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谷歌遭遇最大反断挫败面临拆分风险

商业周刊（中文版） 2024年第13期 16-18页

作者： leah Nylen 程玺(译) 不详

这是20余年来首宗由美国联邦政府起诉科技公司的反垄断案件.8月5日,美国法官裁定Alphabet Inc.旗下的谷歌公司在搜索市场构成非法垄断,这是谷歌遭遇的最大反垄断挫败。这标志着美国司法部和州检察长的重大胜利,而成立25载的谷歌也将因... 详细信息

这是20余年来首宗由美国联邦政府起诉科技公司的反垄断案件.8月5日,美国法官裁定Alphabet Inc.旗下的谷歌公司在搜索市场构成非法垄断,这是谷歌遭遇的最大反垄断挫败。这标志着美国司法部和州检察长的重大胜利,而成立25载的谷歌也将因此面临拆分风险。

关键词：美国司法部反垄断谷歌公司美国联邦政府拆分检察长美国法官挫败

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沙漠彩虹丝兰谷住宅

室内设计与装修 2024年第1期 18-23页

作者： [美国]leah Ring 秋落(编译) 无不详 Another human

经过对丝兰谷多年的考察,室内设计公司Another human的创始人leah Ring决定在此购买一处房产,用来实践她设计敏感性的极端版本。这处房产由4栋年久失修的小屋组成,为Ring提供了一块空白的创作空间。Ring只保留了建筑的外壳,发挥她的想... 详细信息

经过对丝兰谷多年的考察,室内设计公司Another human的创始人leah Ring决定在此购买一处房产,用来实践她设计敏感性的极端版本。这处房产由4栋年久失修的小屋组成,为Ring提供了一块空白的创作空间。Ring只保留了建筑的外壳,发挥她的想象力和创造力,将大胆的色彩、活泼的造型与复古的产品相结合,体现一种趣味性。这处房产既是她的第二个家,也是她室内设计和家具设计的展示场所。

关键词：创作空间丝兰住宅房产 Ring 趣味性敏感性

Methyl-CpG binding proteins in the nervous system

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Cell Research 2005年第4期15卷 255-261页

作者： leah hUTNICK CA 90095-7088 University of California at Los Angeles Department of human Genetics and Interdepartmental Program of Neuroscience David Geffen School of Medicine USA P.O. Box957088

Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain(MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional repressors,mediating gene silencing via DNA cytosine methylation. Mutations in methyl-CpG binding protein 2 (MeCP2) have beenlinked to the human mental retardation disorder Rett syndrome, suggesting an important role for methyl-CpG bindingproteins in brain development and function. This mini-review summarizes the recent advances in studying the diversefunctions of MeCP2 as a prototype for other methyl-CpG binding proteins in the development and function of thevertebrate nervous system.

关键词： MeCP2 MBD proteins DNA methylation neuronal differentiation chromatin remodeling gene silencing histone modification.

17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α

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Acta Pharmaceutica Sinica B 2016年第5期6卷 504-509页

作者： Sung-joon Cho Miaoran Ning Yanyan Zhang leah h.Rubin hyunyoung Jeong Department of Biopharmaceutical Sciences College of PharmacyUniversity of Illinois at Chicago Department of Pharmacy Practice College of PharmacyUniversity of Illinois at Chicago Department of Psychiatry University of Illinois at Chicago

UDP-glucuronosyltransferase 1A9(UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous *** data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users,but the role of estrogen in the regulation of UGT1A9 expression remains *** this study,we investigated the effect of 17β-estradiol(E2) on UGT1A9 expression and the role of ERα in the transcriptional regulation of UGT1A9.E2 significantly increased UGT1A9 promoter activity in hep G2 cells in the presence of ERα.UGT1A9 induction by E2 was abrogated by antiestrogen ICI182,780 in hep G2 cells that constitutively express ERα.Results from transient transfection of ERα mutants into hep G2 cells demonstrated that mutation at DNA-binding domain of ERα abrogates increased UGT1A9 promoter activity by *** and mutation assays of UGT1A9 promoter revealed a putative ERE located within -2262/-1987 *** of healthy human liver tissues revealed significantly higher UGT1A9 expression in women as compared to ***,these findings provide a mechanistic basis for the previous clinical reports and may shed a light on identifying sources for inter-individual variability in UGT1A9-mediated drug metabolism.

关键词： UGT1A9 17β-Estradiol Estrogen receptor Drug metabolism Sex difference

RACK1 regulates neural development

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Neural Regeneration Research 2017年第7期12卷 1036-1039页

作者： leah Kershner Kristy Welshhans Department of Biological Sciences Kent State University Kent OH USA School of Biomedical Sciences Kent State University Kent OH USA

Receptor for activated C kinase 1（RACK1）is an evolutionarily conserved scaffolding protein within the tryptophan-aspartate（WD）repeat family of ***1 can bind multiple signaling molecules concurrently,as well as stabilize and anchor ***1 also plays an important role at focal adhesions,where it acts to regulate cell *** addition,RACK1 is a ribosomal binding protein and thus,regulates *** these numerous functions,little is known about how RACK1 regulates nervous system ***,we review three studies that examine the role of RACK1 in neural *** brief,these papers demonstrate that（1）RACK-1,the *** homolog of mammalian RACK1,is required for axon guidance;（2）RACK1 is required for neurite extension of neuronally differentiated rat PC12cells;and（3）RACK1 is required for axon outgrowth of primary mouse cortical ***,it is evident that RACK1 is critical for appropriate neural development in a wide range of species,and future discoveries could reveal whether RACK1 and its signaling partners are potential targets for treatment of neurodevelopmental disorders or a therapeutic approach for axonal regeneration.

关键词： RACK1 RACK-1 neural development neurite outgrowth axon outgrowth axon guidance

Nutrition management in acute pancreatitis: Clinical practice consideration

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World Journal of Clinical Cases 2020年第9期8卷 1561-1573页

作者： Narisorn Lakananurak leah Gramlich leah Gramlich Department of MedicineUniversity of AlbertaEdmonton T6G 2R3AlbertaCanada Department of Medicine Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand

Acute pancreatitis(AP)is a common gastrointestinal disease and the leading cause of hospital admission and healthcare burden among gastrointestinal disorders in many *** can present with varying degrees of inflammation and disease severity,ranging from self-limiting mild AP to devastating and fatal severe *** factors contribute to malnutrition in AP,especially abnormal metabolism and catabolism related to *** concept of“pancreatic rest”is not *** is however,emerging evidence that supports the use of oral or enteral nutrition to improve nutrition status and to reduce local and systemic inflammation,complications,and *** mild disease,patients are generally able to initiate solid oral diet and do not require specialized nutrition care such as enteral or parenteral *** contrast,nutrition interventions are imperative in moderately severe and severe *** current article aims to review the latest evidence and suggest practical nutrition interventions in patients with AP,including nutrition requirements,routes of nutrition treatment,types of formula,and the role of nutritional supplements,such as glutamine,probiotics,omega-3 fatty acids,and antioxidants.

关键词： Acute pancreatitis Nutrition management Enteral nutrition Parenteral nutrition Nutritional supplement Nutrition assessment

The De of Levinas： Cultivating the heart-Mind of Radical Passivity

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Frontiers of Philosophy in China 2015年第1期10卷 113-129页

作者： leah Kalmanson Sarah Mattice Drake University Des Moines Iowa 50311 USA University of North Florida Jacksonville Florida 32224 USA

This essay explores the early Chinese text Guanzi to address the question of ethical responsibility in the work of Emmanuel Levinas. We begin with the premise that being responsive to the other, feeling the impossibility of renouncing ethical obligation, and experiencing the basic moral asymmetry at the heart of Levinas＇s project all rely on the welcome openness of the subject that Levinas describes as the subject＇s ＂radical passivity.＂ however, his emphasis on infinite responsibility, coupled with the theme of radical passivity, gives the problematic impression that ethics amounts to a never-ending to-do list for the other, and certainly this is not what Levinas means. We turn to the Guanzi, which recommends that the ethically efficacious sage-prince must cultivate a state of passive stillness and inner vacuity. Only because the sage-prince maintains this deferential heart-mind is he freely open and responsive to others. here the sage-prince looks strikingly like a good Levinasian： he is deferential, sensitive to context, and hyper-aware of the limits of his own knowledge. The Guanzi goes on to describe specific practices the sage-prince can employ to cultivate his ethical prowess, including practices of meditation and gentle physical exercises. Taking this insight into Levinas＇s context, we suggest that such practices of self-regulation are necessary to enable effective responsiveness to the other. From this perspective, responsibility is ＂infinite＂ not because I am perpetually beholden to the other＇s whims, but because I am perpetually accountable for calming and clearing my own mind of the unstable emotions, selfish desires, and intellectual machinations that prevent the welcome openness of radical passivity.

关键词： Daoism ethics Guanzi Levinas meditation

Viability and hatchability of brine shrimp Artemia franciscana cysts after passing through the digestive system of eared grebes Podiceps nigricollis

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Journal of Oceanology and Limnology 2023年第4期41卷 1300-1306页

作者： Michael R.CONOVER Mark E.BELL leah M.DELAhOUSSAYE Department of Wildland Resources and Ecology Center LoganUT 84322-5230USA

Brine shrimp Artemia franciscana provide food for many migrating and staging birds that spend summer and fall on Great Salt Lake,Utah,*** produce live young and cysts(hard-walled eggs);these cysts are commercially harvested on Great Salt Lake and support a large industry in *** is unclear the impact that millions of hungry birds have on the Artemia population in the *** help assess that,this study evaluated cyst viability(percentage of cysts that contain an embryo)and hatchability(percent of cysts that hatch)from cysts that had passed through the digestive tract of eared grebes Podiceps nigricollis and cysts obtained directly from Great Salt Lake at the same site where each grebe was *** was significantly higher for cysts collected from the water column(19%)than from the stomach(0.3%)or intestines(3%)of eared *** also was significantly different for cysts collected from the water column(29%),stomach(0.7%),and intestines(5%).These results indicate that eared grebes nutritionally benefit from eating cysts and that they may be an important food source for grebes in late fall after the adult population of Artemia dies off due to the water becoming too ***,enough cysts survive their passage through the digestive system that grebes can vector hatchable cysts to other waterbodies.

关键词： Artemia dispersal eared grebes hatchability invasive species Great Salt Lake salty lakes viability

Growing the FAIR Community at the Intersection of the Geosciences and Pure and Applied Chemistry

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Data Intelligence 2020年第1期2卷 139-150,310,311页

作者： Shelley Stall leah McEwen Lesley Wyborn Nancy hoebelheinrich Ian Bruno American Geophysical Union 2000 Florida Ave.NWWashington DC 20009-1277USA Cornell University Ithaca NY 14853-0001USA Australian National University CanberraAustralian Capital Territory 0200Australia Knowledge Motifs San MateoCA 94401USA The Cambridge Crystallographic Data Centre CambridgeCambridgeshire CB21EZUK

The geoscience and chemistry communities have numerous common practices and dependency on data *** efforts from the International Union on Pure and Applied Chemistry(IUPAC)and the American Geophysical Union(AGU)are to explore and collaborate on approaches and sharing lessons learned on efforts to implement the FAIR Guiding Principles as they apply to data in their respective *** paper summarizes their efforts-to-date highlighting the importance of existing communities,Scientific Unions,standards bodies and societies in taking deliberate steps to move and encourage researcher adoption of the FAIR tenets.

关键词： Geoscience Geophysics Chemistry Crystallography Collaboration