检索结果-南通市图书馆

Nonsense variant of ATP8B1 gene in heterozygosis and benign recurrent intrahepatic cholestasis: A case report and review of literature

引用

World Journal of hepatology 2020年第2期12卷 64-71页

作者： Mariano Piazzolla Nicola castellaneta Antonio Novelli Emanuele Agolini Dario cocciadiferro leonardo Resta Loren Duda Michele Barone Enzo Ierardi Alfredo Di leo Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy Laboratory of Medical Genetics Ospedale Pediatrico Bambino GesùRome 00165Italy Section of Pathology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy

BAcKGROUND Benign recurrent intrahepatic cholestasis is a genetic disorder with recurrent cholestatic jaundice due to ATP8B1 and ABcB11 gene mutations encoding for hepato-canalicular ***,we firstly provide the evidence that a nonsense variant of ATP8B1 gene(c.1558A>T)in heterozygous form is involved in BRIc *** SUMMARY A 29-year-old male showed severe jaundice and laboratory tests consistent with intrahepatic cholestasis despite normal *** and chronic liver diseases with viral,metabolic and autoimmune etiology were *** intra/extra-hepatic bile ducts were demonstrated by magnetic *** biopsy showed:cholestasis in the centrilobular and intermediate zones with bile plugs and intra-hepatocyte pigment,Kupffer’s cell activation/hyperplasia and preserved biliary *** satisfied benign recurrent intrahepatic cholestasis diagnostic criteria,ATP8B1 and ABcB11 gene analysis was ***,we found a novel nonsense variant of ATP8B1 gene(c.1558A>T)in *** variant was confirmed by Sanger sequencing following a standard protocol and tested for familial segregation,showing a maternal *** confirmed a significant reduction of mutated gene related protein(familial intrahepatic cholestasis 1).The patient was treated with ursodeoxycholic acid 15 mg/kg per day and colestyramine 8 g daily with total bilirubin decrease and normalization at the 6th and 12th *** A genetic abnormality,different from those already known,could be involved in familial intrahepatic cholestatic disorders and/or pro-cholestatic genetic predisposition,thus encouraging further mutation detection in this field.

关键词： Benign recurrent intrahepatic cholestasis ATP8B1/ABcB11 genes Jaundice heterozygous variant of ATP8B1 gene(c.1558A>T) Familial inheritance case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

B200和B5000计算机系统所采用的相互连接技术

引用

计算机工程与应用 1965年第7期 2-8页

作者： leo E.Thomas ,Kenneth h. ,李意天

本文阐述B200和B5000电子数据处理系统是如何通过取消所有的人工布线而降低相互连接的成本和提高可靠性的。 B200系统(图1)是介于中小型的商用计算机,它特别适用于处理银行及商业问题。B200系统的单价介于75,000～500,000美元,

关键词：电子数据处理触点 B200 B5000 接地板黝黝电路插件跨接插座电气装置件电路板线路板中央处理机

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

ThE TREATMENT OF OLD DISLOcATION OF ThE ShOULDER

引用

中华医学杂志(英文版) 1936年第9期50卷 1161-1172+1324-1326页

作者： c. M. MENG leo J. MILTNER M.D. Division of Orthopedic Surgery Department of SurgeryPeiping Union Medical College Peiping China

1. The pathological anatomy of old traumatic dislocation of the shoulder is reviewed and discussed. The dangers of late manipulation are cmphasized.2. The iadications for surgical treatment are outlined. Surgical interference is not advised for old dislocation of the shoulder if good function of the arm is present.3. The technique of open redaction is described and the alternativemethods of surgical treatment such as resection, arthroplasty and artbrodesis are mentioned.4. Fifteen cases of old traumatic dislocation of the shoulder (14 anterior and I posterior), treated by open operation, are reported. Open reduction was successful in 13 cases. In one case, resection of the head of the humerus was necessary because of fracture of the surgical neck during operation. In another case, the open reduction was not completed because of uncontrollable hemorrhage.5. Particular emphasis is placed upon the necessity for carefully applied and prolonged past-operative physiotherapeutie treatment.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate

引用

Asian Journal of Andrology 2010年第2期12卷 227-233页

作者： Gideon Sartorius carolyn Fennell Sasa Spasevska leo Turner Ann J. conway David J. handelsman Andrology Department Concord Hospital ＆ ANZA C Research Institute Sydney NSW 2139 Australia

Pain following depot intramuscular （IM） injection of oil vehicle-based drugs has been little studied. This study aimed to determine prospectively the prevalence,determinants,severity and functional consequences of pain during the week after IM injection of 1 000 mg testosterone undecanoate （TU） in a 4-mL castor oil vehicle. Androgendeficient men receiving regular T replacement therapy at an academic andrology clinic were recruited to report pain scores using a coloured visual linear analogue scale at seven times over the first day and daily for a week after a deep IM gluteal injection. The time course and covariables influencing pain scores were analysed by mixed model analysis of variance （ANOVA）. Following 168 injections in 125 men,pain was reported by 80% of men,peaking immediately after injection,reaching only moderate severity,lasting 1-2 days and returning to baseline by day *** pain required little analgesic use and produced minimal interference in daily activities. The time course of pain scores was reproducible in the 43 men who underwent two consecutive injections. Pain was more severe in men who had an earlier painful injection,but less severe in older and more obese men. There were negligible differences in post-injection pain experience between experienced nurses administering injections. Deep IM gluteal injection of depot TU in 4-mL castor oil is well tolerated and post-injection pain is influenced by earlier painful injection experience,as well as age and obesity.

关键词： ageing intramuscular injection obesity pain testosterone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Slab rollback and microcontinent subduction in the evolution of the Zambales Ophiolite complex(Philippines):A review

引用

Geoscience Frontiers 2020年第1期11卷 23-36页

作者： Graciano P.Yumul Jr. carla B.Dimalanta Ricky c.Salapare Karlo L.Queano Decibel V.Faustino-Eslava Edanjarlo J.Marquez Noelynna T.Ramos Betchaida D.Payot Juan Miguel R.Guotana Jillian Aira S.Gabo-Ratio leo T.Armada Jenielyn T.Padrones Keisuke Ishida Shigeyuki Suzuki Apex Mining company Inc. OrtigasPasig CityPhilippines Rushurgent Working Group National Institute of Geological SciencesCollege of ScienceUniversity of the PhilippinesDilimanQuezon CityPhilippines GhD Chino Roces AvenueMakati CityPhilippines Department of Environmental Science Ateneo de Manila UniversityQuezon CityPhilippines School of Environmental Science and Management University of the Philippines-Los BañosLagunaPhilippines Department of Physical Sciences and Mathematics University of the Philippines-ManilaPadre FauraManilaPhilippines Graduate School of Natural Science and Technology Kanazawa UniversityJapan Institute of Renewable Natural Resources University of the Philippines-Los BañosLagunaPhilippines Institute of Socio-Arts and Sciences University of TokushimaTokushimaJapan Department of Earth Sciences Okayama UniversityOkayamaJapan

New radiolarian ages show that the island arc-related Acoje block of the Zambales Ophiolite complex is possibly of Late Jurassic to Early cretaceous *** dating of its plutonic and volcanichypabyssal rocks yielded middle Eocene *** the other hand,the paleontological dating of the sedimentary carapace of the transitional mid-ocean ridge-island arc affiliated coto block of the ophiolite complex,together with isotopic age datings of its dikes and mafic cumulate rocks,also yielded Eocene *** offers the possibility that the Zambales Ophiolite complex could have:(1)evolved from a Mesozoic arc(Acoje block)that split to form a cenozoic back-arc basin(coto block),(2)through faulting,structurally juxtaposed a Mesozoic oceanic crust with a younger cenozoic lithospheric fragment or(3)through the interplay of slab rollback,slab break-off and,at a later time,collision with a microcontinent fragment,caused the formation of an island arc-related ophiolite block(Acoje)that migrated trench-ward resulting into the generation of a back-arc basin(coto block)with a limited subduction *** Meso-cenozoic ophiolite complex is compared with the other oceanic lithosphere fragments along the western seaboard of the Philippines in the context of their evolution in terms of their recognized environments of generation.

关键词： Ophiolite Slab rollback Radiolarians Subduction Zambales Philippines

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

how antibiotic resistances could change helicobacter pylori treatment:A matter of geography?

引用

World Journal of Gastroenterology 2013年第45期19卷 8168-8180页

作者： Enzo Ierardi Floriana Giorgio Giuseppe Losurdo Alfredo Di leo Mariabeatrice Principi Division of Gastroenterology Department of Emergency and Organ Transplantation 70124 Bari Italy

Therapeutic management of helicobacter pylori(***)remains an unsolved ***,no therapeutic regimen is able to cure the infection in all treated patients,and in many the infection persists despite the administration of several consecutive standard *** antibiotic resistance reports describe alarming results,the outcome of therapeutic regimens does not seem to parallel this scenario in most cases,since a successful performance is often reached in more than 80%of ***,the phenomenon of increasing antibiotic resistance is being closely studied,and the results show controversial aspects even in the same geographic *** the continents of Europe,America,Asia,Africa,and Oceania,minimal and maximal values of resistance to the main antibiotics(clarithromycin,amoxicillin,metronidazole,and levofloxacin)feature wide ranges in different *** real enigma is therefore linked to the several different therapeutic regimens,which show results that often do not parallel the in vitro findings even in the same areas.A first aspect to be emphasized is that some regimens are limited by their use in very small geographic ***,not all therapeutic trials have considered bacterial and host factors affecting the therapeutic *** additional use of probiotics may help to reduce adverse events,but their therapeutic impact is *** conclusion,the"ideal therapy",paradoxically,appears to be a"utopia",despite the unprecedented volume of studies in the field and the real breakthrough in medical practice made by the discovery and treatment of *** ample discrepancies observed in the different areas do not encourage the development of therapeutic guidelines that could be valid *** these bases,one of the main challenges for the future might be identifying a successful solution to overcome antibiotic *** this context,geography must be considered a relevant matter.

关键词： helicobacter pylori Antibiotic resistance Geography Therapeutic regimens Therapeutic outcome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

引用

Precision clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox christopher chin Deena Najjar Irina Matei Irenaeus chan carlos cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian c.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane c.hassane Susan M.Bailey Kelly Bolton Jaime Mateus christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The hRh Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&human Performance Group BoulderCO 80302USA children's cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer cancer center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological health Sciences Colorado State UniversityFort CollinsCO 80523USA cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PcR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(chIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of chIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(leo)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

B200及B5000计算机系统中的连接技术

引用

计算机研究与发展 1965年第11期 12-16+40页

作者： leo E.Thomas Kenneth h.White 陈立忠

本文论述在B200和B5000型电子数据处理系统中如何通过取消全部手工接线来降低连接成本和增加连接可靠性的问题。 B200系统(图1)为介于小型与中型之间的商用计算机,适用于银行和商业方面。B5000系统(图2)为用于商业和科学方面的中型至大... 详细信息

本文论述在B200和B5000型电子数据处理系统中如何通过取消全部手工接线来降低连接成本和增加连接可靠性的问题。 B200系统(图1)为介于小型与中型之间的商用计算机,适用于银行和商业方面。B5000系统(图2)为用于商业和科学方面的中型至大型范围的高速计算机。本文将以B5000系统为例,来说明解决相互连接问题的一些方法。尽管B5000系统比B200系统大得多,而且快得多,但是在两个系统中都采用了相同的插件和连接方式。 B200和B5000型电子数据处理系统的设计原则包括: 1.插头座、插件、底板接线

关键词：插头座跨接插座接点连接器电气装置件 B5000 B200 磁性圆盘存储器磁盘存储器底板插针电子数据处理

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Quinolone-based first, second and third-line therapies for helicobacter pylori

引用

World Journal of Pharmacology 2015年第4期4卷 274-280页

作者： Enzo Ierardi Giuseppe Losurdo Floriana Giorgio Andrea Iannone Mariabeatrice Principi Alfredo Di leo Gastro -enterology Section Department of Emergency and Organ Transplantation University of Bari

helicobacter pylori （h. pylori ） is a very common bacterium that infects about 50% of the world population in urban areas and over 90% of people living in rural and developing countries. Fluoroquinolones, a class of antimicrobials, have been extensively used in eradic-ation regimens for h. pylori . Levofloxacin is the most commonly used, and in second-line regimens, is one of the most effective options. however, an increasing resistance rate of h. pylori to fuoroquinolones is being observed, that will likely affect their effectiveness in the near future. Other novel fluoroquinolone molecules, such as moxifoxacin, sitafoxacin, gatifoxacin and gemif-loxacin, have been proposed and showed encouraging results in vitro, although data on their clinical use are still limited. Further studies in large sample trials are needed to confirm their safety and efficacy profile in clinical practice.

关键词： helicobacter pylori Eradication regimens Fluoroquinolones Antibiotic resistance Levofloxacin Rescue treatments

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

维基的建构与应用——“香港文学地景资源库”实践

引用

图书馆论坛 2015年第4期35卷 120-122,F0003页

作者：马辉洪麦乐文香港中文大学新亚书院钱穆图书馆香港中文大学联合书院胡忠多媒体图书馆香港中文大学大学图书馆特藏组

简述香港中文大学香港文学研究中心与图书馆在维基平台上建立的"香港文学地景资源库",及其收录的香港文学散步资源,以此为例阐释协作学习的实践。

关键词：香港中文大学香港文学地景资源库维基文学散步

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：