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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng lei ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Tip-induced or enhanced superconductivity： a way to detect topological superconductivity

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Science Bulletin 2018年第17期63卷 1141-1158页

作者： He Wang lei ma Jian wang Tianjin International Center for Nano Particles and Nano Systems Tianjin University. Tianjin 300072 China International Center for Quantum materials School of Physics Peking University Beijing 100871 China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of Sciences Beijing 100190 China Collaborative Innovation Center of Quantum matter Beijing 100871 China State Key Laboratory of Low-Dimensional Quantum Pllysics Department of Physics Tsinghua University Beijing 100084 China

Topological materials, hosting topological nontrivial electronic band, have attracted widespread attentions. As an application of topology in physics, the discovery and study of topological materials not only enrich the existing theoretical framework of physics, but also provide fertile ground for investigations on low energy excitations, such as Weyl fermions and majorana fermions, which have not been observed yet as fundamental particles. These quasiparticles with exotic physical properties make topological materials the cutting edge of scientific research and a new favorite of high tech. As a typical example, majorana fermions, predicted to exist in the edge state of topological superconductors, are proposed to implement topological error-tolerant quantum computers. Thus, the detection of topological superconductivity has become a frontier in condensed matter physics and materials science. Here, we review a way to detect topological superconductivity triggered by the hard point contact: tip-induced superconductivity(TISC) and tip-enhanced superconductivity(TESC). The TISC refers to the superconductivity induced by a non-superconducting tip at the point contact on non-superconducting materials. We take the elaboration of the chief experimental achievement of TISC in topological Dirac semimetal Cd_3As_2 and Weyl semimetal Ta As as key components of this article for detecting topological superconductivity. Moreover, we also briefly introduce the main results of another exotic effect, TESC, in superconducting Au_2Pb and Sr_2RuO_4 single crystals, which are respectively proposed as the candidates of helical topological superconductor and chiral topological superconductor. Related results and the potential mechanism are conducive to improving the comprehension of how to induce and enhance the topological superconductivity.

关键词： Tip-induced superconductivity Tip-enhanced superconductivity Topological superconductivity Point contact spectroscopy Topological materials

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Generalized message passing detection of SCma systems based on dynamic factor graph for better and flexible performance-complexity tradeoff

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Science China(Information Sciences) 2022年第5期65卷 242-249页

作者： Fangqi DONG Huijuan ZHENG lei ma Sheng TONG State Key Laboratory of Integrated Services Networks Xidian University School of Electronic Engineering Xi'an University of Posts and Telecommunications

Multiuser detection based on the message passing algorithm(MPA) has been considered for sparse code multiple access(SCma) systems. Recently, some complexity-reduced MPA detectors have been proposed, among which the MPA detector based on dynamic factor graph(DFG-MPA) has been shown to outperform other MPA detectors with comparable complexities. However, all these MPA detectors are somehow not very flexible in terms of performance-complexity tradeoff, i.e., the granularities of computational complexity reduction are relatively large. In this paper, a generalized scheme of DFG-MPA, termed as GDFG-MPA, is proposed to make a better and more flexible performance-complexity tradeoff. The proposed scheme features two aspects:(1) instead of banning a message update forever, a banned message update at some iteration is allowed to be updated at later iterations;(2) different numbers of message updates are banned from updating at different iterations. Optimization of GDFG-MPA can be made by allocating banned message updates among iterations. Numerical results have demonstrated that compared to DFG-MPA the proposed GDFG-MPA can achieve much better performance at the same computational complexity or achieve the same performance with much lower complexity. Moreover, the proposed GDFG-MPA is more flexible in tuning the performance and complexity tradeoff.

关键词： sparse code multiple access (SCma) multiuser detection message passing algorithm (MPA) factor graph computational complexity

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Calculation of Entanglement Entropy for Continuous-Variable Entangled State Based on General Two-Mode Boson Exponential Quadratic Operator in Fock Space

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Communications in Theoretical Physics 2008年第3期49卷 590-594页

作者： DAI Fang-Wen ma lei Department of Physics East China Normal University Shanghai 200062 China

We obtain an explicit formula to calculate the entanglement entropy of bipartite entangled state of general two-mode boson exponential quadratic operator with continuous variables in Fock space. The simplicity and gen... 详细信息

关键词： entanglement entropy continuous-variable entangled states linear quantum transformation

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Second Quantization Representation of Quantum Logic Gate Transformations

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Communications in Theoretical Physics 2001年第7期36卷 119-121页

作者： ma lei ZHANG Yong-De Key Laboratory for Optical and magnetic Resonance Spectroscopy East China Normal University Shanghai 200062China Department of Physics East China Normal University Shanghai 200062 China Department of Modern Physics University of Science and Technology of China Hefei 230027 China

By using the theory of multimode linear transformation in Fock space, we offer an effective method to study the quantum logic gates based on fermion states. The forms of some basic quantum logic operations are also ob... 详细信息

关键词： quantum computation, quantum logic gate, quantum bit (qubit)

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Semi-supervised Support Vector Regression Model for Remote Sensing Water Quality Retrieving

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Chinese Geographical Science 2011年第1期21卷 57-64页

作者： WANG Xili FU Li ma lei School of Computer Science Shaanxi Normal University Xi'an 710062 China Department of Geography Western Michigan University Kalamazoo M149008-5424 USA

This paper proposed a semi-supervised regression model with co-training algorithm based on support vector machine, which was used for retrieving water quality variables from SPOT 5 remote sensing data. The model consisted of two support vector regressors (SVRs). Nonlinear relationship between water quality variables and SPOT 5 spectrum was described by the two SVRs, and semi-supervised co-training algorithm for the SVRs was es-tablished. The model was used for retrieving concentrations of four representative pollution indicators―permangan- ate index (CODmn), ammonia nitrogen (NH3-N), chemical oxygen demand (COD) and dissolved oxygen (DO) of the Weihe River in Shaanxi Province, China. The spatial distribution map for those variables over a part of the Weihe River was also produced. SVR can be used to implement any nonlinear mapping readily, and semi-supervis- ed learning can make use of both labeled and unlabeled samples. By integrating the two SVRs and using semi-supervised learning, we provide an operational method when paired samples are limited. The results show that it is much better than the multiple statistical regression method, and can provide the whole water pollution condi-tions for management fast and can be extended to hyperspectral remote sensing applications.

关键词： semi-supervised learning support vector regression co-training water quality retrieving model SPOT 5

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Tension and Drag Forces of Flexible Risers Undergoing Vortex-Induced Vibration

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China Ocean Engineering 2017年第1期31卷 1-10页

作者： SONG lei-jian FU Shi-xiao LI man GAO Yun ma lei-xin State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration Shanghai 200240China marine Design & Research Institute of China Shanghai 200011China State Key Laboratory of Oil and Gas Reservoir Geology and Exploration Southwest Petroleum UniversityChengdu 610500China

This paper presents the results of an experimental investigation on the variation in the tension and the distribution of drag force coefficients along flexible risers under vortex-induced vibration（VIV） in a uniform flow for Reynolds numbers（Re） up to 2.2×10^5. The results show that the mean tension is proportional to the square of the incoming current speed, and the tension coefficient of a flexible riser undergoing VIV can be up to 12. The mean drag force is uniformly and symmetrically distributed along the axes of the risers undergoing VIV. The corresponding drag coefficient can vary between 1.6 and 2.4 but is not a constant value of 1.2, as it is for a fixed cylinder in the absence of VIV. These experimental results are used to develop a new empirical prediction model to estimate the drag force coefficient for flexible risers undergoing VIV for Reynolds number on the order of 10^5, which accounts for the effects of the incoming current speed, the VIV dominant modal number and the frequency.

关键词： Reynolds riser cylinder vortex Vortex hydrodynamic empirical turbulent averaged oscillating

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Influence of Yttrium Addition on the Reduction Property of Tungsten Oxide Prepared via Wet Chemical Method

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Acta Metallurgica Sinica(English Letters) 2020年第2期33卷 275-280页

作者： Nan Liu Zhi Dong Zongqing ma Zhu Qian lei ma Liming Yu Yongchang Liu State Key Lab of Hydraulic Engineering Simulation and Safety School of Materials Science and EngineeringTianjin UniversityTianjin 300072China Tianjin Zhujin Technology Development Corporation Tianjin 300400China

W-Y2O3 composite nanopowders prepared via wet chemical method exhibit unique morphologies and micro *** yttrium addition during chemical reaction process affects not only the composition of tungsten acid hydrate precursors,but also the reduction property of tungsten oxide transformed from *** this study,the morphology evolution of the samples with and without yttrium during reduction process has been studied,and it is found that the addition of yttrium can exert a strong influence on the reduction route of tungsten oxide and the final morphology of tungsten *** cause of the difference of reduction route and tungsten particle morphology is also *** is suggested that the composition of the samples with yttrium at the beginning of reduction is pure cubic system WO3(c-WO3),and the c-WO3 particles have c-WO3 whiskers attached to the *** kind of whiskers is essential for c-WO3 to be reduced directly to tungsten and also helpful to obtain W-Y2O3 powders with small size and good uniformity.

关键词： W–Y2O3 nanopowders Wet chemical method Reduction property

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Application of a multi-field synergy principle in the performance evaluation of convective heat transfer enhancement in a tube

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Chinese Science Bulletin 2012年第13期57卷 1600-1607页

作者： LIU Wei LIU ZhiChun ma lei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China

For laminar and turbulent convective heat transfer, the synergy among vectorial physical quantities of a fluid particle is analyzed to reveal the relation between the multi-field synergy mechanism and heat transfer enhancement. Additionally, the efficiency evaluation criterion (EEC) is proposed to evaluate the overall performance of heat transfer enhancement. Meanwhile, using synergy angles α,β,,γ and η, a unified evaluation system and corresponding evaluation indexes for heat transfer enhancement are suggested. A model of a heat-transfer-enhanced tube inserted with poles in a triangular configuration is built, and a corresponding numerical simulation is conducted to verify the proposed evaluation system and criterion. The calculation results show that there is correlation between synergy angles reflecting the direction of heat transfer enhancement and evaluation criterion reflecting the effect of heat transfer enhancement. In the Re number range of 300-1800, the performance evaluation criterion PEC lies in the range of 1.2-2.3, but the efficiency evaluation criterion EEC lies in the range of 0.33-0.45.

关键词：场协同原理绩效评价对流换热换热强化强化传热管欧洲经济共同体评价标准应用

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Effect of Cavity Decay on Entanglement of Ladder-Type Three-Level Atoms and a Two-Mode Cavity Field

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Communications in Theoretical Physics 2008年第8期50卷 349-354页

作者： GAO Cheng-Yuan LIU Jin-Ming ma lei Institute of Theoretical Physics and Key Laboratory of Optical and magnetic Resonance Spectroscopy Department ofPhysics East China Normal University Shanghai 200062 China

Considering the adiabatical approximation and the large detuning condition, we give the effective Hamiltonian of a ladder-type three levels atom interacting with a bimodal cavity field. If two identical three-level atoms are sent through the cavity one by one, a two-atom entangled state can be generated. With the choice of the appropriate interaction time, a maximally entangled state of two atoms can be obtained if decoherence effect is ignored. Moreover, we discuss the effect of cavity decay on four physical quantities including atomic population probability, residual entanglement of the first atom and the cavity field, concurrence between the two atoms, and fidelity for generating atomic EPR state, all of which decrease with the increase of cavity decay when the other parameters are fixed.

关键词： cavity decay population probability entangled state concurrence

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