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Novel nanocomposites based on a strawberry-like gold-coated magnetite （Fe@Au） for protein separation in multiple myeloma serum samples

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Nano Research 2015年第4期8卷 1189-1198页

作者： Jose E. araujo Carlos Lodeiro Jose L. Capelo Benito Rodrfguez-Gonzalez Alcindo A. dos Santos~ Hugo M. Santos Javier Ferna.ndez-Lodeiro BIOSCOPE Research Group UCIBIO-REQUIMTE Department of Chemistry Faculty of Science and Technology University NOVA of Lisbon 2829-516 Caparica Portugal PROTEOMASS Scientific Society Madan Parque Rua dos Inventores 2825-182 Caparica Portuga Scientific and Technological Research Assistance Centre (CACTI) University of Vigo Vigo Spain Instituto de Quimica Universidade de Sao Paulo Av. Prof. Lineu Prestes 748 CxP 26077 Sao Paulo 05508-000 Brazil

在水的媒介生产与像草莓的金 nanoparticles 部分涂的磁铁矿的一个新过程被报导。对磁场和金基于 nanoparticle 的胶体的系统的光性质的快反应是这新 Fe@Au nanomaterial 的二个主要优点。这些优点允许为在 proteomics 和 biomedicine ... 详细信息

在水的媒介生产与像草莓的金 nanoparticles 部分涂的磁铁矿的一个新过程被报导。对磁场和金基于 nanoparticle 的胶体的系统的光性质的快反应是这新 Fe@Au nanomaterial 的二个主要优点。这些优点允许为在 proteomics 和 biomedicine 的各种各样的目的这新胶体的 nanomaterial 的使用当蛋白质能也绑在表面，和表面罐头，是 functionalized。作为 proof-of-concept，新 Fe@Au nanoparticles 为蛋白质的集中前和分离作为一个工具在 biomarker 发现被估计了从复杂 proteomes。到这个目的，从健康的人的 sera 与从与多重骨髓瘤诊断的病人的 sera 相比。与集体 spectrometry 相结合的这新 Fe@Au nanomaterial 的应用程序允许 53 的鉴定蛋白质，和它也证明了热吃惊蛋白质 HSP75 和血浆朊酶 C1 禁止者是为多重骨髓瘤前进的诊断和控制的潜在的 biomarkers。

关键词：蛋白质分离多发性骨髓瘤血清样品磁铁矿纳米复合材料镀金草莓金纳米粒子

Travelling Waves in Space-Fractional Nonlinear Diffusion with Linear Convection

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Journal of Applied Mathematics and Physics 2017年第2期5卷 462-468页

作者： Felix Silva Costa Marta Raquel araujo Pereira Department of Mathematics and Informatics State University of Maranh&atildeo S&atildeo Luis Brazil Computer Engineering State University of Maranh&atildeo S&atildeo Luis Brazil

In this paper we investigate anomalous diffusion coupled with linear convection, using fractional calculus to describe the anomalous associated memory effects in diffusive term. We get an explicit travelling wave solu... 详细信息

关键词： Fractional Convection-Diffusion Riesz Derivative Travelling Wave Wavefront

Engineering a Localized Surface Plasmon Resonance Platform for Molecular Biosensing

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Open Journal of Applied Sciences 2018年第3期8卷 126-139页

作者： Sajid Farooq Renato E. de araujo Laboratory of Biomedical Optics and Imaging Federal University of Pernambuco Recife Brazil

In this work, we introduce a new perspective on the development of Localized Surface Plasmon Resonance (LSPR) optical biosensors. Computational simulations, focused on the assessment of the LSPR spectrum and spatial distribution of the electromagnetic field enhancement near a metallic nanoparticle, elucidated the behavior of crucial parameters, as figure of merit, bulk and molecular sensitivity, which governs a LSPR sensor performance. Gold and silver nanospheres were explored as starting point to assess plasmonic optical characteristics of the nanostructured sensor platform. Here, for the first time in the literature, Campbell’s model was evaluated exploiting a NP size-dependence approach. The theoretical analyses indicate a nonlinear behavior of the bulk and molecular sensitivity as function of the NP size. Substantial LSPR peak shifts due to the adsorption of molecules layer on a NP surface were observed for nanoparticles with ~5 nm and ~40 nm radius. Moreover, on molecular sensing, LSPR peak shift is also determined by the thickness of adsorbed molecular shell layers. We observed that for 40 nm radius gold and silver nanospheres, significant LSPR peak shift could be induced by small (few nm) thickness change of the adsorbate shell layer. Moreover, this work provides insights on the LSPR behavior due to adsorption of molecular layer on a NP surface, establishing a new paradigm on engineering LSPR biosensor. Furthermore, the proposed approach can be extended to engineer an efficiently use of different nanostructures on molecular sensing.

关键词： Localized Surface Plasmon Resonance Optical Sensor Nanomaterials

The differential genetic signatures related to climatic landscapes for jaguars and pumas on a continental scale

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Integrative Zoology 2021年第1期16卷 2-18页

作者： Marina ZANIN Noa GONZALEZ-BORRAJO Cuauhtémoc CHÁVEZ Yamel RUBIO Bart HARMSEN Claudia KELLER Pablo VILLALVA Ana Carolina SRBEK-araujo Leonora Pires COSTA Francisco PALOMARES Biology Department Federal University of MaranhãoSão LuísBrazil Departamento de Biologia de la Conservación Estación Biológica de DoñanaSevillaSpain Departamento de Ciencias Ambientales Universidad Autónoma MetropolitanaMexico CityMexico Escuela de Biologia Universidad Autónoma de SinaloaCuliacánMexico Panthera New YorkUSA Biodiversity Coordination Amazon Research InstituteManausBrazil Biology Department Vila Velha UniversityVila VelhaBrazil Biological Sciences Department Federal University of Espírito SantoVitóriaBrazil

Modern and paleoclimate changes may have altered species dynamics by shifting species’niche suitability over space and *** analyze whether the current genetic structure and isolation of the two large American felids,jaguar(Panthera onca)and puma(Puma concolor),are mediated by changes in climatic suitability and connection routes over modern and paleoclimatic *** estimate species distribution under 5 climatic landscapes(modern,Holocene,last maximum glaciations[LMG],average suitability,and climatic instability)and correlate them with individuals’genetic isolation through causal modeling on a resemblance *** species exhibit genetic isolation patterns correlated with LMG climatic suitability,suggesting that these areas may have worked as“allele refuges.”However,the jaguar showed higher vulnerability to climate changes,responding to modern climatic suitability and connection routes,whereas the puma showed a continuous and gradual transition of genetic *** differential responsiveness to climate change,both species are subjected to the climatic effects on genetic configuration,which may make them susceptible to future climatic changes,since these are progressing faster and with higher intensity than changes in the ***,the effects of climatic changes should be considered in the design of conservation strategies to ensure evolutionary and demographic processes mediated by gene flow for both species.

关键词： causal modeling climatic landscape ecological niche modeling gene flow linear mixed model

Appropriate search techniques to estimate Weibull function parameters in a Pinus ***

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Journal of Forestry Research 2021年第6期32卷 2423-2435页

作者： Lais Almeida araujo Rafael Menali Oliveira Mario Dobner Jr Carolina Souza Jarochinskie Silva Lucas Rezende Gomide Department of Forest Sciences Federal University of LavrasLavrasMinas GeraisBrazil Department of Agriculture Biodiversity and ForestsFederal University of Santa CatarinaCuritibanosSanta CatarinaBrazil

The Weibull function,a continuous probability distribution,is widely used for diameter distribution modelling,in which parameter estimation performance is affected by stand attributes and fitting *** Weibull cumulative distribution function is nonlinear,and classical fitting methods may provide a not optimal *** the use of artificial intelligence by metaheuristics is reasonable for this optimisation ***,aimed and compared(1)the metaheuristics genetic algorithm and simulated annealing performance over the moment and percentile methods;(2)the hybrid strategy merging the metaheuristics tested and the percentile method and,(3)the metaheuristics fitness functions under basal area and density errors.A long-term experiment in a Pinus taeda stand subjected to crown thinning was *** to our findings,all methods have a similar performance,independent of the thinning regimes and *** pattern of the estimated parameters tends to be acceptable,as b increases over time and c increases after ***,our findings suggest that methods based on metaheuristics have a higher precision than classical methods for estimating Weibull *** to the classification test,the methods that involved simulated annealing stood *** hybrid method involving this metaheuristic also stood out,with accurate *** methods showed the poorest performance,and we therefore suggest the use of simulated annealing due to its faster processing time and high-quality solution.

关键词： Forest management Diameters distribution Weibull function Genetic algorithm Simulated annealing

CFD predictions for hazardous area classification

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Chinese Journal of Chemical Engineering 2019年第1期27卷 21-31页

作者： Andrey Oliveira de Souza Aurélio Moreira Luiz Ant?nio Tavernard Pereira Neto Ant?nio Carlos Brandao de araujo Heleno Bispo da Silva Sidinei Kebler da Silva Jose Jailson Nicacio Alves Federal Institute of Education Science and Technology of Paraiba Petrobras-Petróleo Brasileiro S.A. Federal University of Campina Grande

This study aimed to describe a Computational Fluid Dynamics(CFD) procedure using the ANSYS CFX software 16.1 and Design of Experiments for the determination of volume and extension of explosive atmospheres due to fugitive emissions of flammable *** multidimensional statistical sampling technique Latin Hypercube was used, which defined 100 simulations of random methane gas leak *** CFD model proved to be robust in predicting the extension and volume of the explosive atmosphere for orifice diameters from 0.1 to2.5 mm, pressure from 0.1 MPa to 12 MPa and temperatures from 0 ℃ to 400 ℃.It was found that the calculation domain must be parameterized 8 m in length for each millimeter of the diameter of the source of release to ensure the *** order not to lose precision for very small diameters, the mesh was parameterized with 50 elements along the orifice *** was proved that gravity does not influence the extension and volume of the explosive atmosphere at sonic *** deviation from the ideal gas behavior in the reservoir,achieved by applying the Soave–Redlich–Kwong equation of state, also has not significantly influenced the extension and volume of the explosive *** results showed that the size of the explosive atmosphere varies directly with the diameter of the source emission and reservoir pressure, and inversely with the temperature of the *** diameter of the source is the parameter that has the major effect on the extension of the explosive atmosphere, followed by the pressure and lastly the temperature of the reservoir.

关键词： Computational Fluid Dynamics Computer simulation Safety Fugitive emissions Classified area Flammable gas cloud

Regression of Barrett＇s Esophagus： Is There a Difference between Clinical and Surgical Treatment？

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Journal of Pharmacy and Pharmacology 2017年第12期5卷 928-933页

作者： Ramon Rawache Barbosa Moreira de Lima Fernando Antonio Siqueira Pinheiro Joao Odilo Goncalves Pinto Marcos Andre araujo Accioly Filho Mateus Alves de araujo Paulo Henrique araujo Parente Department of Digestive Surgery Walter Cantideo University Hospital Federal University of Ceara Fortaleza 60430-380 Brazil

Herpetological Diversity of Timor-Leste: Updates and a Review of Species Distributions

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Asian Herpetological Research 2015年第2期6卷 73-131页

作者： Mark O'SHEA Caitlin SANCHEZ Andrew KATHRINER Sven MECKE Venancio LOPES CARVALHO Agivedo VARELA RIBEIRO Zito AFRANIO SOARES Luis LEMOS DE araujo Hinrich KAISER Faculty of Science and Engineering University of Wolverhampton Wulfruna Street Wolverhampton WV1 1LY United Kingdom and West Midland Safari Park Bewdley Worcestershire DY12 LF United Kingdom Department of Biology Victor Valley College Department of Biology Villanova University 800 East Lancaster Avenue Villanova Pennsylvania 19085 USA Department of Herpetology Bronx Zoo 2300 Southern Boulevard Bronx New York 10460 USA Department of Animal Evolution and Systematics Faculty of Biology Philipps Universit?t Marburg Universidade National Timor-Lorosa’e Faculdade de Ciencias da Educa?ao Departamentu da Biologia Avenida Cidade de Lisboa Liceu Dr. Francisco Machado Dili Timor-Leste Department of Vertebrate Zoology National Museum of Natural History Smithsonian Institution

We report the results of five herpetological surveys during 2011-2013 that included visits to all districts of Timor-Leste （Aileu, Ainaro, Baucau, Bobonaro, Dili, Covalima, Ermera, Laut6m, Liquiga, Manatuto, Manufahi, Viqueque） except the Oecusse exclave. Our fieldwork culminated in the discovery of one putative new frog species （genus Kaloula）, at least five putative new lizard species （genera Cyrtodactylus, Cryptoblepharus, and Sphenomorphus）, and two putative new snake species （genera Stegonotus and Indotyphlops）. In addition, we present new distribution records of amphibians and reptiles for 11 of the country＇s 12 contiguous districts, along with additional natural history data. Results from our surveys increase the number of amphibian and reptiles known to occur in Timor-Leste from 22 species before our surveys began to over 60, including over 20 as yet undescribed species.

关键词： Timor-Leste Kaloula Cyrtodactylus Eremiascincus Stegonotus

Scoping review on vector-borne diseases in urban areas:transmission dynamics,vectorial capacity and co-infection

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Infectious Diseases of Poverty 2018年第1期7卷 916-939页

作者： Marcus Eder Fanny Cortes Noemia Teixeira de Siqueira Filha Giovanny Vinicius araujo de Franca Stephanie Degroote Cynthia Braga Valery Ridde Celina Maria Turchi Martelli Public Health England Sierra Leone Country Office FreetownSierra Leone Aggeu Magalhaes Institute(IAM)/Oswaldo Cruz Foundation(Fiocruz) Avenida Professor Moraes Regos/n.Cidade Universitaria.CEP 50RecifePernambuco 740-465Brazil Universidade de Pernambuco(UPE) RecifePernambucoBrazil Liverpool School Of Tropical Medicine(LSTM) LondonUK Secretariat of Health Surveillance Ministry of HealthBrasiliaBrazil University of Montreal School of Public Health(ESPUM) MontrealQuebecCanada IRD(French Institute For Research on Sustainable Development) CEPED(IRD-UniversiteParis Descartes)Universites Paris Sorbonne CitesERL INSERM SAGESUDParisFrance

Background:Transmission dynamics,vectorial capacity,and co-infections have substantial impacts on vector-borne diseases(VBDs)affecting urban and suburban *** key factors can provide insight into priority research areas and offer suggestions for potential *** body:Through a scoping review,we identify knowledge gaps on transmission dynamics,vectorial capacity,and co-infections regarding VBDs in urban ***-reviewed and grey literature published between 2000 and 2016 was *** screened abstracts and full texts to select *** an extraction grid,we retrieved general data,results,lessons learned and recommendations,future research avenues,and practice *** classified studies by VBD and country/continent and identified relevant knowledge *** 773 articles selected for full-text screening,50 were included in the review:23 based on research in the Americas,15 in Asia,10 in Africa,and one each in Europe and *** largest body of evidence concerning VBD epidemiology in urban areas concerned dengue and *** arboviruses covered included chikungunya and West Nile virus,other parasitic diseases such as leishmaniasis and trypanosomiasis,and bacterial rickettsiosis and *** articles retrieved in our review combined transmission dynamics and vectorial capacity;only two combined transmission dynamics and *** review identified significant knowledge gaps on the role of asymptomatic individuals,the effects of co-infection and other host factors,and the impacts of climatic,environmental,and socioeconomic factors on VBD transmission in urban *** included the trade-off from narrowing the search strategy(missing out on classical modelling studies),a lack of studies on co-infections,most studies being only descriptive,and few offering concrete public health *** research is needed on transmission risk in homes and workplaces,given increasingly dynamic and mobil

关键词： Arboviruses Disease vectors Coinfection Urban population Epidemiology Review