检索结果-南通市图书馆

Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： Xi-Guang Cao Yan-Long Chang Kai Chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-Yuan Huang Ze-Yu Huang lei Lang Yu-Lan Li Zhi-Jie Li Tian-Yu Liang Jun Liu Chen-Gui Lu Fa-Tai Mai Yuan Mei Hao Qiu Xiang-Ming Sun xiao-Xing Tang Hu-Lin Wang Qian-Ming Wang le xiao Mu-Yun xiao Jian-Yu Xin Nu Xu Peng Yang Yi-Chen Yang Zhen Yang Zong-Yang Yu Dong-Liang Zhang Jun-Wei Zhang Cheng-Xin Zhao Dou Zhu NνDEx-100 collaboration Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Lanzhou University Lanzhou 730000China Central China Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA North China University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle physics.Observing such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number violation.We propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx experiment.Besides being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological characteristics.This makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββsearches.NvDEx-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by 2025.This report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82)SeF_(6) China Jinping Underground Laboratory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiple disciplinary team management of rare primary splenic malignancy:Two case reports

引用

World Journal of Clinical Cases 2022年第29期10卷 10535-10542页

作者： Hao Luo Tao Wang le xiao Chao Wang Hai Yi Department of General Surgery Center General Hospital of Western TheaterChengdu 610083Sichuan ProvinceChina Department of Pathology General Hospital of Western TheaterChengdu 610083Sichuan ProvinceChina Department of Hematology General Hospital of Western TheaterChengdu 610083Sichuan ProvinceChina

BACKGROUND Malignant splenic tumors are rare but fatal,presenting a challenge in diagnosis and management involving hematology,oncology,and general surgery.By contrast,diagnosing and treating other common malignant tumors(such as lung and gastrointestinal cancer)offers multiple strategies for chemotherapy,radiotherapy,targeted therapy,and immunotherapy with the prospect of a cure.With various specialists involved in clinical multiple disciplinary team(MDT)discussion,personal bias can be minimized.It can also ignite important discussion which can benefit not only one patient but many patients.CASE SUMMARY Here,we report on the MDT diagnosis and management of the malignant splenic tumors littoral cell angiosarcoma and histiocytic sarcoma.Although only two cases of rare primary splenic malignancy are presented,MDT is a novel means of rare disease treatment.CONCLUSION To benefit patients,imaging analysis,safe operation,precise pathology examination,and individualized therapeutic treatment strategies are required.The involvement of various specialists in a clinical MDT discussion minimizes personal bias and can create important ideas to benefit all patients.

关键词： Multiple disciplinary team Splenic malignancy Littoral cell angiosarcoma Histiocytic sarcoma Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Abnormal function of EPHA2/p.R957P mutant in congenital cataract

引用

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1007-1017页

作者： Jing-Jin Zhang Zong-Fu Cao Bi-Ting Zhou Ju-Hua Yang Zhong Li Shuang Lin xiao-le Chen Nan-Wen Zhang Qin Ye Xu Ma Yi-Hua Zhu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFujian Institute of OphthalmologyFujian Provincial Clinical Medical Research Center of Eye Diseases and OptometryFuzhou 350005Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100000China National Human Genetic Resources Center National Research Institute for Family PlanningBeijing 100081China Department of Bioengineering and Biopharmaceutics School of PharmacyFujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To identify genetic defects in a Chinese family with congenital posterior polar cataracts and assess the pathogenicity.METHODS:A four-generation Chinese family affected with autosomal dominant congenital cataract was recruited.Nineteen individuals took part in this study including 5 affected and 14 unaffected individuals.Sanger sequencing targeted hot-spot regions of 27 congenital cataract-causing genes for variant discovery.The pathogenicity of the variant was evaluated by the guidelines of American College of Medical Genetics and InterVar software.Confocal microscopy was applied to detect the subcellular localization of fluorescence-labeled ephrin type-A receptor 2(EPHA2).Co-immunoprecipitation assay was implemented to estimate the interaction between EphA2 and other lens membrane proteins.The mRNA and protein expression were analyzed by reverse transcription-polymerase chain reaction(qRT-PCR)and Western blotting assay,respectively.The cell migration was analyzed by wound healing assay.Zebrafish model was generated by ectopic expression of human EPHA2/p.R957P mutant to demonstrate whether the mutant could cause lens opacity in vivo.RESULTS:A novel missense and pathogenic variant c.2870G>C was identified in the sterile alpha motif(SAM)domain of EPHA2.Functional studies demonstrated the variant’s impact:reduced EPHA2 protein expression,altered subcellular localization,and disrupted interactions with other lens membrane proteins.This mutant notably enhanced human lens epithelial cell migration,and induced a central cloudy region and roughness in zebrafish lenses with ectopic expression of human EPHA2/p.R957P mutant under differential interference contrast(DIC)optics.CONCLUSION:Novel pathogenic c.2870G>C variant of EPHA2 in a Chinese congenital cataract family contributes to disease pathogenesis.

关键词： congenital cataract EPHA2 missense variant function analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Self-enhanced photothermal-chemodynamic antibacterial agents for synergistic anti-infective therapy

引用

Chinese Chemical letters 2023年第2期34卷 452-457页

作者： Ning Guo Yu Xia Yuxi Duan Quanxin Wu le xiao Yaxin Shi Bin Yang Yun Liu Guangdong Key Laboratory for Research and Development of Natural Drugs School of PharmacyGuangdong Medical UniversityZhanjiang 524023China The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's HospitalDepartment of Biomedical EngineeringSchool of Basic Medical SciencesGuangzhou Medical UniversityGuangzhou 511436China The Marine Biomedical Research Institute of Guangdong Zhanjiang 524023China

Cu_(2-x)S nanostructures have been intensively studied as outstanding chemodynamic therapy(CDT)and good photothermal therapy(PTT)antibacterial agents due to their highly efficient Cu(Ⅰ)-initiated Fenton-like catalytic activity and good photothermal conversion property.However,they still suffer from shortage of Cu(Ⅰ)supply in the long-term and comparatively low inherent photothermal conversion efficiency.Herein,we constructed a self-enhanced synergistic PTT/CDT nanoplatform(Cu_(1.94)S@MPN)by coating Cu_(1.94)S nanoparticles with Fe(Ⅲ)/tannic acid based metal-polyphenol networks(MPN).Activated by the acidic bacterial infection microenvironment,Cu_(1.94)S@MPN could be decomposed to continuously release Cu(Ⅱ),Fe(Ⅲ)ions and tannic acid.As the result of tannic acid-involved Cu and Fe redox cycling,Cu(Ⅰ)/Fe(Ⅱ)-rich CDT could be achieved through the highly accelerated catalytic Fenton/Fenton-like reactions.More importantly,experimental results demonstrated that Cu_(1.94)S@MPN exhibited both excellent photothermal antibacterial and photothermal-enhanced CDT properties to eradicate bacteria in vitro and in vivo.Overall,this novel nanotherapeutics has great potential to become a clinic candidate for anti-infective therapy in future.

关键词： Antibacterial Self-enhanced Photothermal therapy Chemodynamic therapy Anti-infective therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

人文经济学:中国式现代化的文化自觉

引用

苏州大学学报（哲学社会科学版） 2024年第3期45卷 19-27页

作者：李晓乐江苏科技大学马克思主义学院江苏镇江212003 苏州大学人文经济学研究院江苏苏州215021

促成经济发展与人文价值的互动融合,实现经济发展从“效用经济到人文/公平经济”的深刻转换,是中国式现代化的深层内核和发展愿景,是中国式现代化人文关怀的真谛。但人文经济和市场/效用经济不是截然断裂的,它不是继市场经济之后新生发... 详细信息

促成经济发展与人文价值的互动融合,实现经济发展从“效用经济到人文/公平经济”的深刻转换,是中国式现代化的深层内核和发展愿景,是中国式现代化人文关怀的真谛。但人文经济和市场/效用经济不是截然断裂的,它不是继市场经济之后新生发的经济形态,而恰恰是以现实市场经济体制为基础,通过市场配置资源以实现人文价值的高级经济形态。在具体样态上,人文经济体现为“以人民为中心”的文化经济,一方面强调一切市场经济实践都要以保障人的幸福和尊严为目的,尊重人的生命及其价值,彰显人文关怀,为人的自由全面发展和价值实现创造现实条件;另一方面,以人民大众作为经济社会发展的根本动力,充分重视文化和人文精神在经济发展过程中的积极作用。在此语境中,学界要强化人文经济学基础理论研究;加强人文经济学的基础设施建设;坚持问题导向,运用人文经济学一般原理对中国式现代化进程中人文与经济融合发展的实践、矛盾和问题进行深入研究和分析,总结和提炼人文经济运行发展的规律性认识,为建构中国特色人文经济学提供思想、学科和实践基础。

关键词：中国式现代化人文经济人文关怀人文精神

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

AIGC技术冲击下外语人才培养的破壁与升级

引用

外语学刊 2024年第2期 75-83页

作者：李雪顾晓乐哈尔滨工业大学人文社科学部外国语学院哈尔滨150001

以ChatGPT为代表的生成式人工智能(AIGC)技术的飞速发展,引爆新一轮人工智能革命,同时也使教育领域面临前所未有的变革。本文旨在探讨破解人工智能时代外语学科发展和人才培养困境的方法和路径。文章基于技术的社会建构论和人机协作教... 详细信息

以ChatGPT为代表的生成式人工智能(AIGC)技术的飞速发展,引爆新一轮人工智能革命,同时也使教育领域面临前所未有的变革。本文旨在探讨破解人工智能时代外语学科发展和人才培养困境的方法和路径。文章基于技术的社会建构论和人机协作教育理论,阐释如何在人工智能(AI)时代和“新文科”建设背景下以AI赋能,实现外语人才培养的破壁与升级。文章提出AI时代外语人才培养新路径,包括拓展立德树人途径、加快构建多元课程体系、创新交叉融合型跨学科课程群、重构教学环境、开辟人机协作式教育模式、智能化评价方式,以培养跨学科、跨领域、懂AI的复合型外语人才。文章强调外语界亟须主动求变,从工业化模式向智能化模式转型,既要坚守立德树人的根本任务,又要调整人才培养的重心与方式,形成“师—机—生”三元协同的育人新生态。

关键词：外语人才培养人工智能 AIGC技术技术的社会建构论人机协作教育理论 “新文科”建设

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Associating liver partition and portal vein ligation for staged hepatectomy in the treatment of colorectal cancer liver metastases

引用

World Journal of Gastrointestinal Surgery 2021年第8期13卷 814-821页

作者： Xu-Dong Wen le xiao Department of Gastroenterology and Hepatology Chengdu First People's HospitalChengdu 610016Sichuan ProvinceChina General Surgery Center The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina

Colorectal cancer(CRC)is a common malignancy of the digestive system.Colorectal liver cancer metastasis(CRLM)occurs in approximately 50%of the patients and is the main cause of CRC mortality.Surgical resection is currently the most effective treatment for CRLM.However,given that the remnant liver volume after resection should be adequate,only a few patients are suitable for radical resection.Since Dr.Hans Schlitt first performed the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)for CRLM in 2012,ALPPS has received considerable attention and has continually evolved in recent years.This review explains the technical origin of the ALPPS procedure for CRLM and evaluates its efficacy,pointing to its favorable postoperative outcomes.We also discuss the patient screening strategies and optimization of ALPPS to ensure long-term survival of patients with CRLM in whom surgery cannot be performed.Finally,further directions in both basic and clinical research regarding ALPPS have been proposed.Although ALPPS surgery is a difficult and high-risk technique,it is still worth exploration by experienced surgeons.

关键词： Associating liver partition and portal vein ligation for staged hepatectomy Colorectal liver cancer metastases Portal embolization Portal ligation Two-stage hepatectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新型模块化钢结构插入式连接节点受力性能研究

引用

工程力学 2024年第1期41卷 30-38页

作者：徐龙河杨晓乐张格北京交通大学土木建筑工程学院北京100044

为推广钢结构集成模块在高层建筑及抗震设防区域的应用,提出了一种具有附加耗能的新型全装配模块化钢结构插入式连接节点,节点采用T型连接件代替传统焊接连接实现模块单元全装配,连接件与摩擦板进行相对滑移提供附加耗能。根据节点受力... 详细信息

为推广钢结构集成模块在高层建筑及抗震设防区域的应用,提出了一种具有附加耗能的新型全装配模块化钢结构插入式连接节点,节点采用T型连接件代替传统焊接连接实现模块单元全装配,连接件与摩擦板进行相对滑移提供附加耗能。根据节点受力及变形机理,推导其初始转动刚度理论公式。建立半装配与全装配模块化钢结构插入式连接节点的精细化数值模型,对比分析两种节点的滞回曲线、耗能能力及应力应变分布规律。结果表明,全装配插入式节点具有饱满的类平行四边形滞回曲线,其初始转动刚度理论计算值与数值结果吻合良好,有效验证了节点刚度公式的准确性。与半装配插入式节点相比,全装配插入式节点最大承载力降低约26.59%,整体能量耗散系数最大增加约70.06%,可通过T型连接件将塑性损伤转移至预设区域,保护主要构件并实现损伤可控,显著提高节点的抗震性能。

关键词：模块化钢结构全装配插入式连接节点数值模拟理论初始转动刚度附加耗能损伤可控

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

老年科护士对皮肤撕裂伤的认知现状及影响因素研究

引用

护理学杂志 2024年第2期39卷 69-71页

作者：张茵梁霄王玫范柏林乐霄华中科技大学同济医学院附属同济医院综合医疗科/老年医学科湖北武汉430030

目的了解老年科护士对皮肤撕裂伤的认知现状,分析其影响因素,为开展相关培训提供参考。方法采用便利抽样法,使用一般资料调查表、皮肤撕裂伤知识评估工具对武汉市3所三级甲等综合医院的286名老年科护士进行横断面调查。结果老年科护士... 详细信息

目的了解老年科护士对皮肤撕裂伤的认知现状,分析其影响因素,为开展相关培训提供参考。方法采用便利抽样法,使用一般资料调查表、皮肤撕裂伤知识评估工具对武汉市3所三级甲等综合医院的286名老年科护士进行横断面调查。结果老年科护士的皮肤撕裂伤认知得分为(9.53±2.02)分。老年科护士对皮肤撕裂伤认知正确率排名前5个条目分属于特殊群体、病因学、分类和观察维度;排名最低的5个条目分属于预防、治疗和风险评估维度。影响老年科护士对皮肤撕裂伤认知水平的主要因素为学历、工作年限、是否为专科护士、皮肤撕裂伤相关培训(均P<0.05),共解释总变异的31.7%。结论老年科护士对皮肤撕裂伤认知水平处于中等偏低水平,对与临床实践相关的预防、治疗和风险评估认知相对不足,应加强相关培训,提高老年科护士对皮肤撕裂伤的关注度,从而提高皮肤撕裂伤整体预防及护理水平。

关键词：老年人皮肤撕裂伤护士风险评估预防治疗认知培训影响因素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

近边界条件下水下爆炸冲击波信号特征研究

引用

舰船科学技术 2024年第4期46卷 6-9页

作者：沈晓乐高鑫中国人民解放军91439部队辽宁大连116041

水下爆炸试验过程中,实测冲击波压力信号很容易产生畸变,对试验结果评估造成困难。通过梳理过往实测试验数据发现,不同介质声学阻抗差异是影响近边界条件下冲击波传播的关键因素。在水面附近由于空气的声学阻抗小于水介质,冲击波曲线会... 详细信息

水下爆炸试验过程中,实测冲击波压力信号很容易产生畸变,对试验结果评估造成困难。通过梳理过往实测试验数据发现,不同介质声学阻抗差异是影响近边界条件下冲击波传播的关键因素。在水面附近由于空气的声学阻抗小于水介质,冲击波曲线会突然下降,产生明显的水面截断效应;钢结构表面受压力波叠加影响,压力曲线会不同程度的提高;水底附近由于底质的复杂性,其声学阻抗差异较大,实测压力场会受入射波、反射波、前驱波、波后扰动等因素的影响,波形曲线呈现更加复杂的特性。

关键词：水下爆炸冲击波压力声学阻抗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：