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Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer

World Journal of Gastrointestinal Oncology 2024年第2期16卷 314-330页

作者： lei zheng Jia Lu Da-Lu Kong Department of Colorectal Cancer Surgery National Clinical Research Center for CancerKey Laboratory of Cancer Immunology and Biotherapy of TianjinTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Infection Management National Clinical Research Center for CancerKey Laboratory of Cancer Immunology and Biotherapy of TianjinTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300060China

BACKGROUND Cyclin-dependent kinase 9(CDK9)expression and autophagy in colorectal cancer(CRC)tissues has not been widely ***9,a key regulator of transcription,may influence the occurrence and progression of *** expression of auto-phagy-related genes BECN1 and drug resistance factor ABCG2 may also play a role in *** normal physiological conditions,autophagy can inhibit tumorigenesis,but once a tumor forms,autophagy may promote tumor ***,understanding the relationship between autophagy and cancer,partic-ularly how autophagy promotes tumor growth after its formation,is a key motivation for this *** To investigate the relationship between CDK9 expression and autophagy in CRC,assess differences in autophagy between left and right colon cancer,and analyze the associations of autophagy-related genes with clinical features and *** We collected tumor tissues and paracarcinoma tissues from colon cancer patients with liver metastasis to observe the level of autophagy in tissues with high levels of CDK9 and low levels of *** also collected primary tissue from left and right colon cancer patients with liver metastasis to compare the autophagy levels and the expression of BECN1 and ABCG2 in the tumor and paracarcinoma *** The incidence of autophagy and the expression of BECN1 and ABCG2 were different in left and right colon cancer,and autophagy might be involved in the occurrence of chemotherapy *** analysis of the rela-tionship between the expression of autophagy-related genes CDK9,ABCG2,and BECN1 and the clinical features and prognosis of colorectal cancer showed that the high expression of CDK9 indicated a poor prognosis in colorectal *** This study laid the foundation for further research on the combination of CDK9 inhibitors and autophagy inhibitors in the treatment of patients with CRC.

关键词： Autophagy Tumorigenesis Tumor tissue Paracarcinoma tissue Expression Left/right colon cancer

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Using NH_(2)-MIL-125(Ti)for efficient removal of Cr(Ⅵ)and Rh B from aqueous solutions:Competitive and cooperative behavior in the binary system

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Journal of Environmental Sciences 2024年第2期136卷 437-450页

作者： lei zheng Lixia Sun Jiangbo Qiu Junling Song Luyi Zou Yue Teng Yongzhong Zong Hongyan Yu School of Environmental and Civil Engineering Jiangnan UniversityWuxi 214122China School of Chemical and Material Engineering Jiangnan UniversityWuxi 214122China Kunming South Water Co. Ltd.Kunming 650501China Jiangsu Key Laboratory of Anaerobic Biotechnology Jiangnan UniversityWuxi 214122China

The coexistence of inorganic and organic contaminants is a challenge for real-life water treatment ***,in this research,we used NH_2-MIL-125(Ti)to evaluate the single adsorption of hexavalent chromium(Cr(Ⅵ))or Rhodamine B(RhB)in an aqueous solution and further investigate simultaneous adsorption experiments to compare the adsorption behavior *** main influencing factors,for example,reaction time,initial concentration,reaction temperature,and pH were studied in *** all reaction systems,the pseudo-second-order kinetic and Langmuir isotherm models were well illuminated the adsorption progress of Cr(Ⅵ)and *** studies showed that the adsorption process was spontaneous and *** compared to the single system,the adsorption capacity of Cr(Ⅵ)in the binary system gradually decreased as the additive amount of RhB increased,whereas the adsorption capacity of RhB in the binary system was expanded *** the binary reaction system contained 100 mg/L Cr(Ⅵ),the removal rate of RhB increased to 97.58%.The formation of Cr(Ⅵ)-RhB and Cr(Ⅲ)-RhB complexes was the cause that provided facilitation for the adsorption of *** findings prove that the interactions during the water treatment process between contaminants may obtain additional benefits,contributing to a better adsorption capacity of co-existing contaminant.

关键词： Adsorption Heavy metal ion Organic dye Simultaneous removal Mechanism studies

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Comparison of bulk snow density measurements using different methods

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Advances in Climate Change Research 2024年第4期15卷 658-668页

作者： Hang SU Xin-Yue ZHONG Bin CAO Yuan-Tao HU lei zheng Tingjun ZHANG State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China Key Laboratory of Remote Sensing of Gansu Province Heihe Remote Sensing Experimental Research StationNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesNational Tibetan Plateau Data CenterInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Climate Centre of Shaanxi Province Xi'an71000China School of Geospatial Engineering and Science Sun Yat-sen University and Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Westem China's Environmental Systems(Ministry of Education).College of Earth and Environmental Sciences Lanzhou Universiny Lanzhou 730000China

Snow density is one of the basic properties used to describe snow cover characteristics,and it is critical for remote sensing retrieval,water resources assessment and modeling *** are many instruments available to measure snow density in ***,there are mea-surement errors of snow density for bulk and layers or gravimetric and electronic instruments,which may affect the accuracy of remote sensing retrieval and model *** in China,due to the noticeable heterogeneity of snowpacks,it is necessary to evaluate in detail the performance and applicability of snow density instruments in different snowpack *** study evaluated the performance of different snow density instruments:the Federal Sampler,the model VS-43 snow density cylinder(VS-43),the wedge snow density cutter(WC1000 and WC25O),and the Snow *** average bulk snow density of all instrument measurements was set as the reference value for *** results showed that as compared with the reference,the VS-43 cylinder presented the best performance for bulk snow density measurement in the measured range with the lowest RMSE(11 kg m-3),BIAS(3 kg m-3),and MRE(1.6%).For layer observation,bulk snow density was overestimated by 8.1%with WC1000 and underestimated by 11.4%with Snow Fork which was the worst performance compared with the reference value,and there were greater measurement errors of snow density in the depth hoar than other snow *** with grassland,the uncertainty of snow density measurements was slightly lower in ***,the Federal Sampler and VS-43 cylinder are more suitable for bulk snow density measurement in deep snowpack regions across China,and it is recommended to use WC1000,WC250 and Snow Fork to measure the snow density of snow layers in the snow stratigraphy.

关键词： Snowdensity Measurement Uncertainty comparison

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Recent advances in cancer-associated fibroblast:Biomarkers,signaling pathways,and therapeutic opportunities

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Chinese Medical Journal 2024年第6期137卷 638-650页

作者： Donger Zhou lei zheng Department of Hepatobiliary-Pancreatic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Sidney Kimmel Comprehensive Cancer Center The Skip Viragh Pancreatic Cancer Center for Clinical Research and Careand The Bloomberg-Kimmel Institute for Immunotherapy at Johns Hopkins University School of MedicineBaltimoreMD 21287USA

Anti-cancer therapies usually focus on tumor cells,but non-tumor stromal components in the tumor microenvironment also play vital roles in tumor initiation and progression,which may be the prognostic factors and potential therapeutic ***-associated fibroblasts(CAFs)are the essential component in the tumor environment,exhibiting high heterogeneity in their cell origin and phenotype with diverse functions that influence tumor angiogenesis,immune systems,and ***-cell RNA sequencing and genetically engineered mouse models have increased our understanding of CAF diversity,and many subtypes have been ***,the precise functions of these subtypes need to be studied and *** of signaling pathways and epigenetic changes in CAFs facilitate understanding of the phenotypes of CAFs and the crosstalk between tumor cells and CAFs to provide potential therapeutic *** clinical trials,including phase III trials targeting CAFs,have been performed ***,few of these trials have generated promising results,which indicates that the complexity of CAFs in the tumor microenvironment remains largely unknown,and in-depth investigations of CAFs should be *** review summarizes the research on CAFs,focusing on the heterogeneity of their phenotypes and functions,specific signaling pathways,and the therapeutic strategies involving ***,we briefly discuss the current technologies commonly used in CAF studies and describe the challenges and future perspectives of CAF research.

关键词： Cancer-associated fibroblasts Tumor microenvironment Anti-cancer therapy Targeted therapy

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Tackling application limitations of high-safetyγ-butyrolactone electrolytes:Exploring mechanisms and proposing solutions

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Journal of Energy Chemistry 2024年第6期93卷 193-201,I0005页

作者： Haojun Wu Zhangyating Xie Guanjie Li lei zheng Zhiwei Zhao Jiarong He Yanbin Shen Jiahao Hu Zhangquan Peng Guiming Zhong Lidan Xing Weishan Li School of Chemistry South China Normal UniversityGuangzhou 510006GuangdongChina National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES(Ministry of Education)Research Center of BMET(Guangdong Province)and Key Lab.of ETESPG(GHEI)South China Normal UniversityGuangzhou 510006GuangdongChina Laboratory of Advanced Spectroelectrochemistry and Li-ion Batteries Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina i-Lab CAS Center for Excellence in NanoscienceSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123JiangsuChina School of Chemical Engineering Faculty of SciencesEngineering and TechnologyThe University of AdelaideSA 5005Australia

Developing wide-temperature and high-safety lithium-ion batteries(LIBs)presents significant challenges attributed to the absence of suitable solvents possessing broad liquid range and non-flammability properties.γ-Butyrolactone(GBL)has emerged as a promising solvent;however,its incompatibility with graphite anode has hindered its *** limitation necessitates a comprehensive investigation into the underlying mechanisms and potential *** this study,we achieve a molecular-level understanding of the perplexing interphase formation process by employing in-situ spectroelectrochemical techniques and density function *** findings reveal that,even at high salt concentrations,GBL consistently occupies the primary Li^(+)solvation sheath,leading to extensive GBL decomposition and the formation of a high-impedance and inorganic-poor solid-electrolyte interphase(SEI)*** to manipulating solvation structures,our research demonstrates that the utilization of filmforming additives with higher reduction potential facilitates the pre-establishment of a robust SEI film on the graphite *** approach effectively inhibits GBL decomposition and significantly enhances the battery's *** study provides the first reported intrinsic understanding of the unique GBLgraphite incompatibility and offers valuable insights for the development of wide-temperature and high-safety LIBs.

关键词： γ-Butyrolactone/Graphite incompatibility Unique solvation structure SEI film Lithium-ion batteries

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打通数据“宝瓶口”:公共数据资源供给的路径和目的

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图书情报知识 2024年第2期41卷 23-27页

作者：郑磊复旦大学国际关系与公共事务学院数字与移动治理实验室上海200433

公共数据只有在市场和社会上得到充分供给和高效利用,才能最大程度地释放出其价值红利。本文基于实地调研对公共数据资源的供给路径和目的进行了初步探讨。在供给路径上,公共数据开放和授权运营两种公共数据供给方式各有其适用的数据类... 详细信息

公共数据只有在市场和社会上得到充分供给和高效利用,才能最大程度地释放出其价值红利。本文基于实地调研对公共数据资源的供给路径和目的进行了初步探讨。在供给路径上,公共数据开放和授权运营两种公共数据供给方式各有其适用的数据类型和利用场景,需要协同推进,发挥各自所长,而不应相互取代或挤压空间。在供给目的上,应着力使公共数据尽最大可能赋能于市场和社会,创造出更全面和长远的价值,而不应只着眼于公共数据在短期内和局部范围内实现了多少利益“变现”。

关键词：公共数据供给数据开放授权运营

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Drainage of ascites in cirrhosis

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World Journal of Hepatology 2024年第9期16卷 1245-1257页

作者： Jia-Xing Yang Yue-Ming Peng Hao-Tian Zeng Xi-Min Lin zheng-lei Xu Department of Gastroenterology The Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina Department of Nursing Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina Department of Gastroenterology Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina

For cirrhotic refractory ascites,diuretics combined with albumin and vasoactive drugs are the first-line choice for ascites ***,their therapeutic effects are limited,and most refractory ascites do not respond to medication treat-ment,necessitating consideration of drainage or surgical ***-sequently,numerous drainage methods for cirrhotic ascites have emerged,including large-volume paracentesis,transjugular intrahepatic portosystemic shunt,peritoneovenous shunt,automated low-flow ascites pump,cell-free and concentrated ascites reinfusion therapy,and peritoneal catheter *** review introduces the advantages and disadvantages of these methods in different aspects,as well as indications and contraindications for this disease.

关键词： Liver cirrhosis ascites Large-volume paracentesis Transjugular intrahepatic portosystemic shunt Peritoneovenous shunt Automated low-flow ascites pump Cell-free and concentrated ascites reinfusion therapy Peritoneal catheter drainage

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Hepatic arterial infusion chemotherapy with anti-angiogenesis agents and immune checkpoint inhibitors for unresectable hepatocellular carcinoma and meta-analysis

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World Journal of Gastroenterology 2024年第4期30卷 318-331页

作者： Yu-Zhe Cao Guang-lei zheng Tian-Qi Zhang Hong-Yan Shao Jia-Yu Pan Zi-Lin Huang Meng-Xuan Zuo Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy State Key Laboratory of Oncology in South ChinaGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy Guangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatic arterial infusion chemotherapy(HAIC)has been proven to be an ideal choice for treating unresectable hepatocellular carcinoma(uHCC).HAIC-based treatment showed great potential for treating ***,large-scale studies on HAIC-based treatments and meta-analyses of first-line treatments for uHCC are *** To investigate better first-line treatment options for uHCC and to assess the safety and efficacy of HAIC combined with angiogenesis inhibitors,programmed cell death of protein 1(PD-1)and its ligand(PD-L1)blockers(triple therapy)under real-world *** Several electronic databases were searched to identify eligible randomized controlled trials for this ***-level pooled analyses of hazard ratios(HRs)and odds ratios(ORs)were *** was a retrospective single-center study involving 442 patients with uHCC who received triple therapy or angiogenesis inhibitors plus PD-1/PD-L1 blockades(AIPB)at Sun Yat-sen University Cancer Center from January 2018 to April *** score matching(PSM)was performed to balance the bias between the *** Kaplan-Meier method and cox regression were used to analyse the survival data,and the log-rank test was used to compare the suvival time between the *** A total of 13 randomized controlled trials were *** alone and in combination with sorafenib were found to be effective treatments(P values for ORs:HAIC,0.95;for HRs:HAIC+sorafenib,0.04).After PSM,176 HCC patients were included in the *** triple therapy group(n=88)had a longer median overall survival than the AIPB group(n=88)(31.6 months vs 14.6 months,P<0.001)and a greater incidence of adverse events(94.3%vs 75.4%,P<0.001).CONCLUSION This meta-analysis suggests that HAIC-based treatments are likely to be the best choice for *** findings confirm that triple therapy is more effective for uHCC patients than AIPB.

关键词： Unresectable hepatocellular carcinoma Hepatic arterial infusion chemotherapy Angiogenesis inhibitors Programmed cell death protein 1 Programmed death ligand 1

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Assessing and Improving the Quality of Undergraduates in Preschool Education Programs in China:The Course Experience

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教育技术与创新 2024年第3期6卷 31-46页

作者： Linxi Zhang lei zheng Ying Zhou School of Educational Sciences Kaili UniversityChina Business School Nankai UniversityTianjingChina Institute of IR4.0 Universiti Kebangsaan MalaysiaMalaysia

This study investigated the current status of course satisfaction among 416 undergraduate students majoring in preschool education from four universities in *** it explored the predictive effects of five influencing factors(teacher instruction,course management,course setting,course environment,and course resources)on student *** SPSS data analysis,the findings revealed that:*** mean value of course experience was M=3.861(out of 5);*** were differences in the satisfaction of undergraduate students'course experience by different background variables;***,course resources,and loyalty had significant predictive power on undergraduate students'satisfaction with course experience;*** instruction(TI)did not significantly predict students'satisfaction with course experience(SCES)(p>0.001);*** instruction(TI)in this study had the highest mean satisfaction score(M=4.191)and the mean satisfaction score was only(M=3.861).The results show that the current status of course satisfaction among Chinese preschool undergraduates is at an moderate level,and there is more space for improvement;although students'satisfaction with teacher instruction(TI)is high,effective teacher instruction does not have a substantial impact on the acquisition of SCES or general competencies,and this passive learning and teaching style leads to a lack of independent learning and active participation among Chinese preschool undergraduate students.

关键词： Higher education Preschool education program Satisfaction Course experience

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备案审查联合审查方式探究:从实践渊源和生成逻辑探索结构属性

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浙江社会科学 2024年第8期 63-74,157页

作者：郑磊浙江大学光华法学院杭州310008

联合审查,是《备案审查决定》新确立的第五类审查方式。借鉴其他职权行使中采行联合审查的实践素材,正好可回应已有四类审查方式的功能空缺,基于此实践渊源和生成逻辑,联合审查在整个审查方式体系中呈现出其结构属性:其实质在审查职权... 详细信息

联合审查,是《备案审查决定》新确立的第五类审查方式。借鉴其他职权行使中采行联合审查的实践素材,正好可回应已有四类审查方式的功能空缺,基于此实践渊源和生成逻辑,联合审查在整个审查方式体系中呈现出其结构属性:其实质在审查职权的联合,不同于作为工作机制的联合审查会议;其途径在关联审查对象,有限依托于人大主导;其功能特点在提高审查质效,目标重点在保障审查效力和实效,而核心关键在协同审查基准。这一方面为进一步论证建构联合审查的重点机制提供了规范原理基础,另一方面,诸如联合审查等“探索”型条款,引入了“完善和加强”备案审查制度的又一种重要的制度化路径,而且,在规范基础上建构规范机制、生成规范内涵,拓展了备案审查释义学的用武之地。

关键词：备案审查审查方式联合审查人大主导移送审查审查基准

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