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PLA2G7: a new player in shaping energy metabolism and lifespan

Signal Transduction and Targeted Therapy 2022年第7期7卷 2128-2129页

作者： lena susanna candels Svea Becker Christian Trautwein Department of Medicine III University Hospital RWTH AachenAachenGermany

In a recent study published in science,Spadaro and colleagues described the downregulation of PLA2G7 through sustained calory restriction as a crucial factor for lowering inflammatory mechanisms and contributing to ***2G7’s identification as a critical regulatory gene is important to better understand the role of adipose tissue metabolism in regulating immune-metabolic *** data show that long-term calorie restriction(CR)improves health and extends life expectancy.1 Chronic 40%CR increases susceptibility to infections in mice,shortening their *** contrast,the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy(CALERIE)analysis found that moderate CR in humans over 24 months did not reduce immune functions.14%sustained CR was associated with improved adipose tissue metabolism,decreased inflammation,and reduced thymic *** et *** that low platelet activating factor acetyl hydrolase(PLA2G7)correlates with immune-metabolic consequences of CR and contributes to decreased inflammation and a longer lifespan in healthy mid-aged adults.1 PLA2G7 is a lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress responses.

关键词： metabolism sustained PLA2

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Magnetotactic bacteria from the human gut microbiome associated with orientation and navigation regions of the brain

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Journal of Oceanology and Limnology 2021年第6期39卷 2044-2052页

作者： Rozalyn A.SIMON Purnika Damindi RANASINGHE Nawroz BARAZANJI Malin Bergman JUNGESTRÖM Jie XU Olga BEDNARSKA lena SERRANDER Maria ENGSTRÖM Dennis A.BAZYLINSKI Åsa V.KEITA susanna WALTER Center for Medical Image Science and Visualization(CMIV) Linköping UniversityLinköping 58183Sweden Department of Health Medicineand Caring SciencesLinköping UniversityLinköping 58183Sweden Division of Infection and Infl ammation Department of Biomedical and Clinical SciencesLinköping UniversityLinköping 58183Sweden Institute of Global Food Security School of Biological SciencesQueen’s University BelfastBelfast BT95DLUnited Kingdom School of Life Sciences University of Nevada at Las VegasLas VegasNevada 89154USA Division of Surgery Orthopedics and OncologyDepartment of Clinical and Experimental MedicineLinköping UniversityLinköping 58183Sweden

Magnetotactic bacteria(MTB),ubiquitous in soil and fresh and saltwater sources have been identified in the microbiome of humans and many *** endogenously produce magnetic nanocrystals enabling them to orient and navigate along geomagnetic *** magnetite deposits have been found throughout the tissues of the human brain,including brain regions associated with orientation such as the cerebellum and hippocampus,the origins of which remain *** over the role and source of MTB in humans,as well as any association with the brain,remain *** performed a metagenomic analysis of the gut microbiome of 34 healthy females as well as grey matter volume analysis in magnetite-rich brain regions associated with orientation and navigation with the goal of identifying specific MTB that could be associated with brain structure in orientation and navigation *** identified seven MTB in the human gut microbiome:Magnetococcus marinus,Magnetospira ***-2,Magnetospirillum magneticum,Magnetospirillum ***-1,Magnetospirillum ***-1,Magnetospirillum gryphiswaldense,and Desulfovibrio *** preliminary results show significant negative associations between multiple MTB with bilateral flocculonodular lobes of the cerebellum and hippocampus(adjusted for total intracranial volume,uncorrected P<0.05).These findings indicate that MTB in the gut are associated with grey matter volume in magnetite-rich brain regions related to orientation and *** preliminary findings support MTB as a potential biogenic source for brain magnetite in *** studies will be necessary to validate and elucidate the relationship between these bacteria,magnetite concentrations,and brain function.

关键词： magnetotactic bacteria human microbiome microbiota-gut-brain axis magnetoreception

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