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Stepwise colloidal lithography toward scalable and various planar chiral metamaterials

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Rare Metals 2024年第2期43卷 723-735页

作者： Xiu Yang Yong Liu Fei-Liang Chen Qian-Qi Lin Rohit Chikkaraddy Shan-Shan Huang Shi-Lin Xian Yi-Dong Hou Jing-lei Du Liang-Ping Xia chun-lei Du School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu610054China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu610054China Zhuhai Multiscale Optoelectronics Technology Co. Ltd.Zhuhai915060China Hybrid Materials for Opto-Electronics Group Department of Molecules and MaterialsMESA+Institute for NanotechnologyMolecules Center and Center for Brain-Inspired Nano SystemsFaculty of Science and TechnologyUniversity of Twente7500 AEEnschedeThe Netherlands School of Physics and Astronomy University of BirminghamBirminghamB152TTUK College of Physics Sichuan UniversityChengdu610065China Key Laboratory of Micro Nano Optoelectronic Devices and Intelligent Perception Systems Yangtze Normal UniversityChongqing408100China

Chiral metamaterials(CMs)composed by artificial chiral resonators have attracted great attentions in the recent decades due to their strong chiroptical resonance and identifiable interaction with chiral materials,facilitating practical applications in chiral biosensing,chiral emission,and display technology.However,the complex geometry of CMs improves the fabrication difficulty and hinders their scalable fabrication for practical applications,especially in the visible and ultraviolet wavelengths.One potential strategy is the colloidal lithography that enables parallel fabrication for scalable and various planar structures.Here,we demonstrate a stepwise colloidal lithography technique that uses sequential deposition from multiple CMs and expand their variety and complexity.The geometry and optical chirality of building blocks from single deposition are systematically investigated,and their combination enables a significant extension of the range of chiral patterns by multiple-step depositions.This approach resulted in a myriad of complex designs with different characteristic sizes,compositions,and shapes,which are particularly beneficial for the development of nanophotonic materials.In addition,we designed a flexible chiral device based on PDMS,which exhibits a good CD value and excellent stability even after multiple inward and outward bendings.The excellent compatibility to various substrates makes the planar CMs more flexible in practical applications in microfluidic biosensing.

关键词： Chiral metamaterials Colloidal lithography Nanophotonics Metasurfaces Plasmonics Nanofabrications Flexible devices

Utilizing bioinformatics for integrated analysis of multiple genes in the diagnosis and pathogenesis of metastatic pheochromocytoma and paraganglioma

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Oncology and Translational Medicine 2024年第1期10卷 13-21页

作者： chun-lei Zhang Rui Wang Fo-Rong Li De-Hui Chang Department ofUrology The 940 Hospital of Joint Logistics Support Force of Chinese PLALanzhouChina Clinical Medicine Department Northwest Minzu UniversityLanzhouChina.

Objective:The aim of the study was to investigate effective diagnostic molecular markers and the specific mechanisms of metastatic pheochromocytomas and paragangliomas(PPGLs).Methods:Data were collected from GEO datasets GSE67066 and GSE60458.The R software and various packages were utilized for the analysis of differentially expressed genes,Gene Ontology analysis,Kyoto Encyclopedia of Genes and Genomes analysis,receiver operating characteristic curve assessment,logistic model construction,and correlation analysis.The NetworkAnalyst tool was used to analyze gene-miRNA interactions and signaling networks.In addition,the TIMER database was used to estimate the immune scores.Results:A total of 203 and 499 differentially expressed genes were identified in GSE67066 and GSE60458,respectively.These genes are implicated in cytokine and cytokine receptor interactions,extracellular matrix–receptor interactions,and platelet activation signaling pathways.Notably,MAMLD1,UST,MATN2,LPL,TWIST1,SFRP4,FRMD6,RBM24,PRIMA1,LYPD1,KCND2,CAMK2N1,SPOCK3,and ALPK3 were identified as the key genes.Among them,MATN2 and TWIST1 were found to be coexpressed with epithelial-mesenchymal transition–linked markers,whereas KCND2 and LPL exhibited associations with immune checkpoint expression and immune cell infiltration.Eight miRNAs were identified as potential regulators of key gene expression,and it was noted that TWIST1 might be regulated by SUZ12.Notably,the area under the curve of the 4-gene model for distinguishing between malignant and benign groups was calculated to be 0.918.Conclusions:The combined gene and mRNA expression model enhances the diagnostic accuracy of assessing PPGL metastatic potential.These findings suggest that multiple genes may play a role in the metastasis of PPGLs through the epithelial-mesenchymal transition and may influence the immune microenvironment.

关键词： Diagnosis Epithelial-mesenchymal transition(EMT) Immunity Metastasis Paraganglioma Pheochromocytoma

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中医药促进慢性创面修复研究进展

中国中西医结合杂志 2024年第2期44卷 250-256页

作者：雷春明单玮上海中医药大学研究生院上海200032 上海中医药大学附属龙华医院中医外科上海200032

慢性难愈性创面俗称慢性溃疡,是指不同病因诱发的经过治疗4周以上仍未愈合也无明显愈合倾向,不能通过正常有序及时的修复达到解剖和功能完整的创面[1],是一种临床常见的外科疾病,特点是病程迁延不愈且容易复发[2]。慢性创面主要包括临... 详细信息

慢性难愈性创面俗称慢性溃疡,是指不同病因诱发的经过治疗4周以上仍未愈合也无明显愈合倾向,不能通过正常有序及时的修复达到解剖和功能完整的创面[1],是一种临床常见的外科疾病,特点是病程迁延不愈且容易复发[2]。慢性创面主要包括临床中的糖尿病溃疡、创伤性溃疡、动/静脉性溃疡、感染性溃疡和压疮等。慢性创面由于原发疾病比较复杂,创面病程长,因此往往病情迁延难愈、反复发作,不仅会对患者造成生理和心理的负担.

关键词：慢性溃疡慢性创面创伤性溃疡静脉性溃疡糖尿病溃疡外科疾病原发疾病压疮

A Comprehensive Understanding of Dietary Effects on C.elegans Physiology

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Current Medical Science 2019年第5期39卷 679-684页

作者： Jie-jun ZHOU lei chun Jian-feng LIU Collaborative Innovation Center for Brain Science College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Diet has been shown to play an important role in human physiology.It is a predominant exogenous factor regulating the composition of gut microbiota,and dietary intervention holds promise for treatment of diseases such as obesity,type 2 diabetes,and malnutrition.Furthermore,it was reported that diet has significant effects on physiological processes of C.elegans,including reproduction,fat storage,and aging.To reveal novel signaling pathways responsive to different diets,C.elegans and its bacterial diet were used as an interspecies model system to mimic the interaction between host and gut microbiota.Most signaling pathways identified in C.elegans are highly conserved across different species,including humans.A better understanding of these pathways can,therefore,help to develop interventions for human diseases.In this article,we summarize recent achievements on molecular mechanisms underlying the response of C.elegans to different diets and discuss their relevance to human health.

关键词： diet gut microbiota metabolites C.elegans

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软坚散结颗粒制备工艺及其质量标准建立

中成药 2024年第4期46卷 1118-1125页

作者：吴玥黄春跃雷春胡晓侯爱君复旦大学药学院上海201203 上海医药工业研究院有限公司创新药物与制药工艺国家重点实验室上海201203 上海交通大学药学院上海200240

目的建立软坚散结颗粒制备工艺及其质量标准。方法优化挥发油包合工艺和颗粒成型工艺,确定颗粒制备工艺。TLC法定性鉴别玄参、浙贝母、莪术、麸炒白术,HPLC法测定哈巴苷、哈巴俄苷、贝母素甲、贝母素乙的含量。结果最佳包合工艺为挥... 详细信息

目的建立软坚散结颗粒制备工艺及其质量标准。方法优化挥发油包合工艺和颗粒成型工艺,确定颗粒制备工艺。TLC法定性鉴别玄参、浙贝母、莪术、麸炒白术,HPLC法测定哈巴苷、哈巴俄苷、贝母素甲、贝母素乙的含量。结果最佳包合工艺为挥发油与β-环糊精比例1∶10,包合时间120 min,包合温度45℃;最优成型工艺为按药辅比1∶0.8混入可溶性淀粉,90%乙醇润湿,制粒。TLC斑点清晰,阴性无干扰。哈巴苷、哈巴俄苷、贝母素甲、贝母素乙在各自范围内线性关系良好(r≥0.999 4),平均加样回收率105.63%~110.87%,RSD 2.9%~5.6%。结论软坚散结颗粒制备工艺稳定可行,并且该制剂质量标准专属性强,重复性好,可用于其质量控制。

关键词：软坚散结颗粒制备工艺质量标准 TLC HPLC

分组密码复杂线性层可分性传播的MILP刻画方法

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软件学报 2024年第4期35卷 1980-1992页

作者：黄明张莎莎洪春雷曾乐向泽军湖北大学数学与统计学学院湖北武汉433062 上海大学通信与信息工程学院上海200444 Faculty of Science The University of MelbourneMelbourne VIC3010Australia

混合整数线性规划(MILP)作为一种自动化搜索工具,被广泛地应用于搜索分组密码的差分、线性、积分等密码性质.提出一种基于动态选取策略构建MILP模型的新技术,该技术在不同的条件下采用不同的约束不等式刻画密码性质的传播.具体地,从可... 详细信息

混合整数线性规划(MILP)作为一种自动化搜索工具,被广泛地应用于搜索分组密码的差分、线性、积分等密码性质.提出一种基于动态选取策略构建MILP模型的新技术,该技术在不同的条件下采用不同的约束不等式刻画密码性质的传播.具体地,从可分性出发根据输入可分性汉明重量的不同,分别采用不同的方法构建线性层可分性传播的MILP模型.最后,将该技术应用于搜索uBlock和Saturnin算法的积分区分器.实验结果表明:对于uBlock128算法,该技术可以搜索到比之前最优区分器多32个平衡比特的8轮积分区分器.除此之外,搜索到uBlock128和uBlock256算法比之前最优区分器更长一轮的9和10轮积分区分器.对于Saturnin256算法,同样搜索到比之前最优区分器更长一轮的9轮积分区分器.

关键词：混合整数线性规划可分性线性层汉明重量积分区分器

基于D-Wave Advantage的量子退火公钥密码攻击算法研究

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计算机学报 2024年第5期47卷 1030-1044页

作者：王潮王启迪洪春雷胡巧云裴植上海大学特种光纤与光接入网重点实验室上海200444

D-Wave专用量子计算机的原理量子退火凭借独特的量子隧穿效应可跳出传统智能算法极易陷入的局部极值,可视为一类具有全局寻优能力的人工智能算法.本文研究了两类基于量子退火的RSA公钥密码攻击算法(分解大整数N=pq):一是将密码攻击数学... 详细信息

D-Wave专用量子计算机的原理量子退火凭借独特的量子隧穿效应可跳出传统智能算法极易陷入的局部极值,可视为一类具有全局寻优能力的人工智能算法.本文研究了两类基于量子退火的RSA公钥密码攻击算法(分解大整数N=pq):一是将密码攻击数学方法转为组合优化问题或指数级空间搜索问题,通过Ising模型或QUBO模型求解,提出了乘法表的高位优化模型,建立新的降维公式,使用D-Wave Advantage分解了 200万整数2269753.大幅度超过普渡大学、Lockheed Martin和富士通等实验指标,且Ising模型系数h范围缩小了 84%,系数J范围缩小了 80%,极大地提高了分解成功率,这是一类完全基于D-Wave量子计算机的攻击算法;二是基于量子退火算法融合密码攻击数学方法优化密码部件的攻击,采用量子退火优化CVP问题求解,通过量子隧穿效应获得比Babai算法更近的向量,提高了 CVP问题中光滑对的搜索效率,在D-Wave Advantage上实现首次50比特RSA整数分解.实验表明,在通用量子计算机器件进展缓慢情况下,D-Wave表现出更好的现实攻击能力,且量子退火不存在NISQ量子计算机VQA算法的致命缺陷贫瘠高原问题:算法会无法收敛且无法扩展到大规模攻击.

关键词： RSA D-Wave 量子退火 CVP 量子隧穿整数分解量子计算

Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum

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Chinese Journal of Natural Medicines 2019年第12期17卷 963-969页

作者： HUANG Guang-Hui lei chun ZHU Ke-Xin LI Jing-Ya LI Jia HOU Ai-Jun School of Pharmacy State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai 201203China National Center for Drug Screening State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Five pairs of optically pure meroterpenoid enantiomers(1 a/1 b-5 a/5 b)and two known compounds(6 and 7)were isolated from Rhododendron fastigiatum.Compounds 1 a/1 b-5 a/5 b were resolved from naturally scalemic mixtures by chiral HPLC.Their structures were elucidated by spectroscopic methods,X-ray crystallographic experiments,and ECD analyses.Compounds 1 a/1 b,2 a/2 b,3 b,4 a/4 b,and 5 a/5 b were new meroterpenoids with different polycyclic systems.Two enantiomeric pairs(2 a/2 b and 3 a/3 b),6,and 7 exhibited inhibitory effects on protein tyrosine phosphatase 1 B(PTP1 B)in vitro.

关键词： Rhododendron fastigiatum Meroterpenoid enantiomers Protein tyrosine phosphatase 1B

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婴儿进行性异位骨化症一例报告

中华骨质疏松和骨矿盐疾病杂志 2024年第2期17卷 145-149页

作者：李政别谊桥王春雷南京大学医学院附属苏州医院内分泌科江苏苏州215000 盐城市第一人民医院ICU 江苏盐城224000 徐州医科大学盐城临床学院内分泌科江苏盐城224000 盐城市第一人民医院内分泌科江苏盐城224000

患儿男,6月龄,因“全身多处结节进行性增大4月”入院,腹部皮肤病损病理检查符合钙质沉积症,基因测序检测显示患儿GNAS基因有一个杂合突变,为移码突变,考虑诊断为进行性异位骨化症。

关键词：进行性骨发育异常异位骨化 GNAS基因