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Pediatric multisystem inflammatory syndrome associated with COVID-19: Insights in pathogenesis and clinical management

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World Journal of Virology 2023年第3期12卷 193-203页

作者： Marcel Silva Luz Fabian Fellipe Bueno lemos Samuel Luca Rocha Pinheiro Hanna Santos Marques Luís Guilherme de Oliveira Silva Mariana Santos Calmon Karolaine da costa Evangelista Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been a major challenge to be faced in recent *** adults suffered the highest morbidity and mortality rates of coronavirus disease 2019,children were thought to be exclusively asymptomatic or to present with mild ***,around April 2020,there was an outbreak of a new clinical syndrome related to SARS-CoV-2 in children-multisystemic inflam-matory syndrome in children(MIS-C)-which comprises a severe and uncon-trolled hyperinflammatory response with multiorgan *** Centers for Disease Control and Prevention considers a suspected case of MIS-C an individual aged2)organ involvement,no alternative plausible diagnoses,and positive for recent SARS-CoV-2 *** its severity,there are no definitive disease management guidelines for this ***,the complex pathogenesis of MIS-C is still not completely understood,although it seems to rely upon immune ***,in this study,we aim to bring together current evidence regarding the pathogenic mechanisms of MIS-C,clinical picture and management,in order to provide insights for clinical practice and implications for future research directions.

关键词： Pediatric multisystem inflammatory disease COVID-19 related Multisystem inflammatory syndrome in children COVID-19 SARS-CoV-2 Etiology Disease management

Immunotherapy in glioblastoma treatment:Current state and future prospects

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World Journal of Clinical Oncology 2023年第4期14卷 138-159页

作者： Samuel Luca Rocha Pinheiro Fabian Fellipe Bueno lemos Hanna Santos Marques Marcel Silva Luz Luís Guilherme de Oliveira Silva Clara Faria Souza Mendes dos Santos Karolaine da costa Evangelista Mariana Santos Calmon Matheus Sande Loureiro Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

Glioblastoma remains as the most common and aggressive malignant brain tumor,standing with a poor prognosis and treatment *** the aggressive standard care,such as surgical resection and chemoradiation,median survival rates are *** this regard,immunotherapeutic strategies aim to become more attractive for glioblastoma,considering its recent advances and *** this review,we provide an overview of the current status and progress in immunotherapy for glioblastoma,going through the fundamental knowledge on immune targeting to promising strategies,such as Chimeric antigen receptor T-Cell therapy,immune checkpoint inhibitors,cytokine-based treatment,oncolytic virus and vaccine-based *** last,it is discussed innovative methods to overcome diverse challenges,and future perspectives in this area.

关键词： Glioblastoma Immunotherapy Tumor microenvironment Chimeric antigen receptor T cell Oncolytic viruses Immune-checkpoint inhibitors Brain cancer

Immune response to Helicobacter pylori infection and gastric cancer development

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World Journal of Meta-Analysis 2021年第3期9卷 257-276页

作者： Breno Bittencourt de Brito Fabian Fellipe Bueno lemos Caroline da Mota Carneiro Andressa Santos Viana Nilo Manoel Pereira Vieira Barreto Gabriela Alves de Souza Assis Barbara Dicarlo costa Braga Maria Luísa Cordeiro Santos Filipe Antônio França da Silva Hanna Santos Marques Natália Oliveira e Silva Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45031900BahiaBrazil

Gastric adenocarcinoma is a global health concern,and Helicobacter pylori(***)infection is the main risk factor for its *** note,the immune response against the pathogen seems to be a determining factor for gastric oncogenesis,and increasing evidence have emphasized several host and bacterium factors that probably influence in this *** development of an inflammatory process against *** involves a wide range of mechanisms such as the activation of pattern recognition receptors and intracellular pathways resulting in the production of proinflammatory cytokines by gastric epithelial *** process culminates in the establishment of distinct immune response profiles that result from the cytokine-induced differentiation of T naïve cells into specific T helper *** released from each type of T helper cell orchestrate the immune system and interfere in the development of gastric cancer in idiosyncratic ***,variants in genes such as single nucleotide polymorphisms have been associated with variable predispositions for the occurrence of gastric malignancy because they influence both the intensity of gene expression and the affinity of the resultant molecule with its *** addition,various repercussions related to some *** virulence factors seem to substantially influence the host immune response against the infection,and many of them have been associated with gastric tumorigenesis.

关键词： Gastric cancer Helicobacter pylori Immune response Virulence factors Polymorphisms

Helicobacter pylori infection in pregnant women:Gastrointestinal symptoms and pregnancy-related disorders

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World Journal of Clinical Infectious Diseases 2023年第5期13卷 49-57页

作者： Luana Kauany de SáSantos Jonathan Santos Apolonio Beatriz Rocha Cuzzuol Bruna Teixeira da costa Vinícius Lima de Souza Gonçalves Ronaldo Teixeira da Silva Júnior Marcel Silva Luz Fabian Fellipe Bueno lemos Samuel Luca Rocha Pinheiro Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Universidade Estadual do Sudoeste da Bahia Campus Vitória da ConquistaVitória da Conquista 45083-900BahiaBrazil

Helicobacter pylori(***)is a gram-negative,flagellated and spiral-shaped bacterial pathogen that impacts approximately 46%among pregnant women globally and has been associated with various maternal-fetal *** deficiency anemia,fetal growth restriction,cardiovascular diseases,and insufficient nutrient absorption can be observed in pregnant women,as well as miscarriages and pregnancy-specific hypertensive disease,such as ***,the evidence supports the influence of *** infection on fetal implantation/placentation failure,and positive strains of the cytotoxin-associated gene A of *** were reported as the most prevalent in these ***,current knowledge indicates a relationship between this infection and the occurrence of hyperemesis gravidarum,characterized by frequent nausea and *** the diagnosis of this bacterial infection,non-invasive approaches such as stool antigen test,urea breath test,and serological tests are more accepted during pregnancy,as they are easy to carry out and ***,the bacteria eradication therapy should consider the risks and benefits for the pregnant woman and her child,with pharmacological intervention depending on the clinical presentation.

关键词： Helicobacter pylori Pregnancy Hyperemesis gravidarum Iron deficiency anemia Pre-eclampsia Fetal growth restriction Miscarriage

Program for Solar Water Heating Systems Based on the F-Chart Method

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Journal of Mechanics Engineering and Automation 2014年第9期4卷 752-762页

作者： Felix do Rego Barros Adriano Gatto lemos Sildenir Alves Ribeiro Manoel Antonio da Fonseca costa Filho Coordination of Industrial Automation CEFET (Federal Center of Technological Education) Rio de Janeiro 20785-902 Brazil Coordination of Automotive Maintenance CEFET (Federal Center of Technological Education) Rio de Janeiro 20785-902 Brazil Department of Mechanical Engineering UERJ (State University of Rio de Janeiro) Rio de Janeiro 20940-200 Brazil

This paper aims at presenting an application developed in Java for optimizing the design of centralized solar water heating systems with forced circulation, based on the f-chart method. The program uses data from the Brazilian Solar Atlas, performance data of flat plate collectors and thermal reservoirs from the standardized tests run within the Brazilian Labeling Program, and values of water consumption of appliances defined by the ABNT. The program finds the inclination of the collector that maximizes the annual solar fraction, or for the winter, and enables the use of arrays in series and parallel collectors. From the investment costs and O & M (operations and maintenance) of solar heating systems, the program carries out economical analysis using classical parameters as net present value, discounted payback and internal rate of return. The program was validated through examples from the book of Duffie & Beckman and also by comparison with the results from a project developed at UFRGS, having obtained good agreement.

关键词：太阳能热水系统图法基础 Java应用程序平板集热器标准化考试强制循环数据显示

COVID-19 mental health care toolkit:an international collaborative effort by Early Career Psychiatrists section

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General Psychiatry 2020年第5期33卷 352-355页

作者： Frances Adiukwu Laura Orsolini Drita Gashi Bytyçi Samer El Hayek Jairo M Gonzalez-Diaz Amine Larnaout Paolo Grandinetti Marwa Nofal Victor Pereira-Sanchez Mariana Pinto da costa Ramdas Ransing Andre Luiz Schuh Teixeira Mohammadreza Shalbafan Joan Soler-Vidal Zulvia Syarif Ganesh Kudva Kundadak Rodrigo Ramalho Department of Neuropsychiatry University of Port Harcourt Teaching HospitalChobaRiversNigeria Department of Clinical Neurosciences/DIMSC School of MedicinePolytechnic University of MarcheAnconaMarcheItaly Mental Health Center Prizren Hospital and University Clinical Service of KosovoPrizrenKosovo Department of Psychiatry American University of BeirutBeirutLebanon CERSAME School of Medicine and Health SciencesUniversidad del Rosario-Clinica Nuestra Senora de la PazBogotaColombia Psychiatry Department D Razi Hospitalfaculty of Medicine of TunisTunis El Manar UniversityTunisTunisia Addictions Service(SerD) Department of Territorial AssistanceASL TeramoTeramoItaly Helwan Mental Health Hospital CairoEgypt Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNew YorkUSA Unit for Social and Community Psychiatry(WHO Collaborating Centre for Mental Health Services Development) Queen Mary University of LondonLondonUK Institute of Biomedical Sciences Abel Salazar University of PortoPortoPortugal Hospital de Magalhaes lemos PortoPortugal Department of Psychiatry BKL Walawalkar Rural Medical CollegeSawardeRatnagiriIndia Department of Childhood and Adolescent Psychiatry Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil Mental Health Research Center Department of PsychiatrySchool of MedicineIran University of Medical SciencesTehranIran(the Islamic Republic of) Fidmag Research Foundation Hermanas HospitalariasBarcelonaSpain Department of Psychiatry Tarakan General HospitalJakartaIndonesia Early Psychosis Intervention Programme Institute of Mental HealthSingapore Department of Social and Community Health School of Populatin HealthUniversity of AucklandAucklandNew Zealand

The collaborative effort of an international research team from the Early Career Psychiatrists section of the World Psychiatry Association has brought about an easy-to-use,quick and stepwise mental health care toolkit for the identification and appropriate referral of those in need of mental health care during the *** simple guide can be applied in the general outpatient setting and is catered for all healthcare professionals,regardless of their expertise within the mental health field with minimal *** is our hope that by incorporating this toolkit into our daily clinical care during the pandemic for high-risk patients and patients with non-specific complaints,we will be able to bridge the mental health gap present in our society.

关键词： Psychiat section clinical

What is the best biological treatment for rheumatoid arthritis? A systematic review of effectiveness

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World Journal of Rheumatology 2015年第2期5卷 108-126页

作者： Jéssica Barreto dos Santos Juliana de Oliveira costa Haliton Alves de Oliveira Junior Lívia Lovato Pires lemos Vnia Eloisa de Araújo Marina Amaral de Avila Machado Alessandra Maciel Almeida Francisco de Assis Acurcio Juliana Alvares Postgraduate Programme in Medicines and Pharmaceutical Assistance College of PharmacyFederal University of Minas GeraisAv.Presidente Antonio Carlos College of Pharmacy Federal University of Minas GeraisAv.Presidente Antonio Carlos Department of Social Pharmacy College of PharmacySUS Collaborating Centre-CCATESFederal University of Minas GeraisAv.Presidente Antonio Carlos College of Medicine Federal University of Minas GeraisAv.Prof.Alfredo Balena

AIM:To evaluate the effectiveness of the biological disease-modifying antirheumatic drugs(b DMARD) in the treatment of rheumatoid arthritis through a systematic review of observational ***:The studies were searched in the Pub Med,EMBASE,Cochrane Controlled Trials Register and LILACS databases(until August 2014),in the grey literature and conducted a manual *** assessed criteria of effectiveness included the EULAR,the disease activity score(daS),the Clinical Disease Activity Index,the Simplified Disease Activity Index,the American College of Rheumatology and the Health Assessment *** meta-analysis was performed with Review Manager 5.2 software using a random effects model.A total of 35 studies were included in this ***:The participants anti-tumor necrosis factor inhibitors(TNF) nave,who used adalimumab(P = 0.0002) and etanercept(P = 0.0006) exhibited greater good EULAR response compared to the participants who used *** difference was detected between adalimumab and etanercept(P = 0.05).The participants who used etanercept exhibited greater remission according to daS28 compared to the participants who used infliximab(P = 0.01).No differences were detected between adalimumab and infliximab(P = 0.12) or etanercept(P = 0.79).Better results were obtained with b DMARD associated with methotrexate than with b DMARD *** good EULAR response and daS 28 was better for combination with methotrexate than b DMARD monotherapy(P = 0.03 e P daS28 reduction compared to those who used anti-TNF agents(P = 0.0002).The participants who used etanercept achieved greater good EULAR response compared to those who did not use that drug(P = 0.007).Studies that assessed reduction of the CdaI score indicated the superiority of abatacept over rituximab(12.4 vs +1.7) and anti-TNF agents(7.6 vs 8.3).The present systematic review with meta-analys

关键词： Systematic review Meta-analysis Effecti-veness Biological disease-modifying antirheumatic drugs Rheumatoid arthritis