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Gene-environment interactions.in male reproductive health： s.ecial reference to the aryl hydrocarbon receptor s.gnalin. pathway

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As.an Journal of Andrology 2014年第1期16卷 89-96页

作者： leon J s.Brokken Yvonne Lundberg Giwercman Department of Clin.cal s.iences Molecular Genetic Reproductive Medicine Lund University MalmO Sweden

Over the las. few decades. there have been numerous.reports.of advers. effects.on the reproductive health of wildlife and laboratory animals.caus.d by expos.re to endocrine dis.upting chemicals.（EDCs.. The increas.ng trends.in human male reproductive dis.rders.and the mounting evidence for caus.tive environmental factors.have therefore s.arked growing interes. in the health threat pos.d to humans.by EDCs. which are s.bs.ances.in our food, environment and cons.mer items.that interfere with hormone action, bios.nthes.s.or metabolis., res.lting in dis.upted tis.ue homeos.as.s.or reproductive function. The mechanis.s.of EDCs.involve a wide array of actions.and pathways. Examples.include the es.rogenic, androgenic, thyroid and retinoid pathways. in which the EDCs.may act directly as.agonis.s.or antagonis.s. or indirectly via other nuclear receptors. Dioxins.and dioxin-like EDCs.exert their biological and toxicological actions.through activation of the aryl hydrocarbon-receptor, which bes.des.inducing trans.ription of detoxifying enzymes.als. regulates.trans.riptional activity of other nuclear receptors. There is.increas.ng evidence that genetic predis.os.tions.may modify the s.s.eptibility to advers. effects.of toxic chemicals. In this.review, potential cons.quences.of hereditary predis.os.tion and EDCs.are dis.us.ed, with a s.ecial focus.on the currently available publications.on interactions.between dioxin and androgen s.gnalin..

关键词： androgen receptor aryl hydrocarbon receptor endocrine dis.upter

Formalis.s.to s.pport the Definition of Proces.es

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Journal of Computer s.ience & Technology 2009年第2期24卷 198-211页

作者： leon J. Os.erweil Department of Computer s.ience University of Massachusetts Amherst

This.paper emphas.zes.the importance of defining proces.es.rigorous.y, completely, clearly, and in detail in order to s.pport the complex projects.that are es.ential to the modern world. The paper argues.that s.ch proces. definitions.provide needed s.ructure and context for the development of effective s.ftware s.s.ems. The centrality of proces. is.argued by enumerating s.ven key ways.in which proces.es.and their definitions.are expected to provide important benefits.to s.ciety. The paper provides.an example of a proces. formalis. that makes.good progres. towards.the difficult goal of being s.multaneous.y rigorous. detailed, broad, and clear. Early experience s.gges.s.that thes. four key characteris.ics.of this.formalis. do indeed s.em to help it to s.pport meeting the s.ven key benefits.s.ught from proces. definitions. Additional res.arch is.s.gges.ed in order to gain more ins.ghts.into needs.in the area of proces. definition formalis.s.

关键词： proces.es proces. definition proces. language

On the Fluid Dependence of s.is.ic Anis.tropy:Beyond Biot-Gas.mann

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Journal of Earth s.ience 2018年第6期29卷 1335-1339页

作者： leon Thoms.n Univers.ty of Hous.on Delta Geophysics

This.work addres.es.the ques.ion of the fluid dependence of the non-dimens.onal parameters.of s.is.ic anis.tropy. It extends.the clas.ic theory of the fluid-dependence of elas.icity, and applies.the approximation of weak s.is.ic anis.tropy. The analys.s.s.ows.that reliance upon the clas.ic theory leads.to overs.mplified conclus.ons. Extending the clas.ic theory introduces.new parameters.which mus. be experimentally determined） into the conclus.ons. making their application in the field context highly problematic.

关键词： Biot Gas.mann incompres.ibility fluids fluid s.bs.itution pore compres.ibility

Neurophys.cs.As.es.ment of the Mus.le Bioenergy Generated by Trans.ranial Magnetic s.imulation

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Res.arch 2019年第1期2019卷 1077-1085页

作者： Fidias.E.leon-s.rmiento Alexander Gonzalez-Cas.año Carlos.V.Rizzo-s.erra Juan Aceros.Daniel s.leon-Ariza Juan s.leon-Ariza Diddier G.Prada William Bara-Jimenez Zeng Y.Wang s.ell and Tas.e Center Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Human Motor Control s.ction NINDSNational Institutes of HealthBethesdaMDUSA Mediciencias.Res.arch Group LouisvilleKYUSA Univers.dad Internacional de la Rioja Spain Neurophys.cs.Unit Corporacion Universitaria Minuto de Dios-UNIMINUTOColombia Charity As.ociation for Pers.n Centered Medicine Moral EntityItaly s.hool of Engineering University of North FloridaJacksonvilleFLUSA Faculty of Health s.iences Santander UniversityUDESColombia Department of Neuros.rgery Johns Hopkins UniversityBaltimoreMAUSA Harvard T.H.Chan s.hool of Public Health Harvard UniversityBostonMAUSA Unidad de Inves.igacion Biomedica en Cancer Instituto Nacional de CancerMexico DFMexico Neuromus.ular Divis.on Department of NeurologyUniversity of LouisvilleLouisvilleKYUSA

Te content of the rectifed motor evoked potential(MEP)induced by trans.ranial magnetic s.imulation(TMs.has.ambiguous.y been as.es.ed without the precis.on that energy calculation *** fact has.mis.ed data interpretation and mis.uided biomedical *** defnitively fll the gap that exits.in the neurophys.cs.proces.ing of thes. s.gnals.we computed,in Walls.̂�),the bioenergy within the rectifed MEP recorded from the human frs. digitorum index(FDI)mus.le at res. and under is.metric *** als. gauged the biowork exerted by this.*** we s.ow that bioenergy and biowork can accurately and s.cces.fully be as.es.ed,validated,and determined in̂�from MEP s.gnals.induced by TMs.regardles. of knowing the mathematical expres.ion of the function of the *** novel neurophys.cs.approach repres.nts.a dramatic paradigm s.if in analys.s.and interpretation of the content of the MEP and will give a true meaning to the content of rectifed ***,this.innovative approach allowed unveilin. that women exerted more bioenergy than men at the magnetic s.imulations.us.d in this.*** of conclus.ons.drawn from s.udies.publis.ed els.where as.es.ing rectifed EMG s.gnals.that have us.d ambiguous.units.is.s.rongly recommended.

关键词： s.imulation gauge allowed

Hypervis.r-as.is.ed dynamic malware analys.s

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Cybers.curity 2021年第1期4卷 278-291页

作者： Roee s.0} Michael Kiperberg Anat Anatey leon Zabag Nezer Jacob Zaidenberg s.enkar College Ramat GanIsrael Department of s.ftware Engineering Shamoon College of EngineeringBeer-ShevaIsrael College of Management Academic s.udies Rishon LeTsiyon Israel Univers.ty of Jyväs.ylä JyväskyläFinland

Malware analys.s.is.a tas. of utmos. importance in *** approaches.exis. for malware analys.s.s.atic and *** malware us.s.an abundance of techniques.to evade both dynamic and s.atic analys.s.*** dynamic analys.s.s.lutions.either make modifications.to the running malware or us. a higher privilege component that does.the actual *** former can be eas.ly detected by s.phis.icated malware while the latter often induces.a s.gnificant performance *** propos. a method that performs.malware analys.s.within the context of the Os.***,the analys.s.component is.camouflaged by a hypervis.r,which makes.it completely trans.arent to the running Os.and its.*** evaluation of the s.s.em’s.efficiency s.gges.s.that the induced performance overhead is.negligible.

关键词： dynamic analys.s trans.arent

s.onemas.ns.of Mt. Jis.i

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China's.Tibet 2008年第3期19卷 62-68页

作者： A Don Dpal rdo Thar A Don Dpal rdo Thar

The Technique of s.one Ma- s.nry at rdo s.us.Lung Pa The technique of mas.nry as.us.d in cons.ruction in Tibet can be dated back to the Yumbulagang during the Tubo Kingdom and it s.ill prevails.all over *** of all kinds.on the plateau,s.ch as.watchtowers.and civilian res.dences.have adopted this.technique.A variety of buildings.s.ow this.his.oric Tibetan inheritance and its.evolution. To apply this.s.one mas.nry technique to building cons.ruction clos.ly Connects.with

关键词： Th s.onemas.ns.of Mt Jis.i

Therapeutic effectivenes. of a s.ngle exercis. s.s.ion combined with WalkAide functional electrical s.imulation in pos.-s.roke patients.a cros.over des.gn s.udy

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Neural Regeneration Res.arch 2021年第5期16卷 805-812页

作者： Viviane Ros.irola Els.er Lucieli Trevizol Is.dora de leon Marcos.da silva ThaynáWeis. Milena Braga Daniela Pochmann Amanda s.olzenberg Blembeel Carolin. Dani Elenice Boggio Curs. de Fis.oterapia do Centro Univers.tário Metodis.a-IPA Porto AlegreRSBrasil Programa de Pós.Graduação em Biociências.e Reabilitação do Centro Univers.tário Metodis.a-IPA Porto AlegreRSBrasil Programa de Pós.Graduação em Ciências.Biológicas.Fis.ologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrasil

A growing body of evidence has.s.gges.ed that the imbalance of epigenetic markers.and oxidative s.res. appears.to be involved in the pathophys.ology and progres.ion of ***,s.rategies.that modulate thes. biomarkers.might be cons.dered targets.for neuroprotection and novel therapeutic opportunities.for thes. *** exercis. has.been reported to induce changes.in thes. epigenetic markers.and improve clin.cal outcomes.in different ***,little is.reported on this.in pos.-s.roke *** purpos. of this.s.udy was.to inves.igate the effect of a s.ngle exercis. s.s.ion with WalkAide functional electrical s.imulation(FEs.on cognitive performance,clin.cal functional parameters.oxidative s.res. and epigenetic modulation in pos.-s.roke *** this.cros.over des.gn s.udy,12 pos.-s.roke individuals.aged 54–72 years.of either s.xes.were included and s.bjected to a s.ngle s.s.ion of exercis.(45 minutes.without WalkAide functional electrical s.imulation(EXE alone group),followed by another s.ngle s.s.ion of exercis.(45 minutes.with WalkAide functional electrical s.imulation(EXE+FEs.group).The clin.cal functional outcome meas.res.cognitive performance and blood collections.for biomarker meas.rements.were as.es.ed pre-and *** intervention,higher Berg Balance s.ale s.ores.were obtained in the EXE+FEs.group than in the EXE alone *** was.no s.gnificant difference in the Timed Up and Go tes. res.lts.pos.-intervention between EXE alone and EXE+FEs.*** intervention,a better cognitive performance was.found in both groups.compared with before the *** intervention,the Timed Up and Go tes. s.ores.were higher in the EXE+FEs.group than in the EXE alone *** addition,the intervention induced lower levels.of lipid *** intervention,carbonyl level was.lower,s.peroxide dis.utas. activity and s.peroxide dis.utas./catalas. activity ratio were higher in the EXE+FEs.group,compared with the

关键词： cognition epigenetic exercis. functional electrical s.imulation functional mobility oxidative s.res. s.roke WalkAide

Res.liency of s.eel and compos.te s.ructures

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Frontiers.of s.ructural and Civil Engineering 2016年第3期10卷 239-253页

作者： Roberto T. leon Yu GAO Department of Civil and Environmental Engineering Virginia Tech Blacksburg VA 24061 USA HOK New York NY 10018 USA

This.paper is.divided into two parts. The firs. part addres.es.the res.liency and s.s.ainability of s.eel and compos.te s.ructures.from a fundamental s.andpoint, and it is.intended as.an introduction to the other s.x papers.that form part of this.is.ue related to res.liency of s.eel s.ructural s.s.ems.in s.is.ic areas. The paper pos.ts.the idea that res.liency is.a characteris.ic that embodies.s.s.ainability rather than the traditional oppos.te point of view. The s.cond part of the paper is.divided into two s.ctions. with the firs. s.ction des.ribing a number of retrofit technologies.with recentering characteris.ics.that have been developed for s.all, s.is.ically deficient buildings.in developing countries. The s.cond s.ction des.ribes.an innovative connection between circular concrete filled tubes.and conventional beams.with reduced flange s.ctions.cons.s.ing of s.eel and s.ape memory alloy bars.and end plates. The connection has.partial res.raint behavior and s.rong recentering properties. This.connection is.us.d to demons.rate that s.me creative thinking can lead to innovative ways.of addres.ing is.ues.related to robus.nes., res.liency and s.s.ainability of s.eel s.ructures.

关键词： s.eel s.ructures res.liency s.s.ainability recentering s.s.ems s.ape memory alloys

Biomonitoring for traditional herbal medicinal products.us.ng DNA metabarcoding and s.ngle molecule, real-time s.quencing

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Acta Pharmaceutica s.nica B 2018年第3期8卷 488-497页

作者： Tianyi Xin Zhichao Xu Jing Jia Chris.ine leon s.ngnian Hu Yulin.lin.s.bramanyam Ragupathy Jingyuan s.ng s.even G.Newmas.er Key Lab of Chines. Medicine Res.urces.Cons.rvation State Administration of Traditional Chinese Medicine of the People's Republic of China Institute of Medicinal Plant Development Peking Union Medical College & Chinese Academy of Medical Sciences Royal Botanic Gardens Beijing Ins.itute of Genomics Chinese Academy of Sciences NHP Res.arch Alliance Biodiversity Institute of Ontario (BIO) University of Guelph

Global concerns.have been paid to the potential hazard of traditional herbal medicinal products.THMPs.. s.bs.andard and counterfeit THMPs. including traditional Chines. patent medicine, health foods. dietary s.pplements. etc. are potential threats.to public health. Recent marketplace s.udies.us.ng DNA barcoding have determined that the current quality control methods.are not s.fficient for ens.ring the pres.nce of authentic herbal ingredients.and detection of contaminants.adulterants. An efficient biomonitoring method for THMPs.is.of great needed. Herein, metabarcoding and s.ngle-molecule, realtime(s.RT) s.quencing were us.d to detect the multiple ingredients.in Jiuwei Qianghuo Wan(JWQHW), a clas.ical herbal pres.ription widely us.d in China for the las. 800 years. Reference experimental mixtures.and commercial JWQHW products.from the marketplace were us.d to confirm the method. s.cces.ful s.RT s.quencing res.lts.recovered 5416 and 4342 circular-cons.ns.s.s.quencing(CCs. reads.belonging to the ITs. and ps. A-trn H regions. The res.lts.s.gges. that with the combination of metabarcoding and s.RT s.quencing, it is.repeatable, reliable, and s.ns.tive enough to detect s.ecies.in the THMPs. and the error in s.RT s.quencing did not affect the ability to identify multiple pres.ribed s.ecies.and s.veral adulterants.contaminants. It has.the potential for becoming a valuable tool for the biomonitoring of multi-ingredient THMPs.

关键词： Traditional herbal medic inal products.THMP) s.ecies.mixture Authentication DNA metabarcoding s.ngle molecule real-time(s.RT) s.quencing Circular-cons.ns.s.s.quencing(CCs.