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Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients

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World Journal of Clinical Oncology 2024年第2期15卷 290-301页

作者： Nhu thi Hanh Vu Huy Minh le diem thi-Ngoc Vo Hoang Anh Vu Nhan Quang le Dung Dang Quy Ho Duc Trong Quach Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam GI Endoscopy Department University Medical Center at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Histology-Embryology and Pathology University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Center for Molecular Biomedicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Endoscopy Cho Ray HospitalHo Chi Minh 700000Viet Nam

BACKGROUND Sessile serrated lesions(SSLs)are considered precancerous colorectal lesions that should be detected and removed to prevent colorectal *** studies in Vietnam mainly investigated the adenoma pathway,with limited data on the serrated *** To evaluate the prevalence,risk factors,and BRAF mutations of SSLs in the Vietnamese *** this is a cross-sectional study conducted on patients with lower gastrointestinal symptoms who underwent colonoscopy at a tertiary hospital in *** were diagnosed on histopathology according to the 2019 World Health Organi-zation *** mutation analysis was performed using the Sanger DNA sequencing *** multivariate logistic regression model was used to determine SSL-associated *** There were 2489 patients,with a mean age of 52.1±13.1 and a female-to-male ratio of 1:*** prevalence of SSLs was 4.2%[95%confidence interval(CI):3.5-5.1].In the multivariate analysis,factors significantly associated with SSLs were age≥40[odds ratio(OR):3.303;95%CI:1.607-6.790],male sex(OR:2.032;95%CI:1.204-3.429),diabetes mellitus(OR:2.721;95%CI:1.551-4.772),and hypertension(OR:1.650,95%CI:1.045-2.605).The rate of BRAF mutations in SSLs was 35.5%.CONCLUSION The prevalence of SSLs was 4.2%.BRAF mutations were present in one-third of *** risk factors for SSLs included age≥40,male sex,diabetes mellitus,and hypertension.

关键词： Colorectal cancer Sessile serrated lesion BRAF mutation Risk factors Diabetes mellitus Hypertension

How to"pick up"colorectal serrated lesions and polyps in daily histopathology practice:From terminologies to diagnostic pitfalls

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World Journal of Clinical Oncology 2024年第9期15卷 1157-1167页

作者： Thai H Tran Vinh H Nguyen diem TN Vo Department of Pathology Da Nang HospitalDa Nang 50000Viet Nam Department of Pathology University Medical Center Ho Chi Minh CityHo Chi Minh 70000Viet Nam Department of Histology-Embryology and Pathology University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 70000Viet Nam

Over the last decade,our knowledge of colorectal serrated polyps and lesions has significantly improved due to numerous studies on this group of precursor *** lesions were misleading as benign before 2010,but they are currently reclassified as precancerous lesions that contribute to 30%of colorectal cancer through the serrated neoplasia *** World Health Organization updated the classification for serrated lesions and polyps of the colon and rectum in 2019,which is more concise and applicable in daily *** responsible authors prescribe that“colorectal serrated lesions and polyps are characterized by a serrated(sawtooth or stellate)architecture of the epithelium.”From a clinical standpoint,sessile serrated lesion(SSL)and SSL with dysplasia(SSLD)are the two most significant *** these advancements,the precise diagnosis of SSL and SSLD based mainly on histopathology remains challenging due to various *** review describes the nomenclature and the terminology of colorectal serrated polyps and lesions and highlights the diagnostic criteria and obstacles encountered in the histopathological diagnosis of SSL and SSLD.

关键词： Sessile serrated lesions Sessile serrated lesions with dysplasia Serrated polyps Sessile serrated adenoma Benign hyperplastic polyps Serrated lesions/polyps

Surface PEGylation of hollow mesoporous silica nanoparticles via aminated intermediate

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Progress in Natural Science:Materials International 2019年第6期29卷 612-616页

作者： thi Ngoc Tram Nguyen diem-Huong Nguyen-Tran Long Giang Bach Tran Hoang Du Truong Ngoc Thuy Trang le Dai Hai Nguyen Tra Vinh University Institute of Applied Materials Science Vietnam Academy of Science and Technology Graduate University of Science and Technology Vietnam Academy of Science and Technology Nguyen Tat Thanh University 5. Institute of Research and Development Duy Tan University

A hybrid of organic/inorganic system, hollow mesoporous silica nanoparticles functionalized with poly(ethylene glycol), was synthesized in the presence of coupling agent and aminated ends. Doxorubicin(DOX) was used as a model drug to evaluate the effect of PEGylation on the loading capacity and release pattern of the *** with transmission electron microscopy(TEM) and scanning electron microscopy(SEM), X-ray diffraction(XRD), nitrogen adsorption-desorption, thermogravimetric analysis(TGA) and Fourier transformed infrared(FTIR) confirmed the PEG conjugation, as well as the amorphous mesoporous nature of the synthesized particles. Due to the capping effect of PEG molecules over the pores in the silica structure, the synthesized system was able to retain higher amount of cargo and establish a controlled manner when releasing.

关键词： Hollow mesoporous silica nanoparticles mPEG PEGylation Surface modification

Response surface method for modeling the removal of carbon dioxide from a simulated gas using water absorption enhanced with a liquid-film-forming device

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Journal of Environmental Sciences 2018年第3期30卷 116-126页

作者： diem-Mai Kim Nguyen Tsuyoshi Imai Thanh-Loc thi Dang Ariyo Kanno Takaya Higuchi Koichi Yamamoto Masahiko Sekine Graduate School of Environmental Sciences and Engineering Yamaguchi University Graduate School of Sciences and Technology for Innovation Yamaguchi University Department of Environmental Science College of Sciences Hue University

this paper presents the results from using a physical absorption process to absorb gaseous CO2mixed with N2using water by producing tiny bubbles via a liquid-film-forming device（LFFD）that improves the solubility of CO2in *** influence of various parameters—pressure,initial CO2concentration,gas-to-liquid ratios,and temperature—on the CO2removal efficiency and its absorption rate in water were investigated and estimated thoroughly by statistical polynomial models obtained by the utilization of the response surface method（RSM）with a central composite design（CCD）.Based on the analysis,a high efficiency of CO2capture can be reached in conditions such as low pressure,high CO2concentration at the inlet,low gas/liquid ratio,and low *** instance,the highest removal efficiency in the RSM–CCD experimental matrix of nearly 80%occurred for run number 20,which was conducted at 0.30 MPa,CO2concentration of 35%,gas/liquid ratio of 0.71,and temperature of 15℃.Furthermore,the coefficients of determination,R^2,were 0.996 for the removal rate and 0.982 for the absorption rate,implying that the predicted values computed by the constructed models correlate strongly and fit well with the experimental *** results obtained provide essential information for implementing this method properly and effectively and contribute a promising approach to the problem of CO2capture in air pollution treatment.

关键词： Carbon dioxide Water dissolution Liquid-film Response surface method (RSM)

Studying on Tyrosinase Inhibition Activity of Some Vietnamese Folk Plants Aims to Use in Skin-Whitening Cosmetics

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American Journal of Plant Sciences 2017年第6期8卷 1319-1328页

作者： Nguyen thi my Hanh Nguyen Kim Phi Phung Quach Ngo diem Phuong Department of Plant Biotech and Biotransformation Faculty of Biology-Biotechnology University of Science Vietnam National University-Ho Chi Minh City Ho Chi Minh City Vietnam Department of Organic Chemistry Faculty of Chemistry University of Science Vietnam National University-Ho Chi Minh City Ho Chi Minh City Vietnam

White mulberry Morus alba and jackfruit Artocarpus heterophyllus are two of seven chosen Vietnamese folk plants which showed the highest tyrosinase inhibition activity. Besides, both of them showed antioxidant and antibacterial activities. Especially, the Sulforhodamine B (SRB) assay test result of the root core extract of M. alba figured out its non-toxicity on foreskin fibroblasts.

关键词： Morus alba Tyrosinase Inhibition Activity Antibacterial Antioxidant

软木塞基碳量子点的水热合成及其生物相融荧光成像应用

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新型炭材料 2022年第3期37卷 595-602页

作者： Quang Ngo Khoa Hieu Nguyen Ngoc Bao Vo Van Quoc Phuoc Vo thi Ngoc le Xuan diem Doc Luong Quang Tri Nguyen Minh Son le Vu Truong Son le Van Thanh Ha Che thi Cam University of Sciences Hue University77 Nguyen HueHueVietnam Faculty of Environmental and Natural Sciences Duy Tan UniversityDa Nang550000Vietnam Institute for Research and Training in Medicine Biology and PharmacyDuy Tan UniversityDa Nang550000Vietnam University of Agriculture and Forestry Hue University102 Phung HungHueVietnam University of Science and Education The University of Da Nang459 Ton Duc ThangLien ChieuDa NangVietnam

以废弃酒瓶软木塞为原料,采用低成本、简单的水热方法合成碳量子点。通过TEM、FTIR、Raman、UV-Vis、PL光谱对碳量子点的结构和光学性能进行分析表征。结果表明,碳量子点的平均直径为6.2±2.7 nm,PL激发谱和碳量子点表面的官能团有关。... 详细信息

以废弃酒瓶软木塞为原料,采用低成本、简单的水热方法合成碳量子点。通过TEM、FTIR、Raman、UV-Vis、PL光谱对碳量子点的结构和光学性能进行分析表征。结果表明,碳量子点的平均直径为6.2±2.7 nm,PL激发谱和碳量子点表面的官能团有关。用硫酸奎宁作为参考,碳量子点的量子效率为1.54%。将获得的碳量子点应用在骨髓间充质干细胞的细胞生物成像上,发现用碳量子点处理后,骨髓间充质干细胞分别在320~380 nm、450~490 nm和450~490 nm范围显示绿色、黄色和红色荧光,表明了碳量子点在荧光成像领域具有潜在的应用价值。

关键词：碳点水热合成荧光荧光图像废酒瓶塞

Co-Infection of Parvovirus B19, CMV and BK Virus after Renal Transplantation

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International Journal of Clinical Medicine 2018年第11期9卷 820-825页

作者： Hoang thi diem Thuy Department of Nephrology and Endocrinology Children Hospital 2 Ho Chi Minh City Vietnam

Background: Parvovirus B19 is the agent causing a regenerative anemia in organ transplant recipients, due to their immunodepressive status. The diagnosis is usually confirmed by the presence of virus in the blood and bone marrow via the PCR technique. There is a potential co-infection with other opportunistic viruses in the transplanted patients. However, this population is not routinely screened for Parvovirus B19 infection. Case Report: A 14-year-old male patient who received living-donor kidney transplantation developed a severely progressive and aregenerative anemia four weeks later. PCR of Parvovirus B19 was positive from bone marrow aspiration. There were concomittant CMV and BK virus co-infection. The treatment included a reduction of immunosuppressants, intravenous gamma globulin. Valganciclovir has been prescribed for three months that could negativate the CMV blood load. At the end, there was an eradication of parvovirus in the bone marrow. Conclusion: this first reported case in Viet Nam which informed that infection with Parvovirus B19 should be investigated in the transplanted population when a regenerative anemia is present. Otherwise, a screening strategy for Parvovirus B19 should also be considered.

关键词： Parvovirus Kidney Transplantation Co-Infection

ROR2 regulates the survival of murine osteosarcoma cells in lung capillaries

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 611-621页

作者： diem thi Phuong Tran Takahiro Kuchimaru Mongkol Pongsuchart Kha The Nguyen John Clyde Co Soriano Tetsuya Kadonosono Shinae Kizaka-Kondoh School of Life Science and Technology Tokyo Institute of TechnologyYokohama 226-8501Japan Center for Molecular Medicine Jichi Medical UniversityTochigi 329-0498Japan

Aim:Lung metastasis is a leading cause of death in patients with osteosarcoma(OS).No effective therapy exists that improves the five-year overall survival rate of OS patients with ***,finding novel therapeutic targets will help develop new treatment strategies for OS patients with lung ***:Based on analysis of gene expression profiles between sublines of the Dunn OS LM8 cell line with high(LM8-H)and low(LM8-L)metastatic ability,we have identified Wnt signal-related genes that play an important role in lung metastasis of *** of the genes was investigated by establishing sublines of gene knockout and assessing their metastatic ability using a mouse lung metastasis *** molecular mechanism underlying the function of the genes was further investigated by in vitro ***:We have identified that receptor tyrosine kinase-like orphan receptor 2(ROR2),a receptor of the non-canonical Wnt signaling pathway,was involved in OS cell survival in lung capillaries during ***8-H knocked out of Ror2(H/Ror2-KO)significantly reduced lung metastasis by decreasing the viability in lung capillaries 48 h after intravenous *** vitro study revealed that ROR2 increased anoikis resistance through AKT *** of ROR2 expression in H/Ror2-KO cells restored their metastatic ability and viability in lung ***:The results demonstrate a novel ROR2 function in OS lung metastasis and may inform new treatment strategies for OS patients.

关键词： Osteosarcoma lung metastasis cell survival lung capillary ROR2

Case Report: Acute Fatty Liver of Pregnancy

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Open Journal of Obstetrics and Gynecology 2017年第10期7卷 1017-1023页

作者： Huynh Nguyen Khanh Trang Hoang thi diem Tuyet Obstetric and Gynecology Department University of Medicine and Pharmacy Ho Chi Minh City Vietnam High Risk Pregnancy Department Hung Vuong Hospital Ho Chi Minh City Vietnam Hung Vuong Hospital Ho Chi Minh City Vietnam

Acute fatty liver of pregnancy (AFLP) is a rare disease in Vietnam. Diagnosis by recorded literature is often difficult to distinguish from viral hepatitis, paraplegia, or bile duct disease, so AFLP diagnosis is often delayed. The prevalence of hepatitis B in Vietnam in pregnant women is estimated at 10% REF _Ref494526757 \r \h [1], preeclampsia is estimated at 0.2% REF _Ref494526760 \r \h [2]. A case pregnant woman has 35.5-week gestational age with AFLP, who was safely delivered both mother and infant at Hung Vuong hospital, Vietnam. A careful history and physical examination, in conjunction with compatible laboratory and ultrasound imaging results, are often sufficient to make the diagnosis, and liver biopsy is rarely indicated. Intensive adjuvant therapy and rapid birth control are essential for maternal and fetal outcomes.

关键词： Acute Fatty Liver of Pregnancy Expeditious Delivery