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Performance of evolutionary optimized machine learning for modeling total organic carbon in core samples of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： leonardo Goliatt c.M.Saporetti L.c.Oliveira E.Pereira Department of computational and Applied Mechanics Federal University of Juiz de ForaJuiz de ForaBrazil Department of computational Modeling Polytechnic InstituteRio de Janeiro State UniversityNova FriburgoBrazil Petrobras Rio de JaneiroBrazil Department of Stratigraphy and Paleontology Rio de Janeiro State UniversityRio de JaneiroBrazil

Rock samples'TOc content is the best indicator of the organic matter in source *** origin rock samples’analysis is used to calculate it manually by *** method requires time and resources because it relies on samples from many well intervals in source ***,research has been done to aid this *** learning algorithms can estimate total organic carbon instead of well logs and stratigraphic *** light of these efforts,the current work present a study on automating the total organic carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and *** algorithms,differential evolution,particle swarm optimization,grey wolf optimization,artificial bee colony,and evolution strategies were used to improve machine learning models to predict *** six metaheuristics were integrated into four machine learning methods:extreme learning machine,elastic net linear model,linear support vector regression,and multivariate adaptive regression *** samples from the YuDong-Nan shale gas field,located in the Sichuan basin,were used to evaluate the hybrid *** findings show that combining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict *** results show that,independent of the metaheuristic used to guide the model selection,optimized extreme learning machines attained the best performance scores according to six *** hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated machine learning Evolutionary algorithms Geology

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characterization of Arroyo Verde Epithermal Deposit:Paragenesis,Mineral Geochemistry,Geochronology and Fluid Inclusions in Lower chon Aike Volcanism,Argentina

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Journal of Earth Science 2024年第1期35卷 62-84页

作者： cecilia Pavón Pivetta leonardo Benedini Paulo Marcos Ma.Agustina cócola Mercedes Virginia Barros Daniel Gregori leonardo Strazzere Anderson costa dos Santos Mauro c.Geraldes Instituto Geologico del Sur(INGEOSUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Universidad Nacional de Rio Negro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Universidade do Estado do Rio de Janeiro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Geobiotec Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is located within the Lower chon Aike volcanism and is developed between 192.6±2.5 Ma(mineralization host rock)and 189.5±2.6 Ma(overlying lava).Marifil volcanic complex is the host rock for these veins,veinlets and *** particular small deposit has developed low to intermediate sulphidation characteristics,with gangue mineral textures associated with several ore *** probe microanalysis determines electrum,silver minerals such as acanthite,and tetrahedrite,related Ag-cu minerals like jalpaite,mckinstryite,stromeyerite,and base metals like chalcopyrite,sphalerite,galena and *** inclusions in quartz of two out of five events indicate that these Low Jurassic veins were formed due to subtle boiling and dilution mechanisms and by low-salinity(3.4 wt.%to 6.7 wt.%Nacl Eq)magmatic-hydrothermal fluid at 225 to 310℃.The fluid inclusion measurements that indicate boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 *** particular character has not been previously recorded for other sectors of the eastern north Patagonian region.

关键词： epithermal deposit Ag minerals mineral geochemistry fluid inclusions chon Aike geochronology

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Spatial analysis of Dengue through the reproduction numbers relating to socioeconomic features:case studies on two Brazilian urban centers

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Infectious Disease Modelling 2024年第1期9卷 142-157页

作者： Ana T.c.Silva Rejane c.Dorn Lívia R.Tomás leonardo B.L.Santos Lacita M.Skalinski Suani T.R.Pinho Departamento de Física Universidade Estadual de Feira de SantanaAv.Transnordestinas/n.Novo HorizonteFeira de Santana44036-900BABrazil Instituto de Física Universidade Federal da BahiaRua Barão de Jeremoabo s/nCampus Universitário de OndinaSalvador40170-115BABrazil centro Nacional de Monitoramento e Alertas de Desastres Naturais(cEMADEN) Estrada Dr.Altino Bondensan500São Josédos Campos12247-016SPBrazil Universidade Estadual de Santa cruz Campus Soane Nazaréde AndradeRodovia Jorge AmadoKm 16SalobrinhoIlhéus45662-900BABrazil Instituto de Saúde coletiva Universidade Federal da BahiaR.Basílio da Gamas/n-CanelaSalvador40110-140BABrazil Instituto Nacional de ciência e Tecnologia-Sistemas complexos Virtual InstitutionBrazil

The study of the propagation of infectious diseases in urban centers finds a close connection with their population's social characteristics and *** work performs a spatial analysis of dengue cases in urban centers based on the basic reproduction numbers,R0,and incidence by planning areas(PAs),as well as their correlations with the Human Development Index(HDI)and the number of *** analyzed dengue epidemics in 2002 at two Brazilian urban centers,Belo Horizonte(BH)and Rio de Janeiro(RJ),using PAs as spatial *** results reveal heterogeneous spatial scenarios for both cities,with very weak correlations between R0 and both the number of trips and the HDI;in BH,the values of R0 show a less spatial heterogeneous pattern than in *** BH,there are moderate correlations between incidence and both the number of trips and the HDI;meanwhile,they weakly correlate for ***,the absence of strong correlations between the considered measures indicates that the transmission process should be treated considering the city as a whole.

关键词： Dengue Mathematical mode lBasic reproduction number Urban mobility Urban indices

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Solar-driven cO_(2) conversion to methane and methanol using different nanostructured cu_(2)O-based catalysts modified with Au nanoparticles

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Journal of Energy chemistry 2024年第4期91卷 287-298页

作者： João Angelo Lima Perini Lilian D.Moura Torquato Juliana Fde Brito Gustavo A.Andolpho Mateus A.Gonçalves leonardo D.De Angelis Lucas D.Germano Susana I.córdoba de Torresi Teodorico c.Ramalho Maria V.Boldrin Zanoni São Paulo State University(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternative Technologies for Detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of Molecular Modelling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil Department of chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto de Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work describes the use of TiO_(2)nanotubes-based electrodes(TNT)modified with cu_(2)O nanostructures and gold nanoparticles for the photoelectroreduction of cO_(2)to produce value-added compounds.A thin layer of polydopamine was used as both an adherent agent and an electron transfer mediator,due to itsπ-conjugated electron *** highest production yield was achieved using a TNT@PDA/Nc/Au40%electrode,with Faradaic efficiencies of 47.4%(110.5μM cm^(-2))and 27.8%(50.4μM cm^(-2))for methanol and methane,*** performance of the photoelectrodes was shown to be cu_(2)O facet-dependent,with cubic structures leading to greater conversion of cO_(2)to methanol(43%)and methane(27%),compared to the octahedral morphology,while a higher percentage of metallic gold on the nanostructured cu_(2)O surface was mainly important for *** functional theory(DFT)calculations supported these findings,attributing the superior photoelectrocatalytic performance of the TNT@PDA/Nc/Au40%electrode for cH4generation to the formation of an OcH3intermediate bonded to Au *** using isotope-labeling and analysis by gas chromatograph-mass(Gc-MS)demonstrated that13cO_(2)was the source for photoelectrocatalytic generation of13cH3OH and13cH313cH2OH.

关键词： cu_(2)O nanocubes Photoelectrocatalysis Polydopamine cO_(2) photoelectroreduction DFT calculations

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In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking

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Journal of Biosciences and Medicines 2024年第7期12卷 214-229页

作者： Luciene Soares Silva Tiago Soares Barbosa Maria Leonisa Sanchez-Nuñez Aldenise Mont Serrat Rosa da Silva Vitor Won-Held Rabelo leonardo dos Santos corrêa Amorim leonardo Alves Miceli Percilene Fazolin Vegi Alice Bernardino Helena carla castro Izabel christina Nunes de Palmer Paixão Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic chemistry at the Institute of chemistry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (Ec50 = 4.3 μM) and the highest selectivity (SI = 342). Mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. Molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 Methyltransferase Antivirals

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combination approaches in hepatocellular carcinoma:How systemic treatment can benefit candidates to locoregional modalities

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World Journal of Gastroenterology 2022年第28期28卷 3573-3585页

作者： leonardo Gomes da Fonseca Raphael L c Araujo Department of Medical Oncology Instituto do Cancer do Estado de Sao PauloUniversity of Sao PauloSão Paulo 01246-000São PauloBrazil Hospital e Maternidade Brasil-Rede D'Or São Luiz Santo André09030-590São PauloBrazil Department of Digestive Surgery Escola Paulista de Medicina-UNIFESPSão Paulo 04023-062São PauloBrazil

The management of hepatocellular carcinoma(Hcc)is challenging because most patients have underlying cirrhosis,and the treatment provides,historically,a limited impact on the natural history of patients with advanced-stage ***,recurrence rates are high for those patients who receive local and locoregional modalities,such as surgical(resection and transplantation)or imageguided(ablation and intra-arterial)*** research has led to new concepts that are reshaping the current clinical *** advancements were achieved in the understanding of the hallmarks that drive *** has primed a successful incorporation of novel agents with different targets,such as anti-angiogenic drugs,targeted-therapies,and immune-checkpoint *** clinical trials have proven efficacy of systemic agents in advanced stage disease,there is no conclusive evidence to support their use in combination with loco-regional *** novel local modalities are being incorporated(e.g.,radioembolization,microwave ablation,and irreversible electroporation),emerging data indicate that locoregional treatments may induce tumor microenvironment changes,such as hyperexpression of growth factors,release of tumor antigens,infiltration of cytotoxic lymphocytes,and modulation of adaptative and innate immune *** trials that evaluated the use of antiangiogenic drugs in the adjuvant setting after ablation or chemoembolization fail to demonstrate a substantial *** efforts are directed to investigate the role of immunotherapy-based regimens in this *** present review aims to describe the current landscape of systemic and locoregional treatments for Hcc,present evidence to support combination approaches,and address future perspectives.

关键词： Liver cancer Hepatocellular carcinoma Immunotherapy Systemic therapy Ablation Embolization

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Synthesis and characterization of lanthanide-doped sodium holmium fluoride nanoparticles for potential application in photothermal therapy

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Frontiers of Materials Science 2019年第4期13卷 389-398页

作者： Kaushik DAS c.A.KUMAR leonardo MIRANDOLA Maurizio cHIRIVAJNTERNATI Jharna cHAUDHURI Department of Mechanical Engineering Texas Tech UniversityLubbockTX 79409USA Department of Physics and Astronomy University of Texas at San AntonioSan AntonioTX 78249USA Department of Atomic and Molecular Physics Manipal UniversityManipal 576104KarnatakaIndia Department of Natural and Physical Sciences Northwest Vista College3535 N Ellison DrSan AntonioTX 78251USA Kiromic BioPharma 7707 Fannin St.Suite 140Houston.TX 77054USA Department of Gastroenterology Hepatology and NutritionUniversity of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Mechanical and Materials Engineering PO Box 751Portland State UniversityPortlandOR 97207-0751USA

Upconversion nanoparticles(Uc NPs)in combination with plasmonic materials have great potential for cancer photothermal ***,sodium holmium fluoride(NaHoF4)is being investigated for luminescence and magnetic resonance imaging(MRI)contrast ***,we present successful synthesis of excellent quality doped NaHoF4 NPs for possible Uc luminescence application and coated for possible photothermal therapy *** NaHoF4 nanocrystals were doped with Yb/Er and coated with gold,gold/silica,silver and polypyrrole(PPy).XRD,XPS and TEM were used to determine structure and morphology of the *** Uc photoluminescence(PL)emission spectra were obtained from the NPs when excited by near-infrared(NIR)light at 980 *** viability and toxicity of the NPs were characterized using pancreatic and ovarian cancer cells with results showing that gold/silica coating produced least toxicity followed by gold coating.

关键词： photothermal therapy upconversion photoluminescence nanoparticle sodium holmium fluoride

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The Puesto Piris Formation: Evidence of basin-development in the North Patagonian Massif during crustal extension associated with Gondwana breakup

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Geoscience Frontiers 2019年第1期10卷 299-314页

作者： leonardo Strazzere Daniel A.Gregori leonardo Benedini Paulo Marcos Mercedes V.Barros Mauro c.Geraldes cecilia Pavon Pivetta Instituto Geológico del Sur Consejo Nacional de Investigaciones Científicas y Técnicas Av cátedra de Geología Minera Universidad Nacional del Sur cátedra de Geología Argentina Universidad Nacional del Sur Av cátedra de Geofísica Departamento de Geología Universidad Nacional del Sur Av Departamento de Geología Regional Facultad de Geología Universidad Estatal de Rio de Janeiro

The Marifil Volcanic complex, exposed in the eastern North Patagonian Massif, Argentina, includes up to 550 m of red conglomerates, sandstones, black siltstones, limestones, and reworked tuff of the Puesto Piris Formation. The basal part of this unit, which was deposited in high-gradient topographic relief, is composed of conglomerates and sandstones with thin layers of reworked tuffs. The lithofacies associations of the basal part indicate that the depositional mechanisms were mantled and gravitational *** middle part of the unit consists of fine sandstones, limestones, and black siltstones that were deposited in low-energy fluvial and lacustrine environments. The outcrops are located along the NEe SW direction and the major thickest units represented by limestones and siltstones, occur near the southeastern border of this NEeS W depocenter. Since the rhyolitic and trachytic lava flows and tuffs of the Marifil Volcanic complex are interbedded with the sedimentary sequences of the Puesto Piris Formation,both units are coeval. Zircon Ue Pb age was obtained for a trachytic lava flow(193.4 ±3.1 Ma) suggesting that sedimentation and volcanism are Sinemurian. This extensional episode was recorded in the eastern,western, and southwestern sectors of the North Patagonian Massif, and is possibly associated with the Gondwana supercontinent breakup.

关键词： Puesto Piris Formation Early Jurassic North Patagonian Massif

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SARS-coV-2 spike protein:flexibility as a new target for fighting infection

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Signal Transduction and Targeted Therapy 2020年第1期5卷 321-323页

作者： ciro leonardo Pierri Laboratory of Biochemistry Molecular and Structural BiologyDepartment of BiosciencesBiotechnologiesBiopharmaceuticsUniversity of BariVia E.Orabona470125 BariItaly BROWSer S.r.l.(https://***/)c/o Department of Biosciences BiotechnologiesBiopharmaceuticsUniversity“Aldo Moro”of BariVia E.Orabona470126 BariItaly

The recent study of Turoňováet al.,is the first to combine cryoelectron tomography,subtomogram averaging,and molecular dynamics simulations for analyzing the structure of the SARS-coV-2 spike protein in situ,1 *** t... 详细信息

关键词： al infection fighting

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New prognostic biomarkers of mortality in patients undergoing liver transplantation for hepatocellular carcinoma

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World Journal of Gastroenterology 2018年第37期24卷 4230-4242页

作者： leonardo Lorente Intensive care Unit Hospital Universitario de Canarias

The outcome prediction of hepatocellular carcinoma(Hcc) patients undergoing liver transplantation(LT) was classically established using various macromorphological factors and serum alpha-fetoprotein levels prior to LT. However, other biomarkers have recently been reported to be associated with the prognosis of Hcc patients undergoing to LT. This review summarizes clinical data on these new biomarkers. High blood levels of malondialdehyde, total antioxidant capacity, caspasecleaved cytokeratin-18, soluble cD40 ligand, substance P, c-reactive protein, and vascular endothelial growth factor, increased neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in blood, high peripheral blood expression of human telomerase reverse transcriptase messenger ribonucleic acid, and high Hcc expression of dickkopf-1 have recently been associated with decreased survival rates. In addition, high blood levels of des-gamma-carboxy prothrombin, and high Hcc expression of glypican-3, E-cadherin and betacatenin have been associated with increased Hcc recurrence. Additional research is necessary to establish the prognostic role of these biomarkers in Hcc prior to LT. Furthermore, some of these biomarkers are also interesting because their potential modulation could help to create new research lines for improving the outcomes of those patients.

关键词： Liver transplantation Hepatocellular carcinoma Biomarkers Outcome Survival Recurrence Genomic

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