma: An open question

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World Journal of Gastroenterology 2015年第14期21卷 4103-4110页

作者： letitia Adela maria streba Cristin Constantin Vere Ion Rogoveanu Costin Teodor streba Internal Medicine Medical SemiologyUniversity of Medicine and Pharmacy of Craiova Research Center of Gastroenterology and Hepatology of Craiova University of Medicine and Pharmacy of Craiova Internal Medicine GastroenterologyUniversity of Medicine and Pharmacy of Craiova

Non-alcoholic liver disease(NAFLD) defines liver abnormalities ranging from simple steatosis to nonalcoholic steatohepatitis with or without cirrhosis development, occurring in the absence of significant alcohol consumption, use of teratogenic medication, or hereditary *** association between NAFLD and metabolic syndrome is well documented and widely ***, type 2 diabetes mellitus(T2DM), and dyslipidemia are the most common metabolic risk factors associated with *** the components of metabolic syndrome, current evidence strongly indicates obesity and diabetes as hepatocellular carcinoma(HCC) risk *** is also growing evidence that suggests an increased risk of HCC in NAFLD patients, even surpassing other etiologies in some high-income *** data demonstrate a parallel rise in prevalence of obesity, diabetes, NAFLD, and *** obesity and its related diseases have steadily afflicted larger populations, HCC incidence is expected to increase in the *** mechanisms that underlie NAFLD development and subsequent progression to nonalcoholic steatohepatitis and cirrhosis(insulin resistance and hyperinsulinemia, oxidative stress, hepatic stellate cell activation, cytokine/adipocytokine signaling pathways, and genetic and environmental factors) appear to play a significant role in the development of NAFLD-related ***, a comprehensive view of molecular mechanisms linking obesity, T2 DM, and NAFLD-related HCC, as well as the exact sequence of molecular events, is still not understood in its ***-quality data are still necessary, and efforts should continue towards better understanding the underlying carcinogenic mechanisms of NAFLD-related *** this paper, we aimed to centralize the most important links supporting these relationships, focusing on obesity, T2 DM, and NAFLD-related HCC, as well as point out the major gaps in knowledge regarding the underlying molecular mechanisms beh

关键词： Diabetes mellitus Hepatocellular carcinoma Metabol

Role of intrahepatic innervation in regulating the activity of liver cells

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World Journal of Hepatology 2014年第3期6卷 137-143页

作者： letitia Adela maria streba Cristin Constantin Vere Alin Gabriel Ionescu Costin Teodor streba Ion Rogoveanu University of Medicine and Pharmacy of Craiova Research Center of Gastroenterology and Hepatology University of Medicine and Pharmacy of Craiova

Liver innervation comprises sympathetic,parasympathetic and peptidergic nerve fibers,organized as either afferent or efferent nerves with different origins and *** anatomy and physiology have been studied in the past 30 years,with different results published over *** are the main cell population of the liver,making up almost 80%of the total liver *** interaction between hepatocytes and nerve fibers is accomplished through a wealth of neurotransmitters and signaling *** this short review,we have taken the task of condensing the most important data related to how the nervous system interacts with the liver and especially with the hepatocyte population,how it influences their metabolism and functions,and how different receptors and transmitters are involved in this complex process.

关键词： Liver innervations Hepatocytes Neurotransmitters Cellular receptors

A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal Models and Experimental Medicine 2024年第3期7卷 367-376页

作者： Lauren S.Kelly Jennifer A.Munley Erick E.Pons Kolenkode B.Kannan Elizabeth M.Whitley letitia E.Bible Philip A.Efron Alicia M.Mohr Department of Surgery and Sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

Background:Severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:Male Sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LCHS),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(BM)erythroid progenitor(CFU-GEMM,BFU-E,and CFU-E)growth,plasma granulocyte colony-stimulating factor(G-CSF)and right lung histologic injury were assessed on day 7,with significance defined as p values<0.05(*).Results:Polytrauma resulted in markedly more profound inhibition of weight gain compared to LCHS(p=0.0002)along with elevated plasma TLR4(p<0.0001),lower hemoglobin(p<0.0001),and enlarged spleen to body weight ratios(p=0.004).Both LCHS and PT demonstrated suppression of CFU-E and BFU-E growth compared to naive(p<0.03,p<0.01).Plasma G-CSF was elevated in PT compared to both na?ve and LCHS(p<0.0001,p=0.02).LCHS and PT demonstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:Multicompartmental injury as described here establishes a reproducible model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

New Episode in PV Trade Dispute

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China International Business 2012年第12期 46-47页

作者： letitia CHENG

China has lodged a complaint with the World Trade Organization （WTO） about European Union（EU） subsidies for photovoltaic （PV） products. The case, launched by China＇s Ministry of Commerce （MOFCOM） on November 5, focuses on subsidies granted by Italy and Greece. According to the law in the two countries, electricity is entitled to certain subsidies if the power is generated by PV installations with the main components produced within the EU or the European Economic Area.

关键词：贸易争端世界贸易组织欧洲联盟发电装置组成部分补贴 WTO 商务部

Henan One of the Biggest Provinces Finally Takes off--Crouching Tiger in the Central Plains

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China International Business 2011年第12期 57-60页

作者： letitia CHENG

Historically called ＂the Central Plains＂, Henan Province is considered the birthplace of the Chinese civilization and the Chinese nation. With rich culture and natural resources, Henan Province has nurtured generations of outstanding people, and remains a big province of population, culture, tourism, agriculture and economy in China.

关键词：河南省中原起飞文化资源中华民族自然资源虎发祥地

When Publishing Meets Digitalization

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China International Business 2013年第5期 44-46页

作者： letitia CHENG

Interview with Shen Lijun, Vice President of the Foreign Language Teaching and Research PressWith so many readers turning away from print books and to electronic devices, traditional publishers may be feeling the pressure of the digital age. Shen Lijun, vice president of the Foreign LanguageTeaching and Research Press （＇FLTRP） calls for the ~ght att^itu^e to embrace the changes brought by digitalization.

关键词：数字化时代传统出版电子设备外语教学出版社外交部 ATT ITU

Welcome to the American Footbal

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China International Business 2013年第5期 36-37页

作者： letitia CHENG

Interview with Nathan Jones, China Federation of American Football representative of the InternationalIn the sports sector at the 2nd China （Beijing） International Fair for Trade in Services （CIFTIS）, there will be several overseas delegates attending the International Sports Service Trade Forum and Sports ServiceExhibition. One of the organizations represented is the International Federation of American Football （IFAF）, which is planning to introduce a brand new sports programme for Chinese youngsters.

关键词：足球体育节目美国国际贸易服务贸易博览会中国青少年

A New Deal for Movies

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China International Business 2012年第4期 38-40页

作者： letitia CHENG

On the screen, Tom Cruise is run- ning through a sandstorm in Dubai： it＇s Mission Impossible：Ghost Protocol. As the hero desperately climbs the outside of the Burj Khalifa tower with fancy gloves and thrilling iumps, Xiao Dong, a student in Tianjin, is watching. The 19-year-old is a Hollywood movie fan, and rarely misses the latest blockbuster.

关键词：电影沙尘暴好莱坞迪拜屏幕