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Assessment of Mg(OH)_(2)/TiO_(2) coating in the Mg-Ca-Zn alloy for improved corrosion resistance and antibacterial performance

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Journal of Magnesium and Alloys 2023年第1期11卷 361-378页

作者： leonardo hernández Jesús Ramón-Sierra Montserrat Soria-Castro Ángel Bacelis Geonel Rodríguez-Gattorno Elizabeth Ortiz-Vázquez Gloria Acosta Applied Physics Department Center for Research and Advanced Studies of the National Polytechnic Institute(CINVESTAV-IPN)Carr.Ant.a Progreso km.6C.P.97310MeridaYucatanMexico Tecnológico Nacional de México/Instituto Tecnológico de Mérida.Av.Tecnológico s/n Km.4.5 ant.Carr.Mérida-Progreso C.P.97118MéridaYucatánMéxico Facultad de Química Universidad Nacional Autónoma de México(UNAM)Av.Universidad 3000C.P.04510CoyoacánCDMXMéxico

The high activity of metallic magnesium and alloys limits its potential in biomedical applications;in recent years,extensive efforts have been devoted to modulating this *** this work,we present Mg(OH)_(2) and TiO_(2)barrier coatings to reduce the degradation of magnesium alloy(Mg-Ca-Zn)*** coatings were deposited by the anodization method and the spin-coating technique,*** anodized layer was coated with TiO_(2)generated from the hydrolysis of 3%weight of TTIP(Ti[OCH(CH_(3))_(2)]_(4),Titanium(IV)isopropoxide)in 2-Propanol deposited by the spin-coating *** the degradation in Ringer’s solution by electrochemical impedance spectroscopy and OCP revealed a 98%reduction in pittings in uncoated samples after 14 days of *** p H measurements revealed that the TiO_(2)coating reduced the alkalization of the physiological environment,keeping the pH at 6.0 *** vitro studies of two types of bacteria(*** and ***)exhibited zones of inhibition in the agar and activity bactericidal(kill time test).The mechanisms behind the improved degradation resistance and enhanced antibacterial activity are presented and discussed *** modification with Mg(OH)_(2)/TiO_(2)coatings is a promising strategy to control the biodegradation of magnesium implants for bone regeneration.

关键词： Magnesium alloy EIS Mg(OH)_(2) TiO_(2) Antibacterial coatings

Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

Influence of oxidation of automatic transmission fluids (ATFs) and sliding distance on friction coefficients of a wet clutch in the running-in stage

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Friction 2021年第2期9卷 401-414页

作者： leonardo Israel FARFAN-CABRERA Ezequiel Alberto GALLARDO-hernÁndez Manuel VITE-TORRES Jesús Gilberto GODÍNEZ-SALCEDO Tecnologico de Monterrey Escuela de Ingeniería y CienciasAve.Eugenio Garza Sada 2501Monterrey 64849México Instituto Politécnico Nacional SEPI-Escuela Superior de Ingeniería Mecánica y EléctricaUnidad ZacatencoGrupo de TribologíaCol.LindavistaCiudad de México 07738México Instituto Politécnico Nacional ESIQIEIPNCol.LindavistaCiudad de México 07738México

In this paper,the influence of oxidation of automatic transmission fluids(ATFs)and sliding distance on the friction coefficients of a wet clutch in approached running-in conditions was *** ATFs were oxidized by a laboratory process approaching oxidation occurred in actual *** was evaluated by means of increase in carbonyl compounds and depletion of zinc dialkyldithiophosphates(ZDDPs)***,the changes in kinematic viscosity and viscosity index were ***-ondisk tests were conducted to replicate the actual sliding contact in a wet *** pin specimens were cut from friction material composite plates and the disks were actual steel separators both from an automotive wet *** coefficient, μ,was measured at progressive sliding velocity,ν,to obtain μ–νcurves at 26 and 100°*** μ–νtests were consecutively run using the same pair of specimens and *** cumulative sliding distance for each μ–νtest generated surface flattening using the *** friction coefficients of the wet clutch increased due to the ATFs oxidation meanwhile the dm/dv values decreased in most *** suggests that ATF oxidation can enhance torque capacity of the wet clutch,but it could reduce anti-shudder *** sliding distance improved the slopes in the μ–νresults using fresh ATFs meanwhile it generated a slope decrease by using aged ATFs.

关键词： wet clutch friction oil oxidation automatic transmission fluid(ATF)

CHARACTERISATION OF RATIONAL AND NURBS DEVELOPABLE SURFACES IN COMPUTER AIDED DESIGN

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Journal of Computational Mathematics 2021年第4期39卷 556-573页

作者： leonardo Fernandez-Jambrina ETSI Navales Universidad Politecnica de Madrid28040-MadridSpain

In this paper we provide a characterisation of rational developable surfaces in terms of the blossoms of the bounding curves and three rational functions∧,M,ν.Properties of developable surfaces are revised in this *** particular,a closed algebraic formula for the edge of regression of the surface is obtained in terms of the functions∧,M,ν,which are closely related to the ones that appear in the standard decomposition of the derivative of the parametrisation of one of the bounding curves in terms of the director vector of the rulings and its *** is also shown that all rational developable surfaces can be described as the set of developable surfaces which can be constructed with a constant∧,M,ν.The results are readily extended to rational spline developable surfaces.

关键词： NURBS Bezier Rational Spline NURBS Developable surfaces

Novel protective penile collar following inflatable penile prosthesis placement: the “Wang Collar”

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Asian Journal of Andrology 2020年第5期22卷 481-484页

作者： leonardo D Borregales Jose Saavedra-Belaunde Run Wang Jonathan Clavell-hernandez Division of Urology The University of Texas Health Science CenterHoustonTX 77030US A MD Anderson Cancer Center HoustonTX 77030U S A St.Joseph Medical Center HoustonTX 77002USA.

Penile rehabilitation after inflatable penile prosthesis(IPP)implantation for the treatment of erectile dysfunction includes leaving the device partially inflated so as to preserve the penile length and to maintain *** a partially inflated device,the penis becomes more sensitive and more susceptible to unintended insults during the immediate postoperative ***“Wang Collar,”a device intended to protect the penis in the early postoperative period,is hereby *** hundred and forty-eight patients had the 44Wang Collar"included as part of their post-1 PP management from August 2014 to February *** protective collar,devised from a polystyrene cup with the bottom removed,is secured with a tape over the previously dressed and partially inflated *** order to evaluate the effectiveness of this device,we conducted surveys on the perioperative staff at three different ***“Wang Collar”has been found to be beneficial in the early postoperative care of *** on the answers to our questionnaire,the perioperative personnel found this device to be highly protective,especially when transporting the patient after IPP surgery,easy to work with,and almost never bothersome or irritative to the *** present a novel penile device after IPP placement,which we have found to improve patient satisfaction in the postoperative *** addition,it eases the care of the patient by the perioperative *** is now our routine to use this device after IPP *** research is necessary to evaluate whether this device can decrease postoperative wound complications.

关键词： erectile dysfunction inflatable penile prosthesis postoperative dressing

DEVELOPABLE SURFACE PATCHES BOUNDED BY NURBS CURVES

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Journal of Computational Mathematics 2020年第5期38卷 715-731页

作者： leonardo Fernandez-Jambrina Francisco Perez-Arribas ETSI Navales Universidad Polit´ecnica de Madrid28040-MadridSpain

In this paper we construct developable surface patches which are bounded by two rational or NURBS curves,though the resulting patch is not a rational or NURBS surface in *** is accomplished by reparameterizing one of the boundary *** reparameterization function is the solution of an algebraic *** the relevant case of cubic or cubic spline curves,this equation is quartic at most,quadratic if the curves are B´ezier or splines and lie on parallel planes,and hence it may be solved either by standard analytical or numerical methods.

关键词： NURBS B´ezier Rational,Spline NURBS Developable surfaces

Self-healing and SDN:bridging the gap

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Digital Communications and Networks 2020年第3期6卷 354-368页

作者： leonardo Ochoa-Aday Cristina Cervell o-Pastor Adriana Fernaandez-Fernaandez Department of Network Engineering Universitat Politecnica de Catalunya(UPC)Esteve Terradas708860CastelldefelsSpain

Achieving high programmability has become an essential aim of network research due to the ever-increasing internet ***-Defined Network(SDN)is an emerging architecture aimed to address this ***,maintaining accurate knowledge of the network after a failure is one of the largest challenges in the *** by this reality,this paper focuses on the use of self-healing properties to boost the SDN *** approach,unlike traditional schemes,is not based on proactively configuring multiple(and memory-intensive)backup paths in each switch or performing a reactive and time-consuming routing computation at the controller ***,the control paths are quickly recovered by local switch actions and subsequently optimized by global controller *** results show that the proposed approach recovers the control topology effectively in terms of time and message load over a wide range of generated ***,scalability issues of traditional fault recovery strategies are avoided.

关键词： Software-defined network Autonomic network management Protocol design Fault tolerance Network management

Mismatch repair protein expression and intratumoral budding in rectal cancer are associated with an increased pathological complete response to preoperative chemoradiotherapy: A case-control study

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World Journal of Clinical Oncology 2018年第7期9卷 133-139页

作者： leonardo S Lino-Silva Armando Gamboa-Domínguez Diego Zú?iga-Tamayo Rosa A Salcedo-hernández Lucely Cetina David Cantú-de-León Surgical Pathology Instituto Nacional de Cancerología Surgical Pathology Instituto Nacional de ciencias Médicas y Nutrición salvador Zubirán Surgical Oncology Instituto Nacional de Cancerología Medical Oncology Instituto Nacional de Cancerología

AIM To determine whether the association of rectal adenocarcinoma with a defective-mismatch repair system(dMMR) was associated with a pathological complete response(pCR) to preoperative *** A case-control study was designed with the aim of determining if patients with rectal adenocarcinoma with dM MR had an associated high pCR rate in response to neoadjuvant chemoradiotherapy(nCRT).RESULTS Seventy-two cases with pCR were compared against 144 controls without pCR. Across 216 cases, the mean age was 56.8 years, 140(64.8%) were men, and 63(29.2%) demonstrated the dMMR system. The pCR was associated with G1 tumors, dMMR, the absence of vascular invasion, and low tumor budding in the pretreatment biopsy. In a multivariant analysis, the factors associated with pCR were dMMR(OR: 2.61; 95%CI: 1.355-5.040, P = 0.004) and a low degree of tumor budding(OR: 2.52; 95%CI: 1.366-4.894, P = 0.025).CONCLUSION We found an independent association between dMMR and a low rate of tumor budding, with a higher rate of pCR, in the basal biopsies of patients with rectal carcinoma subjected to nCRT.

关键词： Rectal cancer Chemoradiotherapy Tumor budding Mismatch repair Pathological complete response

Interpolation of a spline developable surface between a curve and two rulings

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Frontiers of Information Technology & Electronic Engineering 2015年第3期16卷 173-190页

作者： Alicia CANTóN leonardo FERNández-JAMBRINA ETSI Navales Universidad Politécnica de MadridArco de la Victoria 4Madrid 28040Spain

In this paper we address the problem of interpolating a spline developable patch bounded by a given spline curve and the first and the last rulings of the developable surface. To complete the boundary of the patch, a second spline curve is to be given. Up to now this interpolation problem could be solved, but without the possibility of choosing both endpoints for the rulings. We circumvent such difficulty by resorting to degree elevation of the developable surface. This is useful for solving not only this problem, but also other problems dealing with triangular developable patches.

关键词： Developable surfaces Spline surfaces Blossoms