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Major Limb Amputation Secondary to Locally Advanced Cutaneous Squamous Cell Carcinoma in Tropical Environments: Determinants

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Open Journal of Orthopedics 2018年第4期8卷 139-147页

作者： Kouassi Kouamé Jean Eric Yao Loukou Blaise Sery Bada Justin leopold Niaoré M’bra Kouamé Innocent Krah Koffi Léopold Kouassi Aya Adelaide Nathacha Assere Yao Aboh Ganyn Robert Arnaud Kodo Michel Trauma and Orthopedics Department Bouake Teaching Hospital Bouake Ivory Coast

Objective: To identify the determinants of secondary limb amputation in advanced squamous cell carcinoma. Material and Methods: This was a retrospective study carried out in the Orthopedic Traumatology Department of the Bouaké University Hospital in Côte d’Ivoire from January 2013 to December 2016. It involved ten patients with locally advanced skin squamous cell carcinoma, confirmed by histology and having amputated limbs. The parameters studied were: demographic data (gender, age), socio-economic conditions (occupation, place of residence), the risk factors involved, the use of topical self-medication and the use of traditional medicine, antecedents and comorbidities factors, lifestyle, clinical aspects (seat, size), extension assessment (X-ray), anatomo-pathological examination data, duration of evolution of squamous cell carcinoma, the function of the affected limb, the treatment performed, the evolutionary modalities and the equipment. Results: Between 2013 and 2016, ten patients underwent either upper or lower limb amputations following locally advanced squamous cell carcinoma. The average age was 34.1 years (19 - 64 years). There were 7 men (70%) and 3 women (30%) and all our patients were black (sub-Saharan Africa). The majority of our patients were farmers (70%). The risk factors for squamous cell carcinoma were neglected chronic wounds. All our patients recognized during the interrogation a large use of the topicals of traditional medicine for the treatment of the initial cutaneous lesions. In terms of lifestyle, five (50%) were smokers and alcoholics. The mean time to progression of squamous cell carcinoma was 5.9 years. Lesions were localized preferentially to the pelvic limbs six (60%) cases and four (40%) to the limbs chest. The lesion was diagnosed late in all our patients. The size of the tumor in all our patients was greater than 5 cm and had a deep invasion (nerves, vessels and bone). The proximal ipsilateral ganglionic invasion was constant.

关键词： Amputation Squamous Cell Carcinoma Cutaneous Histology

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Research Priorities for Addressing Gender Based Violence in the WHO Africa Region

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Advances in Reproductive Sciences 2021年第1期9卷 50-59页

作者： leopold Ouedraogo Triphonie Nkurunziza Assumpta Muriithi Bigirimana Françoise Chilanga Asmani Hayfa Elamin Souleymane Zan Mihretu Belete Gbenou Dina Dadji Kwami Theopista Kabuteni John Kim Caron Rahn Ali Moazzam Tolu Lemi Blami Dao Issiaka Sombie Okech Mollent Reproductive Maternal Health and Ageing WHO Regional Office for Africa Brazzaville Congo Department of Reproductive Health and Research World Health Organization Geneva Switzerland JHPIEGO Ouagadougou Burkina Faso West Africa Health Organization Ouagadougou Burkina Faso Peak Moments Global HR Solutions Nairobi Kenya

Background: There is an increasing emphasis on conducting research to identify gender based violence issues to enable development of appropriate programs and interventions. However, these efforts are mixed in quality and often raise ethical questions. The increased pressure on policy makers to move to a more evidence-based approach in addressing gender based issues creates the need for this research prioritization activity. Inadequate evaluative evidence in this area poses a challenge in the planning for responsive interventions especially in resource limited settings. The purpose of this paper is to present gender based violence research priority areas for the WHO Africa Region. Methods: We utilized a modified version of the Child Health and Nutrition Research Initiative approach to reach consensus on research priorities on the thematic area of gender based violence. In three phases, we first conducted an online survey with sexual and reproductive health and rights experts in academia, ministries of health, non-governmental organizations and other health actors with a wide range of experiences. These questions were consolidated by three experts from World Health Organization headquarters into themes. Secondly, experts were invited in a meeting in Cape Town South Africa to analyze and generate relevant areas of research based on the themes. Finally, a smaller group of experts prioritized research areas based on agreed criteria. Results: A list of 10 priority research questions for addressing gender based violence were scored and ranked. Four priority research questions scored 30 points out of the possible 30 points and were thus ranked as the highest priority. These included questions that “engage young adolescents in behavioral interventions to influence gender roles”, “determinants of gender based violence analysis”, “both long and short term complications of gender based violence on survivors” and “assessment of

关键词： Gender-Based Violence Gender Human Rights Sexual and Reproductive Health Violence

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Research Priorities for Preventing Unsafe Abortions in the WHO Africa Region

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Advances in Reproductive Sciences 2021年第1期9卷 24-32页

作者： leopold Ouedraogo Triphonie Nkurunziza Assumpta Muriithi Chilanga Asmani Hayfa Elamin Souleymane Zan Mihretu Belete Gbenou Dina Theopista Kabuteni John Bigirimana Françoise Dadji Kwami Kim Caron Rahn Ali Moazzam Tolu Lemi Blami Dao Issiaka Sombie Okech Mollent Reproductive Maternal Health and Ageing WHO Regional Office for Africa Brazzaville Congo Department of Reproductive Health and Research World Health Organization Geneva Switzerland JHPIEGO Ouagadougou Burkina Faso West Africa Health Organization Ouagadougou Burkina Faso Peak Moments Global HR Solutions Nairobi Kenya

Background: Unsafe abortion is a commonly neglected sexual and reproductive health and rights issue despite the serious health problems it causes to women and girls in their reproductive ages. It is classified as a main cause of maternal mortality and morbidity. This paper has considered questions that have the greatest potential to successfully reduce unsafe abortions in the resource poor settings. Methods: We adapted the Child Health and Nutrition Research Initiative (CHNRI) to identify and prioritize many competing sexual and reproductive health and rights research ideas that impact the health of the populations. The implementation was done in three phases which included generation and collection of research ideas from various experts virtually in August 2019 consolidation of the potential questions through thematic analysis conducted in September 2019. Finally, scoring and ranking of the research questions was done in a workshop of experts. Results: Out of a list of 45 priority research questions, two questions were ranked the highest scoring 28 out of the possible 30. The research priorities include: “The effectiveness of interventions (e.g. counseling or incentives or home visits) to increase post abortion uptake and continuance”, “Reducing repeat abortion on improving maternal health outcomes” and “Evaluation of community-based awareness programs to reduce unwanted pregnancies and encourage women to seek help early”. Conclusions: Ten key research priorities in preventing unsafe abortion were identified. The priority list covers areas of focus that could effectively impact preventing unsafe abortions while also acting as a knowledge base for researchers, policy makers and other interested stakeholders who would want to invest in this area.

关键词： Unsafe Abortion Post-Abortion Contraception Sexual and Reproductive Health Unplanned Abortion

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英国食品标准局的营养素度量法在法国食物成分数据库中的应用

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营养健康新观察 2014年第1期 36-37页

作者： Chantal Julia Emmanuelle Kesse-Guyot Mathilde Touvier Caroline Mejean leopold Fezeu Serge Hercberg 刘轶群 Universite Paris 13 Equipe de Recherche en Epidemiologie Nutritionnelle(EREN)Centre de Recherche en Epidemiologie et Biostatistiques Sorbonne Paris Cite(CRESS)UMR 1153 InsermU1125 InraCnam Universite Paris 5 Universite Paris 774 rue Marcel CachinF-93017 Bobigny CedexFrance Departement de Sante Publique Hopital Avicenne(AP-HP)

营养素度量法对于公共卫生措施的建立是一个强有力的工具,它旨在以营养素含量为依据对食物进行分级评价。英国食品标准局(FSA)的营养素度量法(FSA score)已在英国食物数据库中得以验证。但是这个模型是否适用于其它国家食物数据库则还... 详细信息

营养素度量法对于公共卫生措施的建立是一个强有力的工具,它旨在以营养素含量为依据对食物进行分级评价。英国食品标准局(FSA)的营养素度量法(FSA score)已在英国食物数据库中得以验证。但是这个模型是否适用于其它国家食物数据库则还未被评价。本研究旨在评价英国FSA score在法国食物成分数据库中的应用。来源于法国NutriNet-Sante研究的食物成分表的食品根据英国FSA score进行分类,FSA score是以英国通讯署(OfCom)的切点值(‘健康的'总分≤4的食品和总分≤1的饮料;‘不健康的'总分>4的食品和总分>1的饮料)以及分布切点值(五分位的食物,四分位的饮料)。也可根据法国PNNS(Pro-gramme National Nutrition Sante)推荐的食物组对所采用的食品进行分类。从NutriNet-Sante研究(n=4225)具有法国人群中典型的食物中抽取样品,并根据其相对消耗量称量食品。根据OfCom切点值的食物分类与法国PNNS的食物组分类一致:97.8%的水果和蔬菜,90.4%的谷物和薯类以及仅3.8%的含糖零食被认为是健康的食物。此外,FSA score的可变性对于在同一食物组中子分类之间的区分,证实了使用FSA score作为多重分类体系的可行性,例如作为正面营养素标签的基础。英国FSA score在法国食物成分数据库中的应用更好的弥补了目前公共健康的推荐标准。

关键词：营养素度量体系应用食物成分

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Biogenic Synthesis of Silver Nanoparticles Using Guava (<i>Psidium guajava</i>) Leaf Extract and Its Larvicidal Action against <i>Anopheles gambiae</i>

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Journal of Biomaterials and Nanobiotechnology 2020年第1期11卷 49-66页

作者： Agnes Antoinette Ntoumba Francois Eya’ane Meva Wolfgang Eyisap Ekoko Loick Pradel Kojom Foko Etoile Ngo Hondt Carsten Schlüsener Bastian Moll Gisele Etame Loe Philippe Belle Ebanda Kedi Jean Yves Sikapi Fouda Christoph Janiak leopold Gustave Lehman

The progress in the field of nanotechnology has contributed to the development of tools for combating the most critical problems in developing countries. The requirements that such tools should meet are low-cost and resource settings, environmental protection, ease of use, and availability. The use of plant properties for the generation of nanoparticles (NPs), which serve as bioinsecticides to combat the plasticity and resistance of mosquitoes and parasites, is considered possible. Here, we report for the first time the larvicidal activity of silver (Ag) NPs (AgNPs) synthesized from Psidium guajava (P. guajava) extract, which targets the 4th instar larvae of Anopheles gambiae. Concentrations of AgNPs between 0 and 200 ppm were used and their LC50 at 24 h and 48 h were determined as 19.55 ppm and 8.737 ppm, respectively. The AgNPs were stable and highly effective against the larvae of A. gambiae and thereby we anticipate that they can be used to combat vector-borne diseases in developing countries.

关键词： Vector Control Anopheles gambiae Silver Nanoparticles Psidium guajava

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The WHO African Region: Research Priorities on Sexual and Reproductive Health and Rights

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Advances in Reproductive Sciences 2021年第1期9卷 13-23页

作者： leopold Ouedraogo Triphonie Nkurunziza Assumpta Muriithi Theopista Kabuteni John Chilanga Asmani Hayfa Elamin Symplice Mbola Mbassi Souleymane Zan Bigirimana Françoise Mihretu Belete Gbenou Dina Dadji Kwami Kim Caron Rahn Ali Moazzam Tolu Lemi Blami Dao Issiaka Sombie Okech Mollent Reproductive Maternal Health and Ageing WHO Regional Office for Africa Brazzaville Congo Department of Reproductive Health and Research World Health Organization Geneva Switzerland JHPIEGO Ouagadougou Burkina Faso West Africa Health Organization Ouagadougou Burkina Faso Peak Moments Global HR Solutions Nairobi Kenya

Background: Many policy makers deliberating on comprehensive sexual and reproductive health and rights services need reliable evidence to make choices that benefit women, adolescents, children and the wider society. While universal health coverage discourse provides an opportunity to expand access through evidence based interventions, many gaps exist. Research prioritization has proved to be very helpful in identifying relevant areas especially in constrained resource settings. The purpose of this paper is to present the results of the World Health Organization Africa Region research prioritization for sexual and reproductive health and rights. These priorities hope to guide the region for the next three years. Methods: We used the Child Health and Nutrition Research Initiative approach to identify priority questions among many potential areas for research prioritization on sexual and reproductive health and rights. The implementation process was organized in three phases. The first phase involved sending out an online survey to various experts with experience in sexual and reproductive health rights. These questions were received by a technical team from World Health Organization headquarters for review. 634 questions were identified for potential research and grouped into 12 themes. The second phase involved experts who reviewed the questions. The team merged questions with duplications, removed the questions that were out of scope and finally refined the wordings. In the final phase, experts worked in groups to score and rank top ten priority questions for each of the 12 thematic areas. Results: A list of 120 priority questions for sexual and reproductive health and rights were prioritized by 67 participants drawn from 16 organizations. Most of the priority research questions (45%) focused on the theme of gender-based violence, 35% prioritized services in sexual and reproductive health and rights in humanitarian

关键词： Research Priorities Sexual and Reproductive Health and Rights Child Health and Nutrition Research Initiative

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植物的生长和发育

植物的生长和发育

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作者： A.C.·利奥波德(a.C..leopold) P.E.·克里德曼(P.E..Kriedemann)

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Research Priorities for mHealth and Innovative Strategies in Sexual and Reproductive Health and Rights in the WHO Africa Region

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Advances in Reproductive Sciences 2021年第1期9卷 33-40页

作者： leopold Ouedraogo Triphonie Nkurunziza Assumpta Muriithi Chilanga Asmani Hayfa Elamin Souleymane Zan Bigirimana Françoise Mihretu Belete Gbenou Dina Dadji Kwami Mekdes Daba Theopista Kabuteni John Hien Clotaire Kim Caron Rahn Ali Moazzam Tolu Lemi Blami Dao Issiaka Sombie Okech Mollent Reproductive Maternal Health and Ageing WHO Regional Office for Africa Brazzaville Congo Department of Reproductive Health and Research World Health Organization Geneva Switzerland JHPIEGO Ouagadougou Burkina Faso West Africa Health Organization Ouagadougou Burkina Faso Peak Moments Global HR Solutions Nairobi Kenya

Background: The use of mobile phones continues to rise rapidly in the provision of health related services. Many countries have adopted the use of mobiles to provide sexual and reproductive health and rights and especially among the adolescents where specific messages are tailored for various audiences with specific messages. The purpose of this paper is to present the results of a research priority setting exercise on mHealth and innovative strategies. Methods: We adapted Child Health and Nutrition Research Initiative methodology to identify and set research priorities on mHealth and innovative strategies that respond to sexual and reproductive health and rights services. General potential research questions were gathered online from multiple stakeholders in the region and sent for consolidation consolidated to technical experts in World Health Organization headquarters. The second phase involved a meeting with experts to review and thematically analyze the questions list of 33 questions producing a list of 22 research questions. The questions were scored against a six point criteria and ranked accordingly. Ten top priority research questions were identified. Results: Lists of 33 priority research questions for mHealth and innovative strategies were proposed for discussions by 67 stakeholders. The questions were reviewed, scored and ranked in a technical meeting by experts. The highest ranking questions at 87% include evaluation of mHealth for data management and sexual and reproductive health and rights decision making, assessment of innovative local financing techniques to support community based sexual reproductive health and rights and evaluation of the role of mobile technologies in referral and counter referral. Conclusions: Information and communication technology is developing drastically and has a great potential in improving health especially in sexual and reproductive health and rights s

关键词： mHealth Mobile Phones Sexual and Reproductive Health and Rights Technology

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