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Comprehensive review of hemolysis in ventricular assist devices

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World Journal of Cardiology 2020年第7期12卷 334-341页

作者： Christos A Papanastasiou Konstantinos G Kyriakoulis Christina A Theochari Damianos G Kokkinidis Theodoros D Karamitsos leonidas Palaiodimos 1(st)Department of Cardiology AHEPA HospitalAristotle University of ThessalonikiThessaloniki 54621Greece 3(rd)Department of Medicine Sotiria HospitalNational and Kapodistrian University of AthensAthens 11527Greece Department of Internal Medicine Messinia General HospitalKalamata 24100GreeceBronxNY 10461United States Department of Medicine Jacobi Medical CenterAlbert Einstein College of Medicine Department of Medicine Montefiore Medical CenterAlbert Einstein College of MedicineNY 10461United States

Ventricular assist devices(VADs)have played an important role in altering the natural history of end-stage heart ***-grade hemolysis has been traditionally described in patients with VADs,indicating effective device ***,clinically significant hemolysis could be crucial in terms of prognosis,calling for prompt therapeutic *** absence of solid and widely approved diagnostic criteria for clinically significant hemolysis,render the utilization of hemolysis laboratory markers *** incidence varies(5%-18%)depending on definition and among different VAD generations,being slightly higher in continuous-flow devices than in pulsatile *** shear stress of red blood cells and underlying device thrombosis appear to be the main pathogenetic *** certain algorithm is available for the management of hemolysis in patients with VADs,while close clinical and laboratory monitoring remains the cornerstone of *** examinations such as echocardiography ramp test or computed tomography scan could play a role in revealing the underlying *** should be strictly personalized,including either pharmacological(antithrombotic treatment)or surgical interventions.

关键词： Ventricular assist device Hemolysis Thrombosis

Large work function shift of organic semiconductors inducing enhanced interracial electron transfer in organic optoelectronics enabled by porphyrin aggregated nanostructures

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Nano Research 2014年第5期7卷 679-693页

作者： Maria Vasilopoulou Antonios M. Douvas Dimitra G. Georgiadou Vassilios Constantoudis Dimitris Davazoglou Stella Kennou leonidas C. Palilis Dimitra Daphnomili Athanassios G. Coutsolelos Panagiotis Argitis Institute of Nanoscience and Nanotechnology (INN) National Center for Scientific Research "Demokritos' 153 10 Aghia Paraskevi Attikis Athens Greece Department of Chemical Engineering University of Patras 26500 Patras Greece Departmen of Physics University of Patras 26500 Patras Greece Laboratory of Bioinorganic Chemistry Chemistry Department University of Crete Voutes Campus 71003 Heraklion Crete Greece

We report on large work function shifts induced by the coverage of several organic semiconducting （OSC） films commonly used in organic light emitting diodes （OLEDs） and organic photovoltaics （OPVs） with a porphyrin aggregated layer. The insertion between the organic film and the aluminum cathode of an aggregated layer based on the meso-tetrakis（1-methylpyridinium-4-yl） porphyrin chloride （porphyrin 1）, with its molecules adopting a face-to-face orientation parallel to the organic substrate, results in a significant shift of the OSC work function towards lower values due to the formation of a large interfacial dipole and induces large enhancement of either the OLED or OPV device efficiency. OLEDs based on poly[（9,9-dioctylfluorenyl-2,7-diyl）-co-（1,4-benzo-2,1＇,3-thiadiazole）J （F8BT） and incorporating the porphyrin 1 at the cathode interface exhibited current efficiency values up to 13.8 cd/A, an almost three-fold improvement over the efficiency of 4.5 cd/A of the reference device. Accordingly, OPVs based on poly（3- hexylthiophene）（P3HT）, [6,6]-phenyl-C61 butyric acid methyl ester （PC61BM） and porphyrin 1 increased their external quantum efficiencies to 4.4% relative to 2.7% for the reference device without the porphyrin layer. The incorporation of a layer based on the zinc meso-tetrakis （1-methylpyridinium-4-yl）porphyrin chloride （porphyrin 2）, with its molecules adopting an edge-to-edge orientation, also introduced improvements, albeit more modest in all cases, highlighting the impact of molecular orientation.

关键词： porphyrins OLEDs OPVs aggregates

Preoperative Management of Cataract Surgery Candidates: An Evaluation of Their Perception and Preferences

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Open Journal of Ophthalmology 2013年第3期3卷 90-92页

作者： Evgenia Kanonidou Vasileios Konidaris Christina Kanonidou leonidas Papazisis Department of Ophthalmology General Hospital of Veria Veria Greece.

Purpose: To assess the primary visual disability in patients with cataract and to evaluate their preference regarding the visual outcome after surgery. Materials and Methods: 120 patients (66 males, mean age 76.3 years, mean best corrected visual acuity 5.2/10 binocularly) participated. Perception regarding the primary visual disability related to cataract and preference of visual outcome after surgery were assessed by a questionnaire. All study procedures adhered to the principles outlined in the Declaration of Helsinki for research involving human subjects, and all participants gave written informed consent before their participation. Results: 74 patients (61.6%) had difficulty in distant vision, 5 (4.2%) in near vision, 17 (14.2%) mentioned blurred vision, 14 (11.7%) difficulty in driving especially at night, 7 (5.8%) complained about monocular diplopia and 3 (2.5%) about anisometropia. All mentioned that they preferred to obtain clear distant and near vision after cataract surgery. Conclusions: There was an interesting variety in visual disability related to cataract. The difficulty in distant vision was the primary visual deficit in the majority of the patients and the preference for clear distant and near vision was the desired postoperative visual outcome.

关键词： Cataract Visual Outcome Visual Disability Quality of Life

Evolution of Mobility Function in Chinese Elders during the 6 Months of Nutritional Supplementation and Age-adapted Physical Activities: A Feasibility Study

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Biomedical and Environmental Sciences 2021年第11期34卷 900-904页

作者： CHANG Cui Qing KARAGOUNIS leonidas G YU Ying Xiang YIN Jing DONATO-CAPEL Laurencel SHEVLYAKOVA Maya BEAUMONT Maurice HUANG Hong Shi OFFORD Elizabeth A HORCAJADA MarieNoelle Institute of Sports Medicine Peking University Third HospitalBeijing 100191China Nestle Health Science Translation ResearchEpalingesSwitzerland University of Bern Institute of Social and Preventive Medicine(ISPM)BernCH Nestle Research Center Beijing 100095China Nestle Research LausanneSwitzerland

Knee pain and discomfort appear at the early stages of normal aging,which lead to impaired mobility and reduced quality of life(QOL).Among age-related conditions,osteoarthritis(OA)is considered the most significant cause of disability The acceleration of the aging process in China has troubled the middle-aged and elderly with a relatively high prevalence of OA,as recently reported in a meta-analysis pooling and analyzing epidemiological publications on OA in the middleaged and elderly Chinese published from 2000 to2018[1].

关键词： aging impaired acceleration

Assessment of the Most Common Pterygium Symptoms Leading to the Decision for Its Surgical Removal

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Open Journal of Ophthalmology 2013年第3期3卷 68-69页

作者： Vasileios Konidaris Evgenia Kanonidou Christina Kanonidou leonidas Papazisis Department of Ophthalmology General Hospital of Veria Veria Greece.

Purpose: Pterygium is a benign growth of conjunctival tissue frequently related to chronic sunlight exposure and hot and dry climate. Purpose of this study was to evaluate the predominant symptoms in patients with pterygium leading to its surgical removal decision. Methods: 31 patients (19 males, 12 females), mean age 48.75 years old (SD 8.5), with primary pterygium and no other eye disease participated in the study. The predominant symptoms caused by the pterygium were assessed using a questionnaire. Results: The predominant symptoms associated with the pterygium were: discomfort/feeling of foreign body in 31 patients (100%), redness in 23 (74%), increased lacrimation in 17 (55%), aesthetic reasons in 12 (39%), visual disturbance (astigmatism/extension of the pterygium to the optical axis) in 4 (13%). In one case, despite the absence of annoying symptoms, surgical excision was proposed due to the atypical appearance of pterygium. For younger patients, the predominant reason for choosing surgical removal was that the patients are not content with external appearance caused by pterygium and in contrast lacrimation was the predominant reason for the older. In most patients, visual disturbance was not a significant cause although astigmatism in eyes with pterygium was 3.51 D (SD 1.82) and 0.95 D (SD 0.78) in healthy eyes respectively. Discussion: The main symptom in patients with pterygium is foreign body sensation;meanwhile aesthetic consideration and increased lacrimation are the main reasons leading to surgical removal decision for younger and older patients, respectively.

关键词： Pterygium Pterygium Surgery Astigmatism

Imaging the crystal orientation of 2D transition metal dichalcogenides using polarization-resolved second-harmonic generation

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Opto-Electronic Advances 2019年第11期2卷 12-19页

作者： George Miltos Maragkakis Sotiris Psilodimitrakopoulos leonidas Mouchliadis Ioannis Paradisanos Andreas Lemonis George Kioseoglou Emmanuel Stratakis Institute of Electronic Structure and Laser Foundation for Research and Technology-HellasHeraklion Crete 71110Greece Department of Physics University of CreteHeraklion Crete 71003Greece Department of Materials Science and Technology University of CreteHeraklion Crete 71003Greece

We use laser-scanning nonlinear imaging microscopy in atomically thin transition metal dichalcogenides(TMDs)to reveal information on the crystalline orientation distribution,within the 2D *** particular,we perform polarization-resolved second-harmonic generation(PSHG)imaging in a stationary,raster-scanned chemical vapor deposition(CVD)-grown WS2 flake,in order to obtain with high precision a spatially resolved map of the orientation of its main crystallographic axis(armchair orientation).By fitting the experimental PSHG images of sub-micron resolution into a generalized nonlinear model,we are able to determine the armchair orientation for every pixel of the image of the 2D material,with further improved *** pixel-wise mapping of the armchair orientation of 2D WS2 allows us to distinguish between different domains,reveal fine structure,and estimate the crystal orientation variability,which can be used as a unique crystal quality marker over large *** necessity and superiority of a polarization-resolved analysis over intensity-only measurements is experimentally demonstrated,while the advantages of PSHG over other techniques are analysed and discussed.

关键词： nonlinear imaging of 2D materials crystal orientation mapping crystal quality marker polarization-resolved second-harmonic generation atomically thin transition metal dichalcogenides graphene-related materials

Ultrahigh-resolution nonlinear optical imaging of the armchair orientation in 2D transition metal dichalcogenides

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Light(Science & Applications) 2018年第1期7卷 1072-1080页

作者： Sotiris Psilodimitrakopoulos leonidas Mouchliadis Ioannis Paradisanos Andreas Lemonis George Kioseoglou Emmanuel Stratakis Institute of Electronic Structure and Laser Foundation for Research and Technology-HellasHeraklion Crete 71110Greece Department of Physics University of CreteHeraklion Crete 71003Greece Department of Materials Science and Technology University of CreteHeraklion Crete 71003Greece

We used nonlinear laser scanning optical microscopy to study atomically thin transition metal dichalcogenides(TMDs)and revealed,with unprecedented resolution,the orientational distribution of armchair directions and their degree of organization in the two-dimensional(2D)crystal *** particular,we carried out polarization-resolved second-harmonic generation(PSHG)imaging for monolayer WS2 and obtained,with high-precision,the orientation of the main crystallographic axis(armchair orientation)for each individual 120×120 nm^(2) pixel of the 2D crystal *** nanoscale resolution was realized by fitting the experimental PSHG images,obtained with sub-micron precision,to a new generalized theoretical model that accounts for the nonlinear optical properties of *** enabled us to distinguish between different crystallographic domains,locate boundaries and reveal fine *** a consequence,we can calculate the mean orientational average of armchair angle distributions in specific regions of interest and define the corresponding standard deviation as a figure-of-merit for the 2D crystal quality.

关键词： armchair orientation mapping atomically thin transition metal dichalcogenides crystal quality marker graphene-related materials polarization-resolved second-harmonic generation

A Rare Case of a Large Basal Cell Carcinoma of the Vulva

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Open Journal of Obstetrics and Gynecology 2019年第11期9卷 1439-1442页

作者： Christina Stefanaki leonidas Chardalias Konstantina Fragia Dimitrios Rigopoulos Alexander Stratigos First Dermatology Department Andreas Sygros University Skin Hospital Athens Greece Surgery Clinic Areteio University Hospital Athens Greece Histo-Bio Pathology Diagnostic Center Athens Greece

We present an interesting and unusual case of a 5 cm well-demarcated erosive plaque on the labia minora, extending to the vagina in an 85-year-old woman, causing pain and discomfort for 2 years. The patient was treated several times with topical and systemic anti-fungals without benefit. Histopathology revealed a typical superficial spreading basal cell carcinoma (BCC) and the patient was referred to a gynecologist for surgical excision. Our case is an alert of BCCs arising on the genital area because they are rare and patients usually present with large lesions, as they do not seek medical attention for what they consider simple irritation. Physicians easily misdiagnose these cancers as inflammatory or infectious dermatoses.

关键词： Basal Cell Carcinoma BCC Genitalia Differential Diagnosis

Dabigatran,rivaroxaban,and apixaban are superior to warfarin in Asian patients with non-valvular atrial fibrillation:An updated metaanalysis

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World Journal of Cardiology 2021年第4期13卷 82-94页

作者： Wei-Jia Li Paraschos Archontakis-Barakakis leonidas Palaiodimos Dimitrios Kalaitzoglou Lazaros Tzelves Apostolos Manolopoulos Yu-Chiang Wang Stefanos Giannopoulos Robert Faillace Damianos G Kokkinidis Department of Medicine Jacobi Medical CenterBronxNY 10461United States Department of Surgery 424 General Army Hospital of ThessalonikiThessaloniki 56429Greece Department of Urology Sismanogleio HospitalAthens 15126Greece Clinical Research and Evidence-Based Medicine Unit Aristotle University of ThessalonikiThessaloniki 54124Greece Division of Cardiology Rocky Mountain Regional VA Medical CenterDenverCO 80045United States

BACKGROUND Most of the randomized clinical trials that led to the wide use of non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with atrial fibrillation(AF)originated from western *** To systematically review and quantitatively synthesize the real-world data regarding the efficacy and safety of dabigatran,rivaroxaban,and apixaban compared to warfarin for stroke prevention in Asian patients with non-valvular *** Medline,Cochrane,and *** databases were reviewed.A randomeffect model meta-analysis was used and I-square was utilized to assess the *** primary outcome was ischemic *** secondary outcomes were all-cause mortality,major bleeding,intracranial hemorrhage,and gastrointestinal *** Twelve studies from East Asia or Southeast Asia and 441450 patients were ***,rivaroxaban,and apixaban were associated with a significant reduction in the incidence of ischemic stroke[hazard ratio(HR)=0.78,95%confidence interval(CI):0.65-0.94;HR=0.79,95%CI:0.74-0.85,HR=0.70,95%CI:0.62-0.78;respectively],all-cause mortality(HR=0.68,95%CI:0.56-0.83;HR=0.66,95%CI:0.52-0.84;HR=0.66,95%CI:0.49-0.90;respectively),and major bleeding(HR=0.61,95%CI:0.54-0.69;HR=0.70,95%CI:0.54-0.90;HR=0.58,95%CI:0.43-0.78;respectively)compared to *** Dabigatran,rivaroxaban,and apixaban appear to be superior to warfarin in both efficacy and safety in Asians with non-valvular AF.

关键词： Novel oral anticoagulant Direct oral anticoagulant Atrial fibrillation Asian population Dabigatran Rivaroxaban Apixaban Warfarin