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Modern Research in Catalysis 2019年第1期8卷 1-9页

作者： leonid L. Gogin Elena G. Zhizhina Zinaida P. Pai Federal Research Center Boreskov Institute of Catalysis Novosibirsk Russia

1,4-Naphthoquinones (NQ) is a class of organic compounds with a number of important properties. However, the existing methods of their synthesis either give a low NQ yield or multistage and require a lot of time. In the present work new one-pot process of NQ synthesis from hydroquinone (HQ) and substituted 1,3-dienes at room temperature is proposed. The solution of heteropolyacid H7PMo8v4O40 (HPA-4) is used as a bifunctional (acid and redox) catalyst for this process. The influence of a number of factors on key process parameters has been studied. It is demonstrated that unsubstituted and a number of alkyl substituted NQ with the yields of 50% - 80% and purity of 92% - 99% can be obtained by this method. The results obtained allow to significantly simplify the synthesis of NQ directly from HQ in comparison with the described similar methods.

关键词： Hydroquinone Naphthoquinones Heteropolyacid Diene Synthesis

C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance

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Nano Research 2017年第2期10卷 652-671页

作者： Svitlana Prylutska Rostyslav Panchuk Grzegorz Golunski Larysa Skivka Yuriy Prylutskyy vasyl Hurmach Nadya Skorohyd Agnieszka Borowik Anna Woziwodzka Jacek Piosik Olena Kyzyma vasil Garamus leonid Bulavin Maxim Evstigneev Anatoly Buchelnikov Rostyslav Stoika Walter Berger Uwe Ritter Peter Scharff Taras Shevchenko National University of Kyiv 64 Volodymyrska Str. 01601 Kyiv Ukraine Institute of Cell Biology NAS of Ukraine 14-16 Drahomanov 5tr. 79005 Lviv Ukraine Laboratory of Biophysics Intercollegiate Faculty ofBiotechnology UG-MUG Abrahama 58 80-307 Gdansk Poland Joint Institute for Nuclear Research 6 Joliot-Curie Str. 141980 Dubna Moscow reg. Russia Helmholtz-Zentrum Geesthacht: Centre for Materials and Coastal Research 1 Max-Planck Str. 21502 Geesthacht Germany Belgorod State University 85 Pobedy Str. 308015 Belgorod Russia Institute of Cancer Research and Comprehensive Cancer Center Medical University Vienna 1090 8A Borschkegasse Vienna Austria Institute of Chemistry and Biotechnology Technical University ofllmenau 25 Weimarer Str. 98693 Ilmenau Germany

We formulated and analyzed a novel nanoformulation of the anticancer drug cisplatin （Cis） with C60 fullerene （C60＋Cis complex） and showed its higher toxicity toward tumor cell lines in vitro when compared to Cis alone. The highest toxicity of the complex was observed in HL-60/adr and HL-60/vinc chemotherapy- resistant human leukemia cell sublines （resistant to Adriamycin and vinculin, respectively）. We discovered that the action of the C60＋Cis complex is associated with overcoming the drug resistance of the tumor cell lines through observing an increased number of apoptotic cells in the Annexin v/PI assay. Moreover, in vivo assays with Lewis lung carcinoma （LLC） C57BL/6J male mice showed that the C60＋Cis complex increases tumor growth inhibition, when compared to Cis or C60 fullerenes alone. Simultaneously, we conducted a molecular docking study and performed an Ames test. Molecular docking specifies the capability of a C60 fullerene to form van der Waals interactions with potential binding sites on P-glycoprotein （P-gp）, multidrug resistance protein 1 （MRP-1）, and multidrug resistance protein 2 （MRP-2） molecules. The observed phenomenon revealed a possible mechanism to bypass tumor cell drug resistance by the C60＋Cis complex. Additionally, the results of the Ames test show that the formation of such a complex diminishes the Cis mutagenic activity and may reduce the probability of secondary neoplasm formation. In conclusion, the C60＋Cis complex effectively induced tumor cell death in vitro and inhibited tumor growth in vivo, overcoming drug resistance likely by the potential of the C60 fullerene to interact with P-gp, MRP-1, and MRP-2 molecules. Thus, the C60＋Cis complex might be a potential novel chemotherapy modification.

关键词： molecular docking,small-angle X-ray scattering,apoptosis,mutagenic activity lung carcinoma (LLC),cytotoxicity

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小国的大气象亚美尼亚的地道风物

环球人文地理 2024年第1期 36-45页

作者：读书康梁庭俊宣砚 leonid Andronov katiekk2 v unsplash 摄图网

亚美尼亚人将水果杏奉为国宝，爱吃重油重盐的烤肉、大饼。在市中心的购物大街与教堂中，能一窥他们的生活与精神世界。说到葡萄酒，除了法国，亚美尼亚的葡萄酒也是历史悠久。除此以外，随处可见的修道院也是亚美尼亚的标志之一。左页...

亚美尼亚人将水果杏奉为国宝，爱吃重油重盐的烤肉、大饼。在市中心的购物大街与教堂中，能一窥他们的生活与精神世界。说到葡萄酒，除了法国，亚美尼亚的葡萄酒也是历史悠久。除此以外，随处可见的修道院也是亚美尼亚的标志之一。左页大图为当地的葡萄园。右页图为亚美尼亚的修道院。在杰尔穆克的日子，说得上是此行节奏最慢的时候。

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来源：博看期刊

金川铜镍矿床金属硫化物中铂族元素赋存状态及成因

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矿物学报 2015年第S1期35卷 109-页

作者：陈列锰宋谢炎 leonid v.Danyushevsky 中国科学院地球化学研究所矿床地球化学国家重点实验室贵州贵阳550002 ARC Centre of Excellence in Ore Deposits and School of Earth Sciences University of Tasmania

随着激光等离子体质谱(LA-ICP-MS)测试技术的发展,地质学家可以原位分析贱金属硫化物(如磁黄铁矿、镍黄铁矿、黄铜矿等)中铂族元素(PGE)和其它亲铜元素的赋存状态,并进一步用来制约矿床的成因机制。金川矿床位于华北地台边部阿拉善地块... 详细信息

随着激光等离子体质谱(LA-ICP-MS)测试技术的发展,地质学家可以原位分析贱金属硫化物(如磁黄铁矿、镍黄铁矿、黄铜矿等)中铂族元素(PGE)和其它亲铜元素的赋存状态,并进一步用来制约矿床的成因机制。金川矿床位于华北地台边部阿拉善地块西南缘的龙首山推覆体北缘,是仅次于俄罗斯Noril’sk矿床和加拿大Sudbury矿床的世界第三大在采镍矿床。

关键词：金川铜镍矿床铂族元素金属硫化物镍黄铁矿原位分析阿拉善地块等离子体质谱亲铜元素成因机制岩浆通道

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On the way to airborne gravelometry based on 3D spatial data derived from images

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International Journal of Sediment Research 2018年第1期33卷 84-92页

作者： M.Detert L.Kadinski v.Weitbrecht Laboratory of Hydraulics Hydrology and Glaciology VAWETH Zurich

This paper presents basic tests to develop an airborne photogrammetric methodology that derives grain size characteristics of gravel bed rivers. The data acquisition was done using a light weight action cam and a hand-held digital single lens reflex camera. Image processing comprised the structure from motion technique and multiview-stereo algorithms to obtain digital elevation models of non-cohesive gravel beds. Laboratory results indicate that the method accuracy is about four to six times lower than laserscan data when based on action cam data. The accuracy of digital elevation models computed via photos taken by the reflex camera is almost of the same range as the laser data. Field experiments were done to test the performance of image based gravelometry against manual surface sampling. For this application the action cam was mounted to a low-cost quadrocopter, while the reflex camera was operated by *** indicate that this combination has a high potential to generate data from which characteristic grain size parameters can be estimated.

关键词： Airborne photogrammetry Grain size distribution Gravel bed Field work Gravelometry Image analysis Laboratory experiments Structure from motion Surface sampling

Pathophysiology transforms to pathobiology:new technologies and interdisciplinary project-oriented learning

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中国病理生理杂志 2009年第11期25卷 2248-2248页

作者： leonid P. Churilov Yury I. Stroev vladimir J. Utekhin Department ofPathology School ofMedicine State University off.113 bld821st line V.O. St.Petersburg199106 Russia

Integrative role of pathophysiology in medicine is analogous to that of systemic biology among non-medical life sciences. Pathology rooted in morphology,because autopsy and microscopy in early 19th century revealed some loci and elements of disease. However,this was not enough for comprehension of systemic disorders and relations between elements. This promoted the involvement of physiology and birth of pathophysiology. For a long time the methodological options for bedside studies were scarce,so generations of physicians percepted pathophysiology as a science of lab and vivarium only,unlike pathomorphology,had integrated in clinics earlier. This lead to fornication between two sister branches of pathology and teaching of pathology and clinical subjects separated. Methodological progress of 20th century created basis for less or non-invasive patient studies. Current advances of pathochemistry,medical genetics,immunopathology,bioinformatics-give the chance to pathophysiology and pathomorphology spread far beyond the constraint of their historical names and intermingle. Current Pathophysiology grew into clinics (via laboratory and functional diagnosis,which contains clinical experimenting). This promotes re-integration of pathology sister branches,not via absorption,but through mutual shift to clinical correlations. Holistic approach to patient,disease and education is traditional for Russian medicine. In our pathophysiology teaching,classical lab experiments are joint to early start of clinical pathology (6th term),case history analysis,lectures co-delivered by pathologist and clinician with demonstration of patients. Pathomorphologist and clinician are included in state board for pathophysiology exam. In teaching posters pathophysiological,clinical and pathomorphological data are fused. Local net of digital television microscopes gives instant video archive of experimental results added to student's protocols of lab studies. Teaching posters and course papers are co

关键词：病理生理学病原生物学跨学科学习导向项目技术病理生理作用

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A Depth Resolved Insight into Benzoyl CoA Reductase and Benzoate Dioxygenase Gene Copy Numbers within a Marine Sediment Associated with Methane Seepage

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Open Journal of Marine Science 2013年第4期3卷 175-181页

作者： Paul v. Flanagan Brian P. Kelleher Shane S. O’Reilly Michal T. Szpak Xavier Monteys Paul P. Kelly Anna N. Kulakova leonid A. Kulakov Christopher C. R. Allen Geological Survey of Ireland Beggar’s Bush Dublin Ireland School of Biological Sciences Queen’s University Belfast Belfast UK School of Chemical Sciences Dublin City University Dublin Ireland

A marine sediment core obtained from a methane seepage site off the northern coast of Irelandwas analysed, at 3 depths, for catabolic genes associated with the aerobic and anaerobic degradation of aromatic compounds. Catabolic gene copy numbers varied through the core peaking at 2.1 meters below sediment surface (mbsf)-just above the sulphate boundary. Beyond the sulphate boundary gene copy numbers fell considerably, suggesting the boundary may be a critical factor in the degradation of aromatic compounds within marine sediments. At the 2.1 mbsf depth our data also suggest that known benzoyl CoA reductase utilizing bacteria are readily detectable.

关键词： Aromatic Compounds qPCR bcr bdo

Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial

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Stroke & vascular Neurology 2022年第2期7卷 158-165页

作者： Nawaf Yassi Henry Zhao leonid Churilov Bruce C v Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis Department of Medicine and Neurology Melbourne Brain Centre at The Royal Melbourne HospitalThe University of MelbourneParkvilleVictoriaAustralia Population Health and Immunity Division Walter and Eliza Hall Institute of Medical ResearchParkvilleVictoriaAustralia Ambulance victoria MelbourneVictoriaAustralia Melbourne Medical School The University of MelbourneMelbourneVictoriaAustralia Stroke Division The Florey Institute of Neuroscience and Mental HealthParkvilleVictoriaAustralia Department of Neurology Christchurch HospitalChristchurchNew Zealand Department of Neurology Monash Medical CentreMonash UniversityClaytonVictoriaAustralia Department of Interventional Neuroradiology Liverpool HospitalLiverpoolNew South WalesAustralia Department of Neurology Royal Adelaide HospitalAdelaideSouth AustraliaAustralia Department of Neurology Princess Alexandra HospitalWoolloongabbaQueenslandAustralia Department of Neurology Box Hill HospitalEastern HealthBox HillVictoriaAustralia Stroke Centre and Department of Neurology National Taiwan University HospitalTaipeiTaiwan Department of Medicine Dunedin School of MedicineUniversity of OtagoWellingtonNew Zealand Department of Neurosurgery E-Da HospitalYanchaoKaohsiungTaiwan Department of Neurology Alfred HospitalMelbourneVictoriaAustralia Department of Clinical Neuroscience Monash University Central Clinical SchoolMelbourneVictoriaAustralia Department of Medicine Sunshine Coast University HospitalNambourQueenslandAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia Department of Neurology John Hunter HospitalThe University of NewcastleNewcastleNew South WalesAustralia Department of Neurosurgery China Medical University HospitalTaichungTaiwan Department of Internal Medicine Palmerston North HospitalPalmerston NorthNew Zealand Department of Neurology St Vincent's HospitalFitzroyVictoriaAustralia Department of Neurology Royal Prince Alfred HospitalCamperdownNew South WalesAustra

Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of *** acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma *** and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical *** In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with *** size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of *** adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 *** Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching *** efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT *** We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments.

关键词： placebo centre absolute

Association between Exposure to Metals during Pregnancy,Childhood Gut Microbiome,and Risk of Intestinal Inflammation in Late Childhood

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Environment & Health 2024年第10期2卷 739-749页

作者： vishal Midya Manasi Agrawal Jamil M.Lane Chris Gennings leonid Tarassishin Libni A.Torres-Olascoaga Joseph Eggers Jill K.Gregory Mellissa Picker Inga Peter Jeremiah J.Faith Manish Arora Martha M.Tellez-Rojo Robert O.Wright Jean-Frederic Colombel Shoshannah Eggers Department of Environmental Medicine and Climate Science Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Division of Gastroenterology Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Center for Molecular Prediction of Inflammatory Bowel Disease(PREDICT) Department of Clinical MedicineAalborg UniversityCopenhagen 9220Denmark Department of Genetics and Genomic Sciences Icahn School of MedicineNew York 10029-6574New YorkUnited States Center for Research on Nutrition and Health National Institute of Public HealthCuernavaca 62508Mexico Department of Immunology and Immunotherapy Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Department of Epidemiology University of Iowa College of Public HealthIowa City 52242 IowaUnited States Instructional Technology Group Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States

Alterations to the gut microbiome and exposure to metals during pregnancy have been suggested to impact inflammatory bowel ***,how prenatal exposure to metals eventually results in long-term effects on the gut microbiome,leading to subclinical intestinal inflammation,particularly during late childhood,has not been *** is also unknown whether such an interactive effect drives a specific subgroup of children toward elevated susceptibility to intestinal *** used an amalgamation of machine-learning techniques with a regression-based framework to explore if children with distinct sets of gut microbes and certain patterns of exposure to metals during pregnancy(metal−microbial clique signature)had a higher likelihood of intestinal inflammation,measured based on fecal calprotectin(FC)in late *** obtained samples from a well-characterized longitudinal birth cohort from Mexico City(n=108),*** the second and third trimesters of pregnancy,11 metals were measured in whole *** microbial abundances and FC were measured in stool samples from children 9−11 years of *** FC was defined as having FC above 100μg/g of *** identified subgroups of children in whom microbial and metal−microbial clique signatures were associated with elevated FC(false discovery rate(FDR)vated FC:(1)low cesium(Cs)and copper(Cu)in the third trimester and low relative abundance of Eubacterium ventriosum(OR[95%CI]:10.27[3.57,29.52],FDRve abundances of Roseburia inulinivorans and Ruminococcus torques(OR[95%CI]:7.21[1.81,28.77],FDRve higher fecal calprotectin levels in late childhood,denoting an elevated risk of intestinal inflammation.

关键词： exposome metals machine learning microbiome environmental epidemiology intestinal inflammation

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不可逆转的全球老龄化:趋势与应对

延边大学学报(社会科学版) 2024年第5期57卷 129-138+144页

作者： Л.Е.格里宁 А.Л.格里宁 А.В.科罗塔耶夫张广翔师成俄罗斯国立高等经济大学社会政治动荡风险监测实验室莫斯科国立大学全球化进程系吉林大学东北亚研究中心

文章分析了对21世纪社会生活各领域产生重大影响的全球人口老龄化进程。这一进程的影响将取决于其规模和深度，也可以说取决于未来社会的人口结构。同时，现代社会是否能够应对全球人口老龄化所带来日益严峻的挑战也是一大问题。鉴于到2... 详细信息

文章分析了对21世纪社会生活各领域产生重大影响的全球人口老龄化进程。这一进程的影响将取决于其规模和深度，也可以说取决于未来社会的人口结构。同时，现代社会是否能够应对全球人口老龄化所带来日益严峻的挑战也是一大问题。鉴于到21世纪中叶，全球65岁以上人口将有2/3生活在中低收入国家，所以这一挑战尤其令人担忧。全球老龄化已经是不容忽视的时代主题，为老年人提供社会保障和医疗保健服务也将是艰巨的任务。时至今日，不应再将老龄化视作负面现象，而应将老一代人的智慧和经验视为未来社会发展的新机遇。因此，有必要在各领域采取具体措施并实施专门的长期政策，改善老年人的健康水平，提高其生活质量与预期寿命，消除对死亡的偏见。实现这些目标是高度依赖技术进步的，同时全球老龄化进程所催生的新需求也会倒逼技术发展，尤其是在技术爆炸即将到来的背景下，可能会对节省劳动力的技术、延长寿命的技术产生巨大需求，这也将有力地推动医学进步，有助于延长工作年限和提高人类生活质量。

关键词：全球老龄化社会人口结构控制论革命养老金危机老龄歧视