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Decreased incidence of febrile neutropenia in Michigan following masking and social distancing orders for the COVID-19 pandemic: A population based cohort study

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World Journal of Clinical Oncology 2022年第7期13卷 609-615页

作者： Michael Gerard Baracy Jr Karen Hagglund Sanjana Kulkarni Fareeza Afzal Katherine Arends Robert T.Morris leigh ann Solomon Muhammad Faisal Aslam Logan Corey Department of Obstetrics and Gynecology Ascension St.John HospitalDetroitMI 48236United States Medical Research Ascension St John Hospital and Medical CenterDetroitMI 48236United States Surveillance and Infectious Disease Epidemiology Section Michigan Department of Health and Human ServicesLansingMI 48933United States Department of Obstetrics and Gynecology Wayne State University School of MedicineKarmanos Cancer InstituteDetroitMI 48201United States Female Pelvic Medicine and Reconstructive Surgery Ascension St.John HospitalDetroitMI 48236United States Department of Gynecologic Oncology Wayne State UniversityDetroitMI 48202United States

BACKGROUND It has been theorized that 75%-80%of febrile neutropenia(FN)is caused by endogenous pathogens,while up to 20%of cases are thought to be caused by a viral *** is unknown if precautions such as masking and social distancing reduce the risk of FN in susceptible *** To determine whether coronavirus disease 2019(COVID-19)infection mitigation efforts,namely masking and social distancing,were associated with a reduction in the incidence of *** This was a retrospective population based cohort study comparing the incidence of FN in the 13 mo prior to(Year 0)and 13 mo following(Year 1)the public health executive orders(PHEO)in *** was queried for all emergency department(ED)visits from April 1,2019 to March 31,2021 from the National Syndromic Surveillance Program,a program which collects data that is voluntarily submitted by approximately 89%of Michigan *** primary study outcome was the incidence of FN as a proportion of ED visits in the 13-mo before and 13-mo after COVID-19 mitigations efforts,namely masking and social *** hypothesized that there would be a significant decrease in the incidence of FN in the period following the PHEO aimed at reducing the spread of the severe acute respiratory syndrome coronavirus 2 *** There was a total of 8979221 total ED visits captured during the study *** Year 0 there were 5073081 recorded ED visits and 3906140 in Year *** was a significant reduction in the proportion of total ED visits with a diagnosis of FN,decreasing 13.3%across periods(0.15%vs 0.13%,P=0.036).In patients with a hematologic malignancy a more impressive reduction in the incidence of FN was evident following PHEO(22%vs 17%,P=0.02).CONCLUSION We found a significant association between social distancing and mask guidelines implemented on a large public scale with decreased rates of FN,particularly in those with a hematologic *** findings may be useful in the design of future res

关键词： Febrile neutropenia COVID-19 SARS-CoV-2 Malignancy Hematology Public health

EGFR signaling promotes resistance to CHK1 inhibitor prexasertib in triple negative breast cancer

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Cancer Drug Resistance 2020年第4期3卷 980-991页

作者： Kevin J.Lee Griffin Wright Hannah Bryant leigh ann Wiggins Michele Schuler Natalie R.Gassman Department of Physiology and Cell Biology University of South Alabama College of MedicineMobileAL 36688USA Mitchell Cancer Institute University of South AlabamaMobileAL 36604USA Department of Comparative Medicine University of South Alabama College of MedicineMobileAL 36688USA Department of Microbiology and Immunology University of South Alabama College of MedicineMobileAL 36688USA

Aim:Innate resistance to the CHK1 inhibitor prexasertib has been described,but resistance mechanisms are not *** aimed to determine the role epidermal growth factor receptor(EGFR)plays in innate resistance to prexasertib in triple negative breast cancer(TNBC).Methods:Using a panel of pre-clinical TNBC cell lines,we measured the sensitivity to *** examined the effect activation of EGFR had on prexasertib *** measured the synergy of dual blockade of EGFR with erlotinib and CHK1 with prexasertib in TNBC cell lines and ***:EGFR overexpression and activation increased resistance to CHK1 inhibition by *** promoted the phosphorylation of BCL2-associated agonist of cell death(BAD),inactivating its pro-apoptotic *** of EGFR reversed BAD phosphorylation,increasing sensitivity to ***:The use of prexasertib as a monotherapy in TNBC has been limited due to modest clinical *** demonstrated that EGFR activation contributes to innate resistance to prexasertib in TNBC and potentially other *** expression status should be considered in clinical trials examining prexasertib’s use as a monotherapy or combination therapy.

关键词： Triple negative breast cancer CHK1 replication apoptosis drug resistance epidermal growth factor receptor mitogenic signaling

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圣石乌卢鲁

英语教师 2007年第1期7卷 34-35页

作者： leigh ann Henion 西贝

审视着小路陡峭斜坡,我的手掌开始出汗。澳大利亚埃尔斯岩光滑砂岩上的隆起地带安装上了金属支柱,狭窄的通道上配备了粗壮的链子。然而我对攀登仍然有所顾虑。土著人从来不攀登这块被称作乌卢鲁的岩石,因为他们认为它是神圣通道的一部分... 详细信息

审视着小路陡峭斜坡,我的手掌开始出汗。澳大利亚埃尔斯岩光滑砂岩上的隆起地带安装上了金属支柱,狭窄的通道上配备了粗壮的链子。然而我对攀登仍然有所顾虑。土著人从来不攀登这块被称作乌卢鲁的岩石,因为他们认为它是神圣通道的一部分,当地球形成时他们的祖先通过它来到这里。他们不攀登这块岩石是出于对那些早逝祖先的尊重,并且他们要求游客也尽量克制自己,不要去攀登。

关键词：澳大利亚金属支柱土著人岩石通道祖先斜坡砂岩审视隆起

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离婚稀释亲情

英语学习 2013年第9期 33-35页

作者： leigh-ann Smith 漪然(选) 乔敏(注)

小时候过生日，派对不止一个，说起来很酷，事实却很无奈。父母离异后，我小心翼翼地游走在两个家庭之间，这注定了我在任何一个家庭中都只是局外人。十岁时，我厌倦了不同的卧室、不同的衣服，不同的玩具，不同的朋友和不同的规矩，于... 详细信息

小时候过生日，派对不止一个，说起来很酷，事实却很无奈。父母离异后，我小心翼翼地游走在两个家庭之间，这注定了我在任何一个家庭中都只是局外人。十岁时，我厌倦了不同的卧室、不同的衣服，不同的玩具，不同的朋友和不同的规矩，于是提出要停止这种生活。若干年后，于四个不同的家庭而言，我依然是局外人。

关键词：亲情稀释离婚父母离异局外人家庭厌倦朋友

消失中的语言一项新录音计划,旨在拯救濒危语言

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空中英语教室（高级版．彭蒙惠英语） 2019年第3期 24-25,44页

作者： ann M. simmons Tribune Content Agency, LLC. OLIVE CHU(PAGE DESIGN) 徐佩仪(译) 不详

如联合国教科文组织所言:“每一种语言都能反映出一种独特的世界观,有自己的价值体系、哲学观,还有独特的文化特色。”

关键词：语言联合国教科文组织录音濒危价值体系文化特色世界观哲学观

Early-diverging fungal phyla:taxonomy,species concept,ecology,distribution,anthropogenic impact,and novel phylogenetic proposals

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Fungal Diversity 2021年第4期109卷 59-98页

作者： Kerstin Voigt Timothy Y.James Paul M.Kirk AndréL.C.M.de A.Santiago Bruce Waldman Gareth W.Griffith Minjie Fu Renate Radek Jürgen F.H.Strassert Christian Wurzbacher Gustavo Henrique Jerônimo David R.simmons Kensuke Seto Eleni Gentekaki Vedprakash G.Hurdeal Kevin D.Hyde Thuong T.T.Nguyen Hyang Burm Lee Jena Microbial Resource Collection Leibniz Institute for Natural Product Research and Infection BiologyAdolf-Reichwein-Straße 2307745 JenaGermany Institute of Microbiology Faculty of Biological SciencesFriedrich Schiller University JenaNeugasse 2507743 JenaGermany Department of Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA Biodiversity Informatics and Spatial Analysis Jodrell LaboratoryRoyal Botanic Gardens KewSurrey TW93DSUK Department of Mycology Federal University of PernambucoAv.Da Engenharias/nRecifePE 50740-4600Brazil School of Biological Sciences Seoul National UniversitySeoul 08826South Korea Department of Integrative Biology Oklahoma State UniversityStillwaterOK 74078USA Institute of Biological Environmentaland Rural Sciences(IBERS)Aberystwyth UniversityAberystwyth SY233DDWalesUK Institute of Biology/Zoology Evolutionary BiologyFreie Universität Berlin14195 BerlinGermany Leibniz Institute of Freshwater Ecology and Inland Fisheries Ecosystem Research12587 BerlinGermany Department of Civil Geo and Environmental EngineeringTechnical University of MunichGarchingGermany School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Environmental Microbiology Lab Department of Agricultural Biological ChemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186South Korea

The increasing number of new fungal species described from all over the world along with the use of genetics to define taxa,has dramatically changed the classification system of early-diverging fungi over the past several *** number of phyla established for non-Dikarya fungi has increased from 2 to ***,to date,both the classification and phylogeny of the basal fungi are still *** this article,we review the recent taxonomy of the basal fungi and re-evaluate the relationships among early-diverging lineages of fungal *** also provide information on the ecology and distribu-tion in Mucoromycota and highlight the impact of chytrids on amphibian *** concepts in Chytridiomycota,Aphelidiomycota,Rozellomycota,Neocallimastigomycota are discussed in this *** preserve the current application of the genus Nephridiophaga(Chytridiomycota:Nephridiophagales),a new type species,Nephridiophaga blattellae,is proposed.

关键词： Early-diverging fungi Evolution Nuclear large subunit(LSU/28S) Nuclear small subunit(SSU/18S) Molecular phylogeny

论如何加强国际社会对大流行性传染病的防控能力——以推进健康权为视角

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中国卫生法制 2022年第2期30卷 80-88页

作者：雷·卡莫尔·海恩斯埃里克·弗里德曼亚当·贝尔彻徐靖仪(译) 路易斯·加尔沃美国西蒙斯大学公共卫生学系美国波士顿02115 美国奥尼尔全球及国家卫生法研究中心美国华盛顿20001 英国巴斯大学医学院英国巴斯BA27AY 美国乔治敦大学美国华盛顿20001 巴西费尔克鲁斯国际卫生中心巴西菲奥克鲁斯040360

由世界卫生组织举办的全球卫生大会(WHA)将于2021年11月29日至12月1日举行一次特别会议,会议旨在讨论由世卫组织负责起草关于全球大流行性传染病防控的国际条约及相关文书的好处和必要性。鉴于各国政府都在为该大会的召开做准备,日内瓦... 详细信息

由世界卫生组织举办的全球卫生大会(WHA)将于2021年11月29日至12月1日举行一次特别会议,会议旨在讨论由世卫组织负责起草关于全球大流行性传染病防控的国际条约及相关文书的好处和必要性。鉴于各国政府都在为该大会的召开做准备,日内瓦国际发展研究所下辖的全球健康中心组织了一系列由专家学者、政治家、外交家参与的研讨会,并出版了相对应的政策简报。本文是一篇交予2021年世界卫生大会(WHA)的政策简报,探讨了世卫组织正在起草的全球大流行性传染病防控条约。英文原文由全球卫生联盟(the Framework Convention on Global Health Alliance);和日内瓦国际发展研究所下辖的全球健康中心(Global Health Centre at the Graduate Institute of International and Development Studies,Geneva);负责刊登;。中文译文许会导致细微变化,一切以英文原文作为权威版本。

关键词：全球大流行传染病防控政策