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Nuclear receptor coactivator 6 is a crit.cal regulator of NLRP3 inflammasome activation and gouty arthritis

cellular & Molecular Immunology 2024年第3期21卷 227-244页

作者： Kang-Gu lee Bong-Ki Hong Saseong lee Naeun lee Seung-Whan Kim Donghyun Kim Wan-Uk Kim center for Integrative Rheumatoid transcriptomics and Dynamics The Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoul 06591Republic of Korea Department of Pharmacology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Bio-Medical Institute of t.chnology University of UlsanSeoul 05505Republic of Korea Department of Microbiology and Immunology Seoul National University College of MedicineSeoul 03080Republic of Korea Institute of Infectious Diseases Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Rheumatology Department of Internal MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

transcriptional coactivators regulate the rate of gene expression in the *** receptor coactivator 6(NcOA6),a coactivator,has been implicated in embryonic development,metabolism,and cancer pathogenesis,but its role in innate immunity and inflammatory diseases remains ***,we demonstrated that NcOA6 was expressed in monocytes and macrophages and that its level was increased under proinflammatory ***,nuclear NcOA6 was found to translocate to the cytoplasm in activated monocytes and then become incorporated into the inflammasome with NLRP3 and ASc,forming cytoplasmic ***,NcOA6 associated with the AtP hydrolysis motifs in the NAcHt domain of NLRP3,promoting the oligomerization of NLRP3 and ASc and thereby instigating the production of IL-1βand active *** note,Ncoa6 deficiency markedly inhibited NLRP3 hyperactivation caused by the Nlrp3^(R258W) gain-of-function mutation in *** ablation of Ncoa6 substantially attenuated the severity of two NLRP3-dependent diseases,folic-induced acute tubular necrosis and crystal-induced arthritis,in *** with these findings,NcOA6 was highly expressed in macrophages derived from gout patients,and NcOA6-positive macrophages were significantly enriched in gout macrophages according to the transcriptome profiling ***,NcOA6 is a crit.cal regulator of NLRP3 inflammasome activation and is therefore a promising target for NLRP3-dependent diseases,including gout.

关键词： Nuclear receptor coactivator 6 Nuclear-to-cytoplasmic translocation NLRP3 inflammasome NAcHt domain Gouty arthritis

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Difficulties, strategies, and recent research and development of layered sodium transition metal oxide cathode materials for high-energy sodium-ion batteries

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Journal of Energy chemistry 2024年第3期90卷 40-57,I0003页

作者： Kouthaman Mathiyalagan Dongwoo Shin Young-chul lee Department of Nano Science and t.chnology convergence Gachon University1342 Seongnam-DaeroSujeong-GuGyeonggi-DoSeongnam-Si 13120Republic of Korea Department of Bio Nano t.chnology Gachon University1342 Seongnam-DaeroSujeong-GuGyeonggi-DoSeongnam-Si 13120Republic of Korea

Energy-storage systems and their production have attracted significant interest for pract.cal *** are the foundation of sustainable energy sources for electric vehicles(EVs),portable electronic devices(PEDs),*** recent decades,Lithium-ion batteries(LIBs) have been extensively utilized in largescale energy storage devices owing to their long cycle life and high energy ***,the high cost and limited availability of Li are the two main obst.cles for *** this regard,sodium-ion batteries(SIBs) are attractive alternatives to LIBs for large-scale energy storage systems because of the abundance and low cost of sodium *** is one of the most important.components in the battery,which limits cost and performance of a *** the classified cathode structures,layered structure materials have attracted attention because of their high ionic conductivity,fast diffusion rate,and high specific ***,we present a comprehensive review of the classification of layered structures and the preparation of layered ***,the review art.cle discusses extensively about the issues of the layered materials,namely(1) electrochemical degradation,(2) irreversible structural changes,and(3) structural instability,and also it provides strategies to overcome the issues such as elemental phase composition,a small amount of elemental doping,structural design,and surface alteration for emerging *** addition,the art.cle discusses about the recent research development on layered unary,binary,ternary,quaternary,quinary,and senary-based O3-and P2-type cathode materials for high-energy *** review art.cle provides useful information for the development of high-energy layered sodium transition metal oxide P2 and O3-cathode materials for pract.cal SIBs.

关键词： O3-type P2-type cathode materials Sodium-ion batteries Layered structure

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thermoluminescence characterization of natural and synthet.c irradiated ce-monazites

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Journal of Rare Earths 2024年第4期42卷 643-650页

作者： V.correcher c.Boronat J.Garcia-Guinea J.F.Benavente t.Rivera-Montalvo cIEMAt Av.Complutense 4028040MadridSpain MNcN-cSIc J.Gutierrez Abascal 228006MadridSpain Instituto Polit.cnico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

the thermoluminescence(tL)emission of synthet.c and natural ce-monazites was characterized here to determine the potential application in the identification of microscopic defects from a qualitative point of view trying to link each tL peak to a chemical-physical *** kinet.c parameters that lead the luminescence processes were calculated by means of variable heating rate and computing glow curve deconvolution methods and allow identifying three groups of components at~90,130 and 290℃(for the mineral sample)and~90,170,220,270 and 320℃(for the synthet.c cePO_(4):Nd_(0.20),La_(0.25)).the main differences appreciated in these complex tL curves are mainly due to(i)the content of impurities(natural sample contains lanthanides as well as U 0.60%and th 5.22%)and(ii)the degree of crystallinity of the samples which is directly related to the type of impurities(synthet.c monazite relies only on Nd and La).the behavior of the dose response in the range of 1-8 Gy is similar for both samples;the tL intensity increases linearly as the dose increases without.changes in the position of the maxima,denoting first-order kinet.c luminescence *** peak could be mostly associated with structural defects(i.e.,phase transitions),chemical reactions(i.e.,ce3+?ce4+redox reaction,dehydration or dehydroxylation processes)or intrinsic defects(i.e.,Frenkel defects,ODcs or NBOHcs).

关键词： thermoluminescence Kinet.cparameters Phosphate ce-monazite Defects Rare earths

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Self-assembly of tau fragments as a key pathologic event in tauopathies

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Neural Regeneration Research 2024年第12期19卷 2565-2566页

作者： Ly thi Huong Luu Le Jung Hoon lee Min Jae lee Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea

tau protein is encoded by the microtubuleassociated protein tau(MAPt)gene and stabilizes microtubules in the *** has unique biophysical properties that make it both highly water-soluble and positively *** tau is an intrinsically disordered protein lacking defined secondary structures,it.can acquire highly organized-sheet structures and st.ck into a filamentous inclusion such as a paired helical filament(PHF).

关键词： tau pathologic assembly

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Dynamical control of nanoscale light-matter interactions in low-dimensional quantum materials

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Light(Science & Applications) 2024年第2期13卷 236-253页

作者： Yeonjeong Koo taeyoung Moon Mingu Kang Huitae Joo changjoo lee Hyeongwoo lee Vasily Kravtsov Kyoung-Duck Park Department of Physics Pohang University of Science and Technology(POSTECH)Pohang37673Republic of Korea School of Physics and Engineering ITMO UniversitySaint Petersburg197101Russia

tip-enhanced nano-spectroscopy and-imaging have significantly advanced our understanding of low-dimensional quantum materials and their interactions with light,providing a rich insight into the underlying physics at their natural length ***,various functionalities of the plasmonic tip expand the capabilities of the nanoscopy,enabling dynamic manipulation of light-matter interactions at the *** this review,we focus on a new paradigm of the nanoscopy,shifting from the conventional role of imaging and spectroscopy to the dynamical control approach of the tip-induced light-matter *** present three different approaches of tip-induced control of light-matter interactions,such as cavity-gap control,pressure control,and near-field polarization ***,we discuss the nanoscale modifications of radiative emissions for various emitters from weak to strong coupling regime,achieved by the precise engineering of the ***,we introduce recent works on light-matter interactions controlled by tip-pressure and near-field polarization,especially tunability of the bandgap,crystal structure,photoluminescence quantum yield,exciton density,and energy transfer in a wide range of quantum *** envision that this comprehensive review not only contributes to a deeper understanding of the physics of nanoscale light-matter interactions but also offers a valuable resource to nanophotonics,plasmonics,and materials science for future t.chnological advancements.

关键词： quantum precise shifting

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Adverse effects of early-life stress:focus on the rodent neuroendocrine system

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Neural Regeneration Research 2024年第2期19卷 336-341页

作者： Seung Hyun lee Eui-Man Jung Department of Molecular Biology College of Natural SciencesPusan National UniversityBusanRepublic of Korea

Early-life stress is associated with a high prevalence of mental illnesses such as post-traumat.c stress disorders,attention-deficit/hyperactivity disorder,schizophrenia,and anxiety or depressive behavior,which constitute major public health *** the early stages of brain development after birth,events such as synaptogenesis,neuron maturation,and glial differentiation occur in a highly orchestrated manner,and external stress can cause adverse long-term effects throughout *** body utilizes multifaceted mechanisms,including neuroendocrine and neurotransmitter signaling pathways,to appropriately process external *** individuals first exposed to early-life stress deploy neurogenesis as a stress-defense mechanism;however,in adulthood,early-life stress induces apoptosis of mature neurons,activation of immune responses,and reduction of neurotrophic factors,leading to anxiety,depression,and cognitive and memory *** process involves the hypothalamus-pituitary-adrenal axis and neurotransmitters secreted by the central nervous system,including norepinephrine,dopamine,and *** rodent early-life stress model is generally used to experimentally assess the effects of stress during *** paper reviews the use of the early-life stress model and stress response mechanisms of the body and discusses the experimental results regarding how early-life stress mediates stress-related pathways at a high vulnerability of psychiatric disorder in adulthood.

关键词： early-life stress hypothalamic-pituitary-adrenergic axis maternal separation mental illness neurodevelopmental disorder neuroendocrine system neurotransmitter

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Novel Perovskite Oxide Hybrid Nanofibers Embedded with Nanocatalysts for Highly Efficient and Durable Electrodes in Direct.cO_(2) Electrolysis

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Nano-Micro Letters 2024年第5期16卷 214-230页

作者： Akromjon Akhmadjonov Kyung taek Bae Kang taek lee Department of Mechanical Engineering KAISTDaejeon 34141Republic of Korea KAISt Graduate School of Green Growth and Sustainability Daejeon 34141Republic of Korea

the unique characterist.cs of nanofibers in rational electrode design enable effec-tive utilization and maximizing material properties for achieving highly efficient and sustainable cO_(2) reduction reactions( cO_(2)RRs)in solid oxide elec-trolysis cells(SOEcs).However,pract.cal appli-cation of nanofiber-based electrodes faces chal-lenges in establishing sufficient interfacial cont.ct and adhesion with the dense *** t.ckle this challenge,a novel hybrid nanofiber electrode,La_(0.6)Sr_(0.4)co_(0.15)Fe_(0.8)Pd_(0.05)O_(3-δ)(H-LScFP),is developed by strategically incorporating low aspect ratio crushed LScFP nanofibers into the excess porous interspace of a high aspect ratio LScFP nanofiber framework synthesized via electrospinning *** consecutive treatment in 100% H_(2) and cO_(2) at 700°c,LScFP nanofibers form a perovskite phase with in situ exsolved co metal nanocatalysts and a high concentration of oxygen species on the surface,enhancing cO_(2) *** SOEc with the H-LScFP electrode yielded an outstanding current density of 2.2 A cm^(-2) in cO_(2) at 800°c and 1.5 V,setting a new benchmark among reported nanofiber-based *** twinning of the H-LScFP reveals improved cont.ct adhesion and increased reaction sites for cO_(2)*** present work demonstrates a highly catalyt.cally active and robust nanofiber-based fuel electrode with a hybrid structure,paving the way for further advancements and nanofiber applications in cO_(2)-SOEcs.

关键词： Nanofibers Fuel electrodes Digital twinning cO_(2)reduction reaction Solid oxide electrolysis cells

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Effect of Meteorological Data Assimilation on Regional Air Quality Forecasts over the Korean Peninsula

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Journal of Meteorological Research 2024年第2期38卷 262-284页

作者： Yunjae cHO Hyun Mee KIM Eun-Gyeong YANG Yonghee lee Jae-Bum lee Soyoung HA Department of Atmospheric Sciences Yonsei UniversitySeoul 03722Republic of Korea Air Quality Forecasting center National Institute of Environmental ResearchIncheon 22689Republic of Korea National center for Atmospheric Research BoulderCO 80305USA University of Maryland Baltimore county BaltimoreMD 21250USA Global Modeling and Assimilation Office NASA Goddard Space Flight CenterGreenbeltMD 20771USA

the Weather Research and Forecasting model coupled with chemistry(WRF-chem),a type of online coupled chemistry-meteorology model(ccMM),considers the interaction between air quality and meteorology to improve air quality *** data assimilation(DA)can be used to reduce uncertainty in meteorological field,which is one factor causing prediction uncertainty in the *** this study,WRF-chem and three-dimensional variational DA were used to examine the impact of meteorological DA on air quality and meteorological forecasts over the Korean *** nesting model domains were configured over East Asia(outer domain)and the Korean Peninsula(inner domain).three experiments were conducted by using different DA domains to determine the optimal model domain for the meteorological *** the meteorological DA was performed in the outer domain or both the outer and inner domains,the root-mean-square error(RMSE),bias of the predicted part.culate matter(PM)concentrations,and the RMSE of predicted meteorological variables against the observations were smaller than those in the experiment where the meteorological DA was performed only in the inner *** indicates that the improvement of the synopt.c meteorological fields by DA in the outer domain enhanced the meteorological initial and boundary conditions for the inner domain,subsequently improving air quality and meteorological *** to the experiment without meteorological DA,the RMSE and bias of the meteorological and PM variables were smaller in the experiments with *** effect of meteorological DA on the improvement of PM predictions lasted for approximately 58-66 h,depending on the ***,the uncertainty reduction in the meteorological initial condition by the meteorological DA contributed to a reduction of the forecast errors of both meteorology and air quality.

关键词： meteorological data assimilation regional air quality forecast part.culate matter concentration optimal model domain forecast error WRF-chem

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Enhancing BiVO_(4)photoanode performance by insertion of an epitaxial BiFeO_(3)ferroelectric layer

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Journal of Energy chemistry 2024年第2期89卷 71-78,I0003页

作者： Haejin Jang Yejoon Kim Hojoong choi Jiwoong Yang Yoonsung Jung Sungkyun choi Donghyeon lee Ho Won Jang Sanghan lee School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

BiVO_(4)(BVO)is a promising material as the photoanode for use in photoelectrochemical ***,the high charge recombination and slow charge transfer of the BVO have been obst.cles to achieving satisfactory photoelectrochemical *** address this,various modifications have been attempted,including the use of ferroelectric *** materials can form a permanent polarization within the layer,enhancing the separation and transport of photo-excited electron-hole *** this study,we propose a novel approach by depositing an epitaxial BiFeO_(3)(BFO)thin film underneath the BVO thin film(BVO/BFO)to harness the ferroelectric property of *** self-polarization of the inserted BFO thin film simultaneously functions as a buffer layer to enhance charge transport and a hole-blocking layer to reduce charge *** a result,the BVO/BFO photoanodes showed more than 3.5 times higher phot.current density(0.65 mA cm^(-2))at 1.23 V_(RHE)under the illumination compared to the bare BVO photoanodes(0.18 m A cm^(-2)),which is consistent with the increase of the applied bias photon-to-current.conversion efficiencies(ABPE)and the result of electrochemical impedance spectroscopy(EIS)*** results can be attributed to the self-polarization exhibited by the inserted BFO thin film,which promoted the charge separation and transfer efficiency of the BVO photoanodes.

关键词： Photoelectrochemical Photoanode BiVO_(4) Ferroelectric materials BiFeO_(3)

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Rationale and design of tenecteplase Reperfusion therapy in Acute Ischaemic cerebrovascular Events III (tRAcE III): a randomised, phase III, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong Bruce c V campbell Marc Fisher lee H Schwamm Mark Parsons Hao Li Yuesong Pan Xia Meng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina china National clinical Research center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and comprehensive Stroke center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human tNK tissue-type plasminogen activator(rhtNK-tPA)was not inferior to alteplase for ischaemic stroke within *** study aimed to investigate the efficacy and safety of rhtNK-tPA in patients who had an ischaemic stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design tenecteplase Reperfusion therapy in Acute Ischaemic cerebrovascular Events-III(tRAcE III)is a mult.centre,prospective,randomised,open-label,blind endpoint.controlled clinical *** who had an ischaemic stroke due to anterior circulation LVO(internal carotid artery,middle cerebral artery M1 and M2 segments)within 4.5–24hours from last known well(including wake-up stroke and no witness stroke)and with salvageable tissue(ischaemic core volumetch ratio≥1.8 and mismatch volume≥15mL)based on ct perfusion or MRI perfusion-weighted imaging(PWI)were included and randomised to rhtNK-tPA 0.25mg/kg(single bolus)to a maximum of 25mg or standard medical ***,we will exclude patients who are intended for direct *** will be followed up for 90 *** outcomes Primary efficacy outcome is modified Rankin Scale(mRS)score≤1 at 90 *** efficacy outcomes include ordinal distribution of mRS at 90 days,major neurological improvement defined by a decrease≥8 points compared with the initial deficit or a score≤1 on the National Institutes of Health Stroke Scale(NIHSS)at 72 hours,mRS score≤2 at 90 days,the rate of improvement on tmax>6s at 24 hours and NIHSS score change from baseline at *** outcomes are symptomat.c intracerebral haemorrhage within 36 hours and mortality at 90 *** tRAcE III will provide evidence for the efficacy and safety of rhtNK-tPA in patients who had an ischaemic strokes due to anterior circulation LVO beyond *** registration number Nct05141305.

关键词： therapy random Rational

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