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Food Science and Human Wellness 2023年第4期12卷 1287-1299页

作者： Sujin Park YoonA Kim Jaewang lee Hyunsoo Seo Sang-Jip Nam Dong-Gyu Jo Dong-hoon Hyun Department of Life Science Ewha Womans UniversitySeoul 03760South Korea Department of Chemistry and Nano Science Ewha Womans UniversitySeoul 03760South Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419South Korea

Many approaches to neurodegenerative diseases that focus on amyloid-βclearance and gene therapy have not been *** therapeutic applications focus on enhancing neuronal cell survival during the pathogenesis of neurodegenerative diseases,including mitochondrial *** membrane(PM)redox enzymes are crucial in maintaining cellular physiology and redox homeostasis in response to mitochondrial *** phytochemicals are known to induce the expression of detoxifying enzymes under stress *** this study,mechanisms of neuroprotective effects of 4-hydroxycinnamic acid(HCA)were examined by analyzing cell survival,levels of abnormal proteins,and mitochondrial functions in two different neuronal *** protected two neuronal cells exhibited high expression of PM redox enzymes and the consequent increase in the NAD^(+)/NADH *** cultured with HCA showed delayed apoptosis and decreased oxidative/nitrative damage accompanied by decreased ROS production in the *** increased the mitochondrial complexes I and II activities and ATP ***,HCA increased mitochondrial fusion and decreased mitochondrial ***,HCA maintains redox homeostasis and energy metabolism under oxidative/metabolic stress *** findings suggest that HCA could be a promising therapeutic approach for neurodegenerative diseases.

关键词： NADH-quinone oxidoreductase 1(NQO1) Cytochrome b5 reductase 4-Hydroxycinnamic acid Neuroprotection Improved mitochondrial functions

Robotic versus laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: A propensity score-matched analysis

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 154-159页

作者： Dakyum Shin Jaewoo Kwon Jae hoon lee Seo Young Park Yejong Park Woohyung lee Ki Byung Song Dae Wook Hwang Song Cheol Kim Division of Hepato-Biliary and Pancreatic Surgery Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul 05505Korea Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of Medicine29 Saemunan-roJongno-guSeoul 03181Korea Department of Statistics and Data Science Korea National Open University86 Daehak-roJongno-guSeoul 03087Korea

Background: Minimally invasive surgery is becoming increasingly popular in the field of pancreatic surgery. However, there are few studies of robotic distal pancreatectomy(RDP) for pancreatic ductal adenocarcinoma(PDAC). This study aimed to investigate the efficacy and feasibility of RDP for PDAC. Methods: Patients who underwent RDP or laparoscopic distal pancreatectomy(LDP) for PDAC between January 2015 and September 2020 were reviewed. Propensity score matching analyses were performed. Results: Of the 335 patients included in the study, 24 underwent RDP and 311 underwent LDP. A total of 21 RDP patients were matched 1:1 with LDP patients. RDP was associated with longer operative time(209.7 vs. 163.2 min;P = 0.003), lower open conversion rate(0% vs. 4.8%;P < 0.001), higher cost(15 722 vs. 12 699 dollars;P = 0.003), and a higher rate of achievement of an R0 resection margin(90.5% vs. 61.9%;P = 0.042). However, postoperative pancreatic fistula grade B or C showed no significant intergroup difference(9.5% vs. 9.5%). The median disease-free survival(34.5 vs. 17.3 months;P = 0.588) and overall survival(37.7 vs. 21.9 months;P = 0.171) were comparable between the groups. Conclusions: RDP is associated with longer operative time, a higher cost of surgery, and a higher likelihood of achieving R0 margins than LDP.

关键词： Minimally invasive surgery Robotic distal pancreatectomy Laparoscopic distal pancreatectomy Pancreatic ductal adenocarcinoma Propensity score matching

Long-term outcomes of endoscopic submucosal dissection and surgery for undifferentiated intramucosal gastric cancer regardless of size

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World Journal of Gastroenterology 2022年第8期28卷 840-852页

作者： Gil Ho lee Eunyoung lee Bumhee Park Jin Roh Sun Gyo lim Sung Jae Shin Kee Myung lee Choong-Kyun Noh Department of Gastroenterology Ajou University School of MedicineSuwon 16499South Korea Department of Biomedical Informatics Ajou University School of MedicineSuwon 16499South Korea Department of Pathology Ajou University School of MedicineSuwon 16499South Korea

BACKGROUND The clinical outcomes of endoscopic submucosal dissection(ESD)for undifferentiated(UD)intramucosal early gastric cancer(EGC)compared with those of surgery,regardless of lesion size,are not well ***,there is a concern regarding the treatment plan before and after ESD in cases of UD intramucosal EGC within expanded *** To evaluate clinical outcomes of ESD compared with those of surgery in UD intramucosal EGC patients regardless of tumor *** We enrolled patients with UD intramucosal EGC after ESD with complete resection or surgery from January 2005 to August 2020 who met the within or beyond expanded indications with lesion size>2 cm(the only non-curative factor).Overall,123 and 562 patients underwent ESD and surgery,*** propensity-score matching,clinical and long-term outcomes,i.e.,recurrencefree survival(RFS)and overall survival(OS),were *** multivariable Cox proportional hazard model with treatment modality and ESD indication was used to evaluate the recurrence *** After matching,119 patients each were finally enrolled in the ESD and surgery *** median length of hospital stay was shorter in the ESD group than surgery group(4.0 vs 9.0 days,P<0.001).Four cases of recurrence after ESD were local recurrences,all of which occurred within 1 *** recurrence was seven(5.9%)and two(1.7%)in the ESD and surgery groups,*** difference was observed between the two groups with respect to OS(P=0.948).However,the ESD group had inferior RFS compared with the surgery group(P=0.031).ESD was associated with the risk of recurrence after initial treatment in all enrolled patients(hazard ratio,5.2;95%confidence interval:1.0-25.8,P=0.045).CONCLUSION Although OS was similar between the two groups,surveillance endoscopy was important for the ESD than for the surgery group because RFS was inferior and local recurrence was an issue.

关键词： Early gastric cancer Undifferentiated cancer Expanded indication Endoscopic submucosal dissection Surgery

High entropy spinel oxide for efficient electrochemical oxidation of ammonia

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Nano Research 2022年第6期15卷 4785-4791页

作者： Shi He Vasishta Somayaji Mengdi Wang Seung-hoon lee Zhijia Geng Siyuan Zhu Peter Novello Chakrapani V.Varanasi Jie Liu Department of Chemistry Duke UniversityDurhamNC 27708USA U.S.Army Research Office P.O.Box 12211 Research Triangle ParkNC 27709USA

Ammonia has emerged as a promising energy carrier owing to its carbon neutral content and low expense in long-range ***,development of a specific pathway to release the energy stored in ammonia is therefore in urgent *** oxidation provides a convenient and reliable route to attain efficient utilization of ***,we report that the high entropy(Mn,Fe,Co,Ni,Cu)_(3)O_(4)oxides can achieve high electrocatalytic activity for ammonia oxidation reaction(AOR)in non-aqueous *** AOR onset overpotential of(Mn,Fe,Co,Ni,Cu)_(3)O_(4)is 0.70 V,which is nearly 0.2 V lower than that of their most active single metal cation *** mass spectroscopy study reveals that(Mn,Fe,Co,Ni,Cu)_(3)O_(4)preferentially oxidizes ammonia to environmentally friendly diatomic nitrogen with a Faradic efficiency of over 85%.The Xray photoelectron spectroscopy(XPS)result indicates that the balancing metal d-band of Mn and Cu cations helps retain a longlasting electrocatalytic ***,this work introduces a new family of earth-abundant transition metal high entropy oxide electrocatalysts for AOR,thus heralding a new paradigm of catalyst design for enabling ammonia as an energy carrier.

关键词： ammonia electrochemical oxidation high entropy material electrochemical interface renewable energy

Occurrence of human leukocyte antigen B51-related ankylosing spondylitis in a family:Two case reports

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World Journal of Clinical Cases 2022年第3期10卷 992-999页

作者： Mie Jin lim Eul Noh Ro-Woon lee Kyong-Hee Jung Won Park Rheumatology/Internal Medicine Inha UniversityIncheon 22332South Korea Radiology Inha UniversityIncheon 22332South Korea

BACKGROUND Ankylosing spondylitis(AS)is strongly associated with the human leukocyte antigen(HLA)B27 *** regions where conventional polymerase chain reaction for HLA typing is available for antigens such as HLA B27 or HLA B51,it is common to perform the HLA B27 test for evaluation of *** HLA B27-associated clustered occurrences of AS have been reported in families,we report the first case series of HLA B51-related occurrences of AS in a *** SUMMARY A father and his daughters were diagnosed with AS and did not have the HLA B27 *** they were positive for HLA B51,they exhibited no signs of Behçet’s disease(BD).Of the five daughters,one had AS,and three,including the daughter with AS,were positive for HLA *** two daughters with the HLA B51 haplotype(excluding the daughter with AS)exhibited bilateral grade 1 sacroiliitis,whereas the daughters without the HLA B51 haplotype did not have ***,this Korean family exhibited a strong association with the HLA B51 haplotype and clinical sacroiliitis,irrespective of the symptoms of *** It is advisable to check for HLA B51 positivity in patients with AS/spondyloarthropathy who test negative for HLA B27.

关键词： Ankylosing spondylitis Spondyloarthropathy Human leukocyte antigen B51 Human leukocyte antigen B27 Sacroiliitis Case report

Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation

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World Journal of Stem Cells 2022年第3期14卷 245-263页

作者： Min-Jung Kim Won Moon Jeonghoon Heo Sangwook lim Seung-Hyun lee Jee-Yeong Jeong Sang Joon lee Department of Biochemistry Cancer Research Institute Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Internal Medicine Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Molecular Biology and Immunology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Radiation Oncology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of General Surgery Kosin University College of MedicineSeogu 49267BusanSouth Korea Department of Ophthalmology Gospel HospitalKosin University College of MedicineSeo-gu 49267BusanSouth Korea

BACKGROUND Bone marrow(BM)suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to *** concerted efforts,there is no definitive treatment method *** studies have reported using mesenchymal stromal cells(MSCs),but their therapeutic effects are *** We administered and examined the effects of various amounts of adipose-derived MSCs(ADSCs)in mice with radiation-induced BM *** Mice were divided into three groups:Normal control group,irradiated(RT)group,and stem cell-treated group following whole-body irradiation(WBI).Mouse ADSCs(mADSCs)were transplanted into the peritoneal cavity either once or three times at 5×10^(5) cells/200μ*** white blood cell count and the levels of,plasma cytokines,BM mRNA,and BM surface markers were compared between the three *** BM-derived CD34+hematopoietic progenitor cells were co-cultured with human ADSCs(hADSCs)or incubated in the presence of hADSCs conditioned media to investigate the effect on human cells in *** The survival rate of mice that received one transplant of mADSCs was higher than that of mice that received three *** transplantations of ADSCs delayed the repopulation of BM hematopoietic stem ***-inflammatory effects and M2 polarization by intraperitoneal ADSCs might suppress erythropoiesis and induce myelopoiesis in sub-lethally RT *** The results suggested that an optimal amount of MSCs could improve survival rates post-WBI.

关键词： Adipose tissue-derived stem cells Bone marrow suppression Mesenchymal stromal cells Radiation Cell therapy

CO_(2)-adsorbent spongy electrode for non-aqueous Li–O_(2) batteries

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Journal of Energy Chemistry 2022年第2期31卷 646-653页

作者： Yiseul Yoo Giseung lee Min-Gi Jeong Hun-Gi Jung Sunghee Shin Dongjin Byun Taeeun Yim Hee-Dae lim Center for Energy Storage Research Korea Institute of Science and Technology(KIST)Hwarang-ro 14-gil 5Seongbuk-guSeoul 02792Republic of Korea Department of Materials Science and Engineering Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea Department of Chemistry Incheon National University119 Academy-roYeonsu-guIncheon 22012Republic of Korea Department of Chemical and Biological Engineering Korea UniversitySeoul 02841Republic of Korea

Regulation of the Li_(2)CO_(3) byproduct is the most critical challenge in the field of non-aqueous Li–O_(2) *** considerable efforts have been devoted to preventing Li_(2)CO_(3) formation,no approaches have suggested the ultimate solution of utilizing the clean Li_(2)O_(2) reaction instead of that of Li_(2)CO_(3).Even if extremely pure O_(2) is used in a Li–O_(2) cell,its complete elimination is impossible,eventually generating CO_(2) gas during *** this paper,we present the new concept of a CO_(2)-adsorbent spongy electrode(CASE),which is designed to trap the evolved CO_(2) using adsorption *** candidates composed of amine functional groups(–NH2)for capturing CO_(2) were screened,with quadrapurebenzylamine(QPBZA)exhibiting superior CO_(2)-adsorbing ability among the proposed ***,we fabricated the CASE by sandwiching QPBZA between porous carbon layers,which facilitated the transport of gaseous *** new electrode was demonstrated to effectively capture the evolved CO_(2) during charge,therefore altering the reaction pathways to the ideal *** is highly advantageous to mitigate the undesirable CO_(2) incorporation in the next discharge,resulting in improved *** novel concept of a CO_(2)-sponging electrode provides an alternative route to the realization of practically meaningful Li–O_(2) batteries.

关键词： Li-O_(2)battery Benzylamine CO_(2)adsorption Li_(2)CO_(3) Li_(2)O_(2) CO_(2)-sponging electrode

Engineering Geometric Electrodes for Electric Field-Enhanced High-Performance Flexible In-Plane Micro-Supercapacitors

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Energy & Environmental Materials 2023年第4期6卷 114-120页

作者： Jihong Kim Sung Min Wi Jong-Guk Ahn Sangjun Son Hee Young lim Yeonsu Park Hye Ji Eun Jong Bae Park Hyunseob lim Sangyeon Pak A-Rang Jang Young-Woo lee Department of Energy Engineering Soonchunhyang UniversityAsan 31538Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju 61005Korea Jeonju Centre Korea Basic Science InstituteJeonju 54907Korea Prof.S.Pak School of Electronic and Electrical Engineering Hongik UniversitySeoul 04066Korea Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonan 31080Korea

In plane micro-supercapacitors that are miniaturized energy storage components have attracted significant attention due to their high power densities for various ubiquitous and sustainable device systems as well as their facile integration on various flexible/wearable *** implement the micro-supercapacitors in various practical applications that can accompany solid state or gel electrolyte and flexible substrates,ions must be readily transported to electrodes for achieving high power ***,we show large enhancement in electrochemical properties of flexible,inplane micro-supercapacitor using sharp-edged interdigitated electrode design,which was simply fabricated through direct laser scribing *** sharp-edged electrodes allowed strong electric field to be induced at the corners of the electrode fingers which led to the greater accumulation of ions near the surface of electrode,significantly enhancing the energy storage performance of *** electric field-enhanced in-plane micro-supercapacitor showed the volumetric energy density of 1.52 Wh L^(−1)and the excellent cyclability with capacitive retention of 95.4%after 20000 *** further showed various practicability of our sharp-edged design in micro-supercapacitors by showing circuit applicability,mechanical stability,and air *** results present an important pathway for designing electrodes in various energy storage devices.

关键词： electric field enhancement flexible energy storage device microsupercapacitors sharp electrodes

Safety of acupotomy in a real-world setting:A prospective pilot and feasibility study

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Journal of Integrative Medicine 2022年第6期20卷 514-523页

作者： Sang-hoon Yoon Chan-Young Kwon Hee-Geun Jo Jae-Uk Sul Hyangsook lee Jiyoon Won Su Jin Jeong Jun-Hwan lee Jungtae leem Chung-Yeon Korean Medicine Clinic Gangnam-guSeoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusanjin-guBusan 47340Republic of Korea Department of Herbal Pharmacology College of Korean MedicineGachon University1342 Seongnamdae-roSujeong-guSeongnam 13120Republic of Korea Department of Korean Rehabilitation Medicine Dongshin University Korean Medicine HospitalGwangju 61619Republic of Korea Acupuncture and Meridian Science Research Center Kyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea Department of Science in Korean Medicine Graduate SchoolKyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Statistics Support Medical Science Research InstituteKyung Hee University Medical CenterDongdaemun-guSeoul 02447Republic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea Korean Medicine Life Science University of Science&Technology(UST)Campus of Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea College of Korean Medicine Wonkwang UniversityIksanJeollabuk-do54538Republic of Korea

Objective:Acupotomy is a modern acupuncture method that includes modern surgical *** acupotomy is relatively more invasive than filiform acupuncture treatment,it is important to establish the safety profile of this *** justify further large-scale prospective observational studies,this preliminary study was performed to assess the feasibility of the approach and investigate the safety profile and factors potentially associated with adverse events(AEs).Methods:This was a prospective pilot study that assessed the feasibility of a large-scale forthcoming safety study on acupotomy treatment in a real-world *** feasibility(call response rate,dropout rate,response rate for each variable and recruitment per month)and safety profile(incidence,type,severity and causality of AEs,and factors potentially associated with AEs)were ***:A total of 28 participants joined the study from January to May 2018.A follow-up assessment was achieved in 258(1185 treatment points)out of 261 sessions(1214 treatment points).The response rate via telephone on the day after treatment was 87.3%.There were 8 systemic AEs in all the sessions(8/258;3.11%)and 27 local AEs on the total points treated(27/1185;2.28%).Severe AEs did not *** AE and local AE occurrence were associated with blade width and the number of needle stimulations per treatment ***:The findings suggest that it could be feasible to analyze the safety of acupotomy in a realworld ***,the primary data on some relevant AEs could be *** are planning large-scale prospective studies based on these *** registration:Clinical Research Information Service(CRIS)KCT0002849(https://***/cris/search/***/11487).

关键词： Acupotomy Acupuncture Safety Adverse effects Observational study Traditional Chinese medicine

Gouty tenosynovitis with compartment syndrome in the hand: A case report

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World Journal of Clinical Cases 2023年第30期11卷 7492-7496页

作者： Dong Yun lee SuRak Eo SooA lim Jung Soo Yoon Department of Plastic and Reconstructive Surgery DongGuk University Medical CenterGoYang 10326South Korea

BACKGROUND Gout is a common type of inflammatory arthritis caused by the deposition of monosodium urate crystals in the joints and surrounding *** typically appears with abrupt and intense pain,redness,and swelling in the affected *** frequently targets the lower extremities,such as the big ***,rarely,gout can manifest in atypical locations,including the hands,leading to an uncommon presentation known as gouty ***,it can result in significant morbidity owing to the potential for severe complications,such as myonecrosis and compartment *** SUMMARY An 82-year-old male patient with a history of hypertension,cerebral infarction,Parkinson's disease,and recurrent gout attacks sought medical attention because of progressive pain and swelling in the right *** findings revealed forearm swelling,raising concerns of possible tenosynovitis,bursitis,septic arthritis,and compartment syndrome.A fasciotomy was performed to decompress the patient’s hands and *** procedure revealed diffuse tenosynovitis,tophi with a pus-like discharge surrounding the carpal tunnel,and involvement of the flexor and extensor tendon ***,microbiological investigations,including Gram staining,acid-fast bacilli,tuberculosis,and nontuberculous mycobacteria,yielded negative *** patient was ultimately diagnosed with a severe gouty attack with compartment syndrome and *** arthritis and infectious flexor tenosynovitis were ruled *** debridement and inflammation control were initiated,followed by staged closure with a skin *** Septic-like complications can occur in the absence of infection in severe gout attacks with pus-like discharges due to compartment syndrome and *** can be used to differentiate between gouty attacks,septic arthritis,and infectious *** of the flexor and extensor muscles,as in this case,is *** study contributes to the literature

关键词： Compartment syndrome Extensor compartment Gout Tenosynovitis Case report