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Diabetic factors associated with gastrointestinal symptoms in patients with type 2 diabetes

World Journal of Gastroenterology 2010年第14期16卷 1782-1787页

作者： Jeong Hwan Kim Hyung Seok park soon Young Ko Sung Noh Hong In-Kyung Sung Chan Sub Shim Kee-Ho Song Dong-Lim Kim Sook Kyung Kim Jeeyoung Oh Department of Internal Medicine Digestive Disease Center Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Medical Immunology Center Institute of Biomedical Science and Technology Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Department of Internal Medicine Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Department of Neurology Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea

AIM: To determine whether gastrointestinal (GI) symptoms are more frequent in type 2 diabetic patients and to examine which diabetic factors are associated with the symptoms. METHODS: Consecutive subjects with diabetes and age-/gender-matched normal controls were recruited for this study. GI symptoms were assessed using a structured questionnaire divided into two GI symptomcategories (upper and lower GI symptoms), and consisting of 11 individual symptoms. In the diabetic patient group, diabetic complications including peripheral neuropathy, nephropathy and retinopathy, glycosylated hemoglobin (HbA1c) level and diabetes duration were evaluated. RESULTS: Among the total 190 diabetic patients and 190 controls enrolled, 137 (72%) of the diabetic patients and 116 (62%) of the controls had GI symptoms. In the diabetic patient group, 83 (43%) had upper GI symptoms and 110 (58%) lower GI symptoms; in the control group, 59 (31%) had upper GI symptoms and 104 (55%) lower GI symptoms. This difference between the two groups was significant for only the upper GI symptoms (P = 0.02). Among the diabetic factors, the HbA1c level was the only independent risk factor for upper GI symptoms in the multiple logistic regression analysis (odds ratio = 2.01, 95% confidence interval: 1.02-3.95). CONCLUSION: Type 2 diabetes was associated with an increased prevalence of upper GI symptoms and these symptoms appeared to be independently linked to poor glycemic control, as measured by the HbA1c levels.

关键词： Diabetes HbA1c Upper gastrointestinal symptoms

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A novel cleansing score system for capsule endoscopy

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World Journal of Gastroenterology 2010年第7期16卷 875-880页

作者： Sung Chul park Bora Keum Jong Jin Hyun Yeon Seok Seo Yong Sik Kim Yoon Tae Jeen Hoon Jai Chun soon Ho Um Chang Duck Kim Ho Sang Ryu Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Anam HospitalInstitute of Digestive Disease and NutritionKorea University College of MedicineSeoul 136-705South Korea

AIM:To suggest a new cleansing score system for small bowel preparation and to evaluate its clinical ***:Twenty capsule endoscopy cases were reviewed and small bowel preparation was assessed with the new scoring *** the assessment,two visual parameters were used:proportion of visualized mucosa and degree of *** frames from small bowel images were serially selected and scored at 5-min *** correlation coefficient(ICC)was obtained to assess the reliability of the new scoring *** efficacy evaluation and validation,scores of our new scoring system were compared with another previously reported cleansing grading ***:Concordance with the previous system,inter-observer agreement,and intra-patient agreement were excellent with ICC values of 0.82,0.80,and 0.76,*** intra-observer agreements at four-week intervals were also *** cutoff value of adequate image quality was found to be ***:Our new scoring system is simple,efficient,and can be considered to be applicable in clinical practice and research.

关键词： Capsule endoscopy Cleansing score system

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C-terminal domain of hepatitis C virus core protein is essential for secretion

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World Journal of Gastroenterology 2005年第25期11卷 3887-3892页

作者： Soo-Ho Choi Kyu-Jin park So-Yeon Kim Dong-Hwa Choi Jung-Min park soon B. Hwang Ilsong Institute of Life Science

AIM: We have previously demonstrated that hepatitis C virus (HCV) core protein is efficiently released into the culture medium in insect cells. The objective of this study is to characterize the HCV core secretion in insect cells. METHODS: We constructed recombinant baculoviruses expressing various-length of mutant core proteins, expressed these proteins in insect cells, and examined core protein secretion in insect cells. RESULTS: Only wild type core was efficiently released into the culture medium, although the protein expression level of wild type core was lower than those of other mutant core proteins. We found that the shorter form of the core construct expressed the higher level of protein. However, if more than 18 amino acids of the core were truncated at the C-terminus, core proteins were no longer secreted into the culture medium. Membrane flotation data show that the secreted core proteins are associated with the cellular membrane protein, indicating that HCV core is secreted as a membrane complex. CONCLUSION: The C-terminal 18 amino acids of HCV core were crucial for core secretion into the culture media. Since HCV replication occurs on lipid raft membrane structure, these results suggest that HCV may utilize a unique core release mechanism to escape immune surveillance, thereby potentially representing the feature of HCV morphogenesis.

关键词： Hepatitis C virus Core secretion Morphogenesis Virus assembly

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Chest wall metastasis from unknown primary site of hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第13期12卷 2139-2142页

作者： Yil Sik Hyun Ho soon Choi Joong Ho Bae Dae Won Jun Hang Lak lee Oh Young lee Byung Chul Yoon Min Ho lee Dong Hoo lee Choon Shuk Kee Jung Ho Kang Moon Hyang park Department of Internal Medicine Hanyang University College of Medicine SeoulKorea Department of Thoracic Surgery Hanyang University College of Medicine SeoulKorea Department of Pathology Hanyang University College of Medicine SeoulKorea

Previous reports of a solitary metastatic hepatocellular carcinoma have been rare. Because this tumor has a different treatment modality and prognosis, an accurate differential diagnosis is essential. Here we report a rare case of a solitary chest wall metastasis from unknown primary site of hepatocellular carcinoma. It involves a 51-year-old man who was admitted to our hospital because of a palpable left upper chest wall mass. The mass was resected and pathologic examination confirmed a diagnosis of metastatic hepatocellular carcinoma. Despite our investigation, no evidence was found that indicated the primary origin of the hepatocellular carcinoma. Four months later, the patient was admitted again because of spinal cord compression at the third and fourth thoracic vertebrae. Emergent decompressive laminectomy was performed and microscopic features revealed the same pathology as the initial chest wall mass resected 4 months earlier. After one year, a follow-up abdominal computed tomography （CT） still revealed no evidence of primary hepatocellular carcinoma.

关键词： Chest wall Hepatocellular carcinoma Metastasis

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Evaluation of the Mechanical Characteristics of Large Stone Asphalt Mixtures

Evaluation of the Mechanical Characteristics of Large Stone ...

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4～(th) International Conference on Road & Airfield Pavement Technology

作者： TAE soon park YONG JOO KIM Professor Seoul National University of Technology Dept. of Civil Engineering South Korea Research Engineer Center for Construction Technology Seoul National University of Technology South Korea

＜正＞ This study presents the mechanical characteristics, such as the permanent deformation and the crack, of the large stone asphalt mixtures. The creep tests, the resilient modulus tests on three different temperatures, the wheel tracking and the ravelling tests were conducted to evaluate the mechanical properties of the large stone mixtures and the test results were compared with the conventional mixtures and modified asphalt mixtures. The test results show that the interlocking of the aggregate system of the large stone mixtures is stable and less dependent on the binder characteristics in high temperature. This property is known as the rutting resistant parameters for large stone mixture.

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Switching-on of serotonergic calcium signaling in activated hepatic stellate cells

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World Journal of Gastroenterology 2011年第2期17卷 164-173页

作者： Kyu-Sang park Pyo-Jin Sin Dong Hyeon lee Seung-Kuy Cha Min-Jeong Kim Na-Hyun Kim soon-Koo Baik Seong-Woo Jeong In Deok Kong Department of Physiology and Institute of Lifelong Health Yonsei University Wonju College of Medicine Department of Physiology College of MedicinePochon CHA University Department of Basic Nursing Science Keimyung University College of Nursing Department of Internal Medicine Yonsei University Wonju College of Medicine

AIM:To investigate serotonergic Ca 2+ signaling and the expression of 5-hydroxytryptamine(5-HT) receptors,as well as Ca 2+ transporting proteins,in hepatic stellate cells(HSCs) . METHODS:The intracellular Ca 2+ concentration([Ca 2+ ]i) of isolated rat HSCs was measured with a fluorescence microscopic imaging *** PCR was per-formed to determine the transcriptional levels of 5-HT receptors and endoplasmic reticulum(ER) proteins involved in Ca 2+ storage and release in cultured rat HSCs. RESULTS:Distinct from quiescent cells,activated HSCs exhibited[Ca 2+ ]i transients following treatment with 5-HT,which was abolished by U-73122,a phospholipase C *** of 5-HT2A and 5-HT2B receptors,but not 5-HT3,was prominent during trans-differentiation of *** with ritanserin,a 5-HT2 antagonist,inhibited[Ca 2+ ]i changes upon application of *** of type 1 inositol-5'-triphosphate receptor and type 2 sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase were also increased during activation of HSCs and serve as the major isotypes for ER Ca 2+ storage and release in activated *** 2+ binding chaperone proteins of the ER,including calreticulin,calnexin and calsequestrin,were up-regulated following activation of HSCs. CONCLUSION:The appearance of 5-HT-induced[Ca 2+ ]i response accompanied by upregulation of metabotropic 5-HT2 receptors and Ca 2+ transporting/chaperone ER proteins may participate in the activating process of HSCs.

关键词： Hepatic stellate cells 5-hydroxytryptamine Intracellular Ca 2+ transient Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase Inositol-5’-triphosphate receptor Endoplasmic reticulum chaperone

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Glacier Extent and Volume Change(1966～2000) on the Su-lo Mountain in Northeastern Tibetan Plateau,China

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Journal of Mountain Science 2008年第4期5卷 299-309页

作者： WANG Yetang HOU Shugui HONG Sungmin HUR soon Do LIU Yaping State Key Laboratory of Cryospheric Science Cold and Arid Regions Environmental and Engineering Research Institute CAS Lanzhou 73000 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Korea Polar Research Institute Songdo Techno Park 7-50 Songdo-dong Yeonsu-gu Incheon 406-840 Korea

The topographic maps of 1:50,000 scales,aerial photographs taken in 1966,one Landsat image taken in 1999,and SRTM data from 2000 were used to quantify the losses in area and volume of the glaciers on the Su-lo Mountain,in the northeastern Tibetan Plateau,China in the past 30 *** total glacier area decreased from 492.9km2 in 1966 to 458.2km2 in *** volume loss of the studied glaciers reached 1.4 km3 from 1966 to *** agrees with documented changes in other mountain glaciers of the whole Tibetan Plateau.

关键词： Glacier change Su-lo Mountain ETM +image Tibetan Plateau China

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Report of Precision Agriculture in Korea

Report of Precision Agriculture in Korea

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国际农业工程大会

作者： soon cheul Kim Yoeung Kil Cho Chang Ho Kang Woo Pung park Choung Keun lee Yeongnam Agricultural Research Institute 1085 Neai-dong Milyang-city Gyeongnam 627-803 Korea National Institute of Agricultural Engineering 249 Seodun-dong Gwonson-gu Suwon-city Gyeonggi-do 441-100 KOREA National Institute of Agricultural Engineering 249 Seodun-dong Gwonson-gu Suwon-city Gyeonggi-do 441-100 KOREA National Institute of Agricultural Engineering 249 Seodun-dong Gwonson-gu Suwon-city Gyeonggi-do 441-100 KOREA National Institute of Agricultural Engineering 249 Seodun-dong Gwonson-gu Suwon-city Gyeonggi-do 441-100 KOREA

＜正＞ Precision agriculture is the first stage in Korea. However, the research of that has been carrying since 1998 with centering around the Rural Development Administration. Besides, It has been actively working on...

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Efficacy of Pegylated Interferon Monotherapy versus Sequential Therapy of Entecavir and Pegylated Interferon in Hepatitis B e Antigen-Positive Hepatitis B Patients： A Randomized, Multicenter, Phase IIIb Open-Label Study （POTENT Study）

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Chinese Medical Journal 2018年第14期131卷 1645-1651页

作者： Dae Won Jun Sang Bong Ahn Tae Yeob Kim Joo Hyun Sohn Sang Gyune Kim Se Whan lee Byung Ho Kim Dong Joon Kim Ja Kyung Kim Hyoung Su Kim Seong Gyu Hwang Won Choong Choi Won Young Tak Heon Ju lee Ki Tae Yoon Byung Cheol Yun Sung Wook lee soon Koo Baik Seung Ha park Ji Won park Sol Ji park Ji Sung lee Department of Internal Medicine Hanyang University Seoul Hospital Hanyang University Seou104763 Korea Department of Internal Medicine Nowon Eulji Hospital Eulji University Seou101830 Korea Department of Internal Medicine Hanyang University Guri Hospital Hanyang University Guri 11923 Korea Department of Internal Medicine SoonChunHyang University Bucheon Hospital SoonChunHyang University Bucheon 14584 Korea Department of Internal Medicine SoonChunHyang University Cheonan Hospital SoonChunHyang University Cheonan 31151 Korea Department of Internal Medicine Kyung Hee University Hospital Kyung Hee University Seoul 02453 Korea Department of Internal Medicine Chuncheon Sacred Heart Hospital Hallym University Chuncheon 24252 Korea Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University Seou105355 Korea Department of Internal Medicine Gangnam Severance Hospital Yonsei University Seou106273 Korea Department of Internal Medicine CHA Bundang Medical Center CHA University Seongnam 13496 Korea Department of Internal Medicine Sanggye Paik Hospital Inje University Seoul 01757 Korea Department of Internal Medicine Kyungpook National University Hospital Kyungpook National University Daegu 41944 Korea Department of Internal Medicine Yeungnam University Medical Center Yeungnam University Daegu 42415 Korea Department of Internal Medicine Pusan National University Yangsan Hospital Pusan National University Yangsan 50612 Korea Department of Internal Medicine Kosin University Gospel Hospital Kosin University Pusan 49267 Korea Department of Internal Medicine Dong A University Medical Center Dong A University Pusan 49201 Korea Department of Internal Medicine Wonju Severance Christian Hospital Yonsei University Wonju 26426 Korea Department of Internal Medicine Haeundae Paik Hospital Inje University Pusan 48108 Korea Department of Internal Medicine Hallym University Sacred Heart Hospital Hallym University Anyang 14068 Korea Department of Cli

Background： Until now, various types of combined therapy with nucleotide analogs and pegylated interferon （Peg-INF） in patients with hepatitis B patients have been tried. Howe6ver, studies regarding the benefits of de novo combination, late-add on, and sequential treatmentare very limited. The objective of the current study was to identify the efficacy of sequential treatment of Peg-INF after short-term antiviral treatment. Methods： Between June 2010 and June 2015, hepatitis 13 e antigen （HBeAg）-positive patients （n = 162） received Peg-IFN for 48 weeks （mono-treatment group, n = 81） and entecavir （ETV） for 12 weeks with a 48-week course of Peg-IFN starting at week 5 of ETV therapy （sequential treatment group, n = 81）. The primary endpoint was HBeAg seroconversion at the end of follow-up period after the 24-week treatment. The primary endpoint was analyzed using Chi-square test, Fisher＇s exact test, and regression ***： HBeAg seroconversion rate （18.2% vs. 18.2%, t = 0.03, P = 1.000） and seroclearance rate （19.7% vs. 19.7%, t = 0.03, P = 1.000） were same in both mono-treatment and sequential treatment groups. The rate of alanine aminotransferase （ALT） normalization （45.5% vs. 54.5%, t = 1.12, P = 0.296） and serum hepatitis B virus （HBV）-DNA 〈2000 U/L （28.8% vs. 28.8%, t = 0.10, P = 1.000） was not different in sequential and mono-treatment groups at 24 weeks of Peg-INF. Viral response rate （HBeAg seroconversion and serum HBV-DNA 〈2000 U/L） was not different in the two groups （12.1% vs. 16.7%, t = 1.83, P = 0.457）. Baseline HBV-DNA level （7 log10 U/ml vs. 7.5 log10 U/ml, t = 1.70, P = 0.019） and hepatitis B surface antigen titer （3.6 log10 U/ml vs. 4.0 log10 U/ml, t = 2.19, P = 0.020） were lower and predictors of responder in mono-treatment and sequential treatment groups, respectively. Conclusions： The current study shows no differences in HBeAg seroconversion rate, ALT normalization, and HBV-DNA levels between mono-therapy and sequential therapy regimens.

关键词： Entecavir Hepatitis B Peginterferon Alfa-2a

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Effects of oxygen concentration and flow rate on cognitive ability and physiological responses in the elderly

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Neural Regeneration Research 2013年第3期8卷 264-269页

作者： Hyun-Jun Kim Hyun-Kyung park Dae-Woon Lim Mi-Hyun Choi Hyun-Joo Kim In-Hwa lee Hyung-Sik Kim Jin-Seung Choi Gye-Rae Tack soon-Cheol Chung Department of Obstetrics & Gynecology Konkuk University Department of Laboratory Medicine Seoul Clinical Laboratories Department of Information & Communication Engineering Dongguk University Department of Biomedical Engineering Research Institute of Biomedical EngineeringCollege of Biomedical & Health ScienceKonkuk University

The supply of highly concentrated oxygen positively affects cognitive processing in normal young adults. However, there have been few reports on changes in cognitive ability in elderly subjects following highly concentrated oxygen administration. This study investigated changes in cognitive ability, blood oxygen saturation （%）, and heart rate （beats/min） in normal elderly subjects at three different levels of oxygen [21% （1 L/min）, 93% （1 L/min）, and 93% （5 L/min）] administered during a 1-back task. Eight elderly male （75.3 ＋ 4.3 years old） and 10 female （71.1 ＋ 3.9 years old） subjects, who were normal in cognitive ability as shown by a score of more than 24 points in the Mini-Mental State Examination-Korea, participated in the experiment. The experiment consisted of an adaptation phase after the start of oxygen administration （3 minutes）, a control phase to obtain stable baseline measurements of heart rate and blood oxygen saturation before the task （2 minutes） and a task phase during which the 1-back task was performed （2 minutes）. Three levels of oxygen were administered throughout the three phases （7 minutes）. Blood oxygen saturation and heart rate were measured during each phase. Our results show that blood oxygen saturation increased, heart rate decreased, and response time in the 1-back task decreased as the concentration and amount of administered oxygen increased. This shows that administration of sufficient oxygen for optimal cognitive functioning increases blood oxygen saturation and decreases heart rate.

关键词： neural regeneration clinical practice highly concentrated oxygen cognitive task 1-back task cognitive ability blood oxygen saturation heart rate physiological responses elderly grant-supported paper neuroregeneration

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