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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao Ren Cheng Xu Chengkuo lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation

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World Journal of Stem Cells 2022年第3期14卷 245-263页

作者： Min-Jung Kim Won Moon jeonghoon Heo Sangwook Lim Seung-hyun lee Jee-Yeong jeong Sang Joon lee Department of Biochemistry Cancer Research Institute Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Internal Medicine Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Molecular Biology and Immunology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Radiation Oncology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of General Surgery Kosin University College of MedicineSeogu 49267BusanSouth Korea Department of Ophthalmology Gospel HospitalKosin University College of MedicineSeo-gu 49267BusanSouth Korea

BACKGROUND Bone marrow(BM)suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to *** concerted efforts,there is no definitive treatment method *** studies have reported using mesenchymal stromal cells(MSCs),but their therapeutic effects are *** We administered and examined the effects of various amounts of adipose-derived MSCs(ADSCs)in mice with radiation-induced BM *** Mice were divided into three groups:Normal control group,irradiated(RT)group,and stem cell-treated group following whole-body irradiation(WBI).Mouse ADSCs(mADSCs)were transplanted into the peritoneal cavity either once or three times at 5×10^(5) cells/200μ*** white blood cell count and the levels of,plasma cytokines,BM mRNA,and BM surface markers were compared between the three *** BM-derived CD34+hematopoietic progenitor cells were co-cultured with human ADSCs(hADSCs)or incubated in the presence of hADSCs conditioned media to investigate the effect on human cells in *** The survival rate of mice that received one transplant of mADSCs was higher than that of mice that received three *** transplantations of ADSCs delayed the repopulation of BM hematopoietic stem ***-inflammatory effects and M2 polarization by intraperitoneal ADSCs might suppress erythropoiesis and induce myelopoiesis in sub-lethally RT *** The results suggested that an optimal amount of MSCs could improve survival rates post-WBI.

关键词： Adipose tissue-derived stem cells Bone marrow suppression Mesenchymal stromal cells Radiation Cell therapy

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Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor （VEGF）-mediated angiogenesis is determined by their sizes

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Nano Research 2014年第6期7卷 844-852页

作者： Dong hyun Jo Jin Hyoung Kim Jin Gyeong Son Yuanze Piao Tae Geol lee jeong Hun Kim Fight against Angiogenesis-Related Blindness (FARB) Laboratory Clinical Research Institute Seoul National University Seoul 110-744 Republic of Korea Department of Biomedical Sciences College of Medicine Seoul National University Seoul 110-799 Republic of Korea Center for Nano-Bio Convergence World Class Laboratory Korea Research Institute of Standards and Science Daejeon 305-340 Republic of Korea Department of Chemistry and KI for the NanoCentury KAIST Daejeon 305-701 Republic of Korea Graduate School of Convergence Science and Technology Seoul National University Seoul 151-742 & Advanced Institutes of Convergence Technology Suwon 443-270 Republic of Korea Department of Ophthalmology College of Medicine Seoul National University Seoul 110-744 Republic of Korea

Nanoparticles can be involved in biological activities such as apoptosis, angiogenesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inhibit vascular endothelial growth factor （VEGF）-mediated pathological angiogenesis. In this study, we show that anti-angiogenic effect of inorganic nanospheres is determined by their sizes. We demonstrate that 20 nm size gold and silica nanospheres suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological angiogenesis more efficiently than their 100 nm size counterparts. Our results suggest that modulation of the size of gold and silica nanospheres determines their inhibitory activity to VEGF-mediated angiogenesis.

关键词： nanospheres anti-angiogenesis effects inorganic nanoparticles vascular endothelialgrowth factor pathological angiogenesis

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Lithofacies modeling by multipoint statistics and economic evaluation by NPV volume for the early Cretaceous Wabiskaw Member in Athabasca oilsands area, Canada

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Geoscience Frontiers 2018年第2期9卷 441-451页

作者： Kwang hyun Kim Kyungbook lee hyun Suk lee Chul Woo Rhee hyun Don Shin Petroleum and Marine Research Division Korea Institute of Geoscience and Mineral Resources Department of Earth and Environmental Sciences Chungbuk National University Department of Energy Resources Engineering Inha University

The static modeling and dynamic simulation are essential and critical processes in petroleum exploration and development. In this study, lithofacies models for Wabiskaw Member in Athabasca, Canada are generated by multipoint statistics(MPS) and then compared with the models built by sequential indicator simulation(SIS). Three training images(Tls) are selected from modern depositional environments;the Orinoco River Delta estuary, Cobequid bay-Salmon River estuary, and Danube River delta environment. In order to validate lithofacies models, average and variance of similarity in lithofacies are calculated through random and zonal blind-well *** random six-blind-well test, similarity average of MPS models is higher than that of SIS model. The Salmon MPS model closely resembles facies pattern of Wabiskaw Member in subsurface. Zonal blind-well tests show that successful lithofacies modeling for transitional depositional setting requires additional or proper zonation information on horizontal variation, vertical proportion, and secondary *** Wabiskaw Member is frontier oilsands lease, it is impossible to evaluate the economics from production data or dynamic simulation. In this study, a dynamic steam assisted gravity drainage(SAGD)performance indicator(SPIDER) on the basis of reservoir characteristics is calculated to build 3 D reservoir model for the evaluation of the SAGD feasibility in Wabiskaw Member. SPIDER depends on reservoir properties, economic limit of steam-oil ratio, and bitumen price. Reservoir properties like porosity,permeability, and water saturation are measured from 13 cores and calculated from 201 well-logs. Three dimensional volumes of reservoir properties are constructed mostly based on relationships among properties. Finally, net present value(NPV) volume can be built by equation relating NPV and SPIDER. The economic area exceeding criterion of US$ 10,000 is identified, and the ranges of reservoir properties are estimated. NPV-volume-generati

关键词： Oilsands Multipoint statistics (MPS) Reservoir static modeling Economic evaluation Net present value (NPV) SAGD, and SPIDER

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Attractor landscape analysis of the cardiac signaling network reveals mechanism-based therapeutic strategies for heart failure

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Journal of Molecular Cell Biology 2018年第3期10卷 180-194页

作者： Daebeom Park Ho-Sung lee Jun Hyuk Kang Seon-Myeong Kim jeong-Ryeol Gong Kwang-hyun Cho Laboratory for Systems Biology and Bio-inspired Engineering Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Graduate School of Medical Science and Engineering KAIST Daejeon 34141 Republic of Korea

Apoptosis and hypertrophy of cardiomyocytes are the primary causes of heart failure （HF）, a global leading cause of death, and are regulated through the complicated intracellular signaling network, limiting the development of effective treatments due to its complexity. To identify effective therapeutic strategies for HF at a system level, we develop a large-scale comprehensive mathematical model of the cardiac signaling network by integrating all available experimental evidence. Attractor landscape analysis of the network model identifies distinct sets of control nodes that effectively suppress apoptosis and hypertrophy of cardiomyocytes under ischemic or pressure overload-induced HF, the two major types of HF. Intriguingly, our system-level analysis suggests that intervention of these control nodes may increase the efficacy of clinical drugs for HF and, of most importance, different combinations of control nodes are suggested as potentially effective candidate drug targets depending on the types of HF. Our study provides a systematic way of developing mechanism-based therapeutic strategies for HF.

关键词： heart failure mathematical modeling cardiac signaling network systems analysis disease mechanism mechanism-based therapeutic strategy systems biology

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Nanostructured hafnium-doped strontium oxide film for homeotropic/homogeneous convertible liquid crystal alignment depending on the curing temperature

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International Journal of Smart and Nano Materials 2022年第4期13卷 597-611页

作者： Dong hyun Kim Dong Wook lee Jin Young Oh Jonghoon Won Hae-Chang jeong Dae-Shik Seo IT Nano Electronic Device Laboratory Department of Electrical and Electronic EngineeringYonsei UniversitySeoulRepublic of Korea Department of Smart Manufacturing Engineering Changwon National UniversityChangwonGyeongnamRepublic of Korea Department of Electrical Electronic and Control Engineering Changwon National UniversityChangwonGyeongnamRepublic of Korea

A hafnium strontium oxide(HfSrO)liquid crystal(LC)alignment film was efficiently created through brush coating,and its ability to change the LC alignment direction was confirmed.A brush was applied to HfSrO sol coated on an indium-tin oxide substrate,after which the coating was solidified at var-ious curing *** was confirmed that a directional micro/nanostructure was formed above 280°C due to the shear stresses caused by the movement of the brush *** chemical changes were analyzed by using X-ray photoelectron spectroscopy and contact angle *** the curing temperature increased,the prevalence of oxygen bonds increased and the contact angle decreased,thereby increasing the surface *** anisotropic boundary of the micro-grooves and the van der Waals forces due to an increase in surface energy changed the alignment direction of LC mole-cules from vertical to horizontal,as verified through polarized optical microscopy and pretilt angle ***,the efficiency of the brush-coating method,which dramatically simplifies the LC alignment film process,was *** homeotropic/homogeneous LC alignment property of the HfSrO film produced through brush coating depending on the curing temperature provides an innovative approach for LC alignment.

关键词： Brush coating nanostructure solution process liquid crystal alignment

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Humidity-induced synaptic plasticity of ZnO artificial synapses using peptide insulator for neuromorphic computing

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Journal of Materials Science & Technology 2022年第24期119卷 150-155页

作者： Min-Kyu Song Hojung lee jeong hyun Yoon Young-Woong Song Seok Daniel Namgung Taehoon Sung Yoon-Sik lee Jong-Seok lee Ki Tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983South Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826South Korea Soft Foundry Seoul National UniversitySeoul 08826South Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826South Korea

Neuromorphic devices inspired by the human brain have attracted significant attention because of their excellent ability for cognitive and parallel *** study presents ZnO-based artificial synapses with peptide insulators for the electrical emulation of biological *** demonstrated the dynamic responses of the device under various environmental *** proton-conducting property of the tyrosine-rich peptide enables time-dependent responses under ambient conditions such that various aspects of synaptic behaviors are emulated by the *** transition from short-term memory to longterm memory is achieved via electrochemical doping of ZnO by ***,we demonstrate an image classification simulation using a multi-layer perceptron model to evaluate the potential of the device for use in neuromorphic *** neural network based on our device achieved a recognition accuracy of 87.47% for the MNIST handwritten digit *** work proposes a novel device platform inspired by biosystems for brain-mimetic hardware systems.

关键词： Artificial synapse Neuromorphic computing Oxide semiconductor Proton conductor Artificial neural network

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Impacts of optimization strategies on performance,power/energy consumption of a GPU based parallel reduction

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Journal of Central South University 2017年第11期24卷 2624-2637页

作者： Phuong Thi Yen lee Deok-Young lee jeong-Gun Smart Computing Lab. Department of Computer EngineeringHallym UniversityChuncheon 24252Korea College of General Education Hallym UniversityChuncheon 24252Korea

In the era of modern high performance computing, GPUs have been considered an excellent accelerator for general purpose data-intensive parallel applications. To achieve application speedup from GPUs, many of performance-oriented optimization techniques have been proposed. However, in order to satisfy the recent trend of power and energy consumptions, power/energy-aware optimization of GPUs needs to be investigated with detailed analysis in addition to the performance-oriented optimization. In this work, in order to explore the impact of various optimization strategies on GPU performance, power and energy consumptions, we evaluate performance and power/energy consumption of a well-known application running on different commercial GPU devices with the different optimization strategies. In particular, in order to see the more generalized performance and power consumption patterns of GPU based accelerations, our evaluations are performed with three different Nvdia GPU generations(Fermi, Kepler and Maxwell architectures), various core clock frequencies and memory clock frequencies. We analyze how a GPU kernel execution is affected by optimization and what GPU architectural factors have much impact on its performance and power/energy consumption. This paper also categorizes which optimization technique primarily improves which metric(i.e., performance, power or energy efficiency). Furthermore, voltage frequency scaling(VFS) is also applied to examine the effect of changing a clock frequency on these metrics. In general, our work shows that effective GPU optimization strategies can improve the application performance significantly without increasing power and energy consumption.

关键词： parallel reduction GPU code optimization power energy voltage frequency scaling

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A novel electrospinning method for self-assembled tree-like fibrous scaffolds:Microenvironment-associated regulation of MSC behavior and bone regeneration

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Journal of Materials Science & Technology 2022年第20期115卷 52-70页

作者： jeong In Kim Ju Yeon Kim Sung-Ho Kook jeong-Chae lee Cluster for Craniofacial Development and Regeneration Research Institute of Oral Biosciences and School of DentistryJeonbuk National UniversityJeonju 54896Republic of Korea Department of Bionanosystem Engineering Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Bioactive Material Sciences Research Center of Bioactive MaterialsJeonbuk National UniversityJeonju 54896Republic of Korea

Numerous studies highlight advantages of electrospun scaffolds in bone tissue engineering,in which cellular behavior is tightly affected by fiber topographical cues of ***,the classic electrospinning setup limits a desired presentation of biomimetic fibrous microenvironments that sense mechanosignaling and regulate stem cell *** aims of this study were to fabricate advanced asspun scaffolds presenting tree-like microfiber/nanonet networks and to evaluate their regulatory potentials on behavior of human mesenchymal stem cells(h MSCs)and bone *** we developed a novel electrospinning setup that allowed the presentation of patterned Trunk microfibers(TMF)and/or branched nanonet fibers(BNn Fs)in biomimetic fibrous *** the cellular mechanisms,anisotropichierarchical topography of TMF controlled behavior of h MSCs through focal adhesion formation and Yesassociated protein(YAP)induction,whereas BNn F disturbed such mechanosensing responses in the *** fiber microenvironment-related expression and nuclear localization of YAP *** correlated with the potentials of as-spun scaffolds to enhance osteogenic differentiation of the h MSCs and alveolar bone defect healing in an animal ***,this study provides an advanced approach of the modified electrospinning setup for presentation of biomimetic fibrillar microenvironments in as-spun scaffolds along with their application in stem cell behavior regulation and regenerative tissue engineering.

关键词： Electrospinning Advanced biomimetic scaffolds Stem cell behavior Mechanosensing Bone tissue engineering

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Tyrosine-mediated analog resistive switching for artificial neural networks

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Nano Research 2023年第1期16卷 858-864页

作者： Min-Kyu Song Seok Daniel Namgung Hojung lee jeong hyun Yoon Young-Woong Song Kang Hee Cho Yoon-Sik lee Jong-Seok lee Ki Tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently *** have received considerable attention in this regard because of their ability to process and store data at the same ***,fundamental problems with abrupt switching characteristics limit their practical *** address this problem,we utilized the concept of metaplasticity inspired by biosystems and observed gradual switching in the peptide-based memristor at high proton *** unexpectedly high slope value>1.7 in the logI–V curve at low voltage(≤400 mV)was considered the main origin,and it might arise from the modulatory response of proton ions on the threshold of Ag ion migration in the peptide *** the obtained gradual switching property at high proton conductivity,the device showed significantly increased accuracy of image recognition(~82.5%).We believe that such a demonstration not only contributes to the practical application of neuromorphic devices but also expands the bioinspired functional synthetic platform.

关键词： artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network

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