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Effect of Wuziyanzong Pill on sperm quality and calcium ion content in oligoasthenospermia rats

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Journal of Traditional Chinese Medicine 2012年第4期32卷 631-635页

作者： Tongsheng Wang Jinling Huang Deling Wu Qing Li Xiangguo Liu Han Chen lei qiao Dongdong Li Jun Li Department of Pharmacology of Anhui College of Traditional Chinese Medicine College of Pharmacy of Anhui Medical University Department of Chinese Medicine Chemistry of Anhui college of Traditional Chinese Medicine Central Laboratory of Anhui Provincial Hospital

OBJECTIVE： To study the effect of Wuziyanzong treatment on the sperm quality and content of cal- cium ions （Ca2＋） in oligoasthenospermia rats. METHODS： A model of oligoasthenospermia was induced in 50 Sprague Dawley rats by treatment with tripterygium glycosides at 30 mg/kg per day for 8 weeks. They were divided randomly into a model group, a positive group （Huangjingzanyu capsule, 3.01 g/kg）, and low, medium and high dose Wuziyanzong treatment groups （2.30, 4.60, 9.20 g/kg crude drug respectively） with 10 in each group. Another 10 rats were used as a control group. The rats in the control and model groups were administered distilled water, while the rats in the remaining groups were administered Wuziyan- zong for 30 d. The epididymides were removed, spermatozoa recovered and the sperm density and viability were measured. The spermatozoa were pu- rified and the contents of Ca2~ in the cytoplasm and mitochondria were detected by flow cytometry and atomic absorption spectrometry, respectively. RESULTS： After 8 weeks of treatment with tripteryg- ium glycosides, the sperm density, sperm activity and the Ca2~ content of spermatozoa in the model rats were all significantly decreased compared with the control group （all P〈O.05）. After 30 d treatment, the sperm density and activity improved and the Ca2＋ content of sperm were increased significantly in the medium and high dose Wuziyanzong treat- ment groups in comparison with the model group （all P〈O.05）. CONCLUSION： The Wuziyanzong treatment in： creased sperm density, improved sperm viability and enhanced the content of Ca2＋ in the sperm cy- toplasm and mitochondria in this rat model of oli- goasthenospermia.

关键词： Wuziyanzong Sperm count Sperm mo-tility Asthenozoospermia Oligozoospermia Calci-um ions

Diabetes onset at an earlier age and high HbA1c levels as risk factors of diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 269-276页

作者： Rui-Fang Feng Hai-Yang Liu Ya-Lu Liu Qing Xu lei qiao Chao-Ju Gong Yi-Peng Zhang Jie Li Li-Na Guan Wei Fan Mei-Li Li Wen-Jin Li Su-Yan Li Department of Ophthalmology the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhou First People’s HospitalXuzhou Eye Disease Prevention and Treatment InstituteXuzhou 221116Jiangsu ProvinceChina

AIM:To assess the effect of age at diabetes onset and uncontrollable high Hb A1 c levels on the development of diabetic retinopathy(DR)among Chinese type 2 diabetes mellitus(DM)***:This was a cross-sectional survey of diabetic patients in Subei district,*** covering physical measurements,fasting blood-glucose(FBG),glycosylated hemoglobin(Hb A1 c),blood lipid,urinary albumin/creatinine ratio(UACR),ocular fundus examination,and diabetes treatment records were *** independent sample t-test were used to analyze differences.A Logistic regression analysis was applied to study the independent risk factors of ***:A total of 1282 patients with type 2 DM were enrolled,and 191 cases had DR(14.9%).The age at diabetes onset,education level,alcohol consumption,Hb A1 c level,UACR level,and hypoglycemic drugs were independent influencing factors for *** older the onset of diabetes,the less likely to develop DR(OR:0.958,95%CI:0.942-0.975,P=0.000).Patients were then divided in terms of age at diabetes onset as follows:<50 y,50-59 y,60-69 y,and≥70 *** with diabetes onset age<50 y,50-59 y(OR:0.463,95%CI:0.306-0.699,P=0.000),60-69 y(OR:0.329,95%CI:0.203-0.535,P=0.000)and≥70 y(OR:0.232,95%CI:0.094-0.577,P=0.002)were at a lower risk of *** prevalence of DR was highest in patients with diabetes onset age<50 y(29.5%,P<0.05).The Hb A1 c level(8.67±1.97)%and proportion of insulin injection(52.5%)in patients with diabetes onset<40 y were higher than in patients with older diabetes onset age(P<0.05).CONCLUSION:Diabetes onset at an earlier age and uncontrollable high Hb A1 c level could be independent risk factors for DR.

关键词： diabetic retinopathy age diabetes mellitus risk factors HbA1c

中药结合运动疗法治疗脑卒中上肢屈肌痉挛的疗效观察及表面肌电图分析

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中华物理医学与康复杂志 2008年第6期30卷 390-393页

作者：张颖乔蕾陈浩上海市徐汇区中心医院康复医学科上海200031 上海中医药大学附属龙华医院急诊科

目的运用中药结合运动疗法治疗脑卒中患者偏瘫上肢屈肌痉挛，并用改良Ashworth量表分级评定法和表面肌电图的肌电积分值（IEMG）评价上述治疗方法的有效性。方法将66例脑卒中偏瘫上肢屈肌痉挛患者随机分为运动结合中药组（治疗组）和运... 详细信息

目的运用中药结合运动疗法治疗脑卒中患者偏瘫上肢屈肌痉挛，并用改良Ashworth量表分级评定法和表面肌电图的肌电积分值（IEMG）评价上述治疗方法的有效性。方法将66例脑卒中偏瘫上肢屈肌痉挛患者随机分为运动结合中药组（治疗组）和运动疗法组（对照组），4周为1个疗程。所有入组患者治疗前和治疗1个疗程后分别采用改良Ashworth量表进行疗效评定，并采用表面肌电图记录伸肘活动时肱二头肌IEMG的平均值。结果改良Ashworth量表评定结果显示，治疗组患者上肢屈肌痉挛改善的总有效率是94．3％，对照组为64．5％。治疗后，治疗组患者上肢屈肌平均IEMG明显低于对照组（P〈0．05），治疗组患者治疗前、后上肢屈肌平均IEMG的差值明显高于对照组（P〈0．01）。结论与单纯运动疗法相比，中药结合运动疗法可更加明显地改善脑卒中偏瘫上肢屈肌痉挛。

关键词：中药运动疗法脑卒中肌痉挛肌电积分

欠驱动UUV三维轨迹跟踪的反步动态滑模控制

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华中科技大学学报（自然科学版） 2015年第8期43卷 107-113页

作者：徐健汪慢乔磊张耕实哈尔滨工程大学自动化学院黑龙江哈尔滨150001

提出一种欠驱动无人水下航行器(UUV)反步自适应动态滑模控制方法.结合反步和自适应滑模控制技术设计UUV的位置、姿态和时变速度跟踪控制器,采用虚拟速度来代替姿态误差的控制策略,将姿态跟踪控制转化为速度控制,能够有效避免传统反步法... 详细信息

提出一种欠驱动无人水下航行器(UUV)反步自适应动态滑模控制方法.结合反步和自适应滑模控制技术设计UUV的位置、姿态和时变速度跟踪控制器,采用虚拟速度来代替姿态误差的控制策略,将姿态跟踪控制转化为速度控制,能够有效避免传统反步法控制律设计存在的奇异值问题.针对系统模型不精确及时变扰动问题,引入滑模控制技术进行自适应补偿估计,提高了欠驱动UUV在未知环境中的鲁棒性及自适应能力,并基于李雅普诺夫稳定性理论证明了该控制系统误差最终一致有界.仿真结果表明:提出的UUV三维轨迹跟踪反步动态滑模控制方法收敛、有效,能够实现在系统参数不精确及时变扰动情况下的三维轨迹精确跟踪控制.

关键词：欠驱动无人水下航行器三维轨迹跟踪控制反步自适应滑模控制李雅普诺夫稳定性理论

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一种适用于浸入有限元方法的网格自适应方法

北京航空航天大学学报 2020年第3期46卷 588-597页

作者：张华白俊强乔磊刘艳西北工业大学航空学院西安710072 西北工业大学无人系统技术研究院西安710072 航空工业沈阳飞机设计研究所沈阳110035

针对动边界流固耦合的数值模拟问题,基于浸入有限元方法提出了一种耦合流场特征和几何特征的笛卡儿网格局部加密自适应方法,克服了单个自适应指示因子无法精确捕捉固体运动的特征的不足。在耦合自适应策略中,分别以流场涡量和固体位置... 详细信息

针对动边界流固耦合的数值模拟问题,基于浸入有限元方法提出了一种耦合流场特征和几何特征的笛卡儿网格局部加密自适应方法,克服了单个自适应指示因子无法精确捕捉固体运动的特征的不足。在耦合自适应策略中,分别以流场涡量和固体位置作为流场和几何信息指示因子来驱动网格自适应。通过方腔顶盖驱动圆盘流动算例,以圆盘体积守恒和特征点的运动轨迹验证耦合自适应方法的优势。计算结果表明:仅基于流动特征的自适应不能很好地保证圆盘的体积守恒;仅基于几何特征的自适应无法有效追踪圆盘的轨迹;而耦合自适应策略能同时较好地保证两项指标的计算精度,在保证总体计算自由度不变的情况下,圆盘区域速度散度2-范数降低了一个数量级,圆盘的轨迹误差2-范数降低了2个数量级。

关键词：网格自适应浸入有限元方法浸入边界法流固耦合笛卡儿网格

真空冷冻干燥工艺参数对三文鱼片脱水率的影响研究

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食品科技 2006年第10期31卷 119-122页

作者：雷桥俞骏上海水产大学食品学院上海200090

建立了冻干过程中,三文鱼片厚度、箱内真空度和加热搁板温度对脱水率综合影响的数学模型,采用回归分析的方法,确定了三文鱼片脱水率的主要影响因素,并推导出了一定工艺条件下,三文鱼片含水量动态变化的预测模型。

关键词：三文鱼厚度真空度搁板温度脱水率含水量

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γ-Re_(θt)转捩模型的改进和验证

航空动力学报 2015年第10期30卷 2488-2497页

作者：乔磊白俊强华俊徐晶磊张扬西北工业大学航空学院西安710072 中国航空工业集团公司中国航空研究院北京100012 北京航空航天大学能源与动力工程学院北京100191

针对γ-Reθt转捩模型应用在航空外流转捩模拟中存在的湍流区摩擦力系数二次异常跃升问题进行了研究和改进.研究发现前者的原因是边界层指示函数失效.通过以涡量与应变率的比值修正指示因子,改进了边界层范围的估计和转捩临界动量厚度... 详细信息

针对γ-Reθt转捩模型应用在航空外流转捩模拟中存在的湍流区摩擦力系数二次异常跃升问题进行了研究和改进.研究发现前者的原因是边界层指示函数失效.通过以涡量与应变率的比值修正指示因子,改进了边界层范围的估计和转捩临界动量厚度雷诺数的求解,消除了湍流区摩擦力系数异常跃升现象.消除摩擦力系数异常跃升现象后,湍流区摩擦力系数偏小.为此,Langtry曾引入黏性底层指示函数进行修正,但这一修正的作用范围可能溢出边界层,扰乱间歇因子求解.为解决这一问题,构造了基于黏性比、间歇因子和边界层指示函数的限制因子.通过平板Aerospatiale A翼型和雷诺数为2.1×107的NACA 642A015有限翼展直机翼算例的验证,证明上述修正改善了γ-Reθt转捩模型对边界层和黏性底层范围的捕捉,提高了摩擦力系数分布预测的准确度.

关键词：流动转捩边界层转捩模型间歇因子雷诺数经验模型

Organizational Structure,Technological Capability and Independent Innovation Mode——An Empirical Study on China's Technology-intensive Enterprises

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研究与发展管理 2010年第1期22卷 121-121页

作者： ZHANG Guang-lei,LiAO Jian-qiao,ZHOU He-rong

After system-transformation, technology-intensive enterprises weakened R&D activities in scale and level because of the mismatch between their independent innovation mode and organizational structure.

关键词： Innovation Organizational Structure,Technological Capability and Independent Innovation Mode mode An Empirical Study on China’s Technology-intensive Enterprises

Expression of Obesity Hormone Leptin in Human Colorectal Cancer

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Chinese Journal of Cancer Research 2009年第2期21卷 142-146页

作者： Jin-chun Cong Xian-wei Dai Ming-yang Shen Jun-jiang Wang Chun-sheng Chen Hong Zhang lei qiao Department of Colorectal Surgery Shengjing Hospital China Medical University Shenyang 110004 China

Objective： The obesity hormone, leptin, has been found to participate in the development and proliferation of normal and malignant tissues. The aim of this study was to evaluate the role of leptin in human colorectal cancer. Methods： Serum leptin levels were measured via ABC-ELLSA in 30 colorectal cancers and 24 normal controls. Leptin concentration in colorectal cancer was analyzed in terms of selected clinicopathological features and some oncogenes. Results： The mean concentration of leptin was significantly higher for colorectal cancers（3.54±1.46 ng/ml） than normal controls（2.27±0.99 ng/ml）, no gender difference was observed in this study. Leptin expression in poorly differentiated tumors was obviously lower than those in moderately and well differentiated tumors. There were no statistically significant correlations between leptin and the serum CEA and CA199 in colorectal cancers （P〉0.05）, and between leptin and the expressions of K-RAS, P53, APC, DCC genes in tumor tissues （P〉0.05）. Conclusion： Leptin is overexpressed in human colorectal cancer, which is related to the differentiation degrees of the tumor. There is no correlation between leptin expression and changes of oncogenes in colorectal cancers.

关键词： Colorectal cancer Leptin