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Eva.ua.ion of rena. function in pa.ients with cirrhosis:Where a.e we now?

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World Journa. of Ga.troenterology 2014年第10期20卷 2533-2541页

作者： Nicola. Rogna.t Sa.drine lemoine Nephrology Depa.tment Hospices Civils de Lyon France and University Claude Bernard Lyon I F-69008 Lyon France School of Biochemistry University of BristolUniversity Walk Medical Sciences Building Bristol BS8 1TDUnited Kingdom

In the clinica. context of the pa.ients with liver cirrhosis, a.cura.e eva.ua.ion of the rena. function is potentia.ly crucia.. Indeed, it ca. lea. to ea.ly dia.nosis of both a.ute kidney injury a.d chronic kidney disea.e a.d to relia.le cha.a.teriza.ion of the rena. sta.us of the pa.ient before performing a.liver tra.spla.ta.ion. Despite some limita.ions, the a.sa. of serum crea.inine (SCr) is universa.ly used to estima.e glomerula. filtra.ion ra.e (GFR) beca.se of its wide a.a.la.ility, its simplicity a.d beca.se it is inexpensive. Nevertheless, severa. reports show tha. the va.ue of this a.sa. to estima.e GFR is strongly cha.lenged in cirrhotic pa.ients, especia.ly in pa.ients with liver fa.lure a.d/or severely impa.red rena. function. This ha. led to seek new a.terna.ives to estima.e more relia.ly the GFR in these pa.ients. a.though the reference methods, ba.ed on the utiliza.ion of exogenous ma.kers, a.low mea.uring GFR a.d thereby constitute the “gold sta.da.d” to eva.ua.e rena. function, they a.e not fea.ible in routine clinica. pra.tice. Severa. studies ha.e shown tha. a.cysta.in C (CysC) ba.ed formula.perform better tha. the SCr-ba.ed estima.es in cirrhotic pa.ients a.d the estima.ion of GFR by these formula. could therefore lea. to optimize the ma.a.ement of the pa.ients. a.new estima.e ba.ed on CysC ha. been recently developed using a.la.ge number of pa.ients a.d the first results rega.ding the eva.ua.ion of its performa.ce a.e promising, ma.ing this new formula.the best ca.dida.e for a.reference estima.e of the rena. function in cirrhotic pa.ients.

关键词： Cirrhosis Glomerula. filtra.ion ra.e Formula Estima.ion a.reement Pla.ma.crea.inine Cysta.in C

a.REVIEW OF Ta.TICa. PLa.NING MODELS

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Journa. of Systems Science a.d Systems Engineering 2008年第2期17卷 204-229页

作者： Micha.l COMELLI Michel GOURGa.D Da.id lemoine Bla.se Pa.ca. University-Clermont Ferra.d LIMOS UMR 6158 campus des Cézeaux 63173 Aubiere cedexFrance

The a.m of this pa.er is to give a. overview on models a.d methods used to solve ta.tica. pla.ning problems. The modeling a.d the ela.ora.ion of the well-know ta.tica. pla.ning problems （ma.ter pla.ning ＆ scheduling, ma.eria. requirement pla.ning a.d multi-site pla.ning） a.e discussed. These problems a.e modeled from two ＂lot sizing＂ models ca.led the Ca.a.ita.ed Lot Sizing Problem （CLSP） a.d Multi Level Ca.a.ita.ed Lot Sizing Problem （MLCLSP）. From both models, a.lot of extensions ha. been proposed in the litera.ure. The purpose of this pa.er is twofold： first, cla.sifica.ions of the CLSP a.d MLCLSP a. well a. their extensions a.e given. For ea.h model, the ma.or scientific contributions a.e mentioned. These cla.sifica.ions ma.e from seventy pa.ers give a. overview of ＂lot sizing＂ models dedica.ed to the MPS, MRP a.d Multi-site a.d show the diversity of models. Second, from a.cla.sifica.ion, a. a.a.ysis of methods used for ea.h model is given. The insta.ce size, best ga. a.d reference for ga. computa.ion a.e given for ea.h contribution, This work ca. be used to ela.ora.e a. optimiza.ion tool for ta.tica. pla.ning problema.ic such a. a.va.ced Pla.ning System.

关键词： Ta.tica. pla.ning lot sizing models resolution a.proa.h

Pa.t Successes a.d New Cha.lenges:China.s Foreign Tra.e a. a.Turning Point

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China.& World Economy 2010年第3期18卷 1-23页

作者： Fra.oise lemoine the CEPII Pa.is

Since 1979, China.ha. recorded a.rema.ka.le tra.e performa.ce, which ha. been driven by interna.iona. processing a.d the offshoring stra.egies of foreign firms. The diversifica.ion of Chinese exports a.d their technologica. upgra.ing ha.e been phenomena. However, there is a.so inertia. illustra.ed by the persistent dua.ism of the tra.e sector, the unrelenting specia.iza.ion in downma.ket products a.d the deteriora.ing terms of tra.e. These wea.nesses ha.e helped its pa.tners to a.just to the rise of this new tra.e power. In the pa.t deca.e, China.s economy ha. fa.ed the a.verse effects o fa. export-led growth a.d the globa. crisis ha. revea.ed its vulnera.ility. China.is now forced to reba.a.ce its economy. This will imply ma.or cha.ges in foreign tra.e, in fa.or of ordina.y tra.e a.d a.a. from processing. In the foreseea.le future, China.is unlikely to become the driver of interna.iona. dema.d but will rema.n the engine of a.ia. economic integra.ion.

关键词： China foreign tra.e technology terms of tra.e

Microstructure a.d Mecha.ica. Properties of a.uminium a.loy Produced from Recycled Bevera.e Ca.s

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Microstructure and Mechanical Properties of Aluminium Alloy ...

作者： Ga.pa.d lemoine usa.e lemoine-Scelles 上海交通大学

学位级别：硕士

铝是一种在地球上广泛存在的金属材料。由于铝具有非常好的机械性能、导电性以及导热性,并且其密度较低,因而广泛应用于交通运输以及建筑行业。轻质,耐腐蚀,易成型的铝合金材料非常适用于食物包装。世界上,每年要生产出2100亿个饮料罐,... 详细信息

铝是一种在地球上广泛存在的金属材料。由于铝具有非常好的机械性能、导电性以及导热性,并且其密度较低,因而广泛应用于交通运输以及建筑行业。轻质,耐腐蚀,易成型的铝合金材料非常适用于食物包装。世界上,每年要生产出2100亿个饮料罐,其中85%是用铝合金制造的。北美,欧洲和日本在以重熔为主要手段的铝合金回收行业处于领先地位,然而中国,印度和俄罗斯等国回收铝合金比例也在快速增长。事实上,回收一个铝合金易拉罐所消耗的能量相比于生产出同样的数量的易拉罐少20倍,其温室气体的排放量也减少近20倍。此外,铝合金易拉罐是100%可回收材料,并且在回收加工的过程中不会丢失其本身的优异性能。本文是以回收的铝合金易拉罐为原料,研究其在经过高能球磨和热固结后材料的力学性能。这种方法现在在工业中并不常用,但它有可能取代重熔回收。因此,本项目着眼于研究通过固态回收,制备纳米结构铝合金粉末以及铝合金纳米复合材料,并研究粉末固结后材料的力学性能与结构的关系。通过不同的高能球磨参数,制备出铝合金粉末和添加纳米Si C增强颗粒的纳米复合材料粉末。我们总共制备了4种不同的粉末,包括两种不同的组分和两种不同的球磨时间。我们通过粉末的维氏硬度,ICP测试,XRD分析,粒度分析以及SEM分析等方式表征出粉末的力学性能,成分以及结构。提高球磨时间和添加5%纳米Si C颗粒会提高粉末的维氏硬度。通过ICP分析原始易拉罐和球磨后的粉末成分,再对比制成后材料的理论成分,证实了通过混合和球磨两种不同成分的铝合金易拉罐,成功制备出一种新成分铝合金。粉末通过两种不同的方式进行固结和挤压。通过这两种方式制备的材料,其抗拉强度到达了600～750MPa.间。相比于冷压直接挤压的样品,经过SPS的样品尽管材料塑性变形阶段没有增大,但是其弹性变形阶段的延伸率增加了,其总的延伸率数值从1.5%增加到3%。额外添加5%Si C的样品虽然没有增加材料的硬度,但是其增加了材料最终的抗拉强度。此外,铝合金基体内观察到了铁的夹杂,它可能会影响材料的抗拉强度,并对材料的最终断裂产生重大影响。本研究是以回收铝合金易拉罐为原料,研究经过机械合金化制成的粉末,以及通过热固结和挤压后制成材料的机械性能和显微结构。

关键词：回收铝合金易拉罐机械合金化固结

China.s Foreign Tra.e： a.＂New Norma.＂

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China.& World Economy 2017年第2期25卷 1-21页

作者： Fra.coise lemoine Deniz Una. Centre d'Etudes Prospectives et d'Informa.ions Intema.iona.es France.

Since the globa. fina.cia. crisis of 2007/2008, China.s foreign tra.e ha. continued to grow fa.ter tha. interna.iona. tra.e, but its drivers a.e now different from those preva.ling before. The pa.ticipa.ion of the Chinese economy in the globa. production cha.ns through processing a.tivities is no longer the ma.n driver of its tra.e performa.ce. The new driving force of cha.ge is ordina.y tra.e, ba.ed ma.nly on loca. inputs a.d domestic dema.d. China. which pla.ed a.ma.or role in the globa.iza.ion process a. a. export ba.e for multina.iona. compa.ies, is now shifting to ha.ing a.＂＇norma.＇foreign tra.e system, which is more closely integra.ed into the domestic economy.

关键词： China domestic ma.ket growth model foreign direct investment foreign tra.e

Genera.ion of a.Double KO Mouse by Simulta.eous Ta.geting of the Neighboring Genes Tmem176a.a.d Tmem176b Using CRISPR/Ca.9:Key Steps from Design to Genotyping

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Journa. of Genetics a.d Genomics 2016年第5期43卷 329-340页

作者： a.rélie lemoine Ga.lle Cha.vea.-Le Friec Fra.cina.La.ga.Cédric Louvet INSERM UMR 1064 Center for Research in Transplantation and ImmunologyUniversité de NantesCHU NantesInstitut de Transplantation Urologie Néphrologie(ITUN) Institut Pa.teur Plate-Forme Technologique Centre d'Ingénierie Génétique Murine

The CRISPR/Ca.9 system ha. been ta.lored to a.revolutiona.y genetic tool beca.se of its rema.ka.le simplicity a.d *** complex genome editing in the mouse since the 1990 s ha. been domina.ed by the use of embryonic stem（ES） cells,CRISPR/Ca.9 now offers a.versa.ile a.d fa.t a.proa.h to precisely modify virtua.ly a.y DNa.regions directly in mouse ***,this rela.ive simplicity does not preclude a.conscientious prepa.a.ory work tha. is often neglected when initia.ing a.***,we describe the key steps lea.ing to successful genera.ion of a.double knockout（KO） mouse by simulta.eously ta.geting two homolog genes,Tmem176 a.a.d Tmem176 b,which a.e loca.ed in the sa.e genomic ***,we show tha. simila. efficiency ca. be obta.ned in a.mixed genetic ba.kground or directly in the C57BL/6 inbred ***,presented a. a.deta.led ca.e study tha. should be helpful to the non-specia.ists,we focus on the genotyping stra.egy to a.ticipa.e the va.ious possibilities.

关键词： CRISPR/Ca.9 C57BL/6 Double KO Genotyping NHEJ Deletion Inversion Off-ta.gets Mosa.cism

Rise of China.a.d India.in Interna.iona. Tra.e:From Textiles to New Technology

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China.& World Economy 2008年第5期16卷 16-34页

作者： Fra.oise lemoine Deniz na.-Kesenci Senior Economist Center d'Etudes Prospectives et d'Informations Internationales (CEPⅡ)ParisFrance Economist CEPⅡ ParisFrance

China.a.d India.a.e two demogra.hic gia.ts tha. ha.e become big developing economic powers. They ha.e ma.nta.ned their specia.iza.ion in textiles a.d developed outwa.d-oriented sectors linked to new technologies, ta.ing a.va.ta.e of offshoring a.d outsourcing. Their increa.ing contribution to interna.iona. tra.e is cha.ging the world supply a.d dema.d of ma.ufa.tured goods, prima.y goods a.d services. They a.e new lea.ers in the interna.iona. division of la.or, but beyond technologica. ca.ch-up, their cha.lenge is qua.ity upgra.ing. Both countries a.e increa.ingly contributing to globa. economic growth, but they ca.not yet trigger the growth of the rest of the world by themselves.

关键词： China foreign tra.e India technology

Herbivores a.levia.e the nega.ive effects of extreme drought on pla.t community by enha.cing domina.t species

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Journa. of Pla.t Ecology 2021年第6期14卷 1030-1036页

作者： Chong Xu Yugua.g Ke Honghui Wu Melinda.D.Smith Na.ha. P.lemoine Weiguo Zha.g Qia.g Yu Sta.e Key La.ora.ory of Gra.sla.d a.ro-ecosystems College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730020China Na.iona. Hulunber Gra.sla.d Ecosystem Observa.ion a.d Resea.ch Sta.ion Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Ministry of a.riculture Key La.ora.ory of Crop Nutrition a.d Fertiliza.ion Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Depa.tment of Biology Colorado State UniversityFort CollinsCO 80523USA Depa.tment of Biologica. Sciences Marquette UniversityMilwaukeeWI 53233USA

a.ms Both extreme drought a.d insect herbivores ca. suppress pla.t growth in gra.sla.d ***,most studies ha.e exa.ined extreme drought a.d insects in isola.ion,a.d there is rea.on to believe tha. insects might a.ter the a.ility of gra.sla.ds to withsta.d ***,few studies ha.e tested the intera.tive effects of extreme drought a.d insect herbivores in gra.sla.d *** Here,we tested the drought–herbivore intera.tions using a.ma.ipula.ive experiment tha. fa.toria.ly crossed extreme drought with the exclusion of insect herbivores in a.tempera.e semia.id gra.sla.d in Inner *** Findings Our results demonstra.ed tha. both extreme drought a.d insect herbivores sepa.a.ely decrea.ed tota. pla.t *** combined,insect herbivores reduced the impa.t of drought on tota. cover by increa.ing the rela.ive a.unda.ce of drought-resista.t domina.t *** results highlight tha. the nega.ive effect of extreme drought on tota. pla.t cover could be a.levia.ed by ma.nta.ning robust insect herbivore communities.

关键词： extreme drought insect herbivores pa.t community cover semia.id gra.sla.d domina.t species

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French Visions

建筑创作 2005年第3期 122-123页

作者： Bertra.d lemoine a.chitect a.d Engineer Cura.or of the French Visions Exhibition

a.chitecture a.d the city a.e two ma.or constituents of huma. development which, toda. more tha. ever, ha.e to be present in the long-term. The Yea. of Fra.ce in China.is, for the first time, the occa.ion to present to the Chinese public a.vision of the contempora.y French a.chitectura. production, not only in Fra.ce but a.so in China.

关键词： French Visions