检索结果-南通市图书馆

Shear band evolution and acoustic emission characteristics of sandstone containing non-persistent flaws

Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 497-513页

作者： Shuting Miao Peng-Zhi Pan Chuanqing Zhang lei huo State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China CASIC Research Institute of Intelligent Decision Engineering Wuhan430040China

Direct shear tests were conducted on sandstone specimens under different constant normal stresses to study the coalescence of cracks between non-persistent flaws and the shear sliding characteristics of the shear-formed *** image correlation and acoustic emission(AE)techniques were used to monitor the evolution of shear bands at the rock bridge area and microcracking *** experimental results revealed that the shear stresses corresponding to the peak and sub-peak in the stressdisplacement curve are significantly affected by the normal *** localization bands emerged at both the tip of joints and the rock bridge,and their extension and interaction near the peak stress caused a surge in the AE hit rate and a significant decrease in the AE b *** and curvilinear strain bands were detected at low normal stress,while high normal stress generally led to more microcracking events and longer coplanar cracks at the rock bridge ***,an increase in normal stress resulted in a higher AE count rate and more energetic AE events during friction sliding along the shearformed *** was observed that the elastic energy released during the crack coalescence at the prepeak stage was much greater than that released during friction sliding at the post-peak *** than 75%of AE events were located in the low-frequency band(0e100 kHz),and this proportion continued to rise with increasing normal ***,more AE events of low AF value and high RA value were observed in specimens subjected to high normal stress,indicating that greater normal stress led to more microcracks of shear nature.

关键词： Shear band evolution Acoustic emission(AE) Crack coalescence Normal stress Shear sliding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Upregulation of α-ENaC induces pancreatic β-cell dysfunction,ER stress,and SIRT2 degradation

引用

Journal of Biomedical Research 2024年第3期38卷 241-255页

作者： Xue Zhang Dan Zhang lei huo Xin Zhou Jia Zhang Min Li Dongming Su Peng Sun Fang Chen Xiubin Liang Department of Pathophysiology Nanjing Medical UniversityNanjingJiangsu 211166China Department of Pathology Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu 210009China Key Laboratory of Human Functional Genomics of Jiangsu Province Department of Biochemistry and Molecular BiologyNanjing Medical UniversityNanjingJiangsu 211166China Department of Pathology Nanjing Medical UniversityNanjingJiangsu 211166China

Islet beta cells(β-cells)produce insulin in response to high blood glucose levels,which is essential for preserving glucose ***-gated ion channels inβ-cells,including Na+,K+,and Ca2+channels,aid in the release of *** epithelial sodium channel alpha subunit(α-ENaC),a voltage-independent sodium ion channel,is also expressed in human pancreatic endocrine ***,there is no reported study on the function of ENaC in theβ-*** the current study,we found thatα-ENaC was expressed in human pancreatic glandule and pancreatic isletβ-*** the pancreas of db/db mice and high-fat diet-induced mice,and in mouse isletβ-cells(MIN6 cells)treated with palmitate,α-ENaC expression was ***α-ENaC was overexpressed in MIN6 cells,insulin content and glucose-induced insulin secretion were significantly *** the other hand,palmitate injured isletβ-cells and suppressed insulin synthesis and secretion,but increasedα-ENaC expression in MIN6 ***,α-ENaC knockout(Scnn1a−/−)in MIN6 cells attenuatedβ-cell disorder induced by ***,α-ENaC regulated the ubiquitylation and degradation of sirtuin 2 inβ-cells.α-ENaC also modulatedβ-cell function in correlation with the inositol-requiring enzyme 1 alpha/X-box binding protein 1(IRE1α/XBP1)and protein kinase RNA-like endoplasmic reticulum kinase/C/EBP homologous protein(PERK/CHOP)endoplasmic reticulum stress *** results suggest thatα-ENaC may play a novel role in insulin synthesis and secretion in theβ-cells,and the upregulation ofα-ENaC promotes isletβ-cell *** conclusion,α-ENaC may be a key regulator involved in isletβ-cell damage and a potential therapeutic target for type 2 diabetes mellitus.

关键词： α-ENaC pancreaticβ-cells type 2 diabetes mellitus endoplasmic reticulum stress sirtuin 2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

大华会计师事务所声誉损失的影响研究——基于会计师事务所和投资者视角

引用

江苏商论 2024年第3期 88-92页

作者：古晓霍蕾蕾运城学院经济管理系山西运城044000

近些年来会计师事务所声誉损失事件层出不穷,造成了严重的经济后果,也为审计市场带来了前所未有的声誉危机。本文在对大华会计师事务所声誉损失事件介绍的基础上,利用案例分析法和事件分析法分别从会计师事务所自身和投资者视角对会计... 详细信息

近些年来会计师事务所声誉损失事件层出不穷,造成了严重的经济后果,也为审计市场带来了前所未有的声誉危机。本文在对大华会计师事务所声誉损失事件介绍的基础上,利用案例分析法和事件分析法分别从会计师事务所自身和投资者视角对会计师事务所声誉损失造成的影响进行研究。结果表明会计师事务所声誉损失会导致事务所自身降低审计收费、客户流失率上升等。同时,会导致大华会计师事务所客户股价产生累计平均异常收益率的负向波动。最后提出相关建议。

关键词：声誉损失事件分析法大华会计师事务所

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

穿支皮瓣中Choke vessels的相关研究与展望

引用

中国矫形外科杂志 2024年第14期32卷 1309-1313页

作者：霍磊谭琪高加智谢佳宁山东第二医科大学临床医学院山东潍坊261053 潍坊市人民医院创伤骨科山东潍坊261000

Choke vessels作为连接穿支皮瓣中相邻血管体的桥梁,在提高穿支皮瓣存活率方面发挥重要作用。目前,如何提高穿支皮瓣存活率的研究重点是通过施加不同措施增加Choke vessels的供血而改善皮瓣血运。本文通过对Choke vessels在穿支皮瓣中... 详细信息

Choke vessels作为连接穿支皮瓣中相邻血管体的桥梁,在提高穿支皮瓣存活率方面发挥重要作用。目前,如何提高穿支皮瓣存活率的研究重点是通过施加不同措施增加Choke vessels的供血而改善皮瓣血运。本文通过对Choke vessels在穿支皮瓣中的研究进展进行回顾,分析不同干预措施对Choke vessels的影响,旨在为未来提高穿支皮瓣存活率的相关研究提供参考方向。

关键词：穿支皮瓣 Choke vessels 血管内皮生长因子(VEGF)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于焊接变形控制的筒体结构及焊接工艺优化

引用

金属加工（热加工） 2024年第2期 30-33页

作者：霍雷任有路中铁工程装备集团隧道设备制造有限公司河南新乡453000

焊接变形是影响筒体生产制造质量和制造成品率的主要问题。文中分析了筒体焊接变形原因和焊接变形控制措施的局限性,提供了一种能够控制筒体焊接变形的设计结构优化方法,优化了控制筒体焊接变形的焊接工艺,保证了产品的焊接质量和机械... 详细信息

焊接变形是影响筒体生产制造质量和制造成品率的主要问题。文中分析了筒体焊接变形原因和焊接变形控制措施的局限性,提供了一种能够控制筒体焊接变形的设计结构优化方法,优化了控制筒体焊接变形的焊接工艺,保证了产品的焊接质量和机械加工质量,提升了产品的制造成品率,为同类产品或类似产品焊接变形问题的解决,提供了一种优化方法和参考。

关键词：筒体焊接变形设计结构焊接工艺

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

BS700高强钢臂架焊接工艺研究

引用

金属加工（热加工） 2024年第3期 49-53页

作者：霍雷张毅王伟中铁工程装备集团隧道设备制造有限公司河南新乡453000

结合生产实际,通过对BS700高强钢试件的焊接试验和BS700高强钢臂架的焊接实践,从焊接工艺方法、焊缝的外观检查、超声波检测、力学性能检测,以及BS700高强钢臂架焊接生产的焊接变形控制、焊后质量检测等多方面进行了阐述,提供了一种BS70... 详细信息

结合生产实际,通过对BS700高强钢试件的焊接试验和BS700高强钢臂架的焊接实践,从焊接工艺方法、焊缝的外观检查、超声波检测、力学性能检测,以及BS700高强钢臂架焊接生产的焊接变形控制、焊后质量检测等多方面进行了阐述,提供了一种BS700高强钢臂架的焊接工艺方法,为同类产品的工艺实践提供参考。

关键词： BS700高强钢超声波检测力学性能检测焊接变形控制焊接工艺

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Wnt/β联蛋白信号通路在纤维化疾病中的研究进展

引用

医学综述 2024年第9期30卷 1037-1043,1049页

作者：霍雷张全兵周云安徽医科大学第二附属医院康复医学科合肥230601

纤维化疾病涉及肝脏、肺、皮肤、肾脏、心脏等器官,以器官组织内纤维结缔组织增多、实质细胞减少为主要病理改变,持续进展可致器官结构破坏和功能减退,甚至导致器官衰竭,严重威胁人类生命健康。近年认为,Wnt/β联蛋白(β-catenin)信号... 详细信息

纤维化疾病涉及肝脏、肺、皮肤、肾脏、心脏等器官,以器官组织内纤维结缔组织增多、实质细胞减少为主要病理改变,持续进展可致器官结构破坏和功能减退,甚至导致器官衰竭,严重威胁人类生命健康。近年认为,Wnt/β联蛋白(β-catenin)信号通路可能在多种组织纤维化进展过程中发挥调控作用,因此调控Wnt/β-catenin信号通路可能有助于减缓纤维化疾病进展或逆转纤维化进程,但目前其具体作用机制尚不清楚。未来,深入研究Wnt/β-catenin信号通路在纤维化疾病中的作用机制及其调控靶点将为纤维化疾病的临床治疗提供新策略。

关键词：纤维化 Wnt/β联蛋白信号通路转化生长因子-β 上皮-间充质转化

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discussion on back-to-back two-stage centrifugal compressor compact design techniques

引用

Frontiers of Mechanical Engineering 2013年第4期8卷 390-400页

作者： lei huo huoxing LIU School of Jet Propulsion Beihang University

Design a small flow back-to-back two-stage centrifugal compressor in the aviation turbocharger,the compressor is compact structure,small axial length,light *** parts have a great influence on their overall performance ***,the stationary part of the back-to-back two-stage centrifugal compressor should pay full attention to the diffuser,bend,return vane and volute *** also impact downstream return vane,making the flow in circumferential direction is not uniformed,and several blade angle of attack is drastically changed in downstream of the volute with the airflow can not be rotated to required *** of high-pressure rotor blades change due to non-uniformed of flow in circumferential direction,which makes individual blade load distribution changed,and affected blade passage load decreased to reduce the capability of work,the tip low speed range increases.

关键词： back-to-back two-stage centrifugal compressor design Internal flow

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Service Composition Instantiation Based on Cross-Modified Artificial Bee Colony Algorithm

引用

China Communications 2016年第10期13卷 233-244页

作者： lei huo Zhiliang Wang School of Automation University of Science and Technology Beijing School of Computer and Science University of Science and Technology Beijing

Internet of things(IoT) imposes new challenges on service composition as it is difficult to manage a quick instantiation of a complex services from a growing number of dynamic candidate services. A cross-modified Artificial Bee Colony Algorithm(CMABC) is proposed to achieve the optimal solution services in an acceptable time and high accuracy. Firstly, web service instantiation model was established. What is more, to overcome the problem of discrete and chaotic solution space, the global optimal solution was used to accelerate convergence rate by imitating the cross operation of Genetic algorithm(GA). The simulation experiment result shows that CMABC exhibited faster convergence speed and better convergence accuracy than some other intelligent optimization algorithms.

关键词： optimization of service composition optimal service instantiation artificial bee colony algorithm swarm algorithm cross strategy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transmissivity of electromagnetic wave propagating in magnetized plasma sheath using variational method

引用

Plasma Science and Technology 2019年第12期21卷 1-5页

作者： Jianyi CHEN Chengxun YUAN Xiudong SUN lei huo Department of Physics Harbin Institute of TechnologyHarbin 150001People's Republic of China

A variational method is introduced to analyze the transmissivity of an electromagnetic wave propagating in the magnetized plasma sheath. The plasma density is modeled by two parabolic inhomogeneous regions separated by one homogeneous region. The Lagrangian density of the system is constructed based on the fluid energy density and the electromagnetic energy *** total variation of the Lagrangian density is derived. The fluid and electromagnetic fields are numerically solved by expansion in piecewise polynomial function space. We investigate the effect of an external magnetic field on the transmissivity of the electromagnetic wave. It is found that the transmissivity is increased when an external magnetic field is applied. The dependence of transmissivity on the collision frequency between the electrons and the neutral particles has also been studied. We also show that the external magnetic field causes a shift in the critical frequency of the plasma sheath.

关键词： electromagnetic wave propagation variational method wave theory wave propagation plasma sheath

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：