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Optimizing proton pump inhibitors in helicobacter pylori treatment:Old and new tricks to improve effectiveness

World Journal of Gastroenterology 2019年第34期25卷 5097-5104页

作者： Enzo Ierardi Giuseppe Losurdo Rosa Federica La Fortezza Mariabeatrice Principi Michele Barone Alfredo Di leo Section of Gastroenterology Department of Emergency and Organ Transplantation University of Bari

The survival and replication cycle of helicobacter pylori(***)is strictly dependant on intragastric ph,since *** enters replicative phase at an almost neutral ph(6-7),while at acid ph(3-6)it turns into its coccoid form,which is resistant to *** these bases,it is crucial to increase intragastric ph by proton pump inhibitors(PPIs)when an antibiotic-based eradicating therapy needs to be ***,several tricks need to be used to optimize eradication rate of different *** administration of the highest dose as possible of PPI,by doubling or increasing the number of pills/day,has shown to be able to improve therapeutic outcome and has often proposed in rescue therapies,even if specific trials have not been performed.A pre-treatment with PPI before starting antibiotics does not seem to be effective,therefore it is ***,the choice of PPI molecule could have a certain weight,since second-generation substances(esomeprazole,rabeprazole)are likely more effective than those of first generation(omeprazole,lansoprazole).A possible explanation is due to their metabolism,which has been proven to be less dependent on cytochrome P450(cYP)2c19 genetic ***,vonoprazan,a competitive inhibitor of h+/K+-ATPase present on luminal membrane of gastric parietal cells has shown the highest efficacy,due to both its highest acid inhibition power and rapid pharmacologic *** current data come only from Eastern Asia,therefore its strong power needs to be confirmed outside this geographic area in Western countries as well as related to the local different antibiotic resistance rates.

关键词： helicobacter pylori Proton pump inhibitors Eradication cytochrome P450 Optimization

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Atomic and electronic structure of Si dangling bonds in quasi-free-standing monolayer graphene

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Nano Research 2018年第2期11卷 864-873页

作者： Yuya Murata Tommaso cavallucci Valentina Tozzini Niko Pavliček leo Gross Gerhard Meyer Makoto Takamura hiroki hibino Fabio Beltram Stefan heun NEST Istituto Nanoscienze-CNR and Scuola Normale Superiore Pisa Italy IBM Research-Zurich Rüschlikon Switzerland NTT Basic Research Laboratories Atsugi Kanagawa Japan

Si dangling bonds at the interface of quasi-free-standing monolayer graphene （QFMLG） are known to act as scattering centers that can severely affect carrier mobility herein, we investigate the atomic and electronic structure of Si dangling bonds in QFMLG using low-temperature scanning tunneling microscopy/ spectroscopy （STM/STS）, atomic force microscopy （AFM）, and density functional theory （DFT） calculations. Two types of defects with different contrast were observed on a flat graphene terrace by STM and AFM; in particular, their STM contrast varied with the bias voltage. Moreover, these defects showed characteristic STS peaks at different energies, 1.1 and 1.4 eV. The comparison of the experimental data with the DFT calculations indicates that the defects with STS peak energies of 1.1 and 1.4 eV consist of clusters of three and four Si dangling bonds, respectively. The relevance of the present results for the optimization of graphene synthesis is discussed.

关键词： quasi-free-standingmonolayer graphene hydrogen intercalation carrier mobility scanning tunnelingmicroscopy scanning tunnelingspectroscop^atomic force microscop3~density functional theory

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安娜·卡列尼娜

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作者： (俄)列夫·托尔斯泰(leo Tolstoy)

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Role of concomitant therapy for helicobacter pylori eradication: A technical note

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World Journal of Gastroenterology 2016年第38期22卷 8638-8640页

作者： Giuseppe Losurdo Floriana Giorgio Andrea Iannone Mariabeatrice Principi Michele Barone Alfredo Di leo Enzo Ierardi Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of Bari

We read with interest the recent meta-analysis by Lin et al who evaluated the effectiveness of concomitant regimen for helicobacter pylori(h. pylori) in chinese regions. They found that 7-d concomitant regimen is undoubtedly superior to 7-d triple therapy(91.2% vs 77.9%, P however, it is a common belief that a triple therapy lasting 7 d should be definitively removed from the clinical practice for its ineffectiveness. Only its prolongation to 14 d may give satisfactory success rate. Thus, the assessment of an old and outdated treatment versus a more recent and successful one does not seem to bring novel and useful information. Moreover, a 7-d duration has not been ascertained for concomitant regimen, as main guidelines recommend a 10-d schedule for this scheme. Therefore, only studies comparing 10-d concomitant versus 14-d triple seem to be appropriate according to current Guidelines and would clarify which regimen is the most suitable worldwide. Additionally, in this metaanalysis concomitant and sequential therapy showed similar performances, despite it is common opinion that sequential is more prone than concomitant therapy to fail when metronidazole resistance occurs, and china is characterized by high rate of resistance to this antibiotic. None of the included studies evaluated a priori antibiotic resistances, and the lack of this detail hampers the unveiling of this apparent contradiction. In conclusion, the lack of the evaluation of the quality of included trials as well as their high heterogeneity constitute a burdensome limit to draw solid conclusions in this meta-analysis. On the bases of these considerations and the low number of examined trials, we believe that further studies and the knowledge of antibiotic resistances will support with high quality evidence which is the best regimen and its optimal duration.

关键词： helicobacter pylori Eradication Sequential concomitant Triple therapy Antibiotic resistances

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A One-Pot Strategy for the Synthesis of β-Substituted Rhoda-and Irida-carbolong complexes

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chinese Journal of chemistry 2022年第15期40卷 1777-1784页

作者： Binbin Xu Wei Mao chengcheng Wu Jinhua Li Zhengyu Lu Ming Luo Liu leo Liu Lingling Mao Dafa chen haiping Xia Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of catalysis Department of ChemistrySouthern University of Science and TechnologyShenzhenGuangdong 518055China

comprehensive Summary Starting from an organic multiyne,three steps are normally needed for the preparation of non-βphosphonium functionalized rhodaand irida-carbolong ***,a one-pot strategy,by mixing a multiyne,a nucleophile,and Rhcl(cO)(PPh_(3))_(2)/AgBF_(4)or[Ir(ch:cN)(cO)(PPh_(3))_(2)]BF_(4),was developed to achieve a series ofβfunctionalized rhoda-and irida-carbolong ***β-substituents in these complexes can be various c-,N-and O-centered groups,dependent on the nucleophiles *** strategy provides a new convenient route to construct carbolong complexes,which is important for the further development of carbolong chemistry.

关键词： carbolong chemistry Metallacycles Rhodium Iridium Tridentate ligands

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ThE PAThOLOGY AND TREATMENT OF JOINT SPRAIN

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中华医学杂志(英文版) 1935年第6期49卷 521-528页

作者： leo J.MILTNER h.c.FANG From the Division of Orthopedic Surgery Department of Surgery and the Department of PathologyPeiping Union Medical CollegePeipingChina

The term sprain signifies an injury of the soft tissues within oraround a joint when the movements of that joint are carried beyondtheir normal physiological limits,or when the bones entering into theformation of the joint are deflected in some abnormal plane,withoutactual *** conditions such as previous injury or mal-alignment due to congenital or acquired causes(i.e.,congenital clubfoot,rachitic knock knee,etc.),predispose to *** lesions which occur during sprain vary consider-

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Noninvasive molecular analysis of helicobacter pylori : Is it time for tailored first-line therapy?

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World Journal of Gastroenterology 2017年第14期23卷 2453-2458页

作者： Enzo Ierardi Floriana Giorgio Andrea Iannone Giuseppe Losurdo Mariabeatrice Principi Michele Barone Antonio Pisani Alfredo Di leo Gastroenterology Section Department of Emergency and Organ Transplantation University of Bari

The main problem of helicobacter pylori(h. pylori) infection management is linked to antibiotic resistances. This phenomenon has grown in the last decade, inducing a dramatic decline in conventional regimen effectiveness. The causes of resistance are point mutations in bacterial DNA, which interfere with antibiotic mechanism of action, especially clarithromycin and levofloxacin. Therefore, international guidelines have recently discouraged their use in areas with a relevant resistance percentage, suggesting first-line schedules with expected high eradication rates, i.e., bismuth containing or non-bismuth quadruple therapies. These regimens require the daily assumption of a large number of tablets. consequently, a complete adherence is expected only in subjects who may be motivated by the presence of major disorders. however, an incomplete adherence to antibiotic therapies may lead to resistance onset, since sub-inhibitory concentrations could stimulate the selection of resistant mutants. Of note, a recent meta-analysis suggests that susceptibility tests may be more useful for the choice of first than second-line or rescue treatment. Additionally, susceptibility guided therapy has been demonstrated to be highly effective and superior to empiric treatments by both meta-analyses and recent clinical studies. conventional susceptibility test is represented by culture and antibiogram. however, the method is not available everywhere mainly for methodology-related factors and fails to detect hetero-resistances. Polymerase chain reaction(PcR)-based, culture-free techniques on gastric biopsy samples are accurate in finding even minimal traces of genotypic resistant strains and hetero-resistant status by the identification of specific point mutations. The need for an invasive endoscopic procedure has been the most important limit to their spread. A further step has, moreover, been the detection of point mutations in bacterial DNA fecal samples. Few studies on clarithromycin su

关键词： helicobacter pylori Antibiotic resistance Noninvasive molecular test Tailored therapy Stool

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基于计算缩放的光滑粒子水动力学方法模拟飞机油箱剧烈晃动问题

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Acta Mechanica Sinica 2023年第2期39卷 39-48页

作者： calderon-Sanchez Javier Martinez-carrascal Jon Gonzalez leo Miguel cEhINAV Model Basin ETSI NavalesUniversidad Politécnica de MadridMadrid28040Spain

大型民用飞机的机翼设计用于承受从大气阵风到湍流到着陆冲击的各种载荷,机翼是需要进一步研究的重要结构.改进机翼设计的主要方法之一是分析晃动对承载液体的柔性机翼状结构动力学的阻尼效应.这将通过开发实验装置来实现,该装置将有助... 详细信息

大型民用飞机的机翼设计用于承受从大气阵风到湍流到着陆冲击的各种载荷,机翼是需要进一步研究的重要结构.改进机翼设计的主要方法之一是分析晃动对承载液体的柔性机翼状结构动力学的阻尼效应.这将通过开发实验装置来实现,该装置将有助于建立和再现涉及物理领域的数值模型.因此,本工作的目的是使用数值方法光滑粒子流体动力学(SPh)作为主要数值工具,分析晃动在降低飞机结构设计载荷方面的影响.本研究中的一个关键因素是对比例实验的需求,这是评估计算工具是否能够准确近似不同比例的注册测量值的必要步骤.为此,建立了一个垂直振动水槽的数值模型,该模型是一个完全耦合的流固耦合问题.该结构通过质量-弹簧-阻尼器系统建模,对于内部流体,使用δ-SPh方法.特别是,研究了两个开放性问题:第一个问题是,当储罐的初始加速度是标准重力值的十倍时,重力对阻尼和能量耗散现象的影响程度;第二种问题旨在确认,当根据量纲分析对问题参数进行缩放时,SPh方程正确地再现了缩放定律.

关键词： SPh Sloshing Gravity computational scaling

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2007数码相框盛宴齐享

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微型计算机 2007年第12S期27卷 28-32,34页

作者： Frank.c. leo.SMXK 马见田（图）

你希望将自己、家庭、孩子的成长经历记录并展示出来吗？你想过用照片做成叙事诗向朋友展示吗？在朋友来访时搬出厚重的相册已经过时了，还是来尝尝能动态展示煌数码相框吧！

关键词：数码相框成长经历动态展示

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heterodimer formation between c-Jun and Jun B proteins mediated by Epstein Barr virus encoded latent membrane protein 1

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Science china(Life Sciences) 2005年第1期48卷 70-80页

作者： leo M.Lee Laboratory of Molecular Technology SAIc-Frederick

Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) may trigger the transcription factor AP-1 including c-Jun and c-fos. In this report, using a Tet-on LMP1 hNE2 cell line which is a dual-stable LMP1 integrated nasopharyngeal carcinoma (NPc) cell line and the expression of LMP1 in which could be regulated by the Tet-on system, we show that Jun B can efficiently form a new heterodimeric complex with the c-Jun protein under the regulation of LMP1, phosphorylation of c-Jun (ser 63, ser 73) and Jun B is involved in the process of the new heterodimeric formation. We also find that this heterodimeric form can bind to the AP-1 consensus sequence. Transfection studies suggest that JNK interaction protein (JIP) could inhibit the heterodimer formation of c-Jun and Jun B through blocking the AP-1 signaling pathway triggered by LMP1. The interaction and function between c-Jun protein and Jun B protein increase the repertoire of possible regulatory complexes by LMP1 that could play an important role in the regulation of transcription of specific cellular genes in the process of genesis of nasopharyngeal carcinoma.

关键词： Epstein Barr virus, latent membrane protein 1, Jun B, c-Jun, heterodimer, DNA binding, JNK, JIP.

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