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Global burden of viral infectious diseases of poverty based on Global Burden of Diseases Study 2021

贫困所致传染病(英文) 2024年第5期13卷 53-67页

作者： Li Xin-Chen Zhang Yan-Yan Zhang Qi-Yu Liu Jing-Shu Ran Jin-Jun han le-fei Zhang Xiao-Xi School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Health Shanghai Jiao Tong University Shanghai People’s Republic of China School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China

Background Viral infectious diseases of poverty (vIDPs) remain a significant global health challenge. Despite their profound impact, the burden of these diseases is not comprehensively quantified. This study aims to analyze the global burden of six major vIDPs, including coronavirus disease 2019 (COVID-19), HIV/AIDS, acute hepatitis, dengue, rabies, and Ebola virus disease (EVD), using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021).Methods Following the GBD 2021 framework, we analyzed the incidence, mortality, and disability-adjusted life years (DALYs) of the six vIDPs across 204 countries and territories from 1990 to 2021. We examined the association between the Socio-Demographic Index (SDI) and the burden of vIDPs. All estimates were reported as numbers and rates per 100,000 population, calculated using the Bayesian statistical model employed by GBD 2021, with 95% uncertainty intervals (UI).Results In 2021, vIDPs caused approximately 8.7 million deaths and 259.2 million DALYs, accounting for 12.8% and 9.0% of the global all-cause totals, respectively. Globally, the burden of vIDPs varied significantly: COVID-19 caused around 7.9 million (95% UI: 7.5, 8.4) deaths and 212.0 million (95% UI 197.9, 234.7) DALYs in 2021. Acute hepatitis had the second-highest age-standardized incidence rate, with 3411.5 (95% UI: 3201.8, 3631.3) per 100,000 population, while HIV/AIDS had a high age-standardized prevalence rate, with 483.1 (95% UI: 459.0, 511.4) per 100,000 population. Dengue incidence cases rose from 26.5 million (95% UI: 3.9, 51.9) in 1990 to 59.0 million (95% UI: 15.5, 106.9) in 2021. Rabies, although reduced in prevalence, continued to pose a significant mortality risk. EVD had the lowest overall burden but significant outbreak impacts. Age-standardized DALY rates for vIDPs were significantly negatively correlated with SDI: acute hepatitis (r = -0.8,P < 0.0001), rabies (r = -0.7,P < 0.0001), HIV/AIDS (r = -0.6,P < 0.0001), C

关键词： Viral infectious diseases of poverty Global Burden of Disease 2021 Disability-adjusted life years Socio-Demographic Index

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Therapeutic time window of flurbiprofen axetil＇s neuroprotective effect in a rat model of transient focal cerebral ischemia

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Chinese Medical Journal 2008年第24期121卷 2572-2577页

作者： WANG Chen LIU Jun-le SANG han-fei LU Yan DONG Hai-long XIONG Li-ze Department of Anesthesiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi 710032 China

Background The neuroprotective effect of the cyclooxygenase （COX） inhibitor has been demonstrated in acute and chronic neurodegenerative processes. But its function under cerebral ischemic conditions is unclear. This study was designed to evaluate the neuroprotective efficacy of emulsified flurbiprofen axetil （FA, COX inhibitor） and its therapeutic time window in a model of transient middle cerebral artery occlusion （MCAO） in rats. Methods Forty-eight male SD rats were randomly assigned into six groups （n=8 in each group）; three FA groups, vehicle, sham and ischemia/reperfusion （I/R） groups. Three doses of FA （5, 10 or 20 mg/kg, intravenous infusion） were administered just after cerebral ischemia/reperfusion （I/R）. The degree of neurological outcome was measured by the neurologic deficit score （NDS） at 24, 48 and 72 hours after I/R. Mean brain infarct volume percentage （MBIVP） was determined with 2,3,5-triphenyltetrazolium chloride （TTC） staining at 72 hours after I/R. In three other groups （n=8 in each group）, the selected dosage of 10 mg/kg was administrated intravenously at 6, 12 and 24 hours after I/R. Results The three different doses of FA improved NDS at 24, 48 and 72 hours after I/R and significantly reduced MBIVP. However, the degree of MBIVP in the FA 20 mg/kg group differed from that in FA 10 mg/kg group. Of interest is the finding that the neuroprotective effect conferred by 10 mg/kg of FA was also observed when treatment was delayed until 12-24 hours after ischemia reperfusion. Conclusion COX inhibitor FA is a promising therapeutic strategy for cerebral ischemia and its therapeutic time window could last for 12-24 hours after cerebral ischemia reperfusion, which would help in lessening the initial ischemic brain damage.

关键词： cerebral ischemia flurbiprofen axetil neuroprotection neurologic deficit score therapeutic time window

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Assessing food security performance from the One Health concept:an evaluation tool based on the Global One Health Index

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Infectious Diseases of Poverty 2023年第5期12卷 98-99页

作者： Si-Yu Gu Fu-Min Chen Chen-Sheng Zhang Yi-Bin Zhou Tian-Yun Li Ne Qiang Xiao-Xi Zhang Jing-Shu Liu Shu-Xun Wang Xue-Chen Yang Xiao-Kui Guo Qin-Qin Hu Xiao-Bei Deng le-fei han School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China One Health Center Shanghai Jiao Tong University-The University of Edinburgh Shanghai China National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) Shanghai China Minhang District Center for Disease Control and Prevention Shanghai China School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China

Background Food systems instantiate the complex interdependencies across humans,physical environments,and other *** One Health approaches for agri-food system transformation,which adopts integrated and unifying approaches to optimize the overall health of humans,animals,plants,and environments,is crucial to enhance the sustainability of food *** study develops a potential assessment tool,named the global One Health index-Food Security(GOHI-FS),aiming to evaluate food security performance across countries/territories from One Health perspective and identify relevant gaps that need to be improved for sustainable food *** We comprehensively reviewed existing frameworks and elements of food *** indicator framework of GOHI-FS was conceptualized following the structure-process-outcome model and confirmed by expert *** available data in 2020 was collected for each *** weighting strategy was determined by the Fuzzy Analytical Hierarchy *** data for each indicator was normalized and aggregated by weighted arithmetic *** regressions were performed to evaluate the associations of GOHI-FS with health and social-economic *** The GOHI-FS includes 5 first-level indicators,19 second-level indicators and 45 third-level *** were 146 countries/territories enrolled for *** highest average score of first-level indicators was Nutrition(69.8)and the lowest was Government Support and Response(31.3).There was regional heterogeneity of GOHI-FS *** median scores with interquartile range(IQR)were shown in North America(median:76.1,IQR:75.5-76.7),followed by Europe and Central Asia(median:66.9,IQR:60.1-74.3),East Asia and the Pacific(median:60.6,IQR:55.5-68.7),Latin America and the Caribbean(median:60.2,IQR:57.8-65.0),Middle East and North Africa(median:56.6,IQR:52.0-62.8),South Asia(median:51.1,IQR:46.7-53.8),and sub-Saharan Africa(median:41.4,IQR:37.2-46.5).We

关键词： Food security One Health Index Indicator framework Assessment

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Assessment of performance for a key indicator of One Health:evidence based on One Health index for zoonoses in Sub-Saharan Africa

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Infectious Diseases of Poverty 2022年第5期11卷 74-86页

作者： han‑Qing Zhao Si‑Wei fei Jing‑Xian Yin Qin Li Tian‑Ge Jiang Zhao‑Yu Guo Jing‑Bo Xue le‑fei han Xiao‑Xi Zhang Shang Xia Yi Zhang Xiao‑Kui Guo Kokouvi Kassegne Department of Infectious and Tropical Diseases School of Global HealthChinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghai 200025People’s Republic of China One Health Center Shanghai Jiao Tong University-The University of EdinburghShang‑hai 200025People’s Republic of China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Center for Trop‑ical Diseases Research) National Health Commission of the People’s Republic of China(NHC)Key Laboratory of Parasite and Vector BiologyWHO Collaborat‑ing Center for Tropical DiseasesShanghai 200025People’s Republic of China.

Background:Zoonoses are public health threats that cause severe damage *** constitute a key indicator of One Health(OH)and the OH approach is being applied for zoonosis control programmes of zoonotic *** a very recent study,we developed an evaluation system for OH performance through the global OH index(GOHI).This study applied the GOHI to evaluate OH performance for zoonoses in sub-Saharan ***:The framework for the OH index on zoonoses(OHIZ)was constructed including five indicators,15 subindicators and 28 *** available data were referenced to generate the OHIZ database which included both qualitative and quantitative indicators for all sub-Sahara African countries(n=48).The GOHI algorithm was used to estimate scores for *** weights were calculated by adopting the fuzzy analytical hierarchy ***:Overall,five indicators associated with weights were generated as follows:source of infection(23.70%),route of transmission(25.31%),targeted population(19.09%),capacity building(16.77%),and outcomes/case studies(15.13%).Following the indicators,a total of 37 sub-Sahara African countries aligned with OHIZ validation,while 11 territories were excluded for unfit or missing *** OHIZ average score of sub-Saharan Africa was estimated at 53.67/*** highest score was 71.99 from South Africa,while the lowest score was 40.51 from *** is also worth mentioning that Sub-Sahara African countries had high performance in many subindicators associated with zoonoses,e.g.,surveillance and response,vector and reservoir interventions,and natural protected areas,which suggests that this region had a certain capacity in control and prevention or responses to zoonotic ***:This study reveals that it is possible to perform OH evaluation for zoonoses in sub-Saharan Africa by *** from this study provide preliminary research information in advancing knowledge of the evidenced risks to strengthen s

关键词： One Health index One Health performance Zoonoses Sub-Saharan Africa

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Tackling global health security by building an academic community for One Health action

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Infectious Diseases of Poverty 2023年第4期12卷 93-98页

作者： Xiao-Xi Zhang Xin-Chen Li Qi-Yu Zhang Jing-Shu Liu le-fei han Zohar lederman Janna M.Schurer Patrícia Poeta Md.Tanvir Rahman Shi-Zhu Li Kokouvi Kassegne Kun Yin Yong-Zhang Zhu Shang Xia Lu He Qin-Qin Hu le-Shan Xiu Jing-Bo Xue han-Qing Zhao Xi-han Wangv Logan Wu Xiao-Kui Guo Zhao-Jun Wang Bernhard Schwartländer Ming-Hui Ren Xiao-Nong Zhou School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China Institute of One Health Shanghai Jiao Tong UniversityShanghaiPeople’s Republic of China Medical Ethics and Humanities Unit Hong Kong UniversityHong KongPeople’s Republic of China Center for One Health University of Global Health EquityButaroRwanda Microbiology and Antibiotic Resistance Team Department of Veterinary SciencesUniversity of Trás-os-Montes and Alto DouroVila RealPortugal Associate Laboratory for Green Chemistry Chemistry DepartmentUniversity Nova of LisbonLisbonPortugal Veterinary and Animal Research Centre University of Trás-os-Montes and Alto DouroVila RealPortugal Associate Laboratory for Animal and Veterinary Sciences University of Trás-os-Montes and Alto DouroVila RealPortugal Department of Microbiology and Hygiene Bangladesh Agricultural UniversityMymensinghBangladesh National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesShanghaiPeople’s Republic of China Walter and Eliza Hall Institute ParkvilleAustralia Department of Medical Biology University of MelbourneMelbourneAustralia German Ministry of Foreign Affairs(Former Assistant Director General and Chef de Cabinet of Dr Tedros at the World Health Organization) BerlinGermany School of Public Health Peking UniversityBeijingPeople’s Republic of China

Background One Health approach is crucial to tackling complex global public health threats at the interface of humans, animals, and the environment. As outlined in the One Health Joint Plan of Action, the international One Health community includes stakeholders from different sectors. Supported by the Bill & Melinda Gates Foundation, an academic community for One Health action has been proposed with the aim of promoting the understanding and real-world implementation of One Health approach and contribution towards the Sustainable Development Goals for a healthy *** text The proposed academic community would contribute to generating high-quality scientific evidence, distilling local experiences as well as fostering an interconnected One Health culture and mindset, among various stakeholders on different levels and in all sectors. The major scope of the community covers One Health governance, zoonotic diseases, food security, antimicrobial resistance, and climate change along with the research agenda to be developed. The academic community will be supported by two committees, including a strategic consultancy committee and a scientific steering committee, composed of influential scientists selected from the One Health information database. A workplan containing activities under six objectives is proposed to provide research support, strengthen local capacity, and enhance global *** The proposed academic community for One Health action is a crucial step towards enhancing communication, coordination, collaboration, and capacity building for the implementation of One Health. By bringing eminent global experts together, the academic community possesses the potential to generate scientific evidence and provide advice to local governments and international organizations, enabling the pursuit of common goals, collaborative policies, and solutions to misaligned interests.

关键词： One Health Global health Academic community

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Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang fei Long Liyuan han Qifeng han Yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

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Towards a global One Health index: a potential assessment tool for One Health performance

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Infectious Diseases of Poverty 2022年第3期11卷 12-26页

作者： Xiao-Xi Zhang Jing-Shu Liu le-fei han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China One Health Center Shanghai Jiao Tong University-The University of EdinburghShanghaiPeople’s Republic of China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesShanghaiPeople’s Republic of China Shanghai legislative Research Institute ShanghaiPeople’s Republic of China Zhuhai Branch ESPREBeijing Normal University Zhuhai CampusZhuhaiGuangdongPeople’s Republic of China Global Health Academy The University of EdinburghEdinburghUK Food and Agriculture Organization of the United Nations RomeItaly Global Academy of Agriculture and Food Systems The University of EdinburghEdinburghUK Swiss Tropical and Public Health Institute AllschwilSwitzerland University of Basel BaselSwitzerland

Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently ***:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the ***:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be ***:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the

关键词： Antimicrobial resistance Cell-like framework Climate change Food security Global One Health index(GOHI) Global performance assessment Governance Zoonotic diseases

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A One Health information database based on standard bibliometric analysis

Science in One Health

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Science in One Health 2022年第1期1卷 82-89页

作者： Ne Qiang Si-Yu Gu Xin-Yi Wang Xiao-Xi Zhang Shang Xia Jin-Xin Zheng Wen-Feng Gong Robert Bergquist Jin-Jun Ran le-fei han School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghai200025China One Health Center Shanghai Jiao Tong University-The University of EdinburghShanghai200025China National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghai200025China Department of Nephrology Institute of NephrologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Bill&Melinda Gates Foundation Beijing OfficeBeijingChina Geospatial Health Ingerod 407S-45494BrastadSweden School of Public Health Shanghai Jiao Tong University School of MedicineShanghai200025China

Background:One Health is an integrated concept of health that aims to optimize the health of humans,animals,plants,and the *** research gaps and specific expertise areas is important for understanding the role of One Health in *** information on One Health could be used to promote collaboration and research,inspire innovative ideas,and accelerate the translation of evidence-based practices into ***:We searched the Scopus database for publications related to One Health between 2012 and 2021 to extract bibliometric information and investigate the possibility of establishing a dedicated expertise *** matched scholarly information using SciVal to exclude duplicate information and identify scholars’affiliations,countries,and academic *** academic contributions to One Health were evaluated according to their citations,publication impact,publication type,and author ***:A total of 8,313 publications on One Health over a ten-year period were identified,with the number of publications increasing over *** largest number of publications came from the United States and the United *** countries also had the highest number of experts and a high level of international *** identified 500 scholars from 53 countries and 313 affiliations with a median Hirsch Index of 20 who could be included in a One Health expert *** scientists had a median of six publications on One Health,with topics mostly focusing on dengue and antimicrobial ***:A One Health information database could be used as a third-party reference for scholars,a source to track the ongoing academic progress,and support for active scholars in this field of research.

关键词： One Health Database Experts Bibliometric analysis

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A Peridynamics-Based Finite Element Method(PeriFEM)for Quasi-Static Fracture Analysis

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Acta Mechanica Solida Sinica 2022年第3期35卷 446-460页

作者： fei han Zhibin Li State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of TechnologyDalian 116023China

In this paper,a peridynamics-based finite element method(PeriFEM)is proposed for the quasi-static fracture analysis,which is of the consistent computational framework with the classical finite element method(FEM).First,the integral domain of peridynamics is reconstructed,and a new type of element called peridynamic element(PE)is *** PEs are generated by the continuous elements(CEs)of classical FEM,they do not affect each ***,spatial discretization is performed based on PEs and CEs,and the linear equations about nodal displacement are established according to the principle of minimum potential ***,cracks are characterized as degradation of the mechanical properties of ***,the validity of the proposed method is demonstrated through numerical examples.

关键词： Peridynamics Finite element method Fracture Damage

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Corrigendum to‘A One Health information database based on standard bibliometric analysis’[Science in One Health 1(2022)100012]

Science in One Health

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Science in One Health 2022年第1期1卷 91-92页

Following publication of the original article[1],it was found the number of countries with identified One Health publications was incorrectly shown in Table 2,Supplementary data-Multimedia component 3(Table-S2),corresponding text and Fig.3,which should be corrected to *** number of countries with 500 One Health experts identified should be corrected to 53 in the abstract.

关键词： One database Table

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