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The Journal of Biomedical Research 2023年第4期37卷 255-267页

作者： leonid N.Maslov Natalia v.Naryzhnaya Maria Sirotina Alexandr v.Mukhomedzyanov Boris K.Kurbatov Alla A.Boshchenko Huijie Ma Yi Zhang Feng Fu Jianming Pei viacheslav N.Azev vladimir A.Pereverzev Cardiology Research Institute Tomsk National Research Medical Centerthe Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology Hebei Medical UniversityShijiazhuangHebei 050017China Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China The Branch of the Institute of Bioorganic Chemistry Russian Academy of SciencesPushchinoMoscow Oblast 142290Russia Department of Normal Physiology Belarusian State Medical UniversityMinsk 220083Belarus

The role of reactive oxygen species(ROS)in ischemic and reperfusion(I/R)injury of the heart has been discussed for more than 40 *** has been demonstrated that reperfusion triggers a multiple increase in free radical generation in the isolated *** were found to have the ability to mitigate I/R injury of the ***,it is unclear whether their cardioprotective effect truly depends on the decrease of ROS levels in myocardial *** high doses and high concentrations of antioxidants were experimentally used,it is highly likely that the cardioprotective effect of antioxidants depends on their interaction not only with free radicals but also with other *** has been demonstrated that the antioxidant N-2-mercaptopropionyl glycine or NDPH oxidase knockout abolished the cardioprotective effect of ischemic ***,there is evidence that ROS protect the heart against the I/R injury.

关键词： reactive oxygen species free radicals antioxidants heart reperfusion patients

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改进算术优化算法用于稀布平面阵列综合

西安电子科技大学学报 2023年第3期50卷 202-212页

作者：国强刘从业王亚妮王勇 CHERNOGOR leonid 哈尔滨工程大学信息与通信工程学院黑龙江哈尔滨150001 先进船舶通信与信息技术工业和信息化部重点实验室黑龙江哈尔滨150001 乌克兰哈尔科夫国立大学空间无线电物理系乌克兰哈尔科夫61022

针对稀布平面阵列方向图旁瓣电平抑制和零陷综合问题,提出了一种基于改进算术优化算法的阵列天线综合算法。首先,为平衡开发和勘探过程比重,对算术优化算法中的算术优化加速器采用非线性函数重构;其次,采用前三优的个体代替当前最优个... 详细信息

针对稀布平面阵列方向图旁瓣电平抑制和零陷综合问题,提出了一种基于改进算术优化算法的阵列天线综合算法。首先,为平衡开发和勘探过程比重,对算术优化算法中的算术优化加速器采用非线性函数重构;其次,采用前三优的个体代替当前最优个体进行勘探开发,并引入精英变异策略,以增强算法跳出局部最优的能力,提高算法的收敛精度;最后,提出了一种自适应矩阵映射法则,对当前阵元分布进行判断,若其不满足最小阵元间距约束,则通过调整策略对其进行调整,在避免不可行解的同时保证了阵元的自由度。与现有文献中的算法相比,改进的算术优化算法对单峰和多峰标准测试函数的优化精度和稳定性均有一定的提高;在稀布平面阵列旁瓣电平抑制实验和零陷综合实验中,所提算法可以综合出更优的峰值旁瓣电平和零陷深度,证明了所提算法的有效性。

关键词：阵列综合稀布阵列矩阵映射法则算术优化算法

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Myorelaxation in the training process of skilled athletes

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Open Journal of Molecular and Integrative Physiology 2013年第2期3卷 83-86页

作者： Yuriy P. Denisenko Yuriy v. vysochin leonid G. Yatsenko Department of Physical Education St. Petersburg State Technological University of Vegetative Polymers St. Petersburg Russia Department of Theory and Methods of Sports Games Branch of Povolzhskaya State Academy of Physical Culture Sports and Tourism Naberezhnye Chelny Russia

At the present time, a number of various ways of sportspersons’ special physical capability (SPC) based mainly on training and competitive loadings ramp up. They are effective enough to reach the main goal, but none of them provides sportspersons’ health safety. Moreover, with the increase in volume and intensity of the loadings, which in sport have almost reached their limits, the sport traumatism and morbidity rate grow progressively. Proceeding from this, there was an evident necessity for the search of conceptually new ways for a simultaneous solution of these two the most complex and, in the opinion of many research workers, almost incompatible problems—the problem of achieving the highest levels of special physical working capacity, and the problem of sportspersons’ health maintenance and improving-associated by us into one general problem of human motor activity efficiency enhancement. Therefore it is necessary to physiologically substantiated the basic methods and principles of special relaxation training, directed on increase of efficiency of process of training of sportsmen at all stages of the development of athletic skills. Under the efficiency of the motor activity, we understand achieve the highest levels of the special physical performance while maintaining sports longevity and health of athletes.

关键词： Extreme Conditions Protection Functional System Muscle Relaxation Rate Physical Efficiency Central Nervous System Relaxation

The Cherenkov Radiation in the Galaxy’s Halo of Dark Matter

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International Journal of Astronomy and Astrophysics 2013年第3期3卷 285-290页

作者： leonid M. Chechin v. G. Fessenkov Astrophysical Institute Almaty Kamenskoye Plato National Centre for the Space Researches and Technology National Space Agency Republic of Kazakhstan

The effect of light refraction in a galaxy’s halo of dark matter, described by profiles of Navarro-Frenk-White and Burkert, was considered. Powers of the Cherenkov radiation for the refractive indexes of gravitational fields with these profiles were calculated. It was shown that correspondent radiation temperature in the X-rays diapason have the magnitude about T^10-6K . It was also marked that its detection may be the criteria on choosing the preferable dark matter density distribution in a galaxy.

关键词： Dark Matter Profile The Cherenkov Radiation

A new non-electrolytic aluminum extraction method

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Transactions of Nonferrous Metals Society of China 2016年第9期26卷 2509-2517页

作者： Oleg G.PARFENOv Andrey D.KUSTOv leonid A.SOLOvYOv Institute of Chemistry and Chemical Technology of SB RAS

A new method of primary aluminum extraction from alumina was proposed. The method is based on the new reaction AlI3＋（3/2）Zn=Al＋（3/2）ZnI2. In its turn, the exchange reaction AlCl3＋CaI2→AlI3＋CaCl2 is used to get aluminum iodide from aluminum chloride—the product of alumina carbochlorination. These reactions were studied in laboratory experiments as well as additional reactions, which were needed for the main chemicals recycling： Cl2, ZnI2→Zn, CaCl2→CaI2. XRD and SEM methods were used to investigate the phases and morphology of the reaction＇s solid products. The global free energy minimization method was used for the chemical equation＇s calculations. It was shown that aluminum can be effectively extracted from alumina without electrolysis, extreme high temperature and expended chemicals. The estimated specific carbon consumption and CO2 atmospheric pollution rate have to be halves of such values for the contemporary aluminum plant powered by the coal power station.

关键词： aluminum aluminum alloy chlorides iodides zinc iodine high-speed metallurgy

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One-Pot Production of Substituted Anthraquinones via the Diene Synthesis in the Presence of Mo-v-P Heteropoly Acid Solutions

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Modern Research in Catalysis 2014年第2期3卷 575-61页

作者： leonid Gogin Elena Zhizhina Boreskov Institute of Catalysis Novosibirsk Russia

Acid-catalytic 1,3-butadiene condensation with para-quinones followed by the obtained product oxidation may be performed in one stage as one-pot process, if assisted by the aqueous solutions of Mo-v-P heteropoly acids with a composition of HaPzMoyvxOb. 1,4-naphthoquinone (NQ) condensation with 1,3-butadiene in HPA solutions (brutto-composition H15P4Mo18v7O89 and H17P3Mo16v10O89) in the presence of hydrophylic organic solvents (acetone, 1,4-dioxane) provides 70% yield of 9,10-anthraquinone (AQ) containing no less than 90% AQ. In the same conditions reaction NQ with substituted 1,3-butadienes in the presence of the aqueous H17P3Mo16v10O89 (HPA-10) solution allows to prepare substituted AQ with yield up to 90% and purity up to 99%. The catalysts are regenerated by oxygen in separate stage and are reused.

关键词： Substituted 9 10-Anthraquinones Diene Synthesis Mo-v-P Heteropoly Acids Bifunctional Catalysts

One-Pot Process of Anthraquinone Synthesis in the Presence of Mo-v-P Heteropoly Acid Solutions as a Bifunctional Catalysts

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Modern Research in Catalysis 2013年第3期2卷 90-92页

作者： leonid Gogin Elena Zhizhina Boreskov Institute of Catalysis Novosibirsk Russia

Acid-catalytic 1,3-butadiene condensation with para-quinones followed by the obtained product oxidation may be performed in one stage as one-pot process, if assisted by the aqueous solutions of Mo-v-P heteropoly acids with a composition of HaPzMoyvxOb. 1,4-naphthoquinone condensation with 1,3-butadiene in the HPA solutions with no organic solvents yields 9,10-anthraquinone (AQ) mixed with tetrahydro-AQ (THA) and dihydro-AQ (DHA). However, AQ yield and its purity may be considerably improved by using water-mixable organic solvents, e.g., acetone, 1,4-dioxane, as well as high vanadium content HPA such as H15P4Mo18v7O89 and H17P3Mo16v10O89. Process optimization provides 70% yield of reaction product containing no less than 90% AQ.

关键词： 9 10-Anthraquinone Mo-v-P Heteropoly Acids Diene Synthesis Organic Solvents

Two-Component Substance Basing the Direction Dependence of the Cosmological Deceleration Parameter

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International Journal of Astronomy and Astrophysics 2012年第4期2卷 195-198页

作者： leonid M. Chechin v. G. Fessenkov Astrophysical Institute Almaty Kazakhstan

*** description of Hubble’s diagrams asymmetry of and calculating the anisotropy of the deceleration parameter phenomenon, that was recently found by R.-*** and Z.-***. For doing this the concepts of Universe rotation and its two-component model were *** result is in good correlation (case of the upper magnitude index) with the value that was got in [1].Significance. The result of article gives new basing of the Universe rotation axis existence.

关键词： Anisotropy of the Deceleration Parameter Universe Principal Axis

始新世海鸟基辅鸟(Kievornis Averianov et al.,1990)新材料及其亲缘关系的重新评估(英文)

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古脊椎动物学报 2015年第3期53卷 238-244页

作者： Evgeniy ZvONOK Gerald MAYR leonid GOROBETS 乌克兰国立塔拉斯舍甫琴科卢甘斯克大学地理系卢甘斯克91011 德国法兰克福辛氏博物馆鸟类部法兰克福D-60325 乌克兰国家科学院国家自然历史博物馆古脊椎动物学部基辅199034 乌克兰国立基辅塔拉斯舍甫琴科大学生态与环境保护学院基辅01601

描述了始新世基辅鸟类新标本。研究表明基辅鸟类生活在特提斯海中始新世早路特期至早巴顿期,分布范围至少包括乌克兰东部的伊克夫到中部的基辅地区。暂时将基辅鸟归人鹱形目。虽然基辅鸟具有一些鹱形目的典型特征,但缺少鹱形目的衍生特... 详细信息

描述了始新世基辅鸟类新标本。研究表明基辅鸟类生活在特提斯海中始新世早路特期至早巴顿期,分布范围至少包括乌克兰东部的伊克夫到中部的基辅地区。暂时将基辅鸟归人鹱形目。虽然基辅鸟具有一些鹱形目的典型特征,但缺少鹱形目的衍生特征,或许代表了近祖状态。

关键词：乌克兰特提斯海中始新世鹱形目基辅鸟

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Effect of hypoxia and glutamine or glucose deprivation on the expression of retinoblastoma and retinoblastoma-related genes in ERN1 knockdown glioma U87 cell line

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American Journal of Molecular Biology 2012年第1期2卷 21-31页

作者： Dmytro O. Minchenko leonid L. Karbovskyi Serhii v. Danilovskyi Michel Moenner Oleksandr H. Minchenko Department of Molecular Biology Palladin Institute of Biochemistry National Academy of Sciences of Ukraine Kyiv Ukraine Department of Molecular Biology Palladin Institute of Biochemistry National Academy of Sciences of Ukraine Kyiv Ukraine INSERM U920 Molecular Mechanisms of Angiogenesis Laboratory University Bordeaux 1 Talence France Department of Molecular Biology Palladin Institute of Biochemistry National Academy of Sciences of Ukraine Kyiv Ukraine National O.O. Bohomoletz Medical University Kyiv Ukraine INSERM U920 Molecular Mechanisms of Angiogenesis Laboratory University Bordeaux 1 Talence France INSERM U920 Molecular Mechanisms of Angiogenesis Laboratory University Bordeaux 1 Talence France

The expression of retinoblastoma and several retinoblastoma-related genes was studied in glioma cell line U87 and its subline with knockdown of ERN1 (endoplasmic reticulum—nuclei-1), the main endoplasmic reticulum stress sensing and signaling enzyme. It was shown that a blockade of the ERN1 enzyme function increases the expression levels of retinoblastoma, retinoblastoma-like 1 and most retinoblastoma related genes: EID1, JARID1B, E2F1, E2F3, RBAP48 and CTIP, does not change RNF40 and RBAP46 and decreases KDM5A. We have also demonstrated that hypoxia reduces the expression levels of retinoblastoma, EID1, and E2F1 in ERN1-deficient glioma cells only. At the same time, the expression levels of retinoblastoma-like 1, E2F3, RBAP46, RBAP48 and CTIP decrease, while JARID1B and RBBP2 increase in both types of cells in hypoxic conditions, but the expression is much stronger in cells with suppressed function of ERN1. The expression level of JARID1B and KDM-5A mRNA is also enhanced in glutamine deprivation condition in both tested cell types, moreover, this effect is amplified by the blockade of the ERN1 enzyme function. The expression levels of retinoblastoma, EID1, RBAP48, and E2F3 are decreased in glutamine deprivation condition only in ERN1-deficient glioma cells, but RBL1, CTIP, RBAP46, and E2F1—in both tested cell types with more significant effect in ERN1-deficient cells. Glucose deprivation condition leads to a decrease of expression levels of retinoblastoma, RBL1, E2F3, RBAP46, and RBAP48 in both used cell types and of EID1 and E2F1 only in glioma cells with suppressed function of signaling enzyme ERN1. Thus, expression levels of retinoblastoma and most retinoblastoma-related genes are increased under a blockade of ERN1 enzyme function and significantly changed in hypoxia, glucose or glutamine deprivation conditions both in control U87 cells and ERN1-deficient cells, but inhibition of the unfolded protein response sensor ERN1 predominantly enhances these effects. Mor

关键词： mRNA Expression Retinoblastoma RBL1 RBAP48 RBAP46 CTIP KDM5A JARID1B E2F1 E2F3 Glioma Cells ERN1 Hypoxia Glucose Deprivation Glutamine Deprivation