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Serum Concentrations of Tumor Necrosis Factor-α and its Soluble Receptors in Soldiers with and Without Combat-related Posttraumatic Stress Disorder： Influence of Age and Body mass Index

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Chinese medical Journal 2016年第6期129卷 751-752页

作者： Hubertus Himmerich Jorg-Egbert Wolf Peter Zimmermann Antje H Biihler lesca m holdt Daniel Teupser Kenneth C Kirkby Gerd D Willmund Ulrich Wesemann Department of Psychiatry Psychotherapy and Psychotraumatology Bundeswehr Hospital Berlin Germany Department of Psychological medicine King's College London London UK Department of Psychiatry and Psychotherapy University Hospital Leipzig Leipzig Germany Department of Laboratory medicine Ludw g-Max m ans-University Munich Germany Department of Psychiatry University of Tasmania Hobart Tasmania Australia

To the Editor： With great interest we read the original article of Chert et al published in the Chinese medical Journal comparing serum concentrations of cytokines in patients of Han and Li ethnicity with posttraumatic stress disorder （PTSD）. The authors found significantly higher serum concentrations of the cytokines interleukin （IL）-2, IL-6, IL-8, and tumor necrosis factor （TNF）-α in PTSD patients compared to normal controls, and differences in cytokine concentrations according to ethnicity.

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1例患X染色体连锁的肾上腺脑白质营养不良的女性先证者:临床表现、生物学诊断及家系调查结果

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世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 16-17页

作者： lesca G. Vanier m.T. Creisson E. 朱新菊 Laboratoire de Gé né tique Pavillone Hpital Edouard-Herriot 5 place d'Arsonval 69437 Lyon Cedex 03 France

Introduction. - X-linked adrenoleukodystrophy (ALD) is the most frequent type of leukodystrophy (1/17 000 males). The phenotypic range in male patients varies from the severe cerebral presentations in children to the milder myeloneuropathy and to isolate adrenal insufficiency. more than a half of the carrier females display clinical symptoms over the age of 40 years. Observation. - Diagnosis of ALD was raised in a 40 year-old female who presented with spastic paraparesis and sphincterian dysfunction, occurring after the delivery of her first child. There was no family history of ALD. Very long-chain fatty acids (VLCFA) were assayed in her one-year-old son in order to propose appropriate hormonal and neurological survey. His dosage was abnormal and an adrenal insufficiency was subsequently found. A brain mRI will be proposed biannually when he reaches to age of for years. The proband’s mother had an increased level of VLCFA, showing that she was a carrier. Family screening was extended to the proband’s sisters and maternal aunt who already had children, but also to her brother, who may express a mild form of the disease later on, and to her maternal uncles who might be asymptomatic carriers. A frameshift mutation was found in the ABCD1 gene and will allow accurate carrier identification and prenatal diagnosis in the family. Conclusion. - ALD diagnosis should be evoked in a woman affected by myelopathy despite the lack of family history. Such a diagnosis has severe consequences since some of the related males may carry the mutation although they do not display any symptom at time of diagnosis, and because carrier females have a risk to both have a clinical expression of the disease and give birth to an affected boy.

关键词： X染色体连锁先证者家系调查脑白质脑部症状携带者肾上腺功能不全临床发作括约肌功能病型

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