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Chinese Journal of Chemistry 2024年第16期42卷 1839-1845页

作者： Chen-Xi Xia Xin-lei Sun Jinfeng Zhang Yue Ren yan Yu Kuai Wang ling-Guo Meng Key Laboratory of Green and Precise Synthetic Chemistry and Applications Ministry of Education/School of Chemistry and Materials ScienceHuaibeiNormal UniversityHuaibeiAnhui 235000China

Although various routes have been reported for haloazidation,unavoidable problems exist,such as environmentally unfriendly monomer halogen,the need for in situ generation of unstable halogen azides(XN3),applicability to one type of haloazidation and inability to precisely control ***,we developed a universal strategy for haloazidation of alkenes through controlling the reactivity of IBA-N_(3) by switching halogen salts,allowing for the synthesis of a diversity of halogen azide *** studies have shown that by tuning the reactivity of IBA-N_(3) via switching halogen salts,different intermediates can be controllably produced to achieve regioselectivityand chemoselectivity in thehaloazidationof alkenes.

关键词： Haloazidation Alkene IBA-N_(3) Halogen salts Difunctionalization Selectivity Radicals Synthetic methods

Effect of screening colonoscopy frequency on colorectal cancer mortality in patients with a family history of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 354-363页

作者： Li Zheng Bin Li ling lei Li-Jia Wang Zhi-Ping Zeng Jian-Dong yang Department of Gastroenterology The First Hospital of NanchangNanchang 330008Jiangxi ProvinceChina Department of General Surgery The First Hospital of NanchangNanchang 330008Jiangxi ProvinceChina

BACKGROUND Colorectal cancer is a common malignant tumor in China,and its incidence in the elderly is increasing *** bowel disease is a group of chronic non-specific intestinal inflammatory diseases,including ulcerative colitis and Crohn’s *** included the clinicopathological and follow-up data of patients with colorectal cancer who underwent laparoscopic colectomy or open colectomy at our Gastrointestinal Department between January 2019 and December *** indicators,oncological indicators,and survival rates were compared between the *** results of 104 patients who met the above criteria were extracted from the database(laparoscopic colectomy group=63,open colectomy group=41),and there were no statistically significant differences in the baseline data or follow-up time between the two *** Intraoperative blood loss,time to first ambulation,and time to first fluid intake were significantly lower in the laparoscopic colectomy group than in the open colectomy *** differences in overall mortality,tumor-related mortality,and recurrence rates between the two groups were not statistically significant,and survival analysis showed that the differences in the cumulative overall survival,tumor-related survival,and cumulative recurrence-free rates between the two groups were not statistically *** In elderly patients with colorectal cancer,laparoscopic colectomy has better short-term outcomes than open colectomy,and laparoscopic colectomy has superior long-term survival outcomes compared with open colectomy.

关键词： Colorectal cancer Laparoscopic surgery Open surgery Prognosis Laparoscopic colectomy Open colectomy

Breaking the efficiency limitations of dissipative Kerr solitons using nonlinear couplers

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 88-94页

作者： Ming Li Xiao-Xiao Xue yan-lei Zhang Xin-Biao Xu Chun-Hua Dong Guang-Can Guo Chang-ling Zou CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Centerfor Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Department of Electronic Engineering Beijing National Research Center for Information Science and TechnologyTsinghua University Beijing 100084China

Dissipative Kerr solitons(DKS) have long been suffering from poor power conversion efficiency when driven by continuous-wave lasers. By deriving the critical coupling condition of a multimode nonlinear optics system in a generalized theoretical framework,two efficiency limitations of the conventional pump method of DKS are revealed: the effective coupling rate is too small and is also power-dependent. A general approach is provided to resolve this challenge by introducing two types of nonlinear couplers to couple the soliton cavity and CW input through nonlinear processes. The collective coupler opens multiple coupling channels and the self-adaptive coupler builds a power-independent effective external coupling rate to the DKS for approaching the generalized critical coupling condition, which promises near-unity power conversion efficiencies. For instance, a conversion efficiency exceeding 90% is predicted for aluminum nitride microrings with a nonlinear coupler utilizing second-harmonic generation. The mechanism applies to various nonlinear processes, including Raman and Brillouin scattering, and thus paves the way for micro-solitons toward practical applications.

关键词： Kerr frequency comb conversion efficiency nonlinear coupler

Multiple-dimensioned defect engineering for graphite felt electrode of vanadium redox flow battery

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Carbon Energy 2024年第2期6卷 143-153页

作者： Yingqiao Jiang Yinhui Wang Gang Cheng Yuehua Li lei Dai Jing Zhu Wei Meng Jingyu Xi ling Wang Zhangxing He School of Chemical Engineering North China University of Science and TechnologyTangshanChina Tsinghua Shenzhen International Graduate School Institute of Materials ResearchTsinghua UniversityShenzhenChina

The scarcity of wettability,insufficient active sites,and low surface area of graphite felt(GF)have long been suppressing the performance of vanadium redox flow batteries(VRFBs).Herein,an ultra-homogeneous multipledimensioned defect,including nano-scale etching and atomic-scale N,O codoping,was used to modify GF by the molten salt ***_(4)Cl and KClO_(3) were added simultaneously to the system to obtain porous N/O co-doped electrode(GF/ON),where KClO_(3) was used to ultra-homogeneously etch,and O-functionalize electrode,and NH4Cl was used as N dopant,***/ON presents better electrochemical catalysis for VO_(2)+/VO_(2)+ and V3+/V2+ reactions than only O-functionalized electrodes(GF/O)and *** enhanced electrochemical properties are attributed to an increase in active sites,surface area,and wettability,as well as the synergistic effect of N and O,which is also supported by the density functional theory ***,the cell using GF/ON shows higher discharge capacity,energy efficiency,and stability for cycling performance than the pristine cell at 140 mA cm^(−2) for 200 ***,the energy efficiency of the modified cell is increased by 9.7% from 55.2% for the pristine cell at 260 mA cm^(−2).Such an ultra-homogeneous etching with N and O co-doping through“boiling”molten salt medium provides an effective and practical application potential way to prepare superior electrodes for VRFB.

关键词： graphite felt molten salt N O co-doping ultra-homogeneous etching vanadium redox flow battery

抗草甘膦转基因油菜和野芥菜回交1代子2代-子6代在无除草剂选择压下的适合度

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Journal of Plant Ecology 2024年第1期17卷 135-147页

作者： lei Huang Zi-Cheng Shao ling-ling Dai Ai-Qin Zheng Qing-ling Zhang Xiao-lei Wang Sheng Qiang Xiao-ling Song Weed Research Laboratory College of Life SciencesNanjing Agricultural UniversityNanjing 210095China

抗草甘膦转基因油菜和野芥菜回交1代子2代-子6代在无除草剂选择压下的适合度转基因作物的抗性基因能否成功渗入野生或近缘杂草取决于携带转基因回交后代的适合度。为深入了解转基因油菜(Brassica napus)向野芥菜(wild ***)基因流动的生... 详细信息

抗草甘膦转基因油菜和野芥菜回交1代子2代-子6代在无除草剂选择压下的适合度转基因作物的抗性基因能否成功渗入野生或近缘杂草取决于携带转基因回交后代的适合度。为深入了解转基因油菜(Brassica napus)向野芥菜(wild ***)基因流动的生态风险,本文研究了在低密度(5株/m^(2))和高密度(10株/m^(2))下,以及单种和混合种植(野芥菜:BC1F2R-BC1F6R=1:1)下抗草甘膦转基因油菜与野芥菜回交1代子2代到子6代(BC1F2R-BC1F6R)的适合度;并分析回交后代的适合度成分、种植密度和种植方式之间的相关性。研究结果表明:在单种低密度下,与野芥菜相比,回交1代子2代(BC1F2R)和子3代(BC1F3R)具有较低的适合度,而回交1代子4代-子6代(BC1F4R-BC1F6R)具有较高的适合度;无论是单种还是混种,高密度下所有回交后代的适合度均低于野芥菜。相关性分析结果显示,种植密度和种植方式对回交后代(BC1F2R-BC1F6R)的适合度成分有显著影响。这些结果表明,转基因从栽培油菜渗入到野芥菜很大程度上取决于回交后代的特定生长环境。

关键词：野芥菜抗草甘膦转基因油菜回交后代适合度基因漂移

Evaluating serum CXCL12,sCD22,Lp-PLA2 levels and ratios as biomarkers for diagnosis of Alzheimer's disease

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World Journal of Psychiatry 2024年第3期14卷 380-387页

作者： Zeng-ling Liu Fei-Fei Hua lei Qu Na yan Hui-Fang Zhang Department of Neurology Dongying People's HospitalDongying 257000Shandong ProvinceChina

BACKGROUND Grasping the underlying mechanisms of Alzheimer's disease(AD)is still a work in progress,and existing diagnostic techniques encounter various ***,the discovery of dependable biomarkers is essential for early detection,tracking the disease's advancement,and steering treatment *** To explore the diagnostic potential of serum CXCL12,sCD22,Lp-PLA2,and their ratios in AD,aiming to enhance early detection and inform targeted treatment *** The study was conducted in Dongying people's Hospital from January 2021 to December *** included 60 AD patients(AD group)and 60 healthy people(control group).Using a prospective case-control design,the levels of CXCL12,sCD22 and Lp-PLA2 and their ratios were detected by enzyme-linked immunosorbent assay kit in the diagnosis of *** differences between the two groups were analyzed by statistical methods,and the corresponding ratio was constructed to improve the specificity and sensitivity of *** Serum CXCL12 levels were higher in the AD group(47.2±8.5 ng/mL)than the control group(32.8±5.7 ng/mL,P<0.001),while sCD22 levels were lower(14.3±2.1 ng/mL vs 18.9±3.4 ng/mL,P<0.01).Lp-PLA2 levels were also higher in the AD group(112.5±20.6 ng/mL vs 89.7±15.2 ng/mL,P<0.05).Significant differences were noted in CXCL12/sCD22(3.3 vs 1.7,P<0.001)and Lp-PLA-2/sCD22 ratios(8.0 vs 5.2,P<0.05)between the *** operating characteristic analysis confirmed high sensitivity and specificity of these markers and their ratios in distinguishing AD,with area under the curves ranging from CONCLUSION Serum CXCL12 and Lp-PLA2 levels were significantly increased,while sCD22 were significantly decreased,as well as increases in the ratios of CXCL12/sCD22 and Lp-PLA2/sCD22,are closely related to the onset of *** biomarkers and their ratios can be used as potential diagnostic indicators for AD,providing an important clinical reference for early intervention and treatment.

关键词： Alzheimer's disease Biomarkers CXCL12 sCD22 Lp-PLA2

Detection of Novel BEST1 Variations in Autosomal Recessive Bestrophinopathy Using Third-generation Sequencing

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Current Medical Science 2024年第2期44卷 419-425页

作者： Jia-xun LI ling-rui MENG Bao-ke HOU Xiao-lu HAO Da-jiang WANG ling-hui QU Zhao-hui LI lei ZHANG Xin JIN Department of Senior Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China Department of Ophthalmology the 74th Army Group HospitalGuangzhou 510318China

Objective:Autosomal recessive bestrophinopathy(ARB),a retinal degenerative disease,is characterized by central visual loss,yellowish multifocal diffuse subretinal deposits,and a dramatic decrease in the light peak on *** potential pathogenic mechanism involves mutations in the BEST1 gene,which encodes Ca2+-activated Cl−channels in the retinal pigment epithelium(RPE),resulting in degeneration of RPE and *** this study,the complete clinical characteristics of two Chinese ARB families were ***:Pacific Biosciences(PacBio)single-molecule real-time(SMRT)sequencing was performed on the probands to screen for disease-causing gene mutations,and Sanger sequencing was applied to validate variants in the patients and their family ***:Two novel mutations,c.202T>C(chr11:61722628,p.Y68H)and c.867+97G>A,in the BEST1 gene were identified in the two Chinese ARB *** novel missense mutation BEST1 c.202T>C(p.Y68H)resulted in the substitution of tyrosine with histidine in the N-terminal region of transmembrane domain 2 of *** novel variant,BEST1 c.867+97G>A(chr11:61725867),located in intron 7,might be considered a regulatory variant that changes allele-specific binding affinity based on motifs of important transcriptional ***:Our findings represent the first use of third-generation sequencing(TGS)to identify novel BEST1 mutations in patients with ARB,indicating that TGS can be a more accurate and efficient tool for identifying mutations in specific *** novel variants identified further broaden the mutation spectrum of BEST1 in the Chinese population.

关键词： autosomal recessive bestrophinopathy BEST1 gene third-generation sequencing mutation

Intelligent Recognition Using Ultralight Multifunctional Nano‑Layered Carbon Aerogel Sensors with Human‑Like Tactile Perception

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Nano-Micro Letters 2024年第1期16卷 172-186页

作者： Huiqi Zhao Yizheng Zhang lei Han Weiqi Qian Jiabin Wang Heting Wu Jingchen Li Yuan Dai Zhengyou Zhang Chris RBowen ya yang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro‑Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400People’s Republic of China Tencent Robotics X Shenzhen 518054People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Department of Mechanical Engineering University of BathBath BA27AKUK Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004People’s Republic of China

Humans can perceive our complex world through multi-sensory *** limited visual conditions,people can sense a variety of tactile signals to identify objects accurately and ***,replicating this unique capability in robots remains a significant ***,we present a new form of ultralight multifunctional tactile nano-layered carbon aerogel sensor that provides pressure,temperature,material recognition and 3D location capabilities,which is combined with multimodal supervised learning algorithms for object *** sensor exhibits human-like pressure(0.04–100 kPa)and temperature(21.5–66.2℃)detection,millisecond response times(11 ms),a pressure sensitivity of 92.22 kPa^(−1)and triboelectric durability of over 6000 *** devised algorithm has universality and can accommodate a range of application *** tactile system can identify common foods in a kitchen scene with 94.63%accuracy and explore the topographic and geomorphic features of a Mars scene with 100%*** sensing approach empowers robots with versatile tactile perception to advance future society toward heightened sensing,recognition and intelligence.

关键词： Multifunctional sensor Tactile perception Multimodal machine learning algorithms Universal tactile system Intelligent object recognition

Effects of Nitrogen-Regulating Gene AreA on Growth,Pathogenicity,and Fumonisin Synthesis of Fusarium proliferatum

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Rice science 2024年第1期31卷 10-13,I0013-I0017页

作者： SUN lei CHEN Xu ZHOU Qianya ZHANG Tianlei YU Qian LIU Lianmeng HUANG Shiwen WANG ling Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province College of Biological and Food EngineeringHuaihua UniversityHuaihua 418000China State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China

Rice spikelet rot disease not only threatens rice yields but also poses risks to humans and animals due to the production of the category 2B carcinogen fumonisins by the pathogen Fusarium ***(N)metabolism is known to have a significant influence on fungal growth and the synthesis of secondary *** is a global N regulatory gene belonging to the GATA transcription factor *** this study,we observed that theΔAreA mutant exhibited a notable reduction in growth rate and conidium *** experiments revealed thatΔAreA had almost lost its ability to infect rice spikelets.

关键词： metabolism Fusarium Growth

Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

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Chinese Journal of Natural Medicines 2024年第4期22卷 307-317页

作者： TAO lei DOU Renjie CHEN Xueming CAO Yu DAI Zhen HU Ziyan MA Zhi GE Xiaoming ZHANG ling WANG Xiaoping Nanjing Institute for Food and Drug Control Nanjing 211198China State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China

Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress damage. Recent studies have identified both peroxisome proliferator-activated receptor-γ (PPARγ) and endoplasmic reticulum (ER) stress as critical targets for the treatment of IBD. Oroxyloside (C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium (DSS)-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis, including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662 (1 mg·kg^(−1), i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages (BMDM) and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD.

关键词： Oroxyloside ER stress PPARγ Colitis