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Thermal-environment characteristics and comfort of combined radiant-floor (Korean heating system ondol) and convective cooling system

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Journal of Central South University 2013年第12期20卷 3589-3603页

作者： lee kang-guk HONG Won-Hwa School of Architecture Kyungpook National University

The thermal-environment characteristics of the existing forced-convection cooling system were compared with those of the convective cooling system, which combined the radiant-floor cooling system using floor-heating panel typically applied to apartments in South Korea with the forced-convection cooling system using improved fan coil unit. The subjective warm/cool-feeling responses to the combined radiant-floor and convective cooling system in the questionnaire survey conducted among the test subjects were analyzed to establish the basic data for the combined cooling system. The results show that in the thermal-equilibrium condition, the vertical air temperature difference in the model living room is larger in the forced-convection-cooling condition. Most of the subjects feel a proper warm/cool feeling on their entire body, but they feel colder on the foot and lower body in the combined-cooling condition.

关键词： convection cooling temperature ondol thermal comfort fan coil unit combined cooling system

Analyses on performances of heat and multilayer reflection insulators

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Journal of Central South University 2012年第6期19卷 1645-1656页

作者： lee Moo-jin lee kang-guk SEO Won-duck School of Architecture Kyungil UniversityGyeongsan 702701Korea Research Center for Urban Affair Kyungil UniversityGyeongsan 702701Korea Department of Architectural Design Joongbu UniversityGeumsan-gun 701140Korea

This research was conducted to study the performances of the heat and multilayer reflection insulators used for buildings in South Korea to realize eco-friendly, low-energy-consumption, green construction, and to contribute to energy consumption reduction in buildings and to the nation＇s greenhouse gas emission reduction policy （targeting 30% reduction compared to BAUCousiness as usual） by 2020）. The heat insulation performance test is about the temperatures on surfaces of test piece. The high air temperature and the low air temperature were measured to determine the overall heat transfer coefficient and thermal conductivity. The conclusions are drawn that the heat transmission coefficients for each type of existing reflection insulator are： A-1 （0.045 W/（m-K））, A-2 （0.031 W/（m.K））, A-3 （0.042 W/（m.K））, A-4 （0.078 W/（m.K））, and the average heat conductivity is 0.049 W/（m-K）; The heat conductivity for each type of Styrofoam insulator are 0.030 W/（m.K） for B-l, 0.032 W/（m-K） for B-2, 0.037 W/（m＇K） for B-3, 0.037 W/（m.K） for B-4, and the average heat conductivity is 0.035 W/（m＇K） regardless of the thickness of the insulator; The heat conductivity values of the multilayer reflection insulators are converted based on the thickness and type C-1 （0.020 W/（m.K））, C-2 （0.018 W/（m.K））, C-3 （0.016 W/（m.K））, and C-4 （0.012 W/（m.K））; The multilayer reflection insulator keeps the indoor-side surface temperature high （during winter） or low （in summer）, enhances the comfort of the building occupants, and conducts heating and moisture resistance to prevent dew condensation on the glass-outer-wall surface.

关键词： heat reflection insulator multilayer reflection insulator overall heat transfer coefficient thermal conductivity nonflammability vapor permeability eco-friendly construction

Smooth cutting pattern generation technique for membrane structures using geodesic line on subplane and spline interpolation

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Journal of Central South University 2013年第11期20卷 3131-3141页

作者： SHON Su-deok lee Seung-jae lee kang-guk School of Architectural Engineering Korea University of Technology and Education Research Center for Building safety Kyungpook National University

Practical techniques for smooth geodesic patterning of membrane structures were *** the geodesic search,adjustment of the subplane of the extracted elements series was proposed,and various spline approximation methods were used to flatten the strip for the generation of a smooth *** search approach is very simple,and the geodesic line could be easily attained by the proposed method without the need for a difficult computation *** cutting patterning can also be generated by spline approximation without the noise in discrete nodal ***,the geodesic cutting pattern saved about 21%of the required area for the catenary model due to the reduction of the curvature of the planar pattern seam line.

关键词： membrane structures cutting pattern generation geodesic line spline interpolation triangular mesh sub-plane

Sensitivity to electricity consumption in urban business and commercial area buildings according to climatic change

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Journal of Central South University 2012年第3期19卷 770-776页

作者： lee kang-guk KIM Sung-bum HONG Won-hwa Research Center for Urban Affair Kyungil University School of Architecture Kyungpook National University

Recently, urban high temperature phenomenon has become a problem which results from human activities, the increase in energy consumption, and land-cover change in urban areas. As extremely hot weather caused by urban high temperature continues, demand for power is increased and results in the degradation of electricity reserves. The current trend in climate change, regardless of the summer and winter power demand, is likely to have much effect on the power demand. Thus, sensitivity to electricity consumption in urban areas due to climate change was researched. The results show that, 1） the basic unit of the sensitivity to electricity consumption in the target areas is 1.25-1.58W/（m2.℃）; 2） The maximum sensitivity is recorded at around 8：00 pm in the area crowded with commercial and business area. And in the business area, electricity consumption load is even from 9：00 am to 6：00 pm.

关键词： electricity consumption electricity load electricity reserves energy

Characteristics of bifurcation and buckling load of space truss in consideration of initial imperfection and load mode

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第3期14卷 206-218页

作者： Su-deok SHON Seung-jae lee kang-guk lee School of Architectural Engineering Korea University of Technology and Education1800 ChungjeolroCheonan ChungnamRepublic of Korea Research Center for Urban Affair Kyungil UniversityGyeongsan-city GyeongbukRepublic of Korea

This study investigated characteristics of bifurcation and critical buckling load by shape imperfection of space truss,which were sensitive to initial *** critical point and buckling load were computed by the analysis of the eigenvalues and determinants of the tangential stiffness *** two-free-nodes example and star dome were selected for the case study in order to examine the nodal buckling and global buckling by the sensitivity to the eigen buckling mode and the analyses of the influence,and characteristics of the parameters as defined by the load ratio of the center node and surrounding node,as well as rise-span ratio were *** sensitivity to the imperfection of the initial shape of the two-free-nodes example,which occurs due to snapping at the critical point,resulted in bifurcation before the limit point due to the buckling mode,and the buckling load was reduced by the increase in the amount of *** two sensitive buckling patterns of the numerical model are established by investigating the displaced position of the free nodes,and the asymmetric eigenmode greatly influenced the behavior of the imperfection shape whether it was at limit point or ***,the sensitive mode of the two-free-nodes example was similar to the in-extensional basis mechanism of a simplified *** star dome,which was used to examine the influence among several nodes,indicated that the influence of nodal buckling was greater than that of global buckling as the rise-span ratio was ***,global buckling is occurred with reaching bifurcation point as the value of load ratio was higher,and the buckling load level was about 50%-70% of load level at limit point.

关键词： Space truss Geometric nonlinearity Initial imperfection Snap-through Bifurcation Global buckling

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan Meng kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

The influence of thermohaline fronts on chlorophyll a concentrations during spring and summer in the southeastern Yellow Sea

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Acta Oceanologica Sinica 2013年第9期32卷 82-90页

作者： JANG Pung-guk lee Tong Sup kang Jung-Hoon SHIN Kyoungsoon Korea Institute of Ocean Science and Technology/South Sea Institute Department of Oceanography College of Natural SciencesPusan National University

A spatial and temporal variation in physiochemical parameters in the southeastern Yellow Sea （YS） is in- vestigated in the spring and summer of 2009 to 2011. Nutrient show a strong negative relationship with chlorophyll a （Chl a） concentration in spring, and the subsurface chlorophyll a maxima （SCM） layer was associated with the nitracline in summer. In summer, the SCM was usually found within or above the pyc- nocline and at the depths of shoals from the open sea to the coastal sea due to tidal and/or topographical fronts in the southernmost study area. High Chl a concentrations were found in the central southern YS, where the YS cold water layer expanded under the pycnocline and encountered water masses during spring and summer. After a typhoon in the summer of2011, Chl a concentration increased, especially in the central southern YS, where cold waters occurred below the pycnocline. The results suggest that the development of thermohaline fronts may play an important role in the growth and accumulation of phytoplankton biomass in the upper layer of the southeastern YS during spring and summer.

关键词： Yellow Sea Cold Water nutrient chorophyll a thermohaline front

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte