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Cancer Advances 2024年第17期7卷 1-12页

作者： Hui-Juan Cao Chen-Xi Wu Xiao-le.Xian Yong-Sen Jia Yue-Yue Yu Shu Zhao Ting-Ting fu Traditional Chinese Medicine Colle.e North China University of Science and TechnologyTangshan 063210China.

Epithelial-mesenchymal transition is a well-defined,reversible.process in which epithelial cells lose their epithelial phenotype and acquire mesenchymal-like ***-mesenchymal transition contributes significantly to the metastasis,invasion,and development of treatment resistance in cancer *** have been many studies on suppression of tumor epithelial-mesenchymal transition by Chinese medicine in recent years,mainly based on Chinese herbal drug monomers and *** this review,we aim to describe the research progress on Chinese medicine in the t ransforming growth factor beta(T Gf-β)sig naling pathway,we hope these will provide some guidance for further research on Chinese medicine targeting epithelial-mesenchymal transition.

关键词： epithelial-mesenchymal transition cancer Chinese medicine invasion metastasis

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安徽红色文化传播现状及对策研究

铜陵学院学报 2024年第1期23卷 67-71页

作者：周乐中共安徽省委党校科研处安徽合肥230000

安徽依托丰富的红色文化资源,在红色文化的传播上取得了令人瞩目的成果。但由于其红色资源分布不均、配套设施建设薄弱等原因,致使省内红色文化传播面临传播力度不够大、影响范围不够广、数字化程度不够高等问题。文章通过对安徽红色文... 详细信息

安徽依托丰富的红色文化资源,在红色文化的传播上取得了令人瞩目的成果。但由于其红色资源分布不均、配套设施建设薄弱等原因,致使省内红色文化传播面临传播力度不够大、影响范围不够广、数字化程度不够高等问题。文章通过对安徽红色文化发展历史背景及现状的梳理,结合现有传播主体和渠道,针对性地提出以下解决对策:深入挖掘红色资源,加强红色遗产保护;增加基建投入,打造产业矩阵;畅通交流渠道,打磨传播内容;创新数字化传播,加大政策倾斜等。

关键词：红色文化安徽文化传播

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基于态势图序列的多智能群体意图识别

控制与决策 2024年第9期39卷 2941-2949页

作者：杜沁龙霍鑫郑凯周典乐哈尔滨工业大学控制与仿真中心哈尔滨150080 大连海事大学船舶电器工程学院辽宁大连116026 国防科技大学前沿交叉学科学院长沙410073

智能群体的意图识别是多智能体领域的一个热点问题,在自动驾驶、人机交互及国防军事等领域具有广泛应用.由于智能群体规模及环境内障碍物分布具有不确定性,现有意图识别模型的泛化能力往往有限,鉴于此,提出一种基于态势图序列的意图识... 详细信息

智能群体的意图识别是多智能体领域的一个热点问题,在自动驾驶、人机交互及国防军事等领域具有广泛应用.由于智能群体规模及环境内障碍物分布具有不确定性,现有意图识别模型的泛化能力往往有限,鉴于此,提出一种基于态势图序列的意图识别方法,将观测得到的智能群体信息转化为态势图序列,通过态势图序列训练识别模型,从而降低模型对智能体数量的敏感程度.针对含有障碍物的环境,提出阻碍态势的生成方法,从而提高模型对环境变化的适应能力.此外,为降低对专家知识的依赖,采用卷积神经网络估计各个智能体的斥力因子.最后,与其他几种意图识别方法对比并进行消融实验以验证所提出方法的准确性和泛化能力.

关键词：运动态势图意图识别多智能体系统深度学习群体意图长短时记忆网络

壳聚糖基光敏水凝胶在光固化3D打印中的应用

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化工管理 2024年第23期 98-101页

作者：许乐信阳职业技术学院河南信阳464100

壳聚糖是一种生物可降解和生物相容的天然聚合物,在医疗和环境工程等领域有着广泛应用。结合光固化技术,壳聚糖基光敏水凝胶可以开发用于3D打印,利用紫外光快速固化,以形成精确控制的复杂结构。文章描述了光固化3D打印过程中壳聚糖的选... 详细信息

壳聚糖是一种生物可降解和生物相容的天然聚合物,在医疗和环境工程等领域有着广泛应用。结合光固化技术,壳聚糖基光敏水凝胶可以开发用于3D打印,利用紫外光快速固化,以形成精确控制的复杂结构。文章描述了光固化3D打印过程中壳聚糖的选择和预处理方法,适当的光敏剂的选择,以及3D打印设备的调整和打印参数的优化,探讨了壳聚糖基光敏水凝胶的物理和化学性质,并通过光谱分析研究其光敏反应。这些研究成果不仅展示了壳聚糖基水凝胶在3D打印中的应用潜力,也为制造个性化医疗设备和先进材料研究开辟了新的可能性。

关键词：壳聚糖光敏水凝胶光固化3D打印

Effects of total parenteral nutrition on drug metabolism gene expression in mice

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Acta Pharmaceutica Sinica B 2020年第1期10卷 153-158页

作者： Christina ferrucci-Da Silva le.Zhan Jianliang Shen Bo Kong Michael JCampbell Naureen Memon Thomas Hegyi lucy Lu Grace L.Guo Division of Neonatology Department of PediatricsRobert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA Rutgers Cancer Institute of New Jersey New BrunswickNJ 08901USA Department of Mole.ular Biology and Biochemistry Rutgers UniversityPiscatawayNJ 08854USA Department of Pharmacology and Toxicology School of PharmacyRutgers UniversityPiscatawayNJ 08854USA MidAtlantic Neonatology Associates MorristownNJ 07960USA School of Pharmacy University of PittsburghPittsburghPA 15260USA Environmental and Occupational Health Institute Rutgers UniversityPiscatawayNJ 08854USA VA NJ Health Care Systems East OrangeNJ 07018USA Monmouth Medical Center in Long Branch NJ 07740USA

Parenteral nutrition-associated liver disease(PNALD)is a liver dysfunction caused by various risk factors presented in patients receiving total parenteral nutrition(TPN).Omega-6 rich Intralipid?and omega-3 rich Omegaven?are two intravenous lipid emulsions used in *** could affect the hepatic expression of genes in anti-oxidative stress,but it’s unknown whether TPN affects genes in drug *** this study,either Intralipid?-or Omegaven?-based TPN was administered to mice and the expression of a cohort of genes involved in anti-oxidative stress or drug metabolism was analyzed,glutathione(GSH)le.els were measured,and protein le.els for two key drug metabolism geneswere ***,the expression of most genes was downregulated by Intralipid?-based TPN(Gstpl,Gstml,3,6,Nqol,Ho-1,Mt-1,Gclc,Gclm,Cyp2d9,2f2,2b 10,and 3a11).Omegaven?showed similar results as Intralipid?except for preserving the expression of Gstml and Cyp3a11,and increasing *** GSH le.els were decreased by Intralipid?,but increased by Omegaven?.CYP3A11 protein le.els were increased by Omegaven?.In conclusion,TPN reduced the expression of many genes involved in anti-oxidative stress and drug metabolism in ***,Omegaven?preserved expression of Cyp3a11,suggesting another beneficial effect of Omegaven?in protecting liver functions.

关键词： Total parenteral nutrition Glutathione Drug metabolism Liver Parenteral nutritionassociated liver disease

Climate Services Elaboration for Cocoa Cultivation in Côte d’Ivoire: Contribution of CORDEX Climate Projections

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Agricultural Sciences 2024年第3期15卷 358-375页

作者： Adama Bamba fidèle.Yoroba N’Datchoh Evelyne Toure Kouakou Kouadio Mory Ouattara Kakou M’bo Mamadou Cherif Daouda Kone Arona Diedhiou Laboratoire des sciences de la Matière de l’Environnement et de l’Energie Solaire (LASMES) Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire Centre d’Excelle.ce Africain en Changement Climatique Biodiversité et Agriculture Durable (CCBAD) Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire Laboratoire Mixte International Climat-Eau-Energy-Agriculture Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire Station Géophysique de LAMTO N’Douci C&#244te d’Ivoire UfR Bioscience Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire Université Grenoble.Alpes IRD CNRS Grenoble-INP IGE Grenoble France

This study assessed the contribution of climate projections to improving rainfall information for cocoa crops in the central and southern regions of Côte d’Ivoire. Particular attention was paid to fourteen localities in these two climatic zones. Simulation data were obtained from the CORDEX ensemble.and observation data from CHIRPS. They cover the period 1991-2005 for the reference period and the future period from 2021 to 2050 for the RCP4.5 and RCP8.5 scenarios. In addition, the study was based on the water requirements necessary during the critical phase of the cocoa tree (the flowering phase) for a good yield from the cocoa production chain on the one hand, and on a sele.tion of three climate indices CDD, CWD and r95PTOT to study their spatio-temporal changes over two future periods 2021-2035 (near future) and 2036-2050 (medium-term) on the other. These climatic indices influence cocoa cultivation and their use in studies of climatic impacts on agriculture is of prime importance. The analysis of their spatio-temporal changes in this work also contributes to providing climate services based on rainfall, to which cocoa crops are highly sensitive. Our results show that the CDD and CWD indices vary from one region to another depending on latitude. for the fourteen localities studied, the number of consecutive dry days (CDD) could increase between now and 2050, while.the number of consecutive wet days (CWD) could decrease over the period 2021-2035 and then increase over the period 2036-2050. The localities of Tabou, Aboisso and San-Pedro record high numbers of CDD index and CWD index for both projection scenarios. In comparison with the RCP4.5 and RCP8.5 scenarios, these results show that the RCP8.5 scenarios are having an impact on cocoa growing in Côte d’Ivoire.

关键词： Cocoa RCP4.5 RCP8.5 Climate Indices Côte D’ivoire

青稞BBX基因家族鉴定及其对UV-B的响应

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草地学报 2024年第6期32卷 1760-1769页

作者：陈生蓉史国民王乐何涛青海大学省部共建三江源生态与高原农牧业国家重点实验室青海西宁810016 青海大学农牧学院青海西宁810016

B-box(BBX)蛋白是植物中一类重要的转录因子,在控制植物生长发育、响应环境胁迫中起着重要作用。本研究从青稞(Hordeum vulgare *** Hook.f.)全基因组中鉴定出18个青稞BBX基因家族成员,分析了它们的理化性质、基因结构、进化关系及UV-B... 详细信息

B-box(BBX)蛋白是植物中一类重要的转录因子,在控制植物生长发育、响应环境胁迫中起着重要作用。本研究从青稞(Hordeum vulgare *** Hook.f.)全基因组中鉴定出18个青稞BBX基因家族成员,分析了它们的理化性质、基因结构、进化关系及UV-B照射幼苗后的表达特性等。结果表明:青稞BBX基因的编码序列(CDS)长度为636~2 223 bp;分子质量为22.07~54.29 kDa。系统发育分析将18个HvnBBX分为4个亚类。共线性分析表明青稞种内共产生4对片段复制形成的基因对,种间与玉米进化关系更近;HvnBBX启动子区域包含与逆境胁迫、激素、生长发育等相关顺式作用元件。转录组测序结果显示UV-B照射后青稞叶片中有5个BBX基因(HvnBBX2/4/5/6/17)的表达量显著下调,qRT-PCR验证结果与转录组测序一致。上述结果为深入研究HvnBBX基因的抗紫外功能提供参考。

关键词：青稞 BBX基因家族 UV-B照射基因表达

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形成同数字新质生产力相适应的生产关系——基于生产力二重性的理论视角

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上海财经大学学报 2024年第5期26卷 3-14页

作者：武艺扬乐昕许莞璐复旦大学马克思主义学院

新质生产力是符合新发展理念的先进生产力质态。在数字经济时代,数字技术与生产力三要素深度融合,催生以数字化和智能化为关键特征的数字新质生产力。生产关系对于生产力具有反作用,数字新质生产力的发展离不开与之相适应的中国特色社... 详细信息

新质生产力是符合新发展理念的先进生产力质态。在数字经济时代,数字技术与生产力三要素深度融合,催生以数字化和智能化为关键特征的数字新质生产力。生产关系对于生产力具有反作用,数字新质生产力的发展离不开与之相适应的中国特色社会主义生产关系。作为社会主义生产关系核心与集中体现的基本经济制度发挥出强大制度优势,从生产力的物质属性来看,推动科技创新培育数字新质生产力,促进全要素生产率大幅提高；从社会属性来看,保障生产力摆脱“资本属性”和回归“社会本性”,为满足人民美好生活需要服务。在数字新质生产力的发展中,中国特色社会主义所有制为其提供根本保障,分配制度促进发展成果共创共享,市场经济体制保障发展的效率与公平。当前,需要调整体制机制以形成同数字新质生产力更相适应的生产关系,通过探索数据要素产权制度、完善收入分配制度、构建高水平社会主义市场经济体制,推动数字新质生产力加快发展,促进其充分彰显生产力的社会本性,更好地满足人民日益增长的美好生活需要。

关键词：数字新质生产力生产关系数字经济基本经济制度

Towards an actionable.One Health approach

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贫困所致传染病(英文) 2024年第2期13卷 1-6页

作者： Zhang Xiao-Xi le.erman Zohar Han le.fei Schurer Janna M. Xiao Li-Hua Zhang Zhi-Bing Chen Qiu-Lan Pfeiffer Dirk Ward Michael P. Sripa Banchob Gabri?l Sarah Dhama Kuldeep Acharya Krishna Prasad Robertson lucy J. Deem Sharon L. Aenishaenslin Cécile.Dantas-Torres filipe Otranto Domenico Grace Delia Wang Yang Li Peng fu Chao Poeta Patrícia Rahman Md. Tanvir Kassegne Kokouvi Zhu Yong-Zhang Yin Kun Liu Jiming Wang Zhao-Jun Guo Xiao-Kui Gong Wen-feng Schwartl?nder Bernhard Ren Ming-Hui Zhou Xiao-Nong School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Health Shanghai Jiao Tong University Shanghai People’s Republic of China Medical Ethics and Humanities Unit Hong Kong University Hong Kong People’s Republic of China Center for One Health University of Global Health Equity Butaro Rwanda Colle.e of Veterinary Medicine South China Agricultural University Guangzhou People’s Republic of China School of Ecology and Environment Hainan University Haikou Hainan People’s Republic of China Branch of animal and vector-borne diseases Division of Infectious Disease Control Chinese Center for Disease Control and Prevention Beijing People’s Republic of China Centre for Applied One Health Research and Policy Advice Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong Hong Kong SAR People’s Republic of China Department of Pathobiology and Population Sciences Royal Veterinary College London United Kingdom Sydney School of Veterinary Science The University of Sydney Camden Australia Tropical Disease Research Center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand Laboratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium Division of Pathology ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Department of Livestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal Parasitology Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Government Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidémi

Background Despite the increasing focus on strengthening One Health capacity building on global le.el, challe.ges remain in devising and imple.enting real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest *** text This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health *** By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowle.ge, distille. practical experience and actionable.policy advice, guided by strong ethical principle. of One Health.

关键词： One Health Global Health One Health Action Commission Research agenda

骨髓坏死^(18)f-fDG PET/CT与MRI对照分析

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首都医科大学学报 2024年第1期45卷 36-41页

作者：宋乐李慧张卫方北京大学第三医院核医学科北京100191

目的探索骨髓坏死氟-18-脱氧葡萄糖(^(18)f-fluorodeoxyglucose,^(18)f-fDG)正电子发射断层显像/计算机断层显像(positron emission tomography/computed tomography,PET/CT)表现,提高对该病的认识。方法回顾性分析9例磁共振成像(magnetic resonance imaging,MRI)诊断为骨髓坏死患者的PET/CT及临床资料,对照MRI影像,总结病变分布,选择最大病变,分析^(18)f-fDG代谢特点及CT征象。结果患者男6例,女3例,中位年龄28.0岁,均患淋巴瘤。MRI检查髋部6例、胸腰椎2例、膝部1例。6例髂骨病变,内部均为T1加权像(T1-weighted image,T1WI)高信号,T2脂肪抑制像(T2-fat suppressed image,T2fSI)低信号,伴T1WI边缘环状低信号,其中5例内部代谢减低,边缘代谢增高伴骨质硬化;1例密度及代谢未见异常,MRI显示病变狭长。2例脊柱病变T1WI呈等、低信号,T2fSI高信号,其中1例为等代谢,密度稍高;1例代谢减低,密度未见异常。1例股骨病变T1WI高信号,T2fSI低信号,代谢及密度增高。8例PET/CT发现MRI检查范围之外更多病变。8例更早期的PET/CT发现部分病变呈低代谢、等密度。结论^(18)f-fDG代谢减低,后期可伴有边缘线状代谢及密度增高,是骨髓坏死的常见PET/CT影像特点。PET/CT有助于检出骨髓坏死,发现多骨病变。

关键词：骨髓坏死骨坏死氟-18-脱氧葡萄糖正电子发射断层显像/计算机断层扫描