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Ipsilateral motor evoked potentials in a patient with unihemispheric cortical atrophy due to Rasmussen encephalitis

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Neural Regeneration Research 2019年第6期14卷 1025-1028页

作者： Raffaele Nardone Patrick B.Langthaler Andrea Orioli Viviana Versace Giuditta Ilaria Scarano Francesco Brigo leopold saltuari Luca Carnicelli Eugen Trinka Luca Sebastianelli Department of Neurology Franz Tappeiner HospitalMeranoItaly Department of Neurology Hochzirl HospitalZirlAustria Centre for Cognitive Neurosciences Salzburg SalzburgAustria University for Medical Informatics and Health Technology UMITHall in TirolAustria Department of Neurology Christian Doppler KlinikParacelsus Medical UniversitySalzburgAustria Spinal Cord Injury and Tissue Regeneration Center SalzburgAustria Karl Landsteiner Institut für Neurorehabilitation und Raumfahrtneurologie SalzburgAustria Department of Mathematics Paris Lodron University of SalzburgAustria Department of Neurorehabilitation Hospital of VipitenoVipitenoItaly Research Unit for Neurorehabilitation South Tyrol BolzanoItaly Department of Psychology Franz Tappeiner HospitalMeranoItaly Department of Neuroscience Biomedicine and Movement ScienceUniversity of VeronaVeronaItaly

The role of the ipsilaterally descending motor pathways in the recovery mechanisms after unilateral hemispheric damage is still poorly understood. Motor output reorganization was investigated in a 56-year-old male patient with acquired unilateral hemispheric atrophy due to Rasmussen encephalitis. In particular,the ipsilateral corticospinal pathways were explored using focal transcranial magnetic stimulation. In the first dorsal interosseous and wrist extensors muscles, the median amplitudes of the ipsilateral motor evoked potentials induced by transcranial magnetic stimulation in the patient were higher than those of 10 age-matched healthy control subjects. In the biceps brachii muscle, the median amplitudes of the ipsilateral motor evoked potentials were the second largest in the patient compared to the controls. This study demonstrated a reinforcement of ipsilateral motor projections from the unaffected motor cortex to the hemiparetic hand in a subject with acquired unihemispheric cortical damage.

关键词： transcranial magnetic stimulation motor cortex ipsilateral motor evoked potentials ipsilateral motor pathways Rasmussen encephalitis cortical atrophy hemispheric damage

High-speed silicon photonic electro-optic Kerr modulation

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Photonics Research 2024年第1期12卷 51-60页

作者： JONATHAN PELTIER WEIWEI ZHANG leopold VIROT CHRISTIAN LAFFORGUE LUCAS DENIEL DELPHINE MARRIS-MORINI GUY AUBIN FARAH AMAR DENH TRAN XINGZHAO YAN CALLUM G.LITTLEJOHNS CARLOS ALONSO-RAMOS KE LI DAVID J.THOMSON GRAHAM REED LAURENT VIVIEN University Paris-Saclay CNRSCentre for Nanoscience and Nanotechnology(C2N)Palaiseau 91120France University Grenoble Alpes CEALETIGrenoble 38000France Optoelectronics Research Centre Zepler Institute for Photonics and NanoelectronicsFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Silicon-based electro-optic modulators contribute to easing the integration of high-speed and low-power consumption circuits for classical optical communications and data *** the plasma dispersion modulation,an alternative solution in silicon is to exploit the DC Kerr effect,which generates an equivalent linear electro-optical effect enabled by applying a large DC electric *** some theoretical and experimental studies have shown its existence in silicon,limited contributions relative to plasma dispersion have been achieved in high-speed modulation so *** paper presents high-speed optical modulation based on the DC Kerr effect in silicon PIN *** contributions of both plasma dispersion and Kerr effects have been analyzed in different waveguide configurations,and we demonstrated that the Kerr induced modulation is dominant when a high external DC electric field is applied in PIN ***-speed optical modulation response is analyzed,and eye diagrams up to 80 Gbit/s in NRZ format are obtained under a *** of 30 *** work paves the way to exploit the Kerr effect to generate high-speed Pockels-like optical modulation.

关键词： waveguide dispersion effect

中华医学会-欧莱雅中国人健康皮肤/毛发研究项目成果总结——皮肤篇

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中华皮肤科杂志 2024年第5期57卷 464-467页

作者： Michele Verschoore 牛悦青 Stéphane Commo Léopold Muller 魏宇昊甄雅贤刘玮欧莱雅研发和创新中心法国克里希92110 欧莱雅研发和创新中心上海201206 欧莱雅研发和创新中心法国欧奈苏布瓦93600 欧莱雅研发和创新中心美国克拉克07066 空军特色医学中心皮肤科北京100142

中华医学会和欧莱雅集团在2003-2018年间联合启动了“中国人健康皮肤/毛发研究项目”,该项目在助力提高中国皮肤科医生科研能力的同时,获得了大量宝贵的基于中国人群样本的临床和基础研究成果,并以期刊论文、会议报告等形式多次参与国... 详细信息

中华医学会和欧莱雅集团在2003-2018年间联合启动了“中国人健康皮肤/毛发研究项目”,该项目在助力提高中国皮肤科医生科研能力的同时,获得了大量宝贵的基于中国人群样本的临床和基础研究成果,并以期刊论文、会议报告等形式多次参与国内和国际学术交流。本文作者通过整理项目资料和已发表文献,对皮肤相关研究项目的主要成果做一总结.

关键词：皮肤生理学过程皮肤衰老皮肤色素沉着皮肤免疫研究报告

Recent status of fluidized bed technologies for producing iron input materials for steelmaking

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Particuology 2011年第1期9卷 14-23页

作者： Johannes leopold Schenk Department of Metallurgy University of Leoben Franz-Josef-Straβe 18 A-8700 Leoben Austria

Today steel is produced by two steelmaking processes, the basic oxygen furnace and the electric arc furnace, Three types of iron input materials for both processes are liquid hot metal or in solidified form as pig iron, direct reduced iron （DRI） and hot briquetted iron （HB1） as well as steel scrap. Hot metal, pig iron, DRI and HBI are virgin iron materials, which have to be produced from iron ore by the so-called ironmaking technologies. New ironmaking processes based on fluidized bed technology have been developed in the last two decades. The main advantage of these technologies is that fine ore can be directly used in the processes and prior treatment such as sintering or pelletizing can be avoided which is required for the established processes. Theoretical aspects for reduction of fine iron oxides in a fluidized bed reactor system will be explained. The fluidized bed reducing technologies utilized in the most advanced new ironmaking processes for direct use of fine ore, FINMET, Circored, FINEX~ and Hismelt will be compared.

关键词： FINEX  Circored  FINMET  HIsmelt  Fluidized bed Reactor Fine iron ore Ironmaking

Improvement on straightness of metal bar based on straightening stroke-deflection model

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Science China(Technological Sciences) 2009年第7期52卷 1866-1873页

作者： leopold Juergen Fraunhofer Institute for Machine Tools and Forming Technology Chemnitz Germany

The straightening technics is one of important means to improve the straightness of metal bar. A nove way of predicting the straightening stroke is proposed based on mathematical methods and bending experimental and numerical simulation. The experimental and numerical simulation is conducted by following the mathematical load-stroke model of press straightening process under the elastic-plastic theory. For the linear guide rails, as an example, the stroke-deflection model focusing on the straight-ening stroke prediction can be achieved by contrasting and integrating the bending experimental results and finite element methods (FEM) simulation data. And then the formula for predicting the straightening stroke is presented based on the precise straightening stroke-deflection model. The stroke prediction formula with high precision can be applied to the straightening stroke prediction in the high straightness metal bar manufacturing process and automatic straightening machine conveniently.

关键词： straightness straightening stroke deflection stroke prediction metal bar

The Mamfe Basin in the southern Benue trough extension between Cameroon and Nigeria:Gem origin and problem of lithostratigraphic nomenclature and marine transgression

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Acta Geochimica 2023年第3期42卷 495-516页

作者： Milan Stafford Tchouatcha Primus Tamfuh Azinwi Christel Sobdjou Kemteu Augustin Desire Balla Ondoa leopold Darlus Ngantchu Basil Azeh Anong Courage Gabvourta Department of Earth Sciences Faculty of ScienceUniversity of DschangP.O.Box 67DschangCameroon Department of Soil Science Faculty of Agronomy and Agricultural SciencesUniversity of DschangP.O.Box 222DschangCameroon Department of Mining and Mineral Engineering National Higher Polytechnic InstituteUniversity of BamendaP.O.Box 39BambiliCameroon Department of Earth Sciences Faculty of ScienceUniversity of YaoundeIP.O.Box 812Yaounde´Cameroon Department of Earth Sciences Faculty of ScienceUniversity of NgaoundereP.O.Box 454NgaoundereCameroun

The Mamfe Basin has been the subject of many studies,but some debates persist,especially concerning the stratigraphic nomenclature,corundum origin,and marine *** aims of this work are(1)to propose a new lithostratigraphic nomenclature of the Mamfe Basin formation based on new field observations,(2)to determine the source rock distribution and the origin of gem deposits and(3)to correlate the Cameroon section of the Mamfe Basin with the Nigerian *** main results show that the name Manyu River Group is more appropriate as the Manyu River crosses all the facies in the Mamfe sedimentary Basin belonging to the Manyu *** to the facies analysis,the age of deposition,the mineralogic and geochemical data such as the V ***2O3andΣREE ***_(2)O_(3),TiO_(2)MgO,Na_(2)O,P_(2)O_(5),and CaO diagrams,this Group is composed of at least five Formations,including four Cretaceous Formations,from bottom to top:the Etoko Formation(alluvial and fluvial channel to fluvio-lacustrine deposits),the Nfaitok Formation(lagoonal deposits),the Bachuo Ntai Formation(fluvial braided channels or fluvio-deltaic environment)and the Eyumojock/NsanaragatiFormation(fluvio-lacustrine deposits)and the new Cenozoic Formation named Bakebe Formation(fluvio-lacustrine deposits).The gem minerals such as corundum,rutile,or tourmaline in the Cretaceous deposits of the Mamfe Basin are mainly detrital as indicated by the presence of worn shapes and fragments of these *** presence of sapphire in the AlboCenomanian deposits indicates a Precambrian age of the felsic source rock,likely the plutonic rocks such as granite or pegmatite as indicated by the abundance of tourmaline and high LREE/HREE ratios(14.81–34.29)and slightly negative and positive Eu anomalies(0.85–1.15).This marine incursion in the Mamfe Basin was probably from West Nigeria,according to the geographic location of the Mamfe Basin and the general palaeogeographic evolution of the Benue Trough.

关键词： Lithostratigraphy Marine transgression Heavy minerals Sapphires Mamfe Basin Benue Trough

Hybrid LES/URANS Simulation of Rayleigh-Bénard Convection Using BEM

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Computer Modeling in Engineering & Sciences 2020年第4期123卷 1-22页

作者： Primož Kocutar Jure Ravnik leopold Škerget Faculty of Mechanical Engineering University of MariborSmetanova 17SI-2000 MariborSlovenia

In this paper,we develop and test a unified hybrid LES/URANS turbulence model with two different Large Eddy Simulation(LES)turbulence *** numerical algorithm is based on the Boundary Element *** the existing hybrid LES/URANS turbulence model we implemented a new Smagorinsky LES turbulence *** hybrid LES/URANS turbulence model is unified,which means that the LES/URANS interface is changed dynamically during simulation using a physical *** order to define the interface between LES and unsteady Reynolds Averaged Navier Stokes(URANS)zones during the simulation,we use the Reynolds number based on turbulent kinetic energy as a switching *** means that the flow characteristics define where the sub-grid scale or URANS effective viscosity and thermal conductivity are used in the governing equations in the next time *** unified hybrid turbulence models,only one set of governing equations is used for LES and URANS *** developed hybrid LES/URANS model was tested on non-isothermal,unsteady and turbulent Rayleigh-Bénard Convection and compared with an existing model,where LES is based on turbulent kinetic *** hybrid turbulence model was implemented within a numerical algorithm based on the Boundary-Domain Integral Method,where a single domain and sub-domain approaches were *** numerical algorithm uses governing equations written in a velocity-vorticity *** false transient time scheme is used for the kinematics equation.

关键词： Boundary-domain integral method hybrid LES-RANS turbulent fluid flow heat transfer Rayleigh-Bénard Convection

Modelling and simulation of fixtures during grinding

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Science China(Technological Sciences) 2009年第7期52卷 1821-1829页

作者： Matthias KLAERNER Juergen leopold Lothar KROLL Institute of Mechanical and Polymer Engineering Chemnitz University of Technology09107 ChemnitzGermany Fraunhofer Institute for Machine Tools and Forming Technology 09126 ChemnitzGermany

The complex workpiece-fixture behaviour during machining is an essential component of the fixture development *** detail,the forces acting on fixture components have to be analysed.A method for the prediction of the reaction forces due to process and clamping loads is presented in this *** the beginning,detailed information about the workpiece-fixture behaviour during the process is determined by a complex finite element ***,the reduction of the number of elements leads to a smaller model with less computation time,validated and used for the variation of process ***,an analytical description is developed based on the combination of both *** the help of the empiric equation it is possible to predict the reaction forces and the dependency on several process *** method has been validated by modelling shape grinding of a nozzle guide vane.

关键词： clamping forces grinding finite element method fixture

A Scalable Domain Decomposition Method for Ultra-Parallel Arterial Flow Simulations

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Communications in Computational Physics 2008年第10期4卷 1151-1169页

作者： leopold Grinberg George Em Karniadakis Division of Applied Mathematics Brown UniversityProvidence 02912USA

Ultra-parallel flow simulations on hundreds of thousands of processors require new multi-level domain decomposition *** we present such a new two-level method that has features both of discontinuous and continuous Galerkin ***,at the coarse level the domain is subdivided into several big patches and within each patch a spectral element discretization(fine level)is *** interface conditions for the Navier-Stokes equations are developed to connect the patches,relaxing the C0 continuity and minimizing data transfer at the patch *** perform several 3D flow simulations of a benchmark problem and of arterial flows to evaluate the performance of the new method and investigate its accuracy.

关键词： Bioflows spectral elements discontinuous Galerkin parallel computing