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Ambient Air Particulate Matter and Hospital Admissions for Chronic Kidney Disease in china:A Nationwide Case-Crossover Study

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Environment & Health 2024年第8期2卷 553-562页

作者： Juan Chen Huimeng Liu Ge Li Lijun Bai Yunxing jiang Jinxi Wang Chen Wei Yinxiang Li Jian lei Furong Deng Luxia Zhang Xinbiao Guo Shaowei Wu Department of Occupational and Environmental Health School of Public HealthXi’an Jiaotong University Health Science CenterXi’anShaanxi 710061China Key Laboratory of Environment and Genes Related to Diseases Ministry of EducationXi’anShaanxi 710061China Key Laboratory of Trace Elements and Endemic Diseases in Ministry of Health Xi’anShaanxi 710061China Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province Xi’anShaanxi 710061China Shaanxi Provincial institute for Endemic Disease Control Xi’anShaanxi 710003China Yunyi Health Technology Co.Ltd. Beijing 102629China china-Europe Association for Technical and Economic Cooperation Beijing 101318China Renal Division Department of MedicinePeking University First HospitalPeking University Institute of NephrologyBeijing 100034China Advanced institute of Information Technology Peking UniversityHangzhou 311200China National institutes of Health Data Science at Peking University Beijing 100191China

Incident chronic kidney disease(CKD)may be accelerated(could be indicated by repeated admissions to the hospital)by environmental triggers such as ambient particulate matter(PM).Additionally,hospital admission is a sensitive proxy reflecting the disease ***,the association of PM exposure with hospital admissions for CKD is still unknown,let alone the excess risks(ERs)in hospital admissions for CKD due to high PM level *** this study,a two-stage time-stratified case-crossover study was conducted to investigate the association of ambient air PM exposure with hospital admission for CKD in 282 chinese cities of prefecture-level or above during 2013–***-specific associations of single and cumulative 0–3 days lagged exposure to fine particulate matter(PM_(2.5))and inhalable particles(PM_(10))with hospital admissions for total CKD and its subtypes were evaluated by the conditional logistic regression model,then were pooled using the random-effect model.A total of 3,490,416 hospital admissions for CKD were *** found that per interquartile range(IQR)increment in PM_(2.5) at lag02 and per IQR increment in PM_(10) at lag03 were associated with increases of 2.36%(95%CI:1.58%,3.14%)and 2.87%(95%CI:1.91%,3.85%)in hospital admissions for total CKD,*** to control concentrations(PM_(2.5):35μg/m^(3);PM_(10):50μg/m^(3)),the largest ERs in hospital admissions for total CKD were 2.63%(95%CI:2.15%–3.11%)and 4.45%(95%CI:3.85%–5.06%)in association with exposure to heavily excessive PM_(2.5)(≥75μg/m^(3))and PM_(10)(≥150μg/m^(3)),***,the attributable fractions(AFs)for CKD admissions were 2.83%for PM_(2.5) and 3.46%for PM_(10) during the study *** findings suggested that exposure to PM_(2.5) and PM_(10) is associated with substantially increased risk and burden of CKD admissions.

关键词： particulate matter hospital admission chronic kidney disease excess risks case-crossover

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面向精细抓取的刚软耦合仿人手作用力优化

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华中科技大学学报（自然科学版） 2024年第5期52卷 144-149页

作者：李泳耀江磊杜宇丛明中国北方车辆研究所无人中心北京100072 群体协同与自主实验室北京100072 大连交通大学机械工程学院辽宁大连116028 大连理工大学机械工程学院辽宁大连116024

针对精细抓取模式下刚软耦合仿人手柔顺接触的特点,为使其具备类人手的抓取作用力施加能力,首先建立仿人手的抓取力平衡方程和约束优化函数,进而提出基于外罚函数的手指最小作用力优化方法.仿人手可通过施加合适的力实现对不同物体的稳... 详细信息

针对精细抓取模式下刚软耦合仿人手柔顺接触的特点,为使其具备类人手的抓取作用力施加能力,首先建立仿人手的抓取力平衡方程和约束优化函数,进而提出基于外罚函数的手指最小作用力优化方法.仿人手可通过施加合适的力实现对不同物体的稳定抓取,有效避免手指在抓取过程中使物体产生大变形或抓取失败.实验结果表明:每个手指作用力的测量平均值与理论计算值的绝对误差基本处于0~0.14 N范围,相对误差为0~18.57%范围,所提方法满足了刚软耦合仿人手在精细抓取模式下稳定可靠地抓取不同物体的需求.

关键词：仿人手刚软耦合精细抓取柔顺接触手指作用力优化

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Designing salt stress-resilient crops:Current progress and future challenges

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Journal of Integrative Plant Biology 2024年第3期66卷 303-329页

作者： Xiaoyan Liang Jianfang Li Yongqing Yang Caifu jiang Yan Guo State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100094China State Key Laboratory of Nutrient Use and Management College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100194China center for Crop Functional Genomics and molecular Breeding China Agricultural UniversityBeijing 100094China Frontiers Science center for molecular Design Breeding China Agricultural UniversityBeijing 100193China

Excess soil salinity affects large regions of land and is a major hindrance to crop production ***,understanding the molecular mechanisms of plant salt tolerance has scientific importance and practical *** recent decades,studies have characterized hundreds of genes associated with plant responses to salt stress in different plant *** studies have substantially advanced our molecular and genetic understanding of salt tolerance in plants and have introduced an era of molecular design breeding of salt-tolerant *** review summarizes our current knowledge of plant salt tolerance,emphasizing advances in elucidating the molecular mechanisms of osmotic stress tolerance,salt-ion transport and compartmentalization,oxidative stress tolerance,alkaline stress tolerance,and the trade-off between growth and salt *** also examine recent advances in understanding natural variation in the salt tolerance of crops and discuss possible strategies and challenges for designing salt stress-resilient *** focus on the model plant Arabidopsis(Arabidopsis thaliana)and the four most-studied crops:rice(Oryza sativa),wheat(Triticum aestivum),maize(Zea mays),and soybean(Glycine max).

关键词： molecular design breeding salt stress-resilient crop salt tolerance

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Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy

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Science china(Life sciences) 2024年第8期67卷 1676-1696页

作者： Xupeng Zang Shengchen Gu Wenjing Wang Junsong Shi Jianyu Gan Qun Hu Chen Zhou Yue Ding Yanjuan He lei jiang Ting Gu Zheng Xu Sixiu Huang Huaqiang Yang Fanming Meng Zicong Li Gengyuan Cai Linjun Hong Zhenfang Wu State Key Laboratory of Swine and Poultry Breeding Industry National Engineering Research Center for Breeding Swine IndustryCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Agro-Animal Genomics and molecular Breeding South China Agricultural UniversityGuangzhou 510642China Yunfu Subcenter of Guangdong Laboratory for Lingnan Modern Agriculture Yunfu 527300China Guangdong Key Laboratory of Animal Breeding and Nutrition Institute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640China Key Laboratory of South china Modern Biological Seed Industry Ministry of Agriculture and Rural AffairsGuangzhou 510520China

Dynamic crosstalk between the embryo and mother is crucial during ***,we comprehensively profile the single-cell transcriptome of pig peri-implantation embryos and corresponding maternal endometrium,identifying 4 different lineages in embryos and 13 cell types in the ***-specific gene expression characterizes 4 distinct trophectoderm subpopulations,showing development from undifferentiated trophectoderm to polar and mural *** expression of genes in different types of endometrial cells illustrates their molecular response to embryos during ***,we developed a novel tool,ExtraCellTalk,generating an overall dynamic map of maternal-foetal crosstalk using uterine luminal proteins as *** cross-species comparisons,we identified a conserved RBP4/STRA6 pathway in which embryonic-derived RBP4 could target the STRA6 receptor on stromal cells to regulate the interaction with other endometrial *** results provide insight into the maternal-foetal crosstalk during embryo implantation and represent a valuable resource for further studies to improve embryo implantation.

关键词： endometrial remodeling ExtraCellTalk implantation maternal-foetal crosstalk trophoblast

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Influence of expressed TRAIL on biophysical properties of the human leukemic cell line Jurkat

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Cell Research 2004年第2期14卷 161-168页

作者： Kai CHEN~(1,*), Dan LI~(1,*), Yu Hui jiang~1, Wei Juan YAO~1, Xin Juan WANG~2, Xiao Chao WEI~2, Jing GAO~3, Li De XIE~1, Zong Yi YAN~4, Zong Yao WEN~(1**), Shu CHIEN~5 ~1Hemorheology center, Department of Biophysics, School of Basic Medical sciences, Peking University, beijing, 100083, china. ~2Department of Biochemical and molecular Biology, School of Basic Medical sciences, Peking University, beijing, 100083, china. ~3Department of Urology, Medical center, New York University, USA. ~4Department of Mechanics and Engineering Science, Peking University, beijing 100871, china. ~5Department of Bioengineering and Whitaker institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093-0412, USA Department of Biophysics Hemorheology Center School of Basic Medical Sciences Peking University Beijing China Department of Biochemical and molecular Biology School of Basic Medical Sciences Peking University Beijing China Department of Urology Medical Center New York University USA Department of Mechanics and Engineering Science Peking University Beijing China Department of Bioengineering and Whitaker institute of Biomedical Engineering University of California La Jolla USA

The cDNA fragment of human TRAIL (TNF-related apoptosis inducing ligand) was cloned into RevTet-On, a Tetregulated and high-level gene expression system. The gene expression system was constructed in a human leukemic cell line: Jurkat. By using RevTet-On TRAIL gene expression system in Jurkat as a cell model, we studied the influence of TRAIL gene on the changes of cellular apoptosis before and after the TRAIL gene expression, which was induced by adding tetracycline derivative doxycycline (Dox). The results indicated that the cellular apoptosis ratio was largely dependent on the TRAIL gene expression level. Moreover, it was found that the apoptosis-inducing TRAIL could cause significant changes in the biophysical properties of Jurkat cells. The cell surface charge density decreased, the membrane fluidity declined, the elastic coefficients K_I increased, and the proportion of α-helix in membrane protein secondary structure decreased. Thus, the apoptosis-inducing TRAIL gene caused significant changes on

关键词： TRAIL Tet gene expression system Jurkat apoptosis.

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Multiple-Photon Resonance Enabled Quantum Interference in Emission Spectroscopy of N2+

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Ultrafast Science 2024年第2期4卷 1-7页

作者： Xiang Zhang Qi Lu Yalei Zhu Jing Zhao Rostyslav Danylo Liang Xu Mingwei lei Hongbing jiang Chengyin Wu Zhedong Zhang Aurélien Houard Vladimir Tikhonchuk AndréMysyrowicz Qihuang Gong Songlin Zhuang Zengxiu Zhao Yi Liu Shanghai Key Lab of Modern Optical System University of Shanghai for Science and Technology.516Jungong Road200093 ShanghaiChina Department of Physics National University of Defense TechnologyChangsha 410073China Laboratoire d'Optique Appliquee ENSTA ParisEcole Polytechnique CNRSInstitut Polytechnique de Paris828 Boulevard des Marechaux91762 Palaiseau CedexFrance State Key Laboratory for Mesoscopic Physics School of PhysicsPeking UniversityBejing 100871China Department of Physics City University of Hong KongKowloonHong Kong SAR Centre Lasers Intenses et Applications University of Bordeaux-CNRS-CEA351 Cours de la Liberation33405 Talence Cedex France Extreme Light Infrastructure ERIC ELI Beamlines Facility25241 Doln BrezanyCzech Republic CAS center for Excellence in Ultra-intense Laser Science Shanghai 201800China

Quantum interference occurs frequently in the interaction of laser radiation with materials,leading to a series of fascinating effects such as lasing without inversion,electromagnetically induced transparency,Fano resonance,*** quantum interference effects are mostly enabled by single-photon resonance with transitions in the matter,regardless of how many optical frequencies are ***,we report on quantum interference driven by multiple photons in the emission spectroscopy of nitrogen ions that are resonantly pumped by ultrafast infrared laser *** the spectral domain,Fano resonance is observed in the emission spectrum,where a laser-assisted dynamic Stark effect creates the *** the time domain,the fast-evolving emission is measured,revealing the nature of free-induction decay arising from quantum radiation and molecular *** findings clarify the mechanism of coherent emission of nitrogen ions pumped with mid-infrared pump laser and are found to be *** present work opens a route to explore the important role of quantum interference during the interaction of intense laser pulses with materials near multiple photon resonance.

关键词： pumped pump Quantum

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Identification of propranolol and derivatives that are chemical inhibitors of phosphatidate phosphatase as potential broad-spectrum fungicides

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Plant Communications 2024年第1期5卷 215-230页

作者： Juan Zhao Yu Chen Zhifen Ding Yaru Zhou Ruiqing Bi Ziting Qin lei Yang Peng Sun Qiping Sun Guang Chen Daiyuan Sun Xianya jiang Lu Zheng Xiao-Lin Chen Hu Wan Guanghui Wang Qiang Li Huailong Teng Guotian Li National Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryHubei Key Laboratory of Plant PathologyThe Center of Crop NanobiotechnologyHuazhong Agricultural UniversityWuhan 430070China College of Science Huazhong Agricultural UniversityWuhan 430070China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant ProtectionNorthwest A&F UniversityYangling 712100China College of chemistry and Life sciences Sichuan Provincial Key Laboratory for Development and Utilization of Characteristic Horticultural Biological ResourcesChengdu Normal UniversityChengdu 611130China Yangjiang institute of Agricultural sciences Yangjiang 529500China

Plant diseases cause enormous economic losses in agriculture and threaten global food security,and application of agrochemicals is an important method of crop disease *** of disease-resis-tance mechanisms and synthesis of highly bioactive agrochemicals are thus important research ***,we show that propranolol,a phosphatidate phosphatase(Pah)inhibitor,effectively suppresses fungal growth,sporulation,sexual reproduction,and infection of diverse *** MoPah1 enzyme activity of the rice blast fungus Magnaporthe oryzae is inhibited by *** in lipid metabolism are associated with inhibited hyphal growth and appressorium formation caused by propranolol in *** inhibits a broad spectrum of 12 plant pathogens,effectively inhibiting infection of barley,wheat,maize,tomato,and *** improve antifungal capacity,we synthesized a series of propranolol derivatives,one of which shows a 16-fold increase in antifungal ability and binds directly to *** and its derivatives can also reduce the severity of rice blast and Fusarium head blight of wheat in *** together,our results demonstrate that propranolol suppresses fungal development and infection through mechanisms involved in lipid *** and its derivatives may therefore be promising candidates for fungicide development.

关键词： propranolol molecular design chemical modification virulence lipid metabolism Pyricularia oryzae

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A reference-grade genome of the xerophyte Ammopiptanthus mongolicus sheds light on its evolution history in legumes and droughttolerance mechanisms

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Plant Communications 2024年第7期5卷 157-177页

作者： lei Feng Fei Teng Na Li Jia-Cheng Zhang Bian-jiang Zhang Sau-Na Tsai Xiu-Le Yue Li-Fei Gu Guang-Hua Meng Tian-Quan Deng Suk-Wah Tong Chun-Ming Wang Yan Li Wei Shi Yong-Lun Zeng Yue-Ming jiang Weichang Yu Sai-Ming Ngai Li-Zhe An Hon-Ming Lam Jun-Xian He School of Life sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongSha TinNew TerritoriesHong KongChina Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life SciencesSouth China Normal UniversityGuangzhou 510631China BGI-Shenzhen Tech Co. Ltd.Beishan Industrial ZoneYantian DistrictShenzhen 518083China School of Life sciences and Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations Lanzhou UniversityLanzhou 730030China State Key Laboratory of Subtropical Silviculture Zhejiang Agriculture and Forestry UniversityHangzhou 311300China State Key Laboratory of Plant Diversity and Specialty Crops South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China Guangdong Provincial Key Laboratory of Applied Botany&Key Laboratory of South china Agricultural Plant molecular Analysis and Genetic Improvement South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China College of Life sciences and Oceanography Shenzhen UniversityShenzhen 518060China State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry UniversityBeijing 100083China

Plants that grow in extreme environments represent unique sources of stress-resistance genes and *** mongolicus(Leguminosae)is a xerophytic evergreen broadleaf shrub native to semi-arid and desert regions;however,its drought-tolerance mechanisms remain poorly ***,we report the assembly of a reference-grade genome for ***,describe its evolutionary history within the legume family,and examine its drought-tolerance *** assembled genome is 843.07 Mb in length,with 98.7%of the sequences successfully anchored to the nine chromosomes of *** genome is predicted to contain 47611 protein-coding genes,and 70.71%of the genome is composed of repetitive sequences;these are dominated by transposable elements,particularly longterminal-repeat *** analyses revealed two whole-genome duplication(WGD)events at 130 and 58 million years ago(mya)that are shared by the genus Ammopiptanthus and other legumes,but no species-specific WGDs were found within this *** genome reconstruction revealed that the *** genome has undergone fewer rearrangements than other genomes in the legume family,confirming its status as a"relict plant".Transcriptomic analyses demonstrated that genes involved in cuticular wax biosynthesis and transport are highly expressed,both under normal conditions and in response to polyethylene glycol-induced *** induction of genes related to ethylene biosynthesis and signaling was also observed in leaves under dehydration stress,suggesting that enhanced ethylene response and formation of thick waxy cuticles are two major mechanisms of drought tolerance in *** expression of AmERF2,an ethylene response factor unique to ***,can markedly increase the drought tolerance of transgenic Arabidopsis thaliana plants,demonstrating the potential for application of *** genes in crop improvement.

关键词： Ammopiptanthus mongolicus genome sequencing genome evolution drought tolerance cuticular wax ethylene

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Phase transition and chemical decomposition of liquid carbon dioxide and nitrogen mixture under extreme conditions

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chinese Physics B 2016年第2期25卷 312-319页

作者：姜晓旭陈冠宇李玉同程新路唐翠明 Institution of Atomic and molecular Physics Sichuan University beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Technology Development center Central Semiconductor Manufacturing Corporation Department of Physics and Mathematics Sichuan University of Science and Engineering

Thermodynamic and chemical properties of liquid carbon dioxide and nitrogen（CO_（2~–）N_2） mixture under the conditions of extremely high densities and temperatures are studied by using quantum molecular dynamic（QMD） simulations based on density functional theory including dispersion corrections（DFT-D）. We present equilibrium properties of liquid mixture for 112 separate density and temperature points, by selecting densities ranging from ρ = 1.80 g/cm^3 to 3.40 g/cm^3 and temperatures from T = 500 K to 8000 K. In the range of our study, the liquid CO_（2~–）N_2 mixture undergoes a continuous transition from molecular to atomic fluid state and liquid polymerization inferred from pair correlation functions（PCFs）and the distribution of various molecular components. The insulator–metal transition is demonstrated by means of the electronic density of states（DOS）.

关键词： liquid CO2-N2 mixture quantum molecular dynamic (QMD) simulations DFT-D phase transi- tion

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C_(Ar)-Br bond cleavage via cooperative EnT/NHC catalysis: mild access to indolines

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Science china chemistry 2024年第3期67卷 922-927页

作者： Yi-Xiong Dong Cao-Bo Li Ming-lei Jin Zhong-Hua Gao Song Ye beijing National Laboratory for molecular sciences CAS Key Laboratory of Molecular Recognition and FunctionCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of chinese academy of sciences Beijing 100049China

The cooperative visible-light mediated and NHC-catalyzed dearomative arylation-acylation of N-(2-bromobenzoyl)indoles with aldehydes was developed, affording the corresponding highly functionalized polycyclic indolines in moderate to good yields with exclusive diastereoselectivities. Mechanism investigations support the activation of CAr-Br bond via visible-light mediated energy transfer(EnT) and the following single-electron-transfer(SET) with Breslow intermediate under NHC catalysis to give key aryl radical and ketyl radical. This protocol demonstrates the cleavage of CAr-Br bond under mild cooperative EnT/NHC catalysis.

关键词： energy transfer N-heterocyclic carbenes photocatalysis aryl radicals indolines

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