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Late and very late onset group B Streptococcus sepsis:one and the same?

World Journal of Pediatrics 2014年第1期10卷 24-28页

作者： Joseph B Cantey Courtney Baldridge Rachel Jamison leticia a shanley Department of Pediatrics University of Texas Southwestern Medical CenterDallasTXUSA

Background:This study aimed to describe the clinical characteristics of group B Streptococcus(GBS)sepsis in infants aged 4–90 days[late onset(LO)]compared to infants>90 days of age[very late onset(VLO)].Methods:Microbiology records at Children’s Medical Center Dallas were ***,clinical,and outcome data were collected for infants with GBS recovered from blood or cerebrospinal fluid culture from January 1,2006 to July 1,***:Totally 48 infants were identified(42 LO,6 VLO).Infants with VLO sepsis had lower median gestational age(28.5 vs.39 weeks gestation,P<0.001)and longer median nursery admissions(8.8 vs.0.5 weeks,P=0.004).When gestational age was controlled for,there were no differences in clinical presentation,intensive care unit admission,length of stay,neurodevelopmental outcome,and *** with VLO sepsis were more likely to receive vancomycin(83%vs.33%,P=0.02)or third-generation cephalosporins(83%vs.24%,P=0.009),and more likely to continue on those agents even after GBS was ***:Infants with VLO sepsis had lower gestational ages and longer nursery stays than infants with LO *** age at presentation,there were no significant differences in clinical presentations,hospital course,frequency of neurodevelopmental sequelae,and mortality in infants presenting with LO *** GBS *** with VLO sepsis were more likely to receive empiric broad spectrum antimicrobials and more likely to continue receiving broad therapy even following GBS identification.

关键词： group B Streptococcus infant meningitis sepsis

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