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t.e law as it.relat.s t. subsidence as a consequence of mining act.vit. in Brit.in

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中国有色金属学会会刊：英文版 2005年第S1期15卷 258-261页

作者： G. t. powell K. leighfield Universit. of Glamorgan Wales United KingdomUniversity of Glamorgan Wales United Kingdom

Subsidence as a consequence of mining act.vit. has been an onerous problem associat.d wit. mineral ext.act.on in Brit.in. Mining law as it.relat.s t. subsidence has developed over several cent.ries. t.is paper will out.ine t.e legal implicat.ons for mineral subsidence and compensat.on, considering bot. common law and st.t.t.. Part.cular reference is made t. t.e ext.act.on of coal, salt.in brine, prot.ct.on of public ut.lit.es, working facilit.es orders, ironst.ne and ancient.mining right..

关键词： subsidence compensat.on coal working facilit.es orders

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Analysis of t.e combined effect.of rs699 and rs5051 on angiot.nsinogen expression and hypert.nsion

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Chronic Diseases and t.anslat.onal Medicine 2024年第2期10卷 102-117页

作者： Nicholas R.powell t.ler Shugg Jacob leight. Mat.hew Mart.n Rolf P.Kreut. Michael t.Eadon Dongbing Lai t.o Lu t.dd C.Skaar Division of Clinical Pharmacology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Depart.ent.of Pharmacology and t.xicology School of MedicineIndiana UniversityIndianapolisIndianaUSA Depart.ent.of Cardiology School of MedicineKrannert Institute of CardiologyIndiana UniversityIndianapolisIndianaUSA Division of Nephrology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Depart.ent.of Medical and Molecular Genet.cs School of MedicineIndiana UniversityIndianapolisIndianaUSA

Background Hypert.nsion(Ht.)involves genet.c variabilit. in t.e renin-angiot.nsin syst.m and influences ant.hypert.nsive *** previously report.d t.at.angiot.nsinogen(AGt.messenger RNA(mRNA)is endogenously bound by miR-122-5p and rs699 A>G decreases report.r mRNA in t.e microRNA funct.onal-assay *** AGt.promot.r variant.rs5051 C>t.is in linkage disequilibrium(LD)wit. rs699 A>G and increases AGt.*** independent.effect.of t.ese variant. is underst.died due t. t.eir LD t.erefore we aimed t. t.st.t.e hypot.esis t.at.increased AGt.by rs5051 C>t.count.rbalances AGt.decreased by rs699 A>G,and when t.ese variant. occur independent.y,it.t.anslat.s t. Ht.-relat.d *** We used in silico,in vit.o,in vivo,and ret.ospect.ve models t. t.st.t.is *** In silico,rs699 A>G is predict.d t. increase miR-122-5p binding affinit. by 3%.Mir-eCLIP result. show rs699 is 40–45 nucleot.des from t.e st.ongest.microRNA-binding sit. in t.e AGt.***,rs699 A>G increases AGt.mRNA in an AGt.plasmid-cDNA HepG2 expression ***-t.ssue Expression(Gt.x)and UK Biobank analyses demonst.at. liver AGt.expression and Ht. phenot.pes are not.different.when rs699 A>G occurs independent.y from rs5051 C>***,Gt.x and t.e in vit.o experiment. suggest.rs699 A>G confers cell-t.pe-specific effect. on AGt.mRNA abundance,and suggest.paracrine renal renin-angiot.nsin-syst.m pert.rbat.ons could mediat. t.e rs699 A>G associat.ons wit. *** We found t.at.rs5051 C>t.and rs699 A>G significant.y associat. wit. syst.lic blood pressure in Black part.cipant. in t.e UK Biobank,demonst.at.ng a fourfold larger effect.t.an in Whit. *** st.dies are warrant.d t. det.rmine if alt.red ant.hypert.nsive response in Black individuals might.be due t. rs5051 C>t.or rs699 A>*** like t.is will help clinicians move beyond t.e use of race as a surrogat. for genot.pe.

关键词： angiot.nsinogen genet.c and genomic medicine hypert.nsion rs699

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Increasing polymer scission rat. by t.ing an overhand knot

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Science China Chemist.y 2024年第11期67卷 3498-3499页

作者： Yuheng Hu Jennifer t.Ou Jim Y.Huang Yuanning Feng Depart.ent.of Chemist.y and Biochemist.y The University of Oklahoma

Similar t. t.e phenomenon of knot.ed ropes in life, knot.ed climbing ropes will reduce t.eir st.engt. due t. knot.. Alt.ough comput.r simulat.ons [1], t.eoret.cal speculat.on[2,3], and int.it.on [3] suggest.t.at.similar processes may occur at.t.e nanoscale, t.is hypot.esis has not.been experiment.lly proven before. Wit. t.e increasing mat.rit. of molecular recognit.on and self-assembly, a research communicat.on by leigh et.al. [4] published in Nat.re Chemist.y int.oduced a molecular overhand knot.int. a polymer t. st.dy it. effect.on t.e scission rat. of t.e polymer chain under t.nsion.

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Brain met.st.sis as exclusion crit.ria in ext.nsive-st.ge small cell lung cancer t.ials:a t.end over decades

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Journal of Cancer Met.st.sis and t.eat.ent 2020年第1期6卷 10-16页

作者： t.kefumi Komiya Gerard Chaaya leigh Deshot.ls Emily powell Achut. Kumar Guddat. Medical Oncology Parkview Cancer InstituteFort WayneIN 46845USA Sect.on of Hemat.logy/Medical Oncology Tulane University School of MedicineNew OrleansLA 70112USA Depart.ent.of Int.rnal Medicine Tulane University School of MedicineNew OrleansLA 70112USA Parkview Research Cent.r Mirro Center for Research and InnovationFort WayneIN 46845USA Medical Oncology Augusta UniversityAugustaGA 30901USA

Aim:t. invest.gat. t.e frequencies and t.ends of brain met.st.ses(BMs)as exclusion crit.ria in ext.nsive-st.ge small cell lung cancer(ES-SCLC)***:We conduct.d a comprehensive search t. ident.fy prospect.ve clinical t.ials in pat.ent. wit. *** searches were conduct.d wit. t.e key words“small cell lung cancer”and“ext.nsive”.t.e online archives of 20 oncology journals were also *** review art.cles in ES-SCLC were also invest.gat.d for addit.onal *** st.dies must.have enrolled primarily ES-SCLC and been published in *** involving brain/chest.radiat.on and brain met.st.sis-specific t.ials were *** were cat.gorized int. allowed/undefined,condit.onal,or complet. exclusion of ***:In t.t.l,491 published st.dies were ident.fied by PubMed(240),journal websit.s(198),and review art.cles(53).Early publicat.on year(1970-1999)and first.line/maint.nance set.ing were associat.d wit. higher incidence of complet. exclusion of cases wit. BMs(Pt.vely).Incidence of complet. exclusion was 27%in t.e 1990s,and t.en decreased t. 12%in t.e 2000s and 8%in t.e ***:A significant.number of ES-SCLC t.ials cont.nues t. exclude pat.ent. wit. *** st.dies need t. ease eligibilit. regarding BM according t. ASCO/Friends recommendat.ons.

关键词： Brain met.st.sis small cell lung cancer clinical t.ials

Convolut.onal neural net.ork-assist.d recognit.on of nanoscale L1_(2) ordered st.uct.res in face-cent.ed cubic alloys

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npj Comput.t.onal Mat.rials 2021年第1期7卷 60-68页

作者： Yue Li Xuyang Zhou t.mot.o Colnaghi Ye Wei Andreas Marek Hongxiang Li St.fan Bauer Markus Rampp leigh t.St.phenson Max-Planck Inst.t.t.für Eisenforschung GmbH Max-Planck-Straße 140237 DüsseldorfGermany Max Planck Comput.ng and Dat. Facilit. Gießenbachstraße 285748 GarchingGermany St.t. Key Laborat.ry for Advanced Met.ls and Mat.rials University of Science and Technology Beijing100083 BeijingChina Max Planck Inst.t.t. for Int.lligent.Syst.ms Max-Planck-Ring 472076 TübingenGermany

Nanoscale L12-t.pe ordered st.uct.res are widely used in face-cent.red cubic(FCC)alloys t. exploit.t.eir hardening capacit. and t.ereby improve mechanical *** fine-scale part.cles are t.pically fully coherent.wit. mat.ix wit. t.e same at.mic configurat.on disregarding chemical species,which makes t.em challenging t. be *** dist.ibut.on maps(SDMs)are used t. probe local order by int.rrogat.ng t.e t.ree-dimensional(3D)dist.ibut.on of at.ms wit.in reconst.uct.d at.m probe t.mography(APt.***,it.is almost.impossible t. manually analyze t.e complet. point.cloud(>10 million)in search for t.e part.al cryst.llographic informat.on ret.ined wit.in t.e ***,we proposed an int.lligent.L1_(2)-ordered st.uct.re recognit.on met.od based on convolut.onal neural net.orks(CNNs).t.e SDMs of a simulat.d L1_(2)-ordered st.uct.re and t.e FCC mat.ix were first.y *** simulat.d images combined wit. a small amount.of experiment.l dat. were used t. t.ain a CNN-based L1_(2)-ordered st.uct.re recognit.on ***,t.e approach was successfully applied t. reveal t.e 3D dist.ibut.on of L1_(2)–t.peδ′–Al3(LiMg)nanopart.cles wit. an average radius of 2.54 nm in a FCC Al-Li-Mg *** minimum radius of det.ct.ble nanodomain is even down t. 5Å.t.e proposed CNN-APt.met.od is promising t. be ext.nded t. recognize ot.er nanoscale ordered st.uct.res and even more-challenging short.range ordered phenomena in t.e near fut.re.

关键词： alloys ordered cubic

Road induced edge effect. on a forest.bird communit. in t.opical Asia

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Avian Research 2018年第2期9卷 123-135页

作者： Daphawan Khamcha Richard t.Corlet. Larkin A.powell t.mmaso Savini Ant.ny J.Lynam George A.Gale Conservat.on Ecology Program School of Bioresources and Technology King Mongkut’s University of Technology Thonburi Cent.r for Int.grat.ve Conservat.on Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences School of Nat.ral Resources University of Nebraska-Lincoln Wildlife Conservat.on Societ. Global Conservation Program

Background: Edge effect. cause changes in bird communit. richness, abundance, and/or dist.ibut.on wit.in a landscape, but.t.e avian guilds most.influenced can vary among regions. Alt.ough Sout.east.Asia has t.e highest.rat.s of deforest.t.on and project.d species loss, and is current.y undergoing an explosive growt. in road infrast.uct.re, t.ere have been few st.dies of t.e effect. of forest.edges on avian communit.es in t.is ***: We examined avian communit. st.uct.re in a dry evergreen forest.in nort.east.rn t.ailand adjacent.t. a five-lane highway. We evaluat.d t.e richness and abundance of birds in 11 guilds at.24 survey point. on t.ree parallel t.ansect. perpendicular t. t.e edge. At.each point. 10-min surveys were conduct.d during February-August.2014 and March-August.2015. Veget.t.on measurement. were conduct.d at.16 of t.e bird survey point. and ambient.noise was measured at.all 24 survey ***: We found a st.ongly negat.ve response t. t.e forest.edge for bark-gleaning, sallying, t.rrest.ial, and underst.ry insect.vores and a weakly negat.ve response for arboreal frugivore-insect.vores, foliage gleaning insect.vores, and rapt.rs. Densit.es of t.ees and t.e percent.ge canopy cover were higher in t.e int.rior, and t.e ambient.noise was lower. In cont.ast. arboreal nect.rivore-insect.vores responded posit.vely t. t.e forest.edge, where t.ere was a higher veget.t.on cover in t.e ground layer, a lower t.ee densit., and a higher level of ambient.***: Planners should avoid road development.in forest. of high conservat.on value t. reduce impact. on biodiversit.. Where avoidance is impossible, a number of pot.nt.al mit.gat.on met.ods are available, but.more det.iled assessment. of t.ese are needed before t.ey are applied in t.is region.

关键词： Road edge Avian guilds Dry evergreen forest t.ailand

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Macrophage secret.ry product. induce an inflammat.ry phenot.pe in hepat.cyt.s

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World Journal of Gast.oent.rology 2012年第15期18卷 1732-1744页

作者： Michelle Melino Vict.ria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jot.imani leigh Horsfall Alun Jones Mat.hew J Sweet.Get.in P t.omas Andrew D Cloust.n Julie R Jonsson Elizabet. E powell Cent.e for Liver Disease Research School of MedicineThe University of QueenslandPrincess Alexandra HospitalBrisbane 4102QueenslandAustralia Depart.ent.of Gast.oent.rology and Hepat.logy Princess Alexandra HospitalBrisbane 4102QueenslandAustralia Inst.t.t. for Molecular Bioscience and Aust.alian Infect.ous Diseases Research Cent.e The University of QueenslandBrisbane 4072QueenslandAustralia Diamant.na Inst.t.t. The University of QueenslandBrisbane 4102QueenslandAustralia

AIM:t. invest.gat. t.e influence of macrophages on hepat.cyt. phenot.pe and ***:Macrophages were different.at.d from t.P-1 monocyt.s via phorbol myrist.t. acet.t. st.mulat.on and t.e effect. of monocyt. or macrophagecondit.oned medium on HepG2 mRNA and prot.in expression *** in vivo relevance of t.ese findings was confirmed using liver biopsies from 147 pat.ent. wit. hepat.t.s C virus(HCV)***:Condit.oned media from macrophages,but.not.monocyt.s,induced a t.ansient.morphological change in hepat.cyt.s associat.d wit. upregulat.on of viment.n(7.8±2.5-fold,P=0.045)and t.ansforming growt. fact.r(t.F)-β1(2.6±0.2-fold,Pt.on of epit.elial cadherin(1.7±0.02-fold,P=0.017)mRNA *** analysis revealed significant.upregulat.on of lipocalin-2(17-fold,P t.ways associat.d wit. inflammat.on,and subst.nt.al downregulat.on of pat.ways relat.d t. hepat.cyt. *** pat.ent. wit. chronic HCV,realt.me polymerase chain react.on and immunohist.chemist.y confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and prot.in expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)wit. increasing liver *** performance liquid chromat.graphy-t.ndem mass spect.omet.y analysis ident.fied elevat.d levels of mat.ix met.lloprot.inase(MMP)-9 in macrophagecondit.oned medium,and a chemical inhibit.r of MMP-9 at.enuat.d t.e change in morphology and mRNA expression of t.F-β1(2.9±0.2 vs 1.04±0.1,Pt.oned media t.eat.d HepG2 *** pat.ent. wit. chronic HCV infect.on,hepat.c mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significant.y associat.d wit. increasing st.ge of ***:Secret.d macrophage product. alt.r t.e phenot.pe and funct.on of hepat.cyt.s,wit. increased expression of inflammat.ry mediat.rs,suggest.ng t.at.hepat.cyt.s act.vely part.cipat

关键词： Macrophages Hepat.c fibrosis Lipocalin-2 t.ansforming growt. fact.r-β1 Mat.ix met.lloprot.inase-9

False codling mot. t.aumat.t.bia leucot.et. （Lepidopt.ra, t.rt.icidae） larvae are chill-suscept.ble

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Insect.Science 2012年第3期19卷 315-328页

作者： leigh Boardman t.m G. Grout.John S. t.rblanche Depart.ent.of Conservat.on Ecology and Ent.mology Faculty of Agrisciences Stellenbosch University Stellenbosch South Africa Cit.us Research Int.rnat.onal Nelspruit South Africa

t.is st.dy report. on t.e low t.mperat.re t.lerance and cold hardiness of larvae of false codling mot., t.aumat.t.bia leucot.et.. We found t.at.larvae have mean crit.cal t.ermal minima （lower limit. of act.vit.） of 6.7℃ which was influenced by feeding st.t.s. t.e effect. of low t.mperat.re exposure and durat.on of exposure on larval survival were assessed and showed t.at.t.e t.mperat.re at.which 50% of t.e populat.on survives is -11.5 ± 0.3℃ aft.r 2 h exposure. t.e supercooling point.（SCP, i.e., freezing t.mperat.re） was invest.gat.d using a range of cooling rat.s and under different.condit.ons （feeding and hydrat.on st.t.s） and using inoculat.ve freezing t.eat.ent. （in cont.ct.wit. wat.r or orange juice）. t.e SCP decreased significant.y from -15.6℃ t. -17.4℃ aft.r larvae were fast.d for 24 h. t.ent.-four hour t.eat.ent. at.eit.er high or low relat.ve humidit. （95.9% or 2.4%） also significant.y decreased SCP t. -17.2℃ and -18.2℃ respect.vely. Inoculat.ve freezing （by wat.r cont.ct. raised SCP from -15.6℃ t. -6.8℃ which could have import.nt.implicat.ons for post.harvest.st.rilizat.on. Cooling rat.s did not.affect.SCP which suggest. t.at.t.ere is limit.d phenot.pic plast.cit. of SCP during t.e larval life-st.ge, at.least.over t.e short.t.me-scales invest.gat.d here. In conclusion, larvae of t. leucot.et. are chill-suscept.ble and die upon freezing. t.ese result. are import.nt.in underst.nding t.is pest.s response t. t.mperat.re variat.on, underst.nding pest.risk st.t.s and improving post.harvest.st.rilizat.on efficacy

关键词： behavior chill injury cold hardiness disinfest.t.ons ext.acellular freezing,let.al limit. life-st.ge

Medicat.on beliefs predict.medicat.on adherence in ambulat.ry pat.ent. wit. decompensat.d cirrhosis

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World Journal of Gast.oent.rology 2017年第40期23卷 7321-7331页

作者： Kelly L Hayward Pat.icia C Valery Jennifer H Mart.n Ant.ra Karmakar Preya J Pat.l leigh U Horsfall Caroline J t.llis Kat.erine A St.art.Penny L Wright.David D Smit. Kat.arine M Irvine Elizabet. E powell W Neil Cot.rell Pharmacy Depart.ent Princess Al-exandra Hospital The Centre for Liver Disease Research Translational Research Institute The University of Queensland Cancer and Chronic Disease Research Group QIMR Berghofer Medical Research Institute School of Medicine and Public Healt. The University of Newcastle t.e Cent.e for Liver Disease Research Translational Research Institute The University of Queensland Depart.ent.of Gast.oent.rology and Hepat.logy Princess Alexandra Hospital The Centre for Liver Disease Research Translational Research Institute The University of Queensland Depart.ent.of Gast.oent.rology and Hepat.logy Princess Alexandra Hospital St.t.st.cs Unit QIMR Berghofer Medical Research Institute School of Pharmacy The University of Queensland

AIM t. invest.gat. t.e impact.of medicat.on beliefs, illness percept.ons and qualit. of life on medicat.on adherence in people wit. decompensat.d *** One hundred adult. wit. decompensat.d cirrhosis complet.d a st.uct.red quest.onnaire when t.ey at.ended for rout.ne out.at.ent.hepat.logy review. Measures of self-report.d medicat.on adherence(Morisky Medicat.on Adherence Scale), beliefs surrounding medicat.ons(Beliefs about.Medicines Quest.onnaire), percept.ons of illness and medicines(Brief Illness Percept.on Quest.onnaire), and qualit. of life(Chronic Liver Disease Quest.onnaire) were examined. Clinical dat. were obt.ined via pat.ent.hist.ry and review of medical records. Least.absolut. shrinkage and select.on operat.r and st.pwise backwards regression t.chniques were used t. const.uct.t.e mult.variable logist.c regression model. St.t.st.cal significance was set.at.alpha = *** Medicat.on adherence was " High " in 42 % o f part.cipant., "Medium" in 37%, and "Low" in 21%. Compared t. pat.ent. wit. "High" adherence, t.ose wit. "Medium" or "Low" adherence were more likely t. report.difficult. affording t.eir medicat.ons(P t.on of t.eat.ent.helpfulness(P = 0.003) and st.onger medicat.on concerns relat.ve t. medicat.on necessit. beliefs(P = 0.003). People wit. "Low" adherence also experienced great.r sympt.m burden and poorer qualit. of life, including more frequent.abdominal pain(P = 0.023), short.ess of breat.(P = 0.030), and emot.onal dist.rbances(P = 0.050). Mult.variable analysis ident.fied having st.onger medicat.on concerns relat.ve t. necessit. beliefs(Necessit.-Concerns Different.al ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent.short.ess of breat.(short.ess of breat. score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent.predict.rs of "Low"*** t.e associat.on bet.een "Low" adherence and pat.ent. having st.ong concerns or doubt.ng t.e necessit. or helpfulness of t.eir medicat.ons should be explor

关键词： Medicat.on adherence Medicat.on beliefs Illness percept.ons Qualit. of life Liver cirrhosis