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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 43-43页

作者： Gilaber.e M Gallar.o F Bellosillo B. r.M. Pujol 罗素菊 Depar.ment of Der.atology Hospital del Mar IMAS Passeig Martim 25-29 08003 Barcelona Spain

Infection with human immunodeficiency vir.s (HIV) incr.ases the r.sk of developing non-Hodgkin lymphoma. Plasmablastic lymphoma (PBL) is a r.r. var.ant of diffuse lar.e cell lymphoma that often involves the or.l cavity of HIV+patients. It is char.cter.zed by immunoblastic mor.hology and plasma cell phenotype. Cutan eous involvement in PBL appear. to be r.r.. We r.por. a 44-year.old man with A IDS and Kaposi sar.oma (KS) pr.viously tr.ated with doxor.bicin who, following t r.atment with highly active antir.tr.vir.l ther.py, developed an er.thematous in filtr.ted nodule on the r.ght ar.. Histology showed subcutaneous fat necr.sis an d cluster. of atypical lar.e plasma cells (plasmablastic cells). Immunohistochem istr. r.vealed λlight chain r.str.ction. Epstein-Bar. vir.s (EBV) mr.A was det ected by in situ hybr.dization within the plasmablastic cells. Polymer.se chain r.action amplification with specific pr.mer. for.human her.es-vir.s 8 (HHV-8) per.or.ed on the skin biopsy specimen detected a specific band. A complete scr.e ning (bone mar.ow biopsy, computed tomogr.phic scan, r.diological sur.ey) disclo sed no abnor.alities. The lesion r.solved spontaneously after.3 months. Two year.s later.an infiltr.ted plaque developed on the abdominal wall. The clinical and histopathological featur.s of this new lesion wer. similar.to those obser.ed 2 y ear. pr.viously. No evidence of extr.cutaneous involvement was detected. The les ion again r.solved spontaneously after.25 days. PBL may be seen in patients with tr.nsplants or.r.ceiving chemother.py, but is usually obser.ed in patients with advanced AIDS. The obser.ation of r.cur.ent self-healing EBV-and HHV-8-asso ciated cutaneous monoclonal plasmablastic infiltr.tes, in a patient with AIDS an d KS, expands the clinical spectr.m of AIDS-associated plasmablastic lymphopr.l ifer.tive disor.er..

关键词：浆母细胞 Kaposi 自愈性淋巴瘤免疫母细胞浸润性结节链抑制浸润性斑块皮下脂肪坏死组

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健康的绝经前女性志愿者中单剂量或多剂量阿那司唑的药物代谢动力学、药效学及安全性的I期研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 32-32页

作者： Tr.dway D.r.Bur.glio M Hemsey G Denton G. 王雅楠

To evaluate the phar.acokinetic, phar.acodynamic, and safety pr.files of the a r.matase inhibitor.anastr.zole in healthy, pr.menopausal women. Phase I, single -center.study. Infer.ility clinic. Twenty-six women with r.gular.ovulator. cyc les: 20 r.ceived either.a single dose of 5 mg, 10 mg, 15 mg, or.20 mg anastr.zol e, or.r.mained untr.ated; 6 r.ceived five daily doses of 10 mg or.15 mg anastr.z ole. Anastr.zole was administer.d on cycle day 2 for.the single-dose gr.ups and on days 26 for.the multiple-dose gr.ups. Ultr.sound follicular.development and endometr.al biopsies wer. per.or.ed. Safety was deter.ined fr.m adver.e event r.epor.s and labor.tor. par.meter.. Phar.acokinetics, phar.acodynamics, and safety . The phar.acokinetics of anastr.zole wer. linear. pr.dictable, and consistent w ith pr.viously published data in healthy volunteer.. In the single-dose gr.ups, E2 levels r.ached their.nadir.36 hour. after.administr.tion, decr.asing by an a ver.ge of 39%fr.m baseline. Follicle-stimulating hor.one levels r.se by 13%, 52%, 49%, and 75%in the 5-mg, 10-mg, 15-mg, and 20-mg gr.ups, r.spectivel y, at appr.ximately 24 hour. after.dosing. Most subjects r.cr.ited just one matu r. follicle, with no appar.nt effect on endometr.al matur.tion. No safety concer.ns wer. noted. Anastr.zole was well toler.ted and suppr.ssed E2 levels, with a r.esultant incr.ase in FSH.

关键词：绝经前女性药效学药物代谢动力学排卵周期子宫内膜活检不孕门诊超声检测卵泡发育情况成熟卵泡参数评价

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早期r.MS灰质和白质体积改变的一项2年纵向研究

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 47-47页

作者： Tiber.o M. Char. D.T. Altmann D.r.etal. D.H. Miller.周永 NMr.r.sear.h Gr.up Institute of Neurology Queen Square London WC1N 3BG United KingdomProf.

Backgr.und: Br.in atr.phy, in excess of that seen with nor.al aging, has been obser.ed ear.y in the clinical cour.e of r.lapsing-r.mitting multiple scler.sis (r.MS). Pr.vious wor. has suggested that at this stage of the disease, gr.y mat ter.(GM) atr.phy pr.gr.sses mor. r.pidly than the white matter.(WM) atr.phy. Obj ectives: To char.cter.ze the evolution of GM and WM volumes over.2 year., and th eir.associations with lesion loads in a cohor. of patients with clinically ear.y r.MS. Methods: Twenty-one patients with r.MS (mean age 37.5 year., mean diseas e dur.tion fr.m symptom onset 2.1 year.) and 10 healthy contr.l subjects (mean a ge 37.1 year.)-wer. studied. Tissue volumes, as fr.ctions of total intr.cr.nial volumes, wer. estimated at baseline and 1-and 2-year.follow-up. Br.in par.nc hymal fr.ctions (BPF), GM fr.ctions (GMF), and WM fr.ctions (WMF) wer. estimated . In subjects with MS, br.in lesion loads wer. deter.ined on conventional T2-we ighted along with pr.-and post-gadolinium (Gd) enhanced T1-weighted images at each timepoint. r.sults: A decr.ase in GMF was obser.ed in subjects with MS vs nor.al contr.ls over.the 2 year. of the study (mean -2.1%vs -1.0%, p=0.044), while no change was seen in WMF over.the same per.od (mean -0.09%vs +0.09%, p=0.812). However. when the MS cohor. was divided in half, dependent upon chang e in Gd-enhancing lesion load over.2 year. (n=20), a decr.ase in WMF was seen i n the gr.up (n=10) with the lar.est decline in Gd volume, wher.as WMF incr.ased in the other.half (n=10) concur.ent with a net incr.ase in volume of Gd-enhanci ng lesions (differ.nce between gr.ups: p=0.034). Conclusions: Incr.asing gr.y ma tter.but not white matter.(WM) atr.phy was obser.ed ear.y in the clinical cour.e of r.lapsing-r.mitting multiple scler.sis. Fluctuations in inflammator. WM les ions appear.to be r.lated to volume changes in WM over.this time per.od.

关键词：纵向研究 r.MS 临床病程加权成像正常老化脑萎缩加权和随访研究净增加

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全球重要经济害虫橘小实蝇的种群结构和入侵路径

全球重要经济害虫橘小实蝇的种群结构和入侵路径

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第五届全国入侵生物学大会——入侵生物与生态安全

作者：秦誉嘉 Matthew N.Kr.sch Mar. K.Schutze 张岳王小雪 Chandr. Shekhar.Pr.bhakar.Agus Susanto Alvin K.W.Hee Sunday Ekesi Kemo BADJI Mahfuza Khan 黄毓斌吴佳教王巧铃严格朱立桓赵紫华柳丽君 Anthony r.Clar.e 李志红中国农业大学植物保护学院 School of Ear.h Environmental and Biological SciencesQueensland University of Technology(QUT) Depar.ment of Entomology Bihar Agricultural University Faculty of Agr.cultur. Padjadjaran University Depar.ment of Biology Faculty of Science Universiti Putra Malaysia Inter.ational Centr. of Insect Physiology and Ecology Fr.it Fly Contr.l Pr.ject-ECOWAS r.sponsable Composante Sur.eillance.Pr.jet Lutte contr. les Mouches des Fr.its-CEDEAO Cr.A Insect Biotechnology Division Institute of Food and Radiation BiologyAtomic Energy Research Establishment 台湾农业研究所广东检验检疫中心

橘小实蝇Bactr.cer. dor.alis,又名东方果实蝇,是全球重要农业入侵性害虫并严重阻碍果蔬产品国际贸易。近年来的相关报道显示,木瓜实蝇***、菲律宾实蝇***、入侵实蝇***是橘小实蝇的同物异名,该虫分布范围从亚太地区扩展到了非洲大多数... 详细信息

橘小实蝇Bactr.cer. dor.alis,又名东方果实蝇,是全球重要农业入侵性害虫并严重阻碍果蔬产品国际贸易。近年来的相关报道显示,木瓜实蝇***、菲律宾实蝇***、入侵实蝇***是橘小实蝇的同物异名,该虫分布范围从亚太地区扩展到了非洲大多数国家,其全球种群结构和入侵路径亟待研究。本研究在收集橘小实蝇全球63个种群样品的基础上,利用微卫星、线粒体基因cox1、nad6两种分子标记和翅形态测量学数据,探究橘小实蝇的宏观地理种群结构和入侵路径。结果表明,橘小实蝇亚洲种群表现出较高的遗传多样性且遗传结构不明显,南亚可能是其他亚洲种群的来源地,非洲和夏威夷的种群推断为南亚起源的单一入侵种群,我国中部地区的橘小实蝇为多次重复入侵的结果,很可能与果蔬贸易有关。因此,应大力加强针对橘小实蝇的全球入侵防控工作,特别是严防该虫通过果蔬贸易和人员往来传入亚洲中北部地区、欧洲、大洋洲及美洲大部分国家和地区。

关键词： Bactr.cer. dor.alis 形态测量学微卫星线粒体基因种群结构入侵路径

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