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The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime(HADES) framework

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National Science Review 2024年第5期11卷 46-55页

作者： Jakub Vohryzek Joana Cabral Christopher Timmermann Selen Atasoy leor roseman David J.Nutt Robin L.Carhart-Harris Gustavo Deco Morten L.Kringelbach Centre for Eudaimonia and Human Flourishing Linacre CollegeDepartment of Psychiatry University of Oxford Department of Psychiatry University of Oxford Center for Music in the Brain Aarhus University Center for Brain and Cognition Computational Neuroscience GroupDepartment of Information and Communication TechnologiesUniversitat Pompeu Fabra Life and Health Sciences Research Institute School of MedicineUniversity of Minho ICVS/3B's-PT Government Associate Laboratory Centre for Psychedelic Research Department of Brain Sciences Imperial College London Departments of Neurology and Psychiatry University of California San Francisco Institució Catalana de la Recerca i Estudis Avan?ats (ICREA) Department of Neuropsychology Max Planck Institute for Human Cognitive and Brain Sciences School of Psychological Sciences Monash University

The human brain is a complex system, whose activity exhibits flexible and continuous reorganization across space and time. The decomposition of whole-brain recordings into harmonic modes has revealed a repertoire of gradient-like activity patterns associated with distinct brain functions. However, the way these activity patterns are expressed over time with their changes in various brain states remains unclear. Here, we investigate healthy participants taking the serotonergic psychedelic N,N-dimethyltryptamine(DMT) with the Harmonic Decomposition of Spacetime(HADES) framework that can characterize how different harmonic modes defined in space are expressed over time. HADES demonstrates significant decreases in contributions across most low-frequency harmonic modes in the DMT-induced brain state. When normalizing the contributions by condition(DMT and non-DMT), we detect a decrease specifically in the second functional harmonic, which represents the uni-to transmodal functional hierarchy of the brain,supporting the leading hypothesis that functional hierarchy is changed in psychedelics. Moreover, HADES'dynamic spacetime measures of fractional occupancy, life time and latent space provide a precise description of the significant changes of the spacetime hierarchical organization of brain activity in the psychedelic state.

关键词： spatio-temporal brain dynamics DMT harmonic modes

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Extended Moral Responsibility for Kantian Agents

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Journal of Philosophy Study 2013年第8期3卷 758-767页

作者： Herbert roseman Adjunct Professor Society of Senior Scholars Columbia University USA

When two Kantian agents engage in inter-dependent transactions with one another, each agent has the responsibility to assure the morality of the other＇s maxim of action and means to implement the maxim. This proposition is proven to be a logical consequence of Kant＇s moral system and stated formally as the K-Completeness theorem. Transactions that satisfy the theorem are called ＂K-Complete.＂ The theorem is generalized to cover transactions with many agents. The paper then models multi-agent K-Complete transactions using mathematical graph theory and shows that such transactions are distinguished from Kant＇s kingdom of ends. Finally, the paper shows that the extended morality provides Kant＇s moral system with the resources to define an ethical community in such as the one in Religion within the Boundaries of Mere Reason without the introduction of God and a church.

关键词： Kant moral responsibility complete graphs

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经皮肘前深静脉穿刺:一种代替手术切开的方法

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国际护理学杂志 1985年第4期06卷 203-203页

作者： James M. roseman 魏建东

经皮套管插入术在老年、肥胖及因药物成瘾或化疗而致静脉硬化的病人常有困难。对严重循环性虚脱病人,也希望能有一条周围静脉内通路,但却难以获得。此处所述的是一种代替费时且具损伤性的切开的方法,利用臂部深静脉系统,经常迅速的经皮... 详细信息

经皮套管插入术在老年、肥胖及因药物成瘾或化疗而致静脉硬化的病人常有困难。对严重循环性虚脱病人,也希望能有一条周围静脉内通路,但却难以获得。此处所述的是一种代替费时且具损伤性的切开的方法,利用臂部深静脉系统,经常迅速的经皮插入大口径静脉套管,在我的经验中一律成功。操作技术:本法某些方面类似静脉切开,其他方面又类似锁骨下或颈静脉穿刺。在肘窝扪得肱动脉后,上臂缚以止血带。紧靠该动脉搏动内侧或外侧选定一点,常规备皮后,用19G针头刺破此处皮肤。套管穿经皮肤时,此刺破处便可容16～18G静脉套管插入而无阻力且不伤管尖。导管以内针为引

关键词：静脉套管手术套管插入术

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