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Chinese Journal of Polymer Science 2017年第7期35卷 837-845页

作者： le-yuan Song 蒋妮甘志华 State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials College of Life Science and Technology Beijing University of Chemical Technology Beijing 100029 China

Porous hybrid microspheres were fabricated by the synthesized calcium gluconate-g-poly（D,L-lactide）（CG-g- PDLLA） composites. These hybrid microspheres were treated with an alkaline solution for different period of time to control the amount of generated carboxylate groups and remained CG on the surface. The microspheres were then incubated in a supersaturated simulated body fluid （1.5 SBF） solution for different time to investigate their biomimetic mineralization behavior. The depositions were found to have a fine cluster morphology, a similar crystal structure and chemical structure to natural hydroxyapatite, and a medium Ca/P of approximately 1.30. The effect of surface treating time on the structure and mineralization behavior of these microspheres has been discussed in detail. The results indicate that the nucleation and growth of apatite on the surface are influenced by the induced carboxylate groups and the remained CG. The hybrid CG-g- PDLLA microspheres have the potential as a novel alternative in bone tissue engineering.

关键词： Calcium gluconate Poly(D,L-lactide) Mineralization Hydroxyapatite Porous microspheres

A modified Tikhonov regularization method for a Cauchy problem of a time fractional diffusion equation

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Applied Mathematics(A Journal of Chinese Universities) 2019年第3期34卷 284-308页

作者： CHENG Xiao-liang yuan le-le LIANG Ke-wei School of Mathematical Sciences Zhejiang University

In this paper,we consider a Cauchy problem of the time fractional diffusion equation(TFDE)in x∈[0,L].This problem is ubiquitous in science and engineering *** illposedness of the Cauchy problem is explained by its solution in frequency ***,the problem is formulated into a minimization problem with a modified Tikhonov regularization *** gradient of the regularization functional based on an adjoint problem is deduced and the standard conjugate gradient method is presented for solving the minimization *** error estimates for the regularized solutions are obtained under Hp norm priori bound ***,numerical examples illustrate the effectiveness of the proposed method.

关键词： Cauchy problem time-fractional diffusion equation a modified Tikhonov regularization method conjugate gradient method error estimates

Immobilization of antimony in soil and groundwater using ferro-magnesium bimetallic organic frameworks

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Journal of Environmental Sciences 2023年第3期125卷 194-204页

作者： le yuan JianleWang Zuqi Zhong Jiguang Li Hong Deng School of Environment and Energy Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Resource RecyclingSouth China University of TechnologyGuangzhou 510006China Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation Beibu Gulf UniversityQinzhou 535000China Guangdong Engineering and Technology Research Center for Environmental Nanomaterials South China University of TechnologyGuangzhou 510006China

Sb(Ⅲ) is often detected in contaminated soil and groundwater. Hence, high-efficiency technology is needed. In this study, bimetallic organic frameworks were used for the first time to immobilize Sb(Ⅲ) from contaminated soil and groundwater. The materials were synthesized by the hydrothermal method. Both ends of the prepared material were hexagonal tip rods,and the length became shorter as the ratio of Fe/Mg decreased. The bimetallic organic framework with a Fe/Mg feeding ratio of 0.5 was the optimum material for Sb(Ⅲ) removal, which could effectively immobilize Sb(Ⅲ). The adsorption isotherm was fitted well with the Freundlich model, and the optimal adsorption capacity can reach 106.97 mg/g. The adsorption capacity of 84% can be completed in 10 min, which conformed to the pseudo-second-order kinetics. The Fe^(3+)could enhance the stability of the material, and the Mg^(2+)was conducive to freeing up adsorption sites for binding Sb(Ⅲ) and forming stable chemical adsorption. Ion exchange is the predominant mechanism to remove Sb(Ⅲ). After 14 days of remediation of Sb(Ⅲ) contaminated soil, the Toxicity Characteristic leaching Procedure(TCLP)-leached concentrations of Sb(Ⅲ) were reduced by 86%, 91% and 94% when the material dosages were1%, 2% and 3%, respectively. Immobilization of Sb(Ⅲ) in soil resulted in a conversion of antimony speciation from more easily bioavailable species to less bioavailable species, further contributing to reduce the environmental risk of antimony. The results indicate that ferromagnesium bimetallic organic frameworks may serve as a kind of promising materials for the immobilization of Sb(Ⅲ) in contaminated soil and groundwater.

关键词： Antimony Ferro-magnesium bimetallic organic frameworks(MOFs) Soil Groundwater

Irbesartan drug formulated as nanocomposite particles for the enhancement of the dissolution rate

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Particuology 2012年第4期10卷 462-467页

作者： Zhiliang Zhang yuan le Jiexin wang Hong Zhao Jianfeng Chen State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029.China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China

Irbesartan （IBS）, an angiotensin II receptor antagonist, is a poorly water-soluble drug. To enhance the dis- solution rate, IBS nanocomposite particles were produced via an anti-solvent precipitation combined with a spray drying process. Four pharmaceutically acceptable excipients, including three different polymers and one charged surfactant, were evaluated as stabilizers to control the particle size and to prevent the agglomeration of particles. The experiment results indicated that polyvinylpyrrolidone （PVP） combined with sodium dodecyl sulfate （SDS） significantly decreased the particle size and enhanced the stability of drug nanoparticles. As a result, we finally obtained stable IBS nanoparticles with an average size of approx- imately 55 nm. In the dissolution test, the IBS nanocomposite particles showed a significantly enhanced dissolution rate and 100% of the drug dissolved within 20 rain. In contrast, the physical mixture with the same recipe as the IBS nanocomposite particles and the raw 1BS reached only 8% and 40% of drug dissolved in 20 rain, respectively, and both of them did not dissolve completely, even after 120 rain.

关键词： lrbesartanComposite particlesStabilizerDissolution rate

Molecular Cloning and Expression Analysis of an Actin Gene from Chinese Licorice(Glycyrrhiza uralensis Fisch)

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Chemical Research in Chinese Universities 2009年第3期25卷 357-361页

作者： WANG Fang DONG le yuan Jian-jun Department of Biology School of Chemical and Biology Science Quanzhou Normal University Quanzhou 362000 P R. China

A PCR-based homologous cloning strategy was used to identify an actin gene from the roots of Chinese licorice（Glycyrrhiza uralensis Fisch）. Results of sequence analysis indicate that a 1137 bp cDNA with an open reading frame encoding 377 amino acids, actin ortholog, GuActin, was successfully cloned and characterized（GenBank accession No. EU190972）. Thus far, GuActin is the first actin of Chinese licorice that has been identified at a molecular level. Analysis by Northern blot shows that GuActin was expressed strongly in the roots, particularly in radicles than in stems and leaves. These results suggest that GuActin may be a member of the vegetative subfamily of the actin family.

关键词： Actin Gene cloning Chinese licorice(Glycyrrhiza uralensis Fisch) Gene expression

Transcriptome of hepatopancreas in kuruma shrimp Marsupenaeus japonicus under low-salinity stress

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Journal of Oceanology and Limnology 2022年第2期40卷 745-765页

作者： Tingjun CHEN Zhimin LI Jianyong LIU Caifeng LIANG le yuan Guangdong Ocean University Zhanjiang 524088China Guangdong Provincial Shrimp Breeding and Culture Laboratory Guangdong Ocean UniversityZhanjiang 524088China

The kuruma shrimp Marsupenaeus japonicus is one of the most commercially important shrimp species in the *** salinity would aff ect the penetration and immunity,and even led to its death of the ***,little is known about the molecular mechanism of the ***,hepatopancreas of *** reared under low-salinity stress for 6,12,24,48,and 96 h was analyzed and the results were compared with that of the control group using *** removing reads containing adapters,88890960-1051300444 clean reads were generated from 10 libraries in the control group and experimental *** with the control group,811,589,1095,745,and 875 diff erentially expressed genes were obtained in the five treatment *** N50 and N90 lengths of the transcripts were 1746 bp and 436 bp,*** top 20 gene ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways associated with the diff erentially expressed genes were related mainly to osmotic regulation(ion exchange,lipid metabolism and carbohydrate metabolism),immune regulation(cellular and humoral immunity),chitin metabolism,and related *** diff erential expression patterns of nine randomly selected genes were confi rmed by quantitative real-time *** is the fi rst report of osmotic regulation-related genes that are diff erentially expressed under low-salinity stress in the hepatopancreas of ***,we found that *** initiated its own immune regulation under low-salinity *** results will help elucidating the mechanism of osmotic regulation and immune responses in this shrimp species.

关键词： Marsupenaeus japonicus transcriptome osmotic regulation immune responses

High-gravity technology intensified Knoevenagel condensation-Michael addition polymerization of poly (ethylene glycol)-poly (n-butyl cyanoacrylate) for blood-brain barrier delivery

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Chinese Journal of Chemical Engineering 2022年第6期35卷 94-103页

作者： Xingzheng Liu Chuanbo Fu Manting Wang Jiexin Wang Haikui Zou yuan le Jianfeng Chen State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Centre of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China

Poly(ethylene glycol)-poly(n-butyl cyanoacrylate)(PEG-PBCA)is a remarkable drug delivery carrier for permeating blood-brain *** this work,a novel high-gravity procedure was reported to intensify Knoevenagel condensation-Michael addition polymerization of PEG-PBCA.A series of PEG-PBCA containing different block ratios were synthesized with narrow molecular weight distribution of polydispersity indexes less than ***,the reaction time reduced 60%compared to conventional stirred tank reactor *** structures of as-prepared polymers were *** vitro drug delivery performance was *** cytotoxicity of PEG-PBCA to brain microvessel endothelial cells(BMVEC)decreases with the extension of the PEG chain and the shortening of the PBCA *** polymer cellular uptake to BMVECs was better after improving hydrophilicity by PEG *** of bloodbrain barrier permeability demonstrated that medium length of PBCA chain and short PEG chain are favorable for hydrophobic Nile red permeation,while long PEG chain and short PBCA chain are beneficial to delivery water-soluble doxorubicin hydrochloride(Dox).The average apparent permeability coeffi-cient increased 1.7 and 0.25 times than that of raw Nile red and Dox,***-gravity intensi-fied condensation polymerization should have great potential in brain drug delivery system.

关键词： High-gravity technology Knoevenagel condensation-Michael addition polymerization Poly(ethylene glycol)-poly(n-butyl cyanoacrylate) Blood-brain barrier Polymerization Reactors

Recent progress on smart hydrogels for biomedicine and bioelectronics

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Biosurface and Biotribology 2022年第3期8卷 212-224页

作者： Fa Zou Jiefang Xu le yuan Qinyong Zhang Lili Jiang Key Laboratory of Fluid and Power Machinery of Ministry of Education School of Materials Science and EngineeringXihua UniversityChengduChina School of Literature Journalism and CommunicationXihua UniversityChengduChina Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina

The increasing development of biomedicine and bioelectronics has highlighted the requirement for smart materials that can respond to changes in physical and chemical properties under external environments,such as magnetic fields,electric fields,and ***,hydrogels have been widely evaluated as promising candidates for smart materials owing to their intriguing structures comprising a cross‐linked network of polymer chains with interstitial spaces filled with solvent *** feature endows hydrogels with soft and wet characteristics,which not only induce high tissue affinity but also allow the introduction of environmentally responsive nanoparticles to release specific smart ***,we reviewed novel smart hydrogels that can be applied in biomedicine and bioelectronics,and highlighted and discussed existing challenges in current technologies and research.

关键词： bioelectronics biomedicine electrical response magnetic response smart hydrogel thermo‐responsive

Simulation Optimization： A Review on Theory and Applications

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自动化学报 2013年第11期39卷 1957-1968页

作者： WANG Long-Fei SHI le-yuan Department of Industrial Engineering and Management Collegeof Engineering Peking University Beijing 100871 China

模拟优化是在复杂真实系统的分析和优化的一个很强大的工具。在这份报纸，模拟优化的教程介绍和评论被给。模拟优化问题根据决定变量的内在的结构被分类(分离或连续) 。并且为模拟优化的一些重要技术详细被讨论包括他们的原则，实现过... 详细信息

模拟优化是在复杂真实系统的分析和优化的一个很强大的工具。在这份报纸，模拟优化的教程介绍和评论被给。模拟优化问题根据决定变量的内在的结构被分类(分离或连续) 。并且为模拟优化的一些重要技术详细被讨论包括他们的原则，实现过程，优点和劣势，并且应用。未来研究方向也在这篇论文被提供。

关键词：仿真优化应用程序综述结构分类优化问题

Penetrating remote sensing:Next-generation remote sensing for transparent earth

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The Innovation 2023年第6期4卷 15-16页

作者： Lizhe Wang Boxin Zuo yuan le Yifu Chen Jun Li International Research Center of Big Data for Sustainable Development Goals Beijing 100094China School of Computer Science China University of GeosciencesWuhan 430074China School of Geography and Information Engineering China University of GeosciencesWuhan 430074China

Building upon a unified theoretical framework(based on electromagnetic principles and considering interactions with the Earth’s subsurface materials),we consider a synergistic blend of high-spectral,electromagnetic,and diverse multi-physics techniques to introduce a new concept of penetrating remote *** seamlessly amalgamating the interplay between multiple physical fields,penetrating remote sensing allows us to understand the Earth from its surface to its interior,effectively uncovering information about the planet’s internal *** outcome of this new concept encompasses detailed imagery and three-dimensional models,offering insights into the distribution,structure,properties,and dynamic behavior of materials residing within the *** empowers us to delve into the profound layers of the Earth,unveiling its structural composition and evolutionary *** deeper understanding encompasses vital aspects concerning the Earth’s crust,mantle,and core,comprehending temperature distributions,flow patterns,and other crucial information that enriches our knowledge of the planet’s interior.

关键词： Earth planet interior